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The map label for this gene is iolS [H]

Identifier: 23097901

GI number: 23097901

Start: 471839

End: 472774

Strand: Reverse

Name: iolS [H]

Synonym: OB0446

Alternate gene names: 23097901

Gene position: 472774-471839 (Counterclockwise)

Preceding gene: 23097902

Following gene: 23097900

Centisome position: 13.02

GC content: 36.43

Gene sequence:

>936_bases
ATGGCCCAAAACGTAACACTCGGAAAGTCAAATGTAGTCATTAACCCAATCGGTTTAGGCGCTAATGCAGTAGGTGGTCA
CAATATTTATCCAAATTTAGATGAAGAAGTTGGAAAATCACTCATTCAAACAGGAATAGAAAACGGACTTAATTTTATTG
ATACAGCATATGGTTATGGAAATGGTCGTTCAGAAGAGTTAATTGGACAAGCATTAAAAAGGACGGGAAATCGATCTGAT
GTTGTTCTTGCTACCAAGGCTGCACAAACAGTCATAGATGGAGAAGCAGGATTTAACAATTCCCCATCCTTTTTAAAACA
AGCTGTTGACGACAGTCTTAAACGACTGCAAACCGATTATATTGATTTATTCTATATCCATTTTCCTGATGAAAGCACTC
CGAAAGATGAAGCGGTCGGGGCACTGAAAGAATTAAAAGACGCAGGAAAAATACGGTCTATTGGAATATCAAATTTCTCA
CCAGAGCAAGTGAAAGAGGCAAATAAGGACGGATATGTTGACGTACTACAGGGACATTATAATTTATTAAAACGAGATGC
AGAAACAAATTATTTCCCTTACACATTAGATAATAATATTACCTTTATCCCTTACTTTCCTTTCGCTTCTGGAATATTAG
CAGGTAAATATTCTGTAAATAGTACATTCGAAGACTTCCGCTCTAATATGCCGCATTATCAAGGCGATCAATTTAAACAA
ATACTCGCTAAAGTAGATCAGTTAAAACAGCTTGCTTCGGATAAAAACACGGAAGTTGCCCATATTGTACTAGCTTGGTA
TTTAAAACATGACGCTATTGACGCTGTCATCCCTGGTGCTAAACGACCTGAACAAGTCATTAATAACCTTAAAGCGCTAA
ATGTAACACTTACCGATAATGAATTTCGTATGATTAGTGAACTTTTTGCAAAATAA

Upstream 100 bases:

>100_bases
GTAGTCAGGTTTTTTGGAAACCCTCTTAAAGTTCATTTGCTTGTATGAGCGCTTGTAGACTTTTACAATAGAAATATCAA
AACCTAAAGGAGAGATACAA

Downstream 100 bases:

>100_bases
AAATTGAAGTAAAAAAGTGAGAAGCTTGTACTTAATTTCTGCACTCTATCATATCAGATTTTTAGTATAGAATCTGTATA
TCTTAAGAGGAGCATAAATC

Product: oxidoreductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MAQNVTLGKSNVVINPIGLGANAVGGHNIYPNLDEEVGKSLIQTGIENGLNFIDTAYGYGNGRSEELIGQALKRTGNRSD
VVLATKAAQTVIDGEAGFNNSPSFLKQAVDDSLKRLQTDYIDLFYIHFPDESTPKDEAVGALKELKDAGKIRSIGISNFS
PEQVKEANKDGYVDVLQGHYNLLKRDAETNYFPYTLDNNITFIPYFPFASGILAGKYSVNSTFEDFRSNMPHYQGDQFKQ
ILAKVDQLKQLASDKNTEVAHIVLAWYLKHDAIDAVIPGAKRPEQVINNLKALNVTLTDNEFRMISELFAK

Sequences:

>Translated_311_residues
MAQNVTLGKSNVVINPIGLGANAVGGHNIYPNLDEEVGKSLIQTGIENGLNFIDTAYGYGNGRSEELIGQALKRTGNRSD
VVLATKAAQTVIDGEAGFNNSPSFLKQAVDDSLKRLQTDYIDLFYIHFPDESTPKDEAVGALKELKDAGKIRSIGISNFS
PEQVKEANKDGYVDVLQGHYNLLKRDAETNYFPYTLDNNITFIPYFPFASGILAGKYSVNSTFEDFRSNMPHYQGDQFKQ
ILAKVDQLKQLASDKNTEVAHIVLAWYLKHDAIDAVIPGAKRPEQVINNLKALNVTLTDNEFRMISELFAK
>Mature_310_residues
AQNVTLGKSNVVINPIGLGANAVGGHNIYPNLDEEVGKSLIQTGIENGLNFIDTAYGYGNGRSEELIGQALKRTGNRSDV
VLATKAAQTVIDGEAGFNNSPSFLKQAVDDSLKRLQTDYIDLFYIHFPDESTPKDEAVGALKELKDAGKIRSIGISNFSP
EQVKEANKDGYVDVLQGHYNLLKRDAETNYFPYTLDNNITFIPYFPFASGILAGKYSVNSTFEDFRSNMPHYQGDQFKQI
LAKVDQLKQLASDKNTEVAHIVLAWYLKHDAIDAVIPGAKRPEQVINNLKALNVTLTDNEFRMISELFAK

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436966, Length=309, Percent_Identity=28.1553398058252, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI27436964, Length=309, Percent_Identity=28.1553398058252, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI27436962, Length=309, Percent_Identity=28.1553398058252, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI223718702, Length=300, Percent_Identity=30, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI27436969, Length=310, Percent_Identity=26.7741935483871, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI41152114, Length=301, Percent_Identity=29.5681063122924, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4504825, Length=310, Percent_Identity=26.7741935483871, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI41327764, Length=273, Percent_Identity=31.1355311355311, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI27436971, Length=305, Percent_Identity=25.9016393442623, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI223718708, Length=178, Percent_Identity=30.3370786516854, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI45446745, Length=139, Percent_Identity=33.8129496402878, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503285, Length=139, Percent_Identity=33.8129496402878, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI24497585, Length=166, Percent_Identity=30.1204819277108, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI5453543, Length=144, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI310109922, Length=119, Percent_Identity=36.1344537815126, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI310109920, Length=138, Percent_Identity=34.0579710144928, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788070, Length=320, Percent_Identity=32.1875, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI87081735, Length=315, Percent_Identity=32.0634920634921, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1789375, Length=324, Percent_Identity=30.5555555555556, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788081, Length=274, Percent_Identity=28.8321167883212, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789199, Length=334, Percent_Identity=25.748502994012, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787674, Length=311, Percent_Identity=25.4019292604502, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI87082198, Length=285, Percent_Identity=26.3157894736842, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI48994888, Length=278, Percent_Identity=25.8992805755396, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786400, Length=285, Percent_Identity=28.4210526315789, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212645785, Length=312, Percent_Identity=26.2820512820513, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17561298, Length=312, Percent_Identity=26.9230769230769, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17552492, Length=282, Percent_Identity=25.531914893617, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17561300, Length=307, Percent_Identity=26.0586319218241, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538386, Length=311, Percent_Identity=24.7588424437299, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17566692, Length=312, Percent_Identity=25.3205128205128, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=340, Percent_Identity=28.2352941176471, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323998, Length=317, Percent_Identity=25.5520504731861, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319951, Length=324, Percent_Identity=25.3086419753086, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319958, Length=303, Percent_Identity=25.4125412541254, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322615, Length=247, Percent_Identity=24.2914979757085, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321052, Length=145, Percent_Identity=31.0344827586207, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646159, Length=307, Percent_Identity=27.0358306188925, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646155, Length=313, Percent_Identity=26.1980830670927, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 34369; Mature: 34238

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNVTLGKSNVVINPIGLGANAVGGHNIYPNLDEEVGKSLIQTGIENGLNFIDTAYGYG
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCC
NGRSEELIGQALKRTGNRSDVVLATKAAQTVIDGEAGFNNSPSFLKQAVDDSLKRLQTDY
CCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
IDLFYIHFPDESTPKDEAVGALKELKDAGKIRSIGISNFSPEQVKEANKDGYVDVLQGHY
EEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCCCHHHHHHHH
NLLKRDAETNYFPYTLDNNITFIPYFPFASGILAGKYSVNSTFEDFRSNMPHYQGDQFKQ
HHHHHCCCCCCCCEEECCCEEEEEECCCCCCCEECCCCCCCHHHHHHHCCCCCCCHHHHH
ILAKVDQLKQLASDKNTEVAHIVLAWYLKHDAIDAVIPGAKRPEQVINNLKALNVTLTDN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHEEEEEEECC
EFRMISELFAK
HHHHHHHHHCC
>Mature Secondary Structure 
AQNVTLGKSNVVINPIGLGANAVGGHNIYPNLDEEVGKSLIQTGIENGLNFIDTAYGYG
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCC
NGRSEELIGQALKRTGNRSDVVLATKAAQTVIDGEAGFNNSPSFLKQAVDDSLKRLQTDY
CCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
IDLFYIHFPDESTPKDEAVGALKELKDAGKIRSIGISNFSPEQVKEANKDGYVDVLQGHY
EEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCCCHHHHHHHH
NLLKRDAETNYFPYTLDNNITFIPYFPFASGILAGKYSVNSTFEDFRSNMPHYQGDQFKQ
HHHHHCCCCCCCCEEECCCEEEEEECCCCCCCEECCCCCCCHHHHHHHCCCCCCCHHHHH
ILAKVDQLKQLASDKNTEVAHIVLAWYLKHDAIDAVIPGAKRPEQVINNLKALNVTLTDN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHEEEEEEECC
EFRMISELFAK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]