Click here to switch to the map view.

The map label for this gene is glmS

Identifier: 23097690

GI number: 23097690

Start: 259198

End: 261000

Strand: Direct

Name: glmS

Synonym: OB0235

Alternate gene names: 23097690

Gene position: 259198-261000 (Clockwise)

Preceding gene: 23097689

Following gene: 23097691

Centisome position: 7.14

GC content: 37.66

Gene sequence:

>1803_bases
ATGTGCGGAATCGTCGGTTATATTGGACAAAATGATACAAAAGAAATTTTACTAACAGGTTTAGAAAAGCTAGAATATCG
AGGATATGACTCTGCAGGAATTGCAACGCTAAATGATAATGGCGTTCATGTAACAAAAGTAAAAGGTCGTATTGCTACAT
TGCGTGAGGATGTAGATACGACAATTGATTCTACAATGGGGATTGGGCACACACGTTGGGCAACACATGGTGTACCAAGC
GTAATGAATGCTCATCCACATCAAAGTACTTCTGAAAGATTTACTATTGTTCATAACGGTGTTATTGAAAATTATAATGA
TATTAAAAATGAGTACCTTGCAGATGTATCATTTATAAGTGAAACAGATACAGAAGTAATCGTACAATTAATCGAAAAAC
TTCATGAAAAATATCAAGATACAAAAAAAGCTTTTAGCGAAGCAATGAGCCTGCTTAAAGGTTCTTACGCAATTGGATTA
ATTGATGCGGAAGATAGCGAGACACTTTACGTTTCTAAAAATAAGAGCCCACTATTGGTTGGTTTAGGTGATGGTTTTAA
TCTTGTAGCAAGTGATGCAATGGCTACATTAAGAGAAACAGACCAATACTTGGAAATTTTTGATAAAGAAATCGTACTTG
TAAGCCGCAACTATGTAGAAGTACAAACACTTGATGGTCAAGTGGTAGAGCGTAAGCCTTTCACTGCTGAAATAGATGCA
AGTGATACAGAAAAAGGAACTTACCCTCACTTCATGCTAAAAGAAATTGATGAGCAGCCAATTGTAATGCGTAAAATCAT
CCAAGAGTATCAAAATGACAATGGTCAGTTGAAACTTGATCAAGATATTCGAACAGCTATGAAAGATGCAGATCGAATCT
ATATCATTGCAGCAGGAACAAGTTACCATGCTGGATTAGTTGGTAAAGAATTTATTGAAAAACTAGCGAATATTCCAGTT
GAAGTTCATGTAGCAAGTGAATTCTCATATAACATGCCATTACTATCTGAAAAACCATTATTTGTATTTATCTCACAAAG
TGGAGAAACAGCAGATAGTCGTGCCGTATTAGTAAAAATCAAGGAATTAGGACACCCAGCACTTACACTAACAAATGTGC
CAGGTTCTACTCTTTCTCGTGAAGCAAACTATACCATGCATTTACATGCAGGACCTGAAATTGCTGTTGCTTCAACAAAA
GCATATACAGCGCAAATCGCGGTACTTGCTATATTAGCAGTAGATACAGCAAGAGTGAAGGGTCTTGAATTAGACTTTGA
ACCACTTCAAGAGCTTGCAATTGTTGCAAATGCGATGGAAGTACTAACAGATCAAAAAGAAGAATTAGAACAATTAGCAA
GAGATTATTTCGGAACAACACGCAATGCGTTCTTTATCGGACGTAGCACAGACTACCATGTTGCACAAGAAGCAGCGTTA
AAGCTAAAAGAAATCTCTTATATCCAAGCAGAAGGTTTTGCTGGTGGAGAATTAAAACATGGTACGATCGCGCTAATTGA
AGAAGGAACACCAGTTATTGCGTTAACCACTCAAGAAAATGTAAATTACTCTATTCGCGGAAATGTGCAGGAAGTTGTTG
CTCGTGGAGCAAATGCGATGGTCGTAAGCATGAAAGGTCTAGAGCAAGATGAGGATGCATTCGTAATCCCTCATGTGCAT
GAGCTATTAACACCATTAGCAAGTGTTATCCCAATGCAATTACTAGCGTACTATGCTGCACTTCACCGTGACTGTGACGT
TGATAAGCCAAGAAACTTGGCTAAGTCGGTGACAGTTGAGTAA

Upstream 100 bases:

>100_bases
AAGTTGGTGTTCGCAAGGGTTTTCAAAAAAATTACTCTATTGAACACTCACTTAAAGTCGGTCTTTTTGTCTGCCCCTTT
AATTCAAGGAGGACATCGAC

Downstream 100 bases:

>100_bases
TTGAGGTTTAAACTGAACAGTTACAAAAAAGTCGAAAACCTGACAAAAAAATAGAAACCGATTTGAGTAAAAATATTTTT
AAAGAACAACAGGATTAGCT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MCGIVGYIGQNDTKEILLTGLEKLEYRGYDSAGIATLNDNGVHVTKVKGRIATLREDVDTTIDSTMGIGHTRWATHGVPS
VMNAHPHQSTSERFTIVHNGVIENYNDIKNEYLADVSFISETDTEVIVQLIEKLHEKYQDTKKAFSEAMSLLKGSYAIGL
IDAEDSETLYVSKNKSPLLVGLGDGFNLVASDAMATLRETDQYLEIFDKEIVLVSRNYVEVQTLDGQVVERKPFTAEIDA
SDTEKGTYPHFMLKEIDEQPIVMRKIIQEYQNDNGQLKLDQDIRTAMKDADRIYIIAAGTSYHAGLVGKEFIEKLANIPV
EVHVASEFSYNMPLLSEKPLFVFISQSGETADSRAVLVKIKELGHPALTLTNVPGSTLSREANYTMHLHAGPEIAVASTK
AYTAQIAVLAILAVDTARVKGLELDFEPLQELAIVANAMEVLTDQKEELEQLARDYFGTTRNAFFIGRSTDYHVAQEAAL
KLKEISYIQAEGFAGGELKHGTIALIEEGTPVIALTTQENVNYSIRGNVQEVVARGANAMVVSMKGLEQDEDAFVIPHVH
ELLTPLASVIPMQLLAYYAALHRDCDVDKPRNLAKSVTVE

Sequences:

>Translated_600_residues
MCGIVGYIGQNDTKEILLTGLEKLEYRGYDSAGIATLNDNGVHVTKVKGRIATLREDVDTTIDSTMGIGHTRWATHGVPS
VMNAHPHQSTSERFTIVHNGVIENYNDIKNEYLADVSFISETDTEVIVQLIEKLHEKYQDTKKAFSEAMSLLKGSYAIGL
IDAEDSETLYVSKNKSPLLVGLGDGFNLVASDAMATLRETDQYLEIFDKEIVLVSRNYVEVQTLDGQVVERKPFTAEIDA
SDTEKGTYPHFMLKEIDEQPIVMRKIIQEYQNDNGQLKLDQDIRTAMKDADRIYIIAAGTSYHAGLVGKEFIEKLANIPV
EVHVASEFSYNMPLLSEKPLFVFISQSGETADSRAVLVKIKELGHPALTLTNVPGSTLSREANYTMHLHAGPEIAVASTK
AYTAQIAVLAILAVDTARVKGLELDFEPLQELAIVANAMEVLTDQKEELEQLARDYFGTTRNAFFIGRSTDYHVAQEAAL
KLKEISYIQAEGFAGGELKHGTIALIEEGTPVIALTTQENVNYSIRGNVQEVVARGANAMVVSMKGLEQDEDAFVIPHVH
ELLTPLASVIPMQLLAYYAALHRDCDVDKPRNLAKSVTVE
>Mature_600_residues
MCGIVGYIGQNDTKEILLTGLEKLEYRGYDSAGIATLNDNGVHVTKVKGRIATLREDVDTTIDSTMGIGHTRWATHGVPS
VMNAHPHQSTSERFTIVHNGVIENYNDIKNEYLADVSFISETDTEVIVQLIEKLHEKYQDTKKAFSEAMSLLKGSYAIGL
IDAEDSETLYVSKNKSPLLVGLGDGFNLVASDAMATLRETDQYLEIFDKEIVLVSRNYVEVQTLDGQVVERKPFTAEIDA
SDTEKGTYPHFMLKEIDEQPIVMRKIIQEYQNDNGQLKLDQDIRTAMKDADRIYIIAAGTSYHAGLVGKEFIEKLANIPV
EVHVASEFSYNMPLLSEKPLFVFISQSGETADSRAVLVKIKELGHPALTLTNVPGSTLSREANYTMHLHAGPEIAVASTK
AYTAQIAVLAILAVDTARVKGLELDFEPLQELAIVANAMEVLTDQKEELEQLARDYFGTTRNAFFIGRSTDYHVAQEAAL
KLKEISYIQAEGFAGGELKHGTIALIEEGTPVIALTTQENVNYSIRGNVQEVVARGANAMVVSMKGLEQDEDAFVIPHVH
ELLTPLASVIPMQLLAYYAALHRDCDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=32.4599708879185, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=32.0699708454811, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI1790167, Length=615, Percent_Identity=41.1382113821138, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI87082251, Length=309, Percent_Identity=22.0064724919094, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788651, Length=197, Percent_Identity=24.8730964467005, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=720, Percent_Identity=29.4444444444444, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17532899, Length=718, Percent_Identity=29.2479108635098, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17532897, Length=732, Percent_Identity=28.8251366120219, Blast_Score=261, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6322745, Length=454, Percent_Identity=33.920704845815, Blast_Score=236, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6323731, Length=376, Percent_Identity=29.5212765957447, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=33.1707317073171, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21357745, Length=692, Percent_Identity=32.2254335260116, Blast_Score=327, Evalue=2e-89,
Organism=Drosophila melanogaster, GI28573187, Length=266, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_OCEIH (Q8ETM5)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691156.1
- ProteinModelPortal:   Q8ETM5
- SMR:   Q8ETM5
- GeneID:   1015400
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0235
- NMPDR:   fig|221109.1.peg.236
- HOGENOM:   HBG645312
- OMA:   PSAINSH
- ProtClustDB:   PRK00331
- BioCyc:   OIHE221109:OB0235-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 66226; Mature: 66226

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 595-595

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGQNDTKEILLTGLEKLEYRGYDSAGIATLNDNGVHVTKVKGRIATLREDVDT
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHH
TIDSTMGIGHTRWATHGVPSVMNAHPHQSTSERFTIVHNGVIENYNDIKNEYLADVSFIS
HHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHC
ETDTEVIVQLIEKLHEKYQDTKKAFSEAMSLLKGSYAIGLIDAEDSETLYVSKNKSPLLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCEEEE
GLGDGFNLVASDAMATLRETDQYLEIFDKEIVLVSRNYVEVQTLDGQVVERKPFTAEIDA
ECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEEECCCEEEECCCCEEECCC
SDTEKGTYPHFMLKEIDEQPIVMRKIIQEYQNDNGQLKLDQDIRTAMKDADRIYIIAAGT
CCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECHHHHHHHCCCCEEEEEEECC
SYHAGLVGKEFIEKLANIPVEVHVASEFSYNMPLLSEKPLFVFISQSGETADSRAVLVKI
CCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
KELGHPALTLTNVPGSTLSREANYTMHLHAGPEIAVASTKAYTAQIAVLAILAVDTARVK
ECCCCCEEEEECCCCCHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHC
GLELDFEPLQELAIVANAMEVLTDQKEELEQLARDYFGTTRNAFFIGRSTDYHVAQEAAL
CEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
KLKEISYIQAEGFAGGELKHGTIALIEEGTPVIALTTQENVNYSIRGNVQEVVARGANAM
HHHHHHEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCCEEECCCHHHHHHCCCCEE
VVSMKGLEQDEDAFVIPHVHELLTPLASVIPMQLLAYYAALHRDCDVDKPRNLAKSVTVE
EEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGQNDTKEILLTGLEKLEYRGYDSAGIATLNDNGVHVTKVKGRIATLREDVDT
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHH
TIDSTMGIGHTRWATHGVPSVMNAHPHQSTSERFTIVHNGVIENYNDIKNEYLADVSFIS
HHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHC
ETDTEVIVQLIEKLHEKYQDTKKAFSEAMSLLKGSYAIGLIDAEDSETLYVSKNKSPLLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCEEEE
GLGDGFNLVASDAMATLRETDQYLEIFDKEIVLVSRNYVEVQTLDGQVVERKPFTAEIDA
ECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEEECCCEEEECCCCEEECCC
SDTEKGTYPHFMLKEIDEQPIVMRKIIQEYQNDNGQLKLDQDIRTAMKDADRIYIIAAGT
CCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECHHHHHHHCCCCEEEEEEECC
SYHAGLVGKEFIEKLANIPVEVHVASEFSYNMPLLSEKPLFVFISQSGETADSRAVLVKI
CCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
KELGHPALTLTNVPGSTLSREANYTMHLHAGPEIAVASTKAYTAQIAVLAILAVDTARVK
ECCCCCEEEEECCCCCHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHC
GLELDFEPLQELAIVANAMEVLTDQKEELEQLARDYFGTTRNAFFIGRSTDYHVAQEAAL
CEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
KLKEISYIQAEGFAGGELKHGTIALIEEGTPVIALTTQENVNYSIRGNVQEVVARGANAM
HHHHHHEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCCEEECCCHHHHHHCCCCEE
VVSMKGLEQDEDAFVIPHVHELLTPLASVIPMQLLAYYAALHRDCDVDKPRNLAKSVTVE
EEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376