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The map label for this gene is 23097689

Identifier: 23097689

GI number: 23097689

Start: 256357

End: 258153

Strand: Direct

Name: 23097689

Synonym: OB0234

Alternate gene names: NA

Gene position: 256357-258153 (Clockwise)

Preceding gene: 23097688

Following gene: 23097690

Centisome position: 7.06

GC content: 36.78

Gene sequence:

>1797_bases
ATGATTGAATTTCCAAAACCAACAGTAGAACAGTTTTTCCGCACATATACCATCAGCCATTTTAATGTTAGTAAAGACGA
AAATAAGTTAGTCTTCGCAACAAATATAAATGGAACGATGAATTTATGGGCTATGGATCTAAAGGAAGGGAGTAAATTCC
CTTATCAGTTTGCACAAAAAGGAGAGTCTTCTAACTTTACAGCGTTTGACCCAGAAGGGAAATTTGTATTAACAGATTTT
GATAGTGACGGTGATGAAAATTATCAAATTTATGCACTTCCCTATGAAGGCGGGATTCCTAAACCATTAATCACAGGAAA
GCCAGAGGATAAATATTTATTTAGTCACCTCAGTGAAGATGGGAAACGCGTCTATTATAATACGTCTGTGGATAATCCGT
CTTTTTTTAATACACGTGTAAAAGATTTGGAAAATGATTCAGATACATTAATTTATGAAGGTGAGAAAGGGCTCACGCAT
TTGGCAGTTGTTTCTGAGAATGAAGAGGCTCAAGTCTATATTCGTATGTTTGCAAATACGTATAACAATATATTTGTACA
AAAGGGTGAGGAGACAGTATTTTTAACTCCAGACCCAGAGAAAGTTCATGTTTCATTTGAGCCGGTATTTACCGACGATA
ATACGGTGTATTTTCTAACTGATTATGATAGTAATTATCAATATATAGCTAAGTTTGATTTAAATACGAAGAAGTTTGAA
AAAGTATTCGAGTTAGAAGAAGAATCTTTAAGTACGTTGGAATATCATAAAGAAACCAATACATTATATATTGTTTCTGA
AAAAGGTGTGGTAGATAAATTATACCAATACAGCTTGGATAACAAACAATTGATTGAAATGGATACGCCTTTTGAAATTG
TAGAGCAATTGAAAGTTATGAAATCTGGAAACGTGTATGTCTTAGGGCGCACAGCAACACTTCCATTAAATATTTTTGTC
TCAAGTAATGGGAAAGAGTGGGAACAACTTACAACAAACCGAGTGCTTGGAATGGATGAGTCGCAATTAGTTGACCCTGA
AGTAATTACGTATCCTTCTTTTGATGGAATGGAAATAGAAGCATTGTTCTTTAAGGCAAAACCAGAAAATGCTAATGGAT
ACACGGTATTTTGGCCCCATGGTGGACCTCAAGCATCTGAACGTAAGTTTTTCCGTGCAATGTTCCAAAGTATTCTCTAC
CGCGGTTATAATATCTTCGCACCAAACTTCCGTGGAAGTACGGGCTACGGGTCAGAATTTGTAAAAATGGTGGAAAGAGA
TTGGGGCTATGGACCACGATTAGACAATGTAGAAGGAGTCAAGTGGTTATTCGATCAAGGTATTAGCGATCCCGATCATT
TATTCTTAGTAGGTGGAAGTTATGGCGGGTACATGGCATTACTTTTACATGGTAGACATCCAGAATATTTTAAAGCGGTT
ATCGATATATTTGGACCAAGTAACTTATTCTCATTTGTGGAGTCCGTACCAGCGGAATGGAAACCGATTATGGACCGTTG
GGTAGGAGATCCGGAACGCGACAAAGAGCGTTTCATTCGAGATTCTCCAGATACGTATTTAGATTCGATGACAAAACCAA
TGCTGGTGATCCAAGGTGCAAAAGACCCGCGTGTGGTAAAAGCAGAATCTGATCAAATCGTAGAGAAGTTGAAAGCAAAA
GGAAGAGATGTGGAATATTACGTATTAGAAGATGAAGGACATGGATTTTCGAAAAAAGAAAATGAAATAAAAGTATACAC
ATGGATGCTCGATTTTCTCGATAAGCATCAAGGATAA

Upstream 100 bases:

>100_bases
GAGGCGGAGGATGGTAGCACCTTTAGACTGTTACGATGTACGCTCTTCATGATAAAATTAGAAGTATAAAAATAATCAGA
TAAATAAGAGGTGTAATGAG

Downstream 100 bases:

>100_bases
AAAATGAACAAATAAGTTGTAGCTAGAAATGTGAGATACCTTTACAGAACTGGTACTAGGGTTCATTATGAAAGAACCCA
CATTTCAAAGCTGCAACTTT

Product: acylamino-acid-releasing enzyme

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MIEFPKPTVEQFFRTYTISHFNVSKDENKLVFATNINGTMNLWAMDLKEGSKFPYQFAQKGESSNFTAFDPEGKFVLTDF
DSDGDENYQIYALPYEGGIPKPLITGKPEDKYLFSHLSEDGKRVYYNTSVDNPSFFNTRVKDLENDSDTLIYEGEKGLTH
LAVVSENEEAQVYIRMFANTYNNIFVQKGEETVFLTPDPEKVHVSFEPVFTDDNTVYFLTDYDSNYQYIAKFDLNTKKFE
KVFELEEESLSTLEYHKETNTLYIVSEKGVVDKLYQYSLDNKQLIEMDTPFEIVEQLKVMKSGNVYVLGRTATLPLNIFV
SSNGKEWEQLTTNRVLGMDESQLVDPEVITYPSFDGMEIEALFFKAKPENANGYTVFWPHGGPQASERKFFRAMFQSILY
RGYNIFAPNFRGSTGYGSEFVKMVERDWGYGPRLDNVEGVKWLFDQGISDPDHLFLVGGSYGGYMALLLHGRHPEYFKAV
IDIFGPSNLFSFVESVPAEWKPIMDRWVGDPERDKERFIRDSPDTYLDSMTKPMLVIQGAKDPRVVKAESDQIVEKLKAK
GRDVEYYVLEDEGHGFSKKENEIKVYTWMLDFLDKHQG

Sequences:

>Translated_598_residues
MIEFPKPTVEQFFRTYTISHFNVSKDENKLVFATNINGTMNLWAMDLKEGSKFPYQFAQKGESSNFTAFDPEGKFVLTDF
DSDGDENYQIYALPYEGGIPKPLITGKPEDKYLFSHLSEDGKRVYYNTSVDNPSFFNTRVKDLENDSDTLIYEGEKGLTH
LAVVSENEEAQVYIRMFANTYNNIFVQKGEETVFLTPDPEKVHVSFEPVFTDDNTVYFLTDYDSNYQYIAKFDLNTKKFE
KVFELEEESLSTLEYHKETNTLYIVSEKGVVDKLYQYSLDNKQLIEMDTPFEIVEQLKVMKSGNVYVLGRTATLPLNIFV
SSNGKEWEQLTTNRVLGMDESQLVDPEVITYPSFDGMEIEALFFKAKPENANGYTVFWPHGGPQASERKFFRAMFQSILY
RGYNIFAPNFRGSTGYGSEFVKMVERDWGYGPRLDNVEGVKWLFDQGISDPDHLFLVGGSYGGYMALLLHGRHPEYFKAV
IDIFGPSNLFSFVESVPAEWKPIMDRWVGDPERDKERFIRDSPDTYLDSMTKPMLVIQGAKDPRVVKAESDQIVEKLKAK
GRDVEYYVLEDEGHGFSKKENEIKVYTWMLDFLDKHQG
>Mature_598_residues
MIEFPKPTVEQFFRTYTISHFNVSKDENKLVFATNINGTMNLWAMDLKEGSKFPYQFAQKGESSNFTAFDPEGKFVLTDF
DSDGDENYQIYALPYEGGIPKPLITGKPEDKYLFSHLSEDGKRVYYNTSVDNPSFFNTRVKDLENDSDTLIYEGEKGLTH
LAVVSENEEAQVYIRMFANTYNNIFVQKGEETVFLTPDPEKVHVSFEPVFTDDNTVYFLTDYDSNYQYIAKFDLNTKKFE
KVFELEEESLSTLEYHKETNTLYIVSEKGVVDKLYQYSLDNKQLIEMDTPFEIVEQLKVMKSGNVYVLGRTATLPLNIFV
SSNGKEWEQLTTNRVLGMDESQLVDPEVITYPSFDGMEIEALFFKAKPENANGYTVFWPHGGPQASERKFFRAMFQSILY
RGYNIFAPNFRGSTGYGSEFVKMVERDWGYGPRLDNVEGVKWLFDQGISDPDHLFLVGGSYGGYMALLLHGRHPEYFKAV
IDIFGPSNLFSFVESVPAEWKPIMDRWVGDPERDKERFIRDSPDTYLDSMTKPMLVIQGAKDPRVVKAESDQIVEKLKAK
GRDVEYYVLEDEGHGFSKKENEIKVYTWMLDFLDKHQG

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=268, Percent_Identity=23.8805970149254, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25144537, Length=225, Percent_Identity=36.4444444444444, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144540, Length=225, Percent_Identity=36.4444444444444, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17552908, Length=239, Percent_Identity=26.7782426778243, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25144543, Length=121, Percent_Identity=37.1900826446281, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25149159, Length=220, Percent_Identity=29.0909090909091, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 69000; Mature: 69000

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEFPKPTVEQFFRTYTISHFNVSKDENKLVFATNINGTMNLWAMDLKEGSKFPYQFAQK
CCCCCCHHHHHHHHHEEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHC
GESSNFTAFDPEGKFVLTDFDSDGDENYQIYALPYEGGIPKPLITGKPEDKYLFSHLSED
CCCCCCEEECCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCC
GKRVYYNTSVDNPSFFNTRVKDLENDSDTLIYEGEKGLTHLAVVSENEEAQVYIRMFANT
CCEEEEECCCCCCCCCCHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCC
YNNIFVQKGEETVFLTPDPEKVHVSFEPVFTDDNTVYFLTDYDSNYQYIAKFDLNTKKFE
CCEEEEECCCCEEEECCCCCEEEEEEEEEEECCCEEEEEEECCCCCEEEEEECCCHHHHH
KVFELEEESLSTLEYHKETNTLYIVSEKGVVDKLYQYSLDNKQLIEMDTPFEIVEQLKVM
HHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
KSGNVYVLGRTATLPLNIFVSSNGKEWEQLTTNRVLGMDESQLVDPEVITYPSFDGMEIE
CCCCEEEEEEEEEEEEEEEECCCCCHHHHHHHHHEECCCHHHCCCCCEEECCCCCCEEEE
ALFFKAKPENANGYTVFWPHGGPQASERKFFRAMFQSILYRGYNIFAPNFRGSTGYGSEF
EEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHH
VKMVERDWGYGPRLDNVEGVKWLFDQGISDPDHLFLVGGSYGGYMALLLHGRHPEYFKAV
HHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHH
IDIFGPSNLFSFVESVPAEWKPIMDRWVGDPERDKERFIRDSPDTYLDSMTKPMLVIQGA
HHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCEEEEECC
KDPRVVKAESDQIVEKLKAKGRDVEYYVLEDEGHGFSKKENEIKVYTWMLDFLDKHQG
CCCEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEEHHHHHHCCC
>Mature Secondary Structure
MIEFPKPTVEQFFRTYTISHFNVSKDENKLVFATNINGTMNLWAMDLKEGSKFPYQFAQK
CCCCCCHHHHHHHHHEEEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHC
GESSNFTAFDPEGKFVLTDFDSDGDENYQIYALPYEGGIPKPLITGKPEDKYLFSHLSED
CCCCCCEEECCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCC
GKRVYYNTSVDNPSFFNTRVKDLENDSDTLIYEGEKGLTHLAVVSENEEAQVYIRMFANT
CCEEEEECCCCCCCCCCHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCC
YNNIFVQKGEETVFLTPDPEKVHVSFEPVFTDDNTVYFLTDYDSNYQYIAKFDLNTKKFE
CCEEEEECCCCEEEECCCCCEEEEEEEEEEECCCEEEEEEECCCCCEEEEEECCCHHHHH
KVFELEEESLSTLEYHKETNTLYIVSEKGVVDKLYQYSLDNKQLIEMDTPFEIVEQLKVM
HHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
KSGNVYVLGRTATLPLNIFVSSNGKEWEQLTTNRVLGMDESQLVDPEVITYPSFDGMEIE
CCCCEEEEEEEEEEEEEEEECCCCCHHHHHHHHHEECCCHHHCCCCCEEECCCCCCEEEE
ALFFKAKPENANGYTVFWPHGGPQASERKFFRAMFQSILYRGYNIFAPNFRGSTGYGSEF
EEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHH
VKMVERDWGYGPRLDNVEGVKWLFDQGISDPDHLFLVGGSYGGYMALLLHGRHPEYFKAV
HHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHH
IDIFGPSNLFSFVESVPAEWKPIMDRWVGDPERDKERFIRDSPDTYLDSMTKPMLVIQGA
HHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCEEEEECC
KDPRVVKAESDQIVEKLKAKGRDVEYYVLEDEGHGFSKKENEIKVYTWMLDFLDKHQG
CCCEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]