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The map label for this gene is dnaX [H]

Identifier: 23097484

GI number: 23097484

Start: 33477

End: 35186

Strand: Direct

Name: dnaX [H]

Synonym: OB0029

Alternate gene names: 23097484

Gene position: 33477-35186 (Clockwise)

Preceding gene: 23097483

Following gene: 23097485

Centisome position: 0.92

GC content: 37.6

Gene sequence:

>1710_bases
ATGAGTTATCAAGCATTATACCGTGTATGGCGGCCACGAACATTTGAAGATGTAGTAGGACAAACACATATTACTCGAAC
ACTACAAAATGCGATTGAGCAGGATAAATTTTCGCATGCTTATTTATTCTCTGGACCACGTGGAACAGGGAAGACAAGTG
CTGCAAAAATATTTGCGCAAACTATTAATTGTGAGCATGCCCCTGTAAAAGAACCTTGTAATGAATGTGCAGCATGTAGA
GGCATTCAAGATGGATCCGTATCAGATGTTATTGAAATCGATGCTGCTTCCAATACAAGTGTAGATGATATTCGTGATAT
ACGTGATAAAGTGAAGTATGCACCAAGTACGGTGCCATATAAAGTGTACATTATTGATGAGGTACACATGATATCGGTAA
ATGCATTTAATGCTTTACTGAAGACGTTGGAAGAACCACCAAAGCATGTTGTGTTTATTCTTGCAACAACAGAACCACAT
AAAATCCCCTTAACGATTATATCTCGCTGTCAACGTTTTGACTTTAAACCAATTTCTAATCAATCGATTGTTGGAAGAAT
GCAAACGATAATGCAAGCAGAAAATATTCACGTTACGGATGAGGCTTTAGAGTCTGTCGCGCTTGCTGCAGAAGGCGGAA
TGCGAGATGCCTTGAGTATACTGGATCAAGCCATTTCGTATAGTGAAGAGAAAGTCATATTAGAAGATGTTTTAGCAGTT
ACAGGTGGCGTATCGCAAGTCGTGCTTCATAAAGTTGTTTCAGCTATGAATGAAAATAATGTTCAAGAGGTACTAGTAGC
ATTGGATGAGATGATTCGTACCGGTAAAGACCCAGGGAAATTTGTGCAGGATTTAATTTATTTTATGCGAGATCTTCTAT
TATTCAGGAGCTCGGCAAATCTTGCAGATATGCTAGAAAGAGCTGTAGCAGATGATTCATTTAAACAACTGTCAGAACGT
GTATCCAACCAATGGATCCAGCGCTCGATTATTGAATTGAATCAGTGCCAACAAGAAATGAAATGGTCCAATAGCCCGAA
AGTATTTATCGAAATTGCATTACTTACTATTACTAATTATGGACAAGAACATCGTGTTGAAGTTGGTAATAATACAACCG
CTTCTGCTGAATCTGAAGTTGTACTGCAATTACAAAGCAAGATGCAACAGTTGGAAAAAGATATAAAGACATTAAAAGAA
AACCCACCTGCATCTACTACACCAAGTAAACAAACAACAACGGAGCGAAGAAGACCAAATACCCGATCATCTAAAAACAG
TTTTAAGATTCCATATGATCGAATTCGTGATACACTAGGAAGAGCAGAAAAAAGTGAACTAAAAAATGTACACGCGCATT
GGGCTAATTTCTTAAGTAAGTTAAAAACAACAAATGCACCTGCGCATGCTACGATACAAGATAGTAAACCTGCTGCTGCT
TCGGATGATACATTGATTGTTGCATTCAAATATGAAATCCACTGTTCTTTATTTTTAGATCACCGAGAAATGGCAGAATC
GTTACTTGGAGGTCTGGACAAACATCGTACTATCATCCCTATTCCAGAACAAGCATGGAATGAAGTACGTAATGATTATA
TTCAAAATCAGGATAAACCAAAAGAAAACTCTGAAGAACAACAATCAGATCCTGTAGTTGATGAAGCAAGGAAGCTTTTT
GGTGATGACCTATTAGAAATACATGATTAA

Upstream 100 bases:

>100_bases
TGCTAAATAGATGTTCTATGCTTTTCTTCATCTCCAAGGTTCACATGAGACCCTTTCATCGGGTATAATGAAAATTAGAT
TAATAAGGGGAATGTAAACT

Downstream 100 bases:

>100_bases
TAATATAGATAACTATTAAAGGAGGTATTTTCCATGAAGGGAAATATGAATAATATGATGAAGCAGATGCAGAAAATGCA
AAAGAAAATGATGCAAGCAC

Product: DNA polymerase III gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MSYQALYRVWRPRTFEDVVGQTHITRTLQNAIEQDKFSHAYLFSGPRGTGKTSAAKIFAQTINCEHAPVKEPCNECAACR
GIQDGSVSDVIEIDAASNTSVDDIRDIRDKVKYAPSTVPYKVYIIDEVHMISVNAFNALLKTLEEPPKHVVFILATTEPH
KIPLTIISRCQRFDFKPISNQSIVGRMQTIMQAENIHVTDEALESVALAAEGGMRDALSILDQAISYSEEKVILEDVLAV
TGGVSQVVLHKVVSAMNENNVQEVLVALDEMIRTGKDPGKFVQDLIYFMRDLLLFRSSANLADMLERAVADDSFKQLSER
VSNQWIQRSIIELNQCQQEMKWSNSPKVFIEIALLTITNYGQEHRVEVGNNTTASAESEVVLQLQSKMQQLEKDIKTLKE
NPPASTTPSKQTTTERRRPNTRSSKNSFKIPYDRIRDTLGRAEKSELKNVHAHWANFLSKLKTTNAPAHATIQDSKPAAA
SDDTLIVAFKYEIHCSLFLDHREMAESLLGGLDKHRTIIPIPEQAWNEVRNDYIQNQDKPKENSEEQQSDPVVDEARKLF
GDDLLEIHD

Sequences:

>Translated_569_residues
MSYQALYRVWRPRTFEDVVGQTHITRTLQNAIEQDKFSHAYLFSGPRGTGKTSAAKIFAQTINCEHAPVKEPCNECAACR
GIQDGSVSDVIEIDAASNTSVDDIRDIRDKVKYAPSTVPYKVYIIDEVHMISVNAFNALLKTLEEPPKHVVFILATTEPH
KIPLTIISRCQRFDFKPISNQSIVGRMQTIMQAENIHVTDEALESVALAAEGGMRDALSILDQAISYSEEKVILEDVLAV
TGGVSQVVLHKVVSAMNENNVQEVLVALDEMIRTGKDPGKFVQDLIYFMRDLLLFRSSANLADMLERAVADDSFKQLSER
VSNQWIQRSIIELNQCQQEMKWSNSPKVFIEIALLTITNYGQEHRVEVGNNTTASAESEVVLQLQSKMQQLEKDIKTLKE
NPPASTTPSKQTTTERRRPNTRSSKNSFKIPYDRIRDTLGRAEKSELKNVHAHWANFLSKLKTTNAPAHATIQDSKPAAA
SDDTLIVAFKYEIHCSLFLDHREMAESLLGGLDKHRTIIPIPEQAWNEVRNDYIQNQDKPKENSEEQQSDPVVDEARKLF
GDDLLEIHD
>Mature_568_residues
SYQALYRVWRPRTFEDVVGQTHITRTLQNAIEQDKFSHAYLFSGPRGTGKTSAAKIFAQTINCEHAPVKEPCNECAACRG
IQDGSVSDVIEIDAASNTSVDDIRDIRDKVKYAPSTVPYKVYIIDEVHMISVNAFNALLKTLEEPPKHVVFILATTEPHK
IPLTIISRCQRFDFKPISNQSIVGRMQTIMQAENIHVTDEALESVALAAEGGMRDALSILDQAISYSEEKVILEDVLAVT
GGVSQVVLHKVVSAMNENNVQEVLVALDEMIRTGKDPGKFVQDLIYFMRDLLLFRSSANLADMLERAVADDSFKQLSERV
SNQWIQRSIIELNQCQQEMKWSNSPKVFIEIALLTITNYGQEHRVEVGNNTTASAESEVVLQLQSKMQQLEKDIKTLKEN
PPASTTPSKQTTTERRRPNTRSSKNSFKIPYDRIRDTLGRAEKSELKNVHAHWANFLSKLKTTNAPAHATIQDSKPAAAS
DDTLIVAFKYEIHCSLFLDHREMAESLLGGLDKHRTIIPIPEQAWNEVRNDYIQNQDKPKENSEEQQSDPVVDEARKLFG
DDLLEIHD

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=237, Percent_Identity=28.2700421940928, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI194306571, Length=237, Percent_Identity=28.2700421940928, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI194306567, Length=237, Percent_Identity=28.2700421940928, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4506491, Length=247, Percent_Identity=28.7449392712551, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI31881687, Length=247, Percent_Identity=28.7449392712551, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI31563534, Length=221, Percent_Identity=24.8868778280543, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI194306569, Length=157, Percent_Identity=28.0254777070064, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786676, Length=356, Percent_Identity=40.7303370786517, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1787341, Length=160, Percent_Identity=28.75, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=232, Percent_Identity=27.5862068965517, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17554730, Length=224, Percent_Identity=27.2321428571429, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17541988, Length=234, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324039, Length=218, Percent_Identity=27.5229357798165, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322528, Length=296, Percent_Identity=23.6486486486486, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=259, Percent_Identity=23.9382239382239, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859927, Length=292, Percent_Identity=22.9452054794521, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921076, Length=220, Percent_Identity=25.9090909090909, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17647857, Length=279, Percent_Identity=21.8637992831541, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64116; Mature: 63985

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQALYRVWRPRTFEDVVGQTHITRTLQNAIEQDKFSHAYLFSGPRGTGKTSAAKIFAQ
CCHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHH
TINCEHAPVKEPCNECAACRGIQDGSVSDVIEIDAASNTSVDDIRDIRDKVKYAPSTVPY
HHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KVYIIDEVHMISVNAFNALLKTLEEPPKHVVFILATTEPHKIPLTIISRCQRFDFKPISN
EEEEECCEEEEEHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCC
QSIVGRMQTIMQAENIHVTDEALESVALAAEGGMRDALSILDQAISYSEEKVILEDVLAV
CHHHHHHHHHHHHCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
TGGVSQVVLHKVVSAMNENNVQEVLVALDEMIRTGKDPGKFVQDLIYFMRDLLLFRSSAN
HCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
LADMLERAVADDSFKQLSERVSNQWIQRSIIELNQCQQEMKWSNSPKVFIEIALLTITNY
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHCC
GQEHRVEVGNNTTASAESEVVLQLQSKMQQLEKDIKTLKENPPASTTPSKQTTTERRRPN
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCC
TRSSKNSFKIPYDRIRDTLGRAEKSELKNVHAHWANFLSKLKTTNAPAHATIQDSKPAAA
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCC
SDDTLIVAFKYEIHCSLFLDHREMAESLLGGLDKHRTIIPIPEQAWNEVRNDYIQNQDKP
CCCEEEEEEEEEEEEEEEECHHHHHHHHHCCHHCCCEEEECCHHHHHHHHHHHHCCCCCC
KENSEEQQSDPVVDEARKLFGDDLLEIHD
CCCCCHHHCCCHHHHHHHHHCCHHHHCCC
>Mature Secondary Structure 
SYQALYRVWRPRTFEDVVGQTHITRTLQNAIEQDKFSHAYLFSGPRGTGKTSAAKIFAQ
CHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHH
TINCEHAPVKEPCNECAACRGIQDGSVSDVIEIDAASNTSVDDIRDIRDKVKYAPSTVPY
HHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KVYIIDEVHMISVNAFNALLKTLEEPPKHVVFILATTEPHKIPLTIISRCQRFDFKPISN
EEEEECCEEEEEHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCC
QSIVGRMQTIMQAENIHVTDEALESVALAAEGGMRDALSILDQAISYSEEKVILEDVLAV
CHHHHHHHHHHHHCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
TGGVSQVVLHKVVSAMNENNVQEVLVALDEMIRTGKDPGKFVQDLIYFMRDLLLFRSSAN
HCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
LADMLERAVADDSFKQLSERVSNQWIQRSIIELNQCQQEMKWSNSPKVFIEIALLTITNY
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHCC
GQEHRVEVGNNTTASAESEVVLQLQSKMQQLEKDIKTLKENPPASTTPSKQTTTERRRPN
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCC
TRSSKNSFKIPYDRIRDTLGRAEKSELKNVHAHWANFLSKLKTTNAPAHATIQDSKPAAA
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCC
SDDTLIVAFKYEIHCSLFLDHREMAESLLGGLDKHRTIIPIPEQAWNEVRNDYIQNQDKP
CCCEEEEEEEEEEEEEEEECHHHHHHHHHCCHHCCCEEEECCHHHHHHHHHHHHCCCCCC
KENSEEQQSDPVVDEARKLFGDDLLEIHD
CCCCCHHHCCCHHHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]