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The map label for this gene is gcp

Identifier: 161501983

GI number: 161501983

Start: 682439

End: 683449

Strand: Direct

Name: gcp

Synonym: OB0648

Alternate gene names: 161501983

Gene position: 682439-683449 (Clockwise)

Preceding gene: 23098102

Following gene: 23098104

Centisome position: 18.8

GC content: 38.58

Gene sequence:

>1011_bases
ATGAAAAAAGATACGATTATATTAGGTATAGAAACAAGTTGTGATGAAACCGCAGCCTCTGTAGTAAAAAACGGTAGAGA
GATTATGTCCAATGTAGTTGCATCTCAAATTGAAAGTCATAAACGCTTCGGAGGAGTAGTTCCTGAAATTGCATCAAGGC
ATCACGTTGAACAAATTACACTTGTGCTTGAACAAGCAATTACTGAGGCTGATGTTACTTGGGAAGATATAGATGCAATC
GCAGTTACAGAAGGACCAGGATTAGTAGGAGCTTTATTAGTAGGTGTAAATGCAGCGAAAGCATTAGCGTTTGCTAAGAA
GAAACCATTAGTTGGGGTTCACCATATTGCTGGTCATATTTATGCAAATAGACTAGAGCATGAATTTGTGTTTCCGATGT
TAGCCCTTATTGTTTCTGGTGGACACACAGAATTAGTCCTAATGAAGGAACATGGAGACTATGAATTAATAGGGGAGACA
AGAGATGATGCTGCAGGAGAAGCATATGATAAGGTCGCCCGTATGTTGAAATTGCCTTATCCAGGTGGTCCACAAATTGA
TCGCTTAGCTGCTAAAGGTGAGGAAACGATTGAATTTCCTCGTGCTTGGTTAGAAGCAGATAGTTATGATTTTAGTTTTA
GTGGATTGAAGTCTGCCGTTATAAATAAAATTCATAACGCAAAGCAACGTGATTTGACGTTAAGTGCAGAAGATATTGCT
GCAAGTTTTCAAGCGAGTGTTGTGGAAGTACTGACAGAAAAAACATATCGTGCAGCGAAAGAATATAACGTAAATCAAGT
TATTGTAGCGGGTGGAGTAGCTGCTAATACAGGTTTAAGAAAAAGCCTAGAGAAACGTTTCTCAGGCGAAGATTTTCCAT
TATATATTCCACCAATTCAATTATGTACAGATAATGCTGCAATGATTGCCGCAGCAGGTACGATATCGTTTGAAAAGGGG
CATCGTTCATTACTCGATTTAAATGCAAATCCTTCACTTATACTGAGTTAG

Upstream 100 bases:

>100_bases
AATCCTTATATAGAAAATTTGGTTTAGTTCCTGGTGGAGTTCGTAAGAGGTATTACACGGATAATCACGAGGATGCTATT
GTAATGTGGGTGAATCTGAA

Downstream 100 bases:

>100_bases
TCACAGGTTATTCACAGGGGTGTGGATATATCCTGTAGATAAGCTACATTATCATCTTTTAAATGTGGATGAAAAAAGTG
GATAACTGTTCATTCGGCTG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKKDTIILGIETSCDETAASVVKNGREIMSNVVASQIESHKRFGGVVPEIASRHHVEQITLVLEQAITEADVTWEDIDAI
AVTEGPGLVGALLVGVNAAKALAFAKKKPLVGVHHIAGHIYANRLEHEFVFPMLALIVSGGHTELVLMKEHGDYELIGET
RDDAAGEAYDKVARMLKLPYPGGPQIDRLAAKGEETIEFPRAWLEADSYDFSFSGLKSAVINKIHNAKQRDLTLSAEDIA
ASFQASVVEVLTEKTYRAAKEYNVNQVIVAGGVAANTGLRKSLEKRFSGEDFPLYIPPIQLCTDNAAMIAAAGTISFEKG
HRSLLDLNANPSLILS

Sequences:

>Translated_336_residues
MKKDTIILGIETSCDETAASVVKNGREIMSNVVASQIESHKRFGGVVPEIASRHHVEQITLVLEQAITEADVTWEDIDAI
AVTEGPGLVGALLVGVNAAKALAFAKKKPLVGVHHIAGHIYANRLEHEFVFPMLALIVSGGHTELVLMKEHGDYELIGET
RDDAAGEAYDKVARMLKLPYPGGPQIDRLAAKGEETIEFPRAWLEADSYDFSFSGLKSAVINKIHNAKQRDLTLSAEDIA
ASFQASVVEVLTEKTYRAAKEYNVNQVIVAGGVAANTGLRKSLEKRFSGEDFPLYIPPIQLCTDNAAMIAAAGTISFEKG
HRSLLDLNANPSLILS
>Mature_336_residues
MKKDTIILGIETSCDETAASVVKNGREIMSNVVASQIESHKRFGGVVPEIASRHHVEQITLVLEQAITEADVTWEDIDAI
AVTEGPGLVGALLVGVNAAKALAFAKKKPLVGVHHIAGHIYANRLEHEFVFPMLALIVSGGHTELVLMKEHGDYELIGET
RDDAAGEAYDKVARMLKLPYPGGPQIDRLAAKGEETIEFPRAWLEADSYDFSFSGLKSAVINKIHNAKQRDLTLSAEDIA
ASFQASVVEVLTEKTYRAAKEYNVNQVIVAGGVAANTGLRKSLEKRFSGEDFPLYIPPIQLCTDNAAMIAAAGTISFEKG
HRSLLDLNANPSLILS

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=338, Percent_Identity=36.9822485207101, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI8923380, Length=323, Percent_Identity=34.984520123839, Blast_Score=162, Evalue=3e-40,
Organism=Escherichia coli, GI1789445, Length=335, Percent_Identity=44.7761194029851, Blast_Score=273, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17557464, Length=324, Percent_Identity=29.9382716049383, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71995670, Length=321, Percent_Identity=32.0872274143302, Blast_Score=141, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320099, Length=364, Percent_Identity=32.6923076923077, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322891, Length=354, Percent_Identity=30.225988700565, Blast_Score=132, Evalue=6e-32,
Organism=Drosophila melanogaster, GI20129063, Length=340, Percent_Identity=32.9411764705882, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21357207, Length=328, Percent_Identity=32.0121951219512, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_OCEIH (Q8ESI6)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691569.2
- ProteinModelPortal:   Q8ESI6
- SMR:   Q8ESI6
- MEROPS:   M22.001
- GeneID:   1016053
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0648
- NMPDR:   fig|221109.1.peg.654
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   OIHE221109:OB0648-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36327; Mature: 36327

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDTIILGIETSCDETAASVVKNGREIMSNVVASQIESHKRFGGVVPEIASRHHVEQIT
CCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVLEQAITEADVTWEDIDAIAVTEGPGLVGALLVGVNAAKALAFAKKKPLVGVHHIAGHI
HHHHHHHHHCCCCHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
YANRLEHEFVFPMLALIVSGGHTELVLMKEHGDYELIGETRDDAAGEAYDKVARMLKLPY
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHCCCC
PGGPQIDRLAAKGEETIEFPRAWLEADSYDFSFSGLKSAVINKIHNAKQRDLTLSAEDIA
CCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHCCCEECHHHHH
ASFQASVVEVLTEKTYRAAKEYNVNQVIVAGGVAANTGLRKSLEKRFSGEDFPLYIPPIQ
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHCHHHHHHHHHHHCCCCCCEECCCHH
LCTDNAAMIAAAGTISFEKGHRSLLDLNANPSLILS
EECCCCEEEEEECEEEECCCCCEEEECCCCCCEEEC
>Mature Secondary Structure
MKKDTIILGIETSCDETAASVVKNGREIMSNVVASQIESHKRFGGVVPEIASRHHVEQIT
CCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVLEQAITEADVTWEDIDAIAVTEGPGLVGALLVGVNAAKALAFAKKKPLVGVHHIAGHI
HHHHHHHHHCCCCHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
YANRLEHEFVFPMLALIVSGGHTELVLMKEHGDYELIGETRDDAAGEAYDKVARMLKLPY
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHCCCC
PGGPQIDRLAAKGEETIEFPRAWLEADSYDFSFSGLKSAVINKIHNAKQRDLTLSAEDIA
CCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHCCCEECHHHHH
ASFQASVVEVLTEKTYRAAKEYNVNQVIVAGGVAANTGLRKSLEKRFSGEDFPLYIPPIQ
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHCHHHHHHHHHHHCCCCCCEECCCHH
LCTDNAAMIAAAGTISFEKGHRSLLDLNANPSLILS
EECCCCEEEEEECEEEECCCCCEEEECCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376