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The map label for this gene is uhpB [H]

Identifier: 22127691

GI number: 22127691

Start: 4249083

End: 4249820

Strand: Direct

Name: uhpB [H]

Synonym: y3820

Alternate gene names: 22127691

Gene position: 4249083-4249820 (Clockwise)

Preceding gene: 22127690

Following gene: 161484734

Centisome position: 92.36

GC content: 48.1

Gene sequence:

>738_bases
TTGGCACAAAGTCTAACAGGTCTGCTCTTGGGATCCGGCATTCAACGACAGCGGGAGTTGAACGATCAACTACAAATAAA
ATTGAACGAAAACCGTGAGTTGGCTAAAGCATTAGTGGTTTCTGAGGAGCATACACGGCACGATGTCGCGCGTGAGTTAC
ATGATGAAGTGGGGCAAACCGTAACGGTTATCCGTACCCAAGCCAGTATTATTAAACGTCTGACCACCCAGCAACCGGTA
CTGACCAGTGCAGAGATGATAGAAACTGCGGCATTGCGGGTTTATGATGGTGTCCATGACGTATTGGCTAAATTATGGCC
AGCGGCATTAAATAATTTGCCGCTGTCGGCCGCCATCGCTGCATTGATGCGCGAACTCATTCCGCAAGACCAGTCGGTGC
TCGGTGTGCTTAACTGGCAGGTCAATGACCATCCGATGGATGAGACGTTGAAAATTACGCTTTACCGTATATGTCAGGAG
GGGGTGACCAATGCTTATCGGCATGGTGCCGCCAGCCGAATTGAAATTAATGCACGGCAGGATAACCAACAGATATATCT
AACGATTAGCGATAATGGTAAAGGTATCGATTTAGCCTCAATTACTCCAGGCTATGGGCTACGGGGTATTCAGTCACGGG
TCAGTGCGTTTGGGGGCAATGTGAGCCTAAGCGTTGATAACGGTACTTGCTTAAATGTGACCCTGCCCACAGTTTCTTTG
TCTACAAAAGGAAACTAA

Upstream 100 bases:

>100_bases
GCCGGGGTTATAGCAGAAGCTAATCCTGAGTAAAACGGTGGATCAATATTGGGCCGTTGGTGGAGATATAAGTGGATCAC
TTTTCATCCGTCGTTGACAG

Downstream 100 bases:

>100_bases
GAAATATTCTCGTTGGTAGCGAGAATTCCCCCGTGTGTTTTCATACACATGCAGATGATGATTATTGCACTTACAAAATA
CCCTGAGGCCCGAGATGTGG

Product: sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MAQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQTVTVIRTQASIIKRLTTQQPV
LTSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYRICQE
GVTNAYRHGAASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSL
STKGN

Sequences:

>Translated_245_residues
MAQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQTVTVIRTQASIIKRLTTQQPV
LTSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYRICQE
GVTNAYRHGAASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSL
STKGN
>Mature_244_residues
AQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQTVTVIRTQASIIKRLTTQQPVL
TSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYRICQEG
VTNAYRHGAASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSLS
TKGN

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=232, Percent_Identity=43.5344827586207, Blast_Score=185, Evalue=2e-48,
Organism=Escherichia coli, GI1788812, Length=209, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 26768; Mature: 26637

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQT
CCCCHHHHHHCCCHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCE
VTVIRTQASIIKRLTTQQPVLTSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIA
EEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYRICQEGVTNAYRHGAASRIEINARQ
HHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
DNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSL
CCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEECEEEE
STKGN
CCCCC
>Mature Secondary Structure 
AQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQT
CCCHHHHHHCCCHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCE
VTVIRTQASIIKRLTTQQPVLTSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIA
EEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYRICQEGVTNAYRHGAASRIEINARQ
HHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
DNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSL
CCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEECEEEE
STKGN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]