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The map label for this gene is lysA [H]

Identifier: 22127060

GI number: 22127060

Start: 3505383

End: 3506645

Strand: Reverse

Name: lysA [H]

Synonym: y3184

Alternate gene names: 22127060

Gene position: 3506645-3505383 (Counterclockwise)

Preceding gene: 22127062

Following gene: 22127058

Centisome position: 76.22

GC content: 50.99

Gene sequence:

>1263_bases
ATGCCACGCGCACTGAATGACCGTTCTTCAGCACTGACTGCCCAAAATCTGATTGCATTGCCTGAGCGTTTTGGTTGCCC
GGTGTGGGCCTATGATGGTGATATTATTGCTGAGCGTATTAATCAATTACGCCATTTTGATGTTATCCGCTTCGCGCAAA
AAGCCTGTTCGAATATCCATATACTGCGCCTGATGCGTGAGCAAGGTGTTAAGGTTGATTCGGTATCTTTGGGTGAAATC
GAGCGTGCCTTGCACGCGGGTTATCAACCGGGGCAGGAACCTGCCGAAATTGTCTTCACGGCTGATTTACTGGATCAGGC
GACCTTATTGCGCGTTACTGAATTGAATATCCCGGTCAATGCCGGGTCTATCGATATGTTGGATCAACTGGGGCAACAGG
CTCCGGGTCACCCTGTTTGGCTGCGCGTCAATCCGGGCTTTGGTCATGGGCATAGCCAGAAAACCAATACCGGCGGTGAA
AACAGCAAACACGGCATTTGGCATGAAGAACTCCCTCGCGCACTCAAGAAAATTGAGCACTATGGCTTAACACTGGTGGG
GATTCATATGCATATTGGCTCGGGTGTCGATTATCAACACCTTGAGCAAGTCTGCGATGCCATGGTTCAGCAAGTGATTA
CCTTAGGGCACGATATCAGTGCTATCTCCGCTGGCGGTGGGTTATCGATCCCCTATCAGTTTGGCGATGATGTGATTGAT
ACTGAACACTATTATGGGTTATGGAATAGCGCCAGAGAGCGAATTGCTGCTCATTTGGGCCACCCGGTTAGCCTTGAAAT
TGAACCTGGCCGCTTCCTGGTAGCAGAGTCTGGTGTATTGATCGCTCAGGTTCGTGCTGTTAAGGATATGGGCCGCCGGC
ATTATGTCTTGGTTGATGCCGGGTTTAACGATCTGATGCGTCCAGCGATGTATGGCAGTTATCACCATATTTCATTGCTT
CCTGCGGATGGGCGCGATCTGACGTCAGCTCCGCTGATTGATACCGTGGTTGCTGGCCCGCTTTGCGAATCTGGCGATGT
CTTCACTCAGCAAGAGGGCGGAGGTGTGGAGACCCTTGCTCTGCCTGCTGCGGTTATTGGCGATTATCTGGTCTTCCATG
ATACGGGGGCTTATGGCGCGTCGATGTCATCTAACTACAACAGCCGCCCGTTATTACCTGAAGTACTGTTTGAAAAGGGC
CAACCGCGCTTGATCCGCCGCCGTCAAACCATTGAAGAATTGATTGACCTGGAACGCGTTTAA

Upstream 100 bases:

>100_bases
GGCGTCATTTCCGCCGCCCATTATTGGGTACCTCATTTAATACATTATTCAGCACATTGATGAGCTCGTACATTAATGGC
TACACAATTAGGAAATACTT

Downstream 100 bases:

>100_bases
TCAGTGTCATCCCGTAGGCTTGGCGGGCTGGCCACAGAGTGGCGGCGAACCAGTGTTGGGCTGAACATATTGGTAATTTC
GGGTAACGGTGTGTTGTTGG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MPRALNDRSSALTAQNLIALPERFGCPVWAYDGDIIAERINQLRHFDVIRFAQKACSNIHILRLMREQGVKVDSVSLGEI
ERALHAGYQPGQEPAEIVFTADLLDQATLLRVTELNIPVNAGSIDMLDQLGQQAPGHPVWLRVNPGFGHGHSQKTNTGGE
NSKHGIWHEELPRALKKIEHYGLTLVGIHMHIGSGVDYQHLEQVCDAMVQQVITLGHDISAISAGGGLSIPYQFGDDVID
TEHYYGLWNSARERIAAHLGHPVSLEIEPGRFLVAESGVLIAQVRAVKDMGRRHYVLVDAGFNDLMRPAMYGSYHHISLL
PADGRDLTSAPLIDTVVAGPLCESGDVFTQQEGGGVETLALPAAVIGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEKG
QPRLIRRRQTIEELIDLERV

Sequences:

>Translated_420_residues
MPRALNDRSSALTAQNLIALPERFGCPVWAYDGDIIAERINQLRHFDVIRFAQKACSNIHILRLMREQGVKVDSVSLGEI
ERALHAGYQPGQEPAEIVFTADLLDQATLLRVTELNIPVNAGSIDMLDQLGQQAPGHPVWLRVNPGFGHGHSQKTNTGGE
NSKHGIWHEELPRALKKIEHYGLTLVGIHMHIGSGVDYQHLEQVCDAMVQQVITLGHDISAISAGGGLSIPYQFGDDVID
TEHYYGLWNSARERIAAHLGHPVSLEIEPGRFLVAESGVLIAQVRAVKDMGRRHYVLVDAGFNDLMRPAMYGSYHHISLL
PADGRDLTSAPLIDTVVAGPLCESGDVFTQQEGGGVETLALPAAVIGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEKG
QPRLIRRRQTIEELIDLERV
>Mature_419_residues
PRALNDRSSALTAQNLIALPERFGCPVWAYDGDIIAERINQLRHFDVIRFAQKACSNIHILRLMREQGVKVDSVSLGEIE
RALHAGYQPGQEPAEIVFTADLLDQATLLRVTELNIPVNAGSIDMLDQLGQQAPGHPVWLRVNPGFGHGHSQKTNTGGEN
SKHGIWHEELPRALKKIEHYGLTLVGIHMHIGSGVDYQHLEQVCDAMVQQVITLGHDISAISAGGGLSIPYQFGDDVIDT
EHYYGLWNSARERIAAHLGHPVSLEIEPGRFLVAESGVLIAQVRAVKDMGRRHYVLVDAGFNDLMRPAMYGSYHHISLLP
ADGRDLTSAPLIDTVVAGPLCESGDVFTQQEGGGVETLALPAAVIGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEKGQ
PRLIRRRQTIEELIDLERV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=77.3722627737226, Blast_Score=661, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46167; Mature: 46036

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00591 GLYCOSYL_HYDROL_F10 ; PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRALNDRSSALTAQNLIALPERFGCPVWAYDGDIIAERINQLRHFDVIRFAQKACSNIH
CCCCCCCCHHHHHHHHHHHCHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMREQGVKVDSVSLGEIERALHAGYQPGQEPAEIVFTADLLDQATLLRVTELNIPVN
HHHHHHHCCCEECCCCHHHHHHHHHCCCCCCCCCHHEEEEHHHHCCHHEEEEEEECCCCC
AGSIDMLDQLGQQAPGHPVWLRVNPGFGHGHSQKTNTGGENSKHGIWHEELPRALKKIEH
CCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
YGLTLVGIHMHIGSGVDYQHLEQVCDAMVQQVITLGHDISAISAGGGLSIPYQFGDDVID
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHCCCCCCC
TEHYYGLWNSARERIAAHLGHPVSLEIEPGRFLVAESGVLIAQVRAVKDMGRRHYVLVDA
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCEEEEEEEC
GFNDLMRPAMYGSYHHISLLPADGRDLTSAPLIDTVVAGPLCESGDVFTQQEGGGVETLA
CHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCEEHHH
LPAAVIGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEKGQPRLIRRRQTIEELIDLERV
HHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PRALNDRSSALTAQNLIALPERFGCPVWAYDGDIIAERINQLRHFDVIRFAQKACSNIH
CCCCCCCHHHHHHHHHHHCHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMREQGVKVDSVSLGEIERALHAGYQPGQEPAEIVFTADLLDQATLLRVTELNIPVN
HHHHHHHCCCEECCCCHHHHHHHHHCCCCCCCCCHHEEEEHHHHCCHHEEEEEEECCCCC
AGSIDMLDQLGQQAPGHPVWLRVNPGFGHGHSQKTNTGGENSKHGIWHEELPRALKKIEH
CCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
YGLTLVGIHMHIGSGVDYQHLEQVCDAMVQQVITLGHDISAISAGGGLSIPYQFGDDVID
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHCCCCCCC
TEHYYGLWNSARERIAAHLGHPVSLEIEPGRFLVAESGVLIAQVRAVKDMGRRHYVLVDA
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCEEEEEEEC
GFNDLMRPAMYGSYHHISLLPADGRDLTSAPLIDTVVAGPLCESGDVFTQQEGGGVETLA
CHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCEEHHH
LPAAVIGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEKGQPRLIRRRQTIEELIDLERV
HHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]