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The map label for this gene is clcA [H]

Identifier: 22124713

GI number: 22124713

Start: 896388

End: 897830

Strand: Direct

Name: clcA [H]

Synonym: y0800

Alternate gene names: 22124713

Gene position: 896388-897830 (Clockwise)

Preceding gene: 161484863

Following gene: 22124714

Centisome position: 19.48

GC content: 50.1

Gene sequence:

>1443_bases
ATGACTCATTCAACGCAACAACTTTCTCCTGAAGGCGTCGCTGAAGGCAAGCGTGGCCGTTTGATCCGTGAACTGGTTAA
TCGTGATAAGACACCCTTAATTATTCTTATCATGGCCGCTGTTGTCGGTGTGGTAACGGGATTATTAGGCGTAGCATTTG
ATCGCGGTGTCGATTGGGTCCAGCAACAGCGGCTGCTAGCGCTGGCTAATGTCGCGGATTACGCACTCTTGGTGTGGCCT
CTGGCTTTTATCATGTCCGCACTGCTAGCGATGATGGGCTATTTTTTGGTTAGTCGCTTTGCTCCTGAGGCTGGGGGGTC
TGGGATCCCCGAAATCGAAGGGGCAATGGAGGAAATGCGGCCAGTGCGCTGGTGGCGCGTAATCCCTGTTAAATTTATTG
GCGGCCTTGGGACATTGGGCGCAGGAATGGTTTTAGGCCGTGAAGGACCCATGGTCCAAATGGGGGGCAACAGTGGGCGA
ATGATCGTGGATATTTTTCGTTTGCGTAGCCCGGAAGCCCGTCATTCACTATTAGCAACCGGTGCAGCCGCAGGGCTGTC
TGCGGCATTTAATGCCCCGCTGGCAGGGATTCTGTTTGTTATCGAAGAGATGCGCTCGCAATTTCGCTACAGCCTAGTCT
CTATTAAAGCCGTATTTATCGGGGTGATTACCTCAACGATTGTTTACCGCTATTTTAATGGTGAACGTGCAATTATTGAG
GTCGGTAAACTCAGTGATGCTCCGCTAAACACCCTTTGGCTTTATTTATTATTAGGCATTATTTTTGGTGCTGTGGGCGT
CATATTCAATGCCCTTATCTTTCGAACACAAGATATGTTTGTGCGCTTTCATGGTGGTGATTGGCGTAAATTAGTTCTGA
TCGGTGGCTTGCTTGGCGGAATGTGCGGTTTATTAGCACTGCTTCATGGCAATGCGGTGGGAGGGGGGTTTGCATTGATC
CCTATCGCGGCAGCCGGTAATTTCAGCATCGGCATGCTGTTGTTCATTTTTATCGCTCGGGTCATCACGACCTTGCTGTG
TTTTGGATCGGGCGCTCCAGGGGGAATATTTGCCCCAATGTTGGCATTAGGGACCATTTTGGGGACCGCATTTGGTCTGT
CTTGCGCGCACTTTTTCCCACAATATGGCATCGAAGCCGGTACTTTCGCCATTGCGGGTATGGGCGCACTGTTTGCTGCC
TCAGTACGTGCACCGTTGACTGGGATCGTATTGGTACTGGAAATGACCGATAATTATCAGCTTATTTTACCGATGATTGT
TACCTGCCTGGGAGCGACGTTGATCGCTCAATTTATGGGGGGGAAACCGTTGTATTCGGCCATCCTAGCTCGCACATTAG
CCAAGCAAGAGCAAGCGCGTGCCACGGTAATAGCACAAGAACCGGCGGTTGAAAATACCCCACAAATAGGCAAAATAATA
TAA

Upstream 100 bases:

>100_bases
CATTTCATGGCTATATGGCGGCGCACCATGAGTTCATAGACTAGACTCTGGTTACATCAAATTTGTATTATGTATTGCTC
AACTGATAAACAAATTAACT

Downstream 100 bases:

>100_bases
CATTAGCCCTGAGTACTTGAATGAAATACTCAGGTATTAGATAATCGAGCCATAGATCAGGCTGCCAGTGTAGTAACCTG
CAACGCGAAGTAGTAACCTG

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MTHSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWVQQQRLLALANVADYALLVWP
LAFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGR
MIVDIFRLRSPEARHSLLATGAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIE
VGKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGGMCGLLALLHGNAVGGGFALI
PIAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAA
SVRAPLTGIVLVLEMTDNYQLILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQIGKII

Sequences:

>Translated_480_residues
MTHSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWVQQQRLLALANVADYALLVWP
LAFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGR
MIVDIFRLRSPEARHSLLATGAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIE
VGKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGGMCGLLALLHGNAVGGGFALI
PIAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAA
SVRAPLTGIVLVLEMTDNYQLILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQIGKII
>Mature_479_residues
THSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWVQQQRLLALANVADYALLVWPL
AFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGRM
IVDIFRLRSPEARHSLLATGAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIEV
GKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGGMCGLLALLHGNAVGGGFALIP
IAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAAS
VRAPLTGIVLVLEMTDNYQLILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQIGKII

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI189217923, Length=481, Percent_Identity=24.3243243243243, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI189217921, Length=481, Percent_Identity=24.3243243243243, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4557473, Length=477, Percent_Identity=24.3186582809224, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI55770838, Length=462, Percent_Identity=23.1601731601732, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI55770840, Length=462, Percent_Identity=23.1601731601732, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI153252026, Length=451, Percent_Identity=23.2815964523282, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786350, Length=447, Percent_Identity=72.7069351230425, Blast_Score=591, Evalue=1e-170,
Organism=Escherichia coli, GI87081943, Length=318, Percent_Identity=28.6163522012579, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17532615, Length=431, Percent_Identity=23.4338747099768, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980828, Length=484, Percent_Identity=23.5537190082645, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71980824, Length=484, Percent_Identity=23.5537190082645, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17559050, Length=427, Percent_Identity=25.9953161592506, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980820, Length=489, Percent_Identity=23.721881390593, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71985148, Length=505, Percent_Identity=23.3663366336634, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71985141, Length=502, Percent_Identity=23.5059760956175, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322500, Length=487, Percent_Identity=22.3819301848049, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24665008, Length=460, Percent_Identity=25, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551566, Length=437, Percent_Identity=25.1716247139588, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281361606, Length=452, Percent_Identity=23.6725663716814, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161078208, Length=452, Percent_Identity=23.6725663716814, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28573073, Length=452, Percent_Identity=23.6725663716814, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI28573075, Length=452, Percent_Identity=23.6725663716814, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 51075; Mature: 50943

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWV
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QQQRLLALANVADYALLVWPLAFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
PVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGRMIVDIFRLRSPEARHSLLAT
HHHHHEEEHHHHHCCHHHHCCCEEECCCCCEEEECCCCCCEEEEHHHHCCCHHHHHHHHH
GAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VGKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHH
MCGLLALLHGNAVGGGFALIPIAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPM
HHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAASVRAPLTGIVLVLEMTDNYQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCE
LILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQIGKII
EHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
THSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWV
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QQQRLLALANVADYALLVWPLAFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
PVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGRMIVDIFRLRSPEARHSLLAT
HHHHHEEEHHHHHCCHHHHCCCEEECCCCCEEEECCCCCCEEEEHHHHCCCHHHHHHHHH
GAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VGKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHH
MCGLLALLHGNAVGGGFALIPIAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPM
HHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAASVRAPLTGIVLVLEMTDNYQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCE
LILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQIGKII
EHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA