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The map label for this gene is kdtA [H]

Identifier: 22124006

GI number: 22124006

Start: 94743

End: 96128

Strand: Direct

Name: kdtA [H]

Synonym: y0086

Alternate gene names: 22124006

Gene position: 94743-96128 (Clockwise)

Preceding gene: 22124005

Following gene: 22124007

Centisome position: 2.06

GC content: 49.71

Gene sequence:

>1386_bases
ATGAATAACCACGGCTCAATGTGGTGCTCCGCCCTCCTAGCCGGAAAGAGCCTTTTTTGCCCAGATATGGTATTATTCTT
AATAATCCATATAAATGAAATTGATAGAATGCTGCTGCGTTTATACCAGGTATTACTCTACCTTATTCAACCTCTGATTT
GGCTGCGTTTACTATTACGTAGCCGTAAAGCCCCCGCTTATCGCAAGCGTTGGGGGGAACGCTATGGTTTTTGTGCCGGT
AAAGTCGTTGCTGGCGGTATCATGCTGCATTCCGTTTCAGTCGGGGAAACACTGGCTGCAATCCCATTGGTCAGAGCATT
ACGCCACCGTTACCCGTCGCTGCCTATCACGGTGACCACGATGACGCCTACCGGCTCAGAGCGCGTCCAGTCTGCTTTTG
GTAAAGATGTTCACCACGTTTATTTACCTTATGATCTCCCCGGCTCTGTGAACCGTTTCCTTGACCAGGTCAATCCCAAA
CTGGTTATCATCATGGAAACTGAACTTTGGCCTAACCTGATCAACACTCTGCATCGCCGTAAGATCCCACTGGTTATTGC
CAATGCACGTCTTTCTGCCCGCTCTGCGGCAGGTTACAAGAAGATCGGTAGTTTTATCCGCACTATACTGCAACGGATCA
CGTTGATTGCGGCACAGAACCAAGAGGATGGTGACCGCTTCATCGAACTGGGGCTTAAACGTTCCCAGCTCACCGTGACG
GGTAGTCTGAAGTTTGATATTTCTGTCACACCGGAGTTGGCAGCCAGAGCGGTGACATTACGCCGCCAATGGGCACCGCA
CCGCCCCGTTTGGATTGCGACTAGCACACATGACGGTGAAGAAACTATCTTGTTGGAAGCCCATCGGCAGCTATTACAAC
AGTTCCCAACATTGCTACTGATCCTGGTACCTCGCCATCCTGAACGCTTCGGAAAGGCCGTTGAATTAACACAAAAGATA
GGCTTGAGTTATACATTACGTAGTAAAGGTGAAGTGCCCTCGAGTAGCACCCAAGTCGTTATCGGCGACACGATGGGTGA
GCTGATGCTGCTGTACGGTATTGCCGACCTGGCCTTTGTTGGCGGTAGTTTGGTTGAACGTGGCGGTCATAACCCACTGG
AAGCAGCGGCTCATGCTATTCCCGTGTTGATGGGCCCACATACCTTTAACTTTAAAGATATTTGCGCCAAGCTGGAGCAG
GCTGAAGGGTTAATTACCGTGACTGATACTCTATCGCTGGTAAAAGAAATCACGGTGTTACTGACTGATGAAGATTGCCG
CCTCTACTATGGCCGCCACGCGGTTGATGTCTTACATGAAAATCAGGGCGCATTACAGCGGTTATTACATTTGTTGGAGC
CTTATCTGCCACAACGGAGCCACTAA

Upstream 100 bases:

>100_bases
ATCTAGTGCAATAGACAATGAAAATGATTCTCATTTTGTAATAAAAAATCAATAAATAGCCTCTCTTTTATCACTCAGAG
CAAGATATTATATTCTTCCT

Downstream 100 bases:

>100_bases
ATGGGTACCAAAAAACGTCTGTCGGTGGTGATGATAACCAAGAATGAAGCCTCTCTGCTGACGGACTGTTTGGCATCCGT
GGCCTGGGCTGATGAAATAA

Product: 3-deoxy-D-manno-octulosonic-acid transferase

Products: NA

Alternate protein names: KDO transferase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNNHGSMWCSALLAGKSLFCPDMVLFLIIHINEIDRMLLRLYQVLLYLIQPLIWLRLLLRSRKAPAYRKRWGERYGFCAG
KVVAGGIMLHSVSVGETLAAIPLVRALRHRYPSLPITVTTMTPTGSERVQSAFGKDVHHVYLPYDLPGSVNRFLDQVNPK
LVIIMETELWPNLINTLHRRKIPLVIANARLSARSAAGYKKIGSFIRTILQRITLIAAQNQEDGDRFIELGLKRSQLTVT
GSLKFDISVTPELAARAVTLRRQWAPHRPVWIATSTHDGEETILLEAHRQLLQQFPTLLLILVPRHPERFGKAVELTQKI
GLSYTLRSKGEVPSSSTQVVIGDTMGELMLLYGIADLAFVGGSLVERGGHNPLEAAAHAIPVLMGPHTFNFKDICAKLEQ
AEGLITVTDTLSLVKEITVLLTDEDCRLYYGRHAVDVLHENQGALQRLLHLLEPYLPQRSH

Sequences:

>Translated_461_residues
MNNHGSMWCSALLAGKSLFCPDMVLFLIIHINEIDRMLLRLYQVLLYLIQPLIWLRLLLRSRKAPAYRKRWGERYGFCAG
KVVAGGIMLHSVSVGETLAAIPLVRALRHRYPSLPITVTTMTPTGSERVQSAFGKDVHHVYLPYDLPGSVNRFLDQVNPK
LVIIMETELWPNLINTLHRRKIPLVIANARLSARSAAGYKKIGSFIRTILQRITLIAAQNQEDGDRFIELGLKRSQLTVT
GSLKFDISVTPELAARAVTLRRQWAPHRPVWIATSTHDGEETILLEAHRQLLQQFPTLLLILVPRHPERFGKAVELTQKI
GLSYTLRSKGEVPSSSTQVVIGDTMGELMLLYGIADLAFVGGSLVERGGHNPLEAAAHAIPVLMGPHTFNFKDICAKLEQ
AEGLITVTDTLSLVKEITVLLTDEDCRLYYGRHAVDVLHENQGALQRLLHLLEPYLPQRSH
>Mature_461_residues
MNNHGSMWCSALLAGKSLFCPDMVLFLIIHINEIDRMLLRLYQVLLYLIQPLIWLRLLLRSRKAPAYRKRWGERYGFCAG
KVVAGGIMLHSVSVGETLAAIPLVRALRHRYPSLPITVTTMTPTGSERVQSAFGKDVHHVYLPYDLPGSVNRFLDQVNPK
LVIIMETELWPNLINTLHRRKIPLVIANARLSARSAAGYKKIGSFIRTILQRITLIAAQNQEDGDRFIELGLKRSQLTVT
GSLKFDISVTPELAARAVTLRRQWAPHRPVWIATSTHDGEETILLEAHRQLLQQFPTLLLILVPRHPERFGKAVELTQKI
GLSYTLRSKGEVPSSSTQVVIGDTMGELMLLYGIADLAFVGGSLVERGGHNPLEAAAHAIPVLMGPHTFNFKDICAKLEQ
AEGLITVTDTLSLVKEITVLLTDEDCRLYYGRHAVDVLHENQGALQRLLHLLEPYLPQRSH

Specific function: Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA [H]

COG id: COG1519

COG function: function code M; 3-deoxy-D-manno-octulosonic-acid transferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family [H]

Homologues:

Organism=Escherichia coli, GI1790064, Length=425, Percent_Identity=79.7647058823529, Blast_Score=707, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001296
- InterPro:   IPR007507 [H]

Pfam domain/function: PF00534 Glycos_transf_1; PF04413 Glycos_transf_N [H]

EC number: 2.-.-.-

Molecular weight: Translated: 51697; Mature: 51697

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNHGSMWCSALLAGKSLFCPDMVLFLIIHINEIDRMLLRLYQVLLYLIQPLIWLRLLLR
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKAPAYRKRWGERYGFCAGKVVAGGIMLHSVSVGETLAAIPLVRALRHRYPSLPITVTT
CCCCCHHHHHHCHHCCCCHHHHHHCHHHEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEE
MTPTGSERVQSAFGKDVHHVYLPYDLPGSVNRFLDQVNPKLVIIMETELWPNLINTLHRR
ECCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHC
KIPLVIANARLSARSAAGYKKIGSFIRTILQRITLIAAQNQEDGDRFIELGLKRSQLTVT
CCCEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEE
GSLKFDISVTPELAARAVTLRRQWAPHRPVWIATSTHDGEETILLEAHRQLLQQFPTLLL
EEEEEEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEE
ILVPRHPERFGKAVELTQKIGLSYTLRSKGEVPSSSTQVVIGDTMGELMLLYGIADLAFV
EEECCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
GGSLVERGGHNPLEAAAHAIPVLMGPHTFNFKDICAKLEQAEGLITVTDTLSLVKEITVL
CHHHHHCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHEEE
LTDEDCRLYYGRHAVDVLHENQGALQRLLHLLEPYLPQRSH
EECCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNNHGSMWCSALLAGKSLFCPDMVLFLIIHINEIDRMLLRLYQVLLYLIQPLIWLRLLLR
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKAPAYRKRWGERYGFCAGKVVAGGIMLHSVSVGETLAAIPLVRALRHRYPSLPITVTT
CCCCCHHHHHHCHHCCCCHHHHHHCHHHEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEE
MTPTGSERVQSAFGKDVHHVYLPYDLPGSVNRFLDQVNPKLVIIMETELWPNLINTLHRR
ECCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHC
KIPLVIANARLSARSAAGYKKIGSFIRTILQRITLIAAQNQEDGDRFIELGLKRSQLTVT
CCCEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEE
GSLKFDISVTPELAARAVTLRRQWAPHRPVWIATSTHDGEETILLEAHRQLLQQFPTLLL
EEEEEEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEE
ILVPRHPERFGKAVELTQKIGLSYTLRSKGEVPSSSTQVVIGDTMGELMLLYGIADLAFV
EEECCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
GGSLVERGGHNPLEAAAHAIPVLMGPHTFNFKDICAKLEQAEGLITVTDTLSLVKEITVL
CHHHHHCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHEEE
LTDEDCRLYYGRHAVDVLHENQGALQRLLHLLEPYLPQRSH
EECCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]