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The map label for this gene is nox.3 [H]

Identifier: 21911307

GI number: 21911307

Start: 1792422

End: 1793954

Strand: Direct

Name: nox.3 [H]

Synonym: SpyM3_1771

Alternate gene names: 21911307

Gene position: 1792422-1793954 (Clockwise)

Preceding gene: 21911306

Following gene: 21911309

Centisome position: 94.31

GC content: 43.84

Gene sequence:

>1533_bases
ATGGCATTAAGTCCTGATATTAAAGAACAACTTGCCCAATACCTCACCCTGTTAGAAGCTGATCTTGTTTTGCAAGTTTC
CCTTGGTGACAATGAGCAGTCTCAAAAAGTCAAAGACTTTGTGGAAGAAATAGCTGCTATGTCTGAGCGTATTTCTATTG
AAAACATCACTTTAGACCGACAACCAAGCTTTAAGGTTGCGAAAAAAGGTCACGATAGTGGGGTTGTCTTTGCCGGCCTT
CCTTTAGGCCACGAATTGACGTCCTTTATTCTTGCTCTCTTGCAAGTATCTGGACGTGCTCCAAAAGTGGATCAAGATGT
TATTGATCGCATCAAGGCCATTGACCGTCCGTTGCATTTTGAAACTTATGTCAGCTTAACCTGCCATAACTGCCCAGATG
TTGTTCAAGCTTTAAACATTATGTCCGTCTTGAACGACAAGATTTCACACACTATGGTAGAAGGCGGCATGTTCCAAGAT
GAAGTGAAAGCCAAAGGCATTATGTCTGTCCCTACTGTCTTTTTAGACGGGGAGGAATTCACTTCTGGTCGTGCTACCAT
TGAGCAACTCTTAGAACAAGTCGCTGGCCCACTTTCTGAGGAAGCCTTTGCTGATAAAGGCCTCTATGATGTCCTTGTTA
TTGGTGGTGGCCCTGCGGGCAATAGCGCTGCTATCTATGCAGCTCGTAAAGGACTAAAAACAGGTTTACTTGCTGAAACC
TTTGGTGGTCAGGTCATGGAAACTGTCGGCATCGAAAACATGATTAGTACCCTTTACACTGAAGGACCAAAATTAATGGC
CGAAGTGGAGGCCCATACTAAGTCTTATGATGTTGATATTATCAAAGCACAACTAGCTACTTCTATTGAGAAAAAAGAAA
ACATCGAGGTTACTCTAGCTAATGGTGCGGTTTTACAAGCCAAAACTGCTATCTTAGCTCTTGGGGCCAAATGGCGTAAC
ATTAATGTTCCTGGTGAAGATGAATTCCGTAATAAAGGGGTGACTTACTGCCCTCACTGTGACGGTCCTCTCTTTGAAGG
CAAAGATGTTGCTGTTATCGGTGGTGGTAACTCCGGTTTAGAAGCGGCCCTTGATTTGGCTGGTCTTGCTAAACACGTTT
ACGTTTTAGAATTCTTGCCCGAGCTCAAAGCTGACAAAGTGCTTCAAGACCGCGCAGCTAAGACTAACAATCTGACCATC
ATCAAAAATGTTGCTACTAAGGATATTGTTGGAGAGGACCATGTTACAGGTCTTAGCTACACTGAGCGTGATAGCGGTGA
AGACAAACACCTTGACCTTGAAGGGGTCTTTGTTCAAATTGGTCTTGTTCCAAACACAGCTTGGCTCAAAGATAGTGGTG
TCAACCTAACCGACCGCGGTGAAATCATTGTGGATAAACATGGGTCAACCAATATTCCTGGTATCTTTGCTGCTGGGGAC
TGTACTGATTCAGCTTATAAACAAATCATTATTTCCATGGGGTCTGGTGCTACTGCTGCCATCGGTGCCTTTGACTACTT
GATTCGTCAATAA

Upstream 100 bases:

>100_bases
CAGGTGAAGTTTGTCCAGCTAAATGGAAAGAAGGCGCTGAAACTTTGACACCAAGTCTTGATTTAGTTGGTAAAATTTAA
TAAATTTTAGGAGGAAAGCT

Downstream 100 bases:

>100_bases
AACAGCATATTTAAAAGAAGTTTTGAGCTAACGCTCAAAGCTTCTTTTTGAAATTTTTTAAAGAATACGACCTCGATCAA
CCGTGAGTTGTCCTTTTTTA

Product: putative NADH oxidase/alkyl hydroperoxidase

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDRQPSFKVAKKGHDSGVVFAGL
PLGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHFETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQD
EVKAKGIMSVPTVFLDGEEFTSGRATIEQLLEQVAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAET
FGGQVMETVGIENMISTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLANGAVLQAKTAILALGAKWRN
INVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGLEAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNLTI
IKNVATKDIVGEDHVTGLSYTERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGD
CTDSAYKQIIISMGSGATAAIGAFDYLIRQ

Sequences:

>Translated_510_residues
MALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDRQPSFKVAKKGHDSGVVFAGL
PLGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHFETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQD
EVKAKGIMSVPTVFLDGEEFTSGRATIEQLLEQVAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAET
FGGQVMETVGIENMISTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLANGAVLQAKTAILALGAKWRN
INVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGLEAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNLTI
IKNVATKDIVGEDHVTGLSYTERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGD
CTDSAYKQIIISMGSGATAAIGAFDYLIRQ
>Mature_509_residues
ALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDRQPSFKVAKKGHDSGVVFAGLP
LGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHFETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQDE
VKAKGIMSVPTVFLDGEEFTSGRATIEQLLEQVAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAETF
GGQVMETVGIENMISTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLANGAVLQAKTAILALGAKWRNI
NVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGLEAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNLTII
KNVATKDIVGEDHVTGLSYTERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGDC
TDSAYKQIIISMGSGATAAIGAFDYLIRQ

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone [H]

COG id: COG3634

COG function: function code O; Alkyl hydroperoxide reductase, large subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=281, Percent_Identity=24.5551601423488, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI65787454, Length=281, Percent_Identity=24.5551601423488, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI226437568, Length=281, Percent_Identity=24.5551601423488, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI87081763, Length=518, Percent_Identity=50.1930501930502, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1787114, Length=309, Percent_Identity=33.9805825242718, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320560, Length=320, Percent_Identity=33.125, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6321898, Length=323, Percent_Identity=32.5077399380805, Blast_Score=136, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012081
- InterPro:   IPR013027
- InterPro:   IPR002109
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 54781; Mature: 54650

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDR
CCCCHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECC
QPSFKVAKKGHDSGVVFAGLPLGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHF
CCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
ETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQDEVKAKGIMSVPTVFLDGEEF
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEECCEEEECCCCC
TSGRATIEQLLEQVAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAET
CCHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCCCCCEEHEEHHCCHHCHHHHH
FGGQVMETVGIENMISTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLA
HCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEE
NGAVLQAKTAILALGAKWRNINVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGL
CCCEEEHHHEEEEECCCEEECCCCCCHHHHCCCCEECCCCCCCCCCCCCEEEEECCCCCH
EAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNLTIIKNVATKDIVGEDHVTGLSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCCC
TERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGD
CCCCCCCCCEEEEEEEEEEEEECCCCCEECCCCCCCCCCCCEEEECCCCCCCCEEEEECC
CTDSAYKQIIISMGSGATAAIGAFDYLIRQ
CCHHHHHHEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDR
CCCHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECC
QPSFKVAKKGHDSGVVFAGLPLGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHF
CCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
ETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQDEVKAKGIMSVPTVFLDGEEF
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEECCEEEECCCCC
TSGRATIEQLLEQVAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAET
CCHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCCCCCEEHEEHHCCHHCHHHHH
FGGQVMETVGIENMISTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLA
HCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEE
NGAVLQAKTAILALGAKWRNINVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGL
CCCEEEHHHEEEEECCCEEECCCCCCHHHHCCCCEECCCCCCCCCCCCCEEEEECCCCCH
EAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNLTIIKNVATKDIVGEDHVTGLSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCCC
TERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGD
CCCCCCCCCEEEEEEEEEEEEECCCCCEECCCCCCCCCCCCEEEECCCCCCCCEEEEECC
CTDSAYKQIIISMGSGATAAIGAFDYLIRQ
CCHHHHHHEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1917890; 2760020 [H]