| Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
|---|---|
| Accession | NC_004070 |
| Length | 1,900,521 |
Click here to switch to the map view.
The map label for this gene is adh2 [H]
Identifier: 21909572
GI number: 21909572
Start: 58683
End: 61325
Strand: Direct
Name: adh2 [H]
Synonym: SpyM3_0036
Alternate gene names: 21909572
Gene position: 58683-61325 (Clockwise)
Preceding gene: 21909571
Following gene: 21909573
Centisome position: 3.09
GC content: 40.33
Gene sequence:
>2643_bases ATGACTGAAGGACATAATACTGTTGAAACAACCTCTGTTTCTGTGACAATTGATGCTCTTGTTCAAAAAGGTTTAGCTGC TCTTGCAGAGATGCGTAAGCTTGACCAAGAACAAGTTGATTATATCGTAGCCAAAGCTTCTGTTGCTGCTTTGGATGCTC ACGGTGAACTTGCTAAACATGCTTATGAAGAAACAGGTCGCGGTGTCTTTGAAGATAAAGCAACAAAAAATCTATTTGCT TGTGAGCATGTGGTTAATAACATGCGCCATCAAAAAACAGTAGGAATTATTGAAGAAGATGATGTGACAGGTTTGACATT AATTGCTGAGCCGGTTGGTGTTATCTGTGGGATTACACCAACAACTAACCCAACTTCAACAGCTATCTTTAAATCTTTGA TCTCGTTAAAAACACGTAATCCAATTATTTTTGCCTTTCACCCATCAGCACAAGAATCATCAGCGCATGCCGCTCGTATT GTTCGTGATGCTGCTATTGCCGCTGGTGCTCCTGAAAATTGTGTGCAGTGGGTTGAAACACCATCACTTGAAGCAACAAA TGCTTTGATGAATCATGACGGCATTGCCACTATCCTTGCGACAGGTGGAAATGCAATGGTTAAAGCGGCATACTCATGTG GGAAACCTGCCCTTGGGGTAGGTGCTGGTAACGTTCCAGCTTATGTTGAAAAATCTGCTAACATCCGCCAAGCCGCTCAT GATATTGTGATGTCTAAATCATTTGATAACGGTATGGTCTGTGCGTCTGAACAAGCTGTTATCGTGGACAAAGAAATCTA TGACGATTTTGTAGCAGAATTCAAATCTTACCATACTTATTTTGTAAATAAAAAAGAAAAAGCCCTTCTTGAAGAATTCT GTTTTGGTGCCAAAGCAAATAGCAAAAACTGTGCTGGTGCAAAATTAAATCCAAATATTGTAGGAAAACCAGCTACTTGG ATTTCAGCACAAGCTGGATTTACTGTTCCAGAAGGAACCAATATTCTTGCTGCAGAATGTAAAGAAGTTTCAGAAAATGA GCCTTTAACACGTGAAAAATTATCTCCAGTCATTGCTGTTTTGAAATCTGAATCACGTGAAGACGGTGTTGAAAAAGCTC GTCAAATGGTTGAATTTAATGGACTCGGTCACTCAGCTGCCATTCATACAGCAGATGCAGAGTTGGCAAAAGAATTTGGA ACTAGAATCCGTGCTATCCGCGTCATCTGGAATTCACCTTCTACATTTGGTGGTATCGGGGATGTTTACAATGCTTTCTT GCCATCATTGACTCTTGGTTGTGGTTCGTATGGACGTAACGCAGTTGGTGATAACGTTAGTGCTATAAATCTCTTGAACA TCAAAAAAGTAGGAAGACGTAGAAATAATATGCAATGGTTTAAAGTTCCTTCAAAAACATACTTCGAACGTGATTCAATT CAATATTTGCAAAAATGTCGTGACGTTGAACGTGTCATGATTGTTACAGATCACGCTATGGTTGAGCTTGGTTTCTTGGA TCGTATCATTGAACAACTTGATCTTCGTCGCAATAAAGTTGTTTATCAGATCTTTGCTGAAGTAGAACCAGATCCAGACA TTACAACTGTTATGAAAGGTACTGAATTAATGCGTACCTTCAAACCAGACACCATTATTGCCCTTGGCGGGGGATCTCCT ATGGATGCAGCCAAAGTTATGTGGCTCTTTTATGAACAACCAGAAGTTGATTTCCATGACCTCGTTCAAAAATTCATGGA TATCCGCAAACGTGCGTTCAAATTCCCAGAACTTGGTAAGAAAACAAAATTTGTTGCTATCCCAACAACTTCTGGAACAG GTTCAGAGGTGACACCATTTGCCGTTATCTCTGACAAAGCAAATAATCGTAAATATCCAATCGCTGATTACTCATTAACA CCAACTGTAGCCATTGTTGACCCAGCTTTGGTATTGACTGTTCCAGGCTTTATTGCTGCTGATACTGGTATGGACGTTTT GACACACGCAACCGAAGCTTACGTGTCACAAATGGCCAATGACTTTACGGATGGTTTAGCTCTTCAAGCCATTAAAATTG TTTTTGATAATCTTGAAAAATCAGTTAAAACAGCCGATTTTGAAGCACGTGAAAAGATGCACAATGCGTCAACTATGGCA GGTATGGCTTTCGCCAATGCATTCTTAGGTATTTCTCACTCAATGGCGCATAAAATTGGCGCACAATTCCATACCGTACA CGGACGTACAAATGCAATTCTTTTGCCGTATGTTATCCGCTATAATGGAACTCGTCCAGCTAAAACAGCAACATGGCCTA AGTATAATTACTACCGTGCGGATGAAAAATACCAAGACATTGCGAAATTGTTAGGGCTTTCAGCTTCTACACCAGAAGAA GCAGTGGAATCTTATGCGAAAGCTGTTTATGATCTGGGTTGCCGAGTTGGTATTCAAATGAACTTCAAAGCTCAAGGTAT CGACGAAAACGAATGGAAAGAACATTCTCGTGAATTGGCTTACCTTGCTTATGAAGACCAATGTTCACCTGCTAACCCAC GTCTTCCAATGGTTGATCACATGCAAGAAATTATTGAAGATGCTTACTATGGTTATGCTGAACGTCCAGGACGACGTAAG TGA
Upstream 100 bases:
>100_bases TCACAAATTTATTGTGAAATGATTTACAAAATTTCAAAAAGTGCTATAATAATTTTGTAAACAAAATTGTGAAACTTTTA ACAAGATAAAGGAGTCTCAA
Downstream 100 bases:
>100_bases TTTTTAATGTTGATACCAGGAAATGATTTCTTATGATTAAAGTCATAAGAAATCATTTTATTTTCTAAATATATCATTTA TATCCAGTGTCAGAAAATGT
Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase
Products: NA
Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH; Pyruvate-formate-lyase deactivase; PFL deactivase [H]
Number of amino acids: Translated: 880; Mature: 879
Protein sequence:
>880_residues MTEGHNTVETTSVSVTIDALVQKGLAALAEMRKLDQEQVDYIVAKASVAALDAHGELAKHAYEETGRGVFEDKATKNLFA CEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARI VRDAAIAAGAPENCVQWVETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH DIVMSKSFDNGMVCASEQAVIVDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPATW ISAQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAVLKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFG TRIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSI QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKGTELMRTFKPDTIIALGGGSP MDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLT PTVAIVDPALVLTVPGFIAADTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMA GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLSASTPEE AVESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELAYLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK
Sequences:
>Translated_880_residues MTEGHNTVETTSVSVTIDALVQKGLAALAEMRKLDQEQVDYIVAKASVAALDAHGELAKHAYEETGRGVFEDKATKNLFA CEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARI VRDAAIAAGAPENCVQWVETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH DIVMSKSFDNGMVCASEQAVIVDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPATW ISAQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAVLKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFG TRIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSI QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKGTELMRTFKPDTIIALGGGSP MDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLT PTVAIVDPALVLTVPGFIAADTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMA GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLSASTPEE AVESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELAYLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK >Mature_879_residues TEGHNTVETTSVSVTIDALVQKGLAALAEMRKLDQEQVDYIVAKASVAALDAHGELAKHAYEETGRGVFEDKATKNLFAC EHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIV RDAAIAAGAPENCVQWVETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAHD IVMSKSFDNGMVCASEQAVIVDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPATWI SAQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAVLKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFGT RIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSIQ YLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKGTELMRTFKPDTIIALGGGSPM DAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTP TVAIVDPALVLTVPGFIAADTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMAG MAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLSASTPEEA VESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELAYLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK
Specific function: This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent
COG id: COG1012
COG function: function code C; NAD-dependent aldehyde dehydrogenases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]
Homologues:
Organism=Homo sapiens, GI133922590, Length=331, Percent_Identity=27.4924471299094, Blast_Score=101, Evalue=2e-21, Organism=Escherichia coli, GI1787493, Length=867, Percent_Identity=47.8662053056517, Blast_Score=773, Evalue=0.0, Organism=Escherichia coli, GI1789163, Length=401, Percent_Identity=33.9152119700748, Blast_Score=209, Evalue=5e-55, Organism=Escherichia coli, GI87082107, Length=415, Percent_Identity=32.7710843373494, Blast_Score=189, Evalue=7e-49, Organism=Escherichia coli, GI48994951, Length=398, Percent_Identity=32.9145728643216, Blast_Score=181, Evalue=1e-46, Organism=Escherichia coli, GI1788797, Length=385, Percent_Identity=30.9090909090909, Blast_Score=156, Evalue=4e-39, Organism=Escherichia coli, GI1789386, Length=387, Percent_Identity=23.5142118863049, Blast_Score=81, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17537053, Length=255, Percent_Identity=29.0196078431373, Blast_Score=114, Evalue=3e-25, Organism=Saccharomyces cerevisiae, GI6321181, Length=418, Percent_Identity=31.5789473684211, Blast_Score=189, Evalue=2e-48, Organism=Saccharomyces cerevisiae, GI6324950, Length=323, Percent_Identity=24.1486068111455, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI24657991, Length=378, Percent_Identity=28.3068783068783, Blast_Score=102, Evalue=1e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001670 - InterPro: IPR018211 - InterPro: IPR016161 - InterPro: IPR016163 - InterPro: IPR016162 - InterPro: IPR015590 - InterPro: IPR012079 [H]
Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]
EC number: =1.1.1.1; =1.2.1.10 [H]
Molecular weight: Translated: 96614; Mature: 96483
Theoretical pI: Translated: 6.37; Mature: 6.37
Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTEGHNTVETTSVSVTIDALVQKGLAALAEMRKLDQEQVDYIVAKASVAALDAHGELAKH CCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH AYEETGRGVFEDKATKNLFACEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITP HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCEEEECCC TTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIVRDAAIAAGAPENCVQWVET CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCC PSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH CCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHH DIVMSKSFDNGMVCASEQAVIVDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKAN HHHHHCCCCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCCCC SKNCAGAKLNPNIVGKPATWISAQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAV CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH LKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFGTRIRAIRVIWNSPSTFGGIG HHCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCEEEEEEEECCCCCCCCHH DVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSI HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECCCHHHHCHHHH QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKG HHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHH TELMRTFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGK HHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCC KTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFIAA CCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCEEE DTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRA HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEC DEKYQDIAKLLGLSASTPEEAVESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELA CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHCCEE YLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK EEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC >Mature Secondary Structure TEGHNTVETTSVSVTIDALVQKGLAALAEMRKLDQEQVDYIVAKASVAALDAHGELAKH CCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH AYEETGRGVFEDKATKNLFACEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITP HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCEEEECCC TTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIVRDAAIAAGAPENCVQWVET CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCC PSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH CCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHH DIVMSKSFDNGMVCASEQAVIVDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKAN HHHHHCCCCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCCCC SKNCAGAKLNPNIVGKPATWISAQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAV CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH LKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFGTRIRAIRVIWNSPSTFGGIG HHCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCEEEEEEEECCCCCCCCHH DVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSI HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECCCHHHHCHHHH QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKG HHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHH TELMRTFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGK HHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCC KTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFIAA CCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCEEE DTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRA HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEC DEKYQDIAKLLGLSASTPEEAVESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELA CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHCCEE YLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK EEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]