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The map label for this gene is adh1 [H]

Identifier: 21909573

GI number: 21909573

Start: 61578

End: 62594

Strand: Direct

Name: adh1 [H]

Synonym: SpyM3_0037

Alternate gene names: 21909573

Gene position: 61578-62594 (Clockwise)

Preceding gene: 21909572

Following gene: 21909574

Centisome position: 3.24

GC content: 42.38

Gene sequence:

>1017_bases
ATGAAAGCCGTAGTTGTTAATCAAGCTAGTACAGGTGTCGAAGTTGTTGAGCATGATCTTCCAAATGTTGGTCATGGTGA
AGCGCTTGTTAAAGTAGAATACTGTGGTGTTTGTCATACTGATTTACACGTTGCACATGGCGATTTTGGTCAGGTACCAG
GACGTATTTTGGGGCACGAAGGTATTGGTATAGTAGAAGAAATTGGAGAAGGCGTAACATCCTTAAAGGTTGGTGATCGT
GTCTCTATTGCATGGTTCTTTGAAGGATGTGGTCATTGCGAATACTGTACTACAGGACGTGAGACACTTTGTCGTAGTGT
TAAAAATGCTGGATACAGTGTTGATGGAGGAATGAGTGAATATGCAGTAGTAACAGCTGATTATGCAGTTAAAGTTCCAG
AAGGTTTAGACCCGGCTCAAGCTTCTTCCATTACTTGTGCTGGTGTAACAACTTATAAAGCTATTAAAGAGGCAGGTGCT
GCTCCAGGCCAATGGATTGTTATCTTTGGGGCAGGTGGCCTTGGAAATCTGGCTGTTCAATACGCTAAAAAAGTCTTTAA
TGCACATGTTGTCGCAGTGGACATTAATAATGATAAACTTGAGTTAGCTAAAGAAGTTGGCGCAGATATTGTAGTTAACG
GCAAAGAAATTGAAGATGTTCCAGGCTATATTCAAGAAAAAACCGGTGGAGCACATGGTGTTGTGGTAACGGCTGTTTCT
AAAGTTGCTTTTAACCAAGCAATTGATAGTGTCCGTGCCGGTGGGACAGTTGTAGCCGTAGGTCTTCCATCAGAATACAT
GGAACTGTCTATCGTAAAAACTGTTTTAGATGGTATCAAAGTGGTCGGATCACTTGTAGGGACACGTAAAGACTTGGAAG
AAGCCTTTGCCTTTGGTGCAGAAGGTCTGGTTGTTCCGGTTGTCGAAAAAGTTCCAGTTGACACTGCTCCAGAAGTCTTT
GATGAAATGGAACGTGGTTTAATCCAAGGGCGCAAGGTCTTAGATTTCATCAGCTAA

Upstream 100 bases:

>100_bases
TTCAGAAACTTTTCAGGTTTCTGTTGACTTTCATTGTGAAAAGATGTACAATTTATTTGTAACCGATTACAAATAAGTCA
TTATTAGATGGAGGACTGAT

Downstream 100 bases:

>100_bases
ACATACAAATGTATTAAATATGAGATAAGCCTAAGTTGTTTAAACTTGATTCCAAATAAAATAGCACTCTCGAGTATCAG
AAAACATTTTTGACTCGAGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase I; ADH I [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKAVVVNQASTGVEVVEHDLPNVGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHEGIGIVEEIGEGVTSLKVGDR
VSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSEYAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGA
APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGAEGLVVPVVEKVPVDTAPEVF
DEMERGLIQGRKVLDFIS

Sequences:

>Translated_338_residues
MKAVVVNQASTGVEVVEHDLPNVGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHEGIGIVEEIGEGVTSLKVGDR
VSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSEYAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGA
APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGAEGLVVPVVEKVPVDTAPEVF
DEMERGLIQGRKVLDFIS
>Mature_338_residues
MKAVVVNQASTGVEVVEHDLPNVGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHEGIGIVEEIGEGVTSLKVGDR
VSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSEYAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGA
APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGAEGLVVPVVEKVPVDTAPEVF
DEMERGLIQGRKVLDFIS

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=345, Percent_Identity=30.4347826086957, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4501933, Length=351, Percent_Identity=29.6296296296296, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4501929, Length=341, Percent_Identity=29.3255131964809, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI262073058, Length=295, Percent_Identity=29.4915254237288, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI71743840, Length=295, Percent_Identity=29.4915254237288, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI71565154, Length=250, Percent_Identity=33.6, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=26.6467065868263, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71565152, Length=349, Percent_Identity=27.2206303724928, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI156523966, Length=224, Percent_Identity=31.6964285714286, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501939, Length=224, Percent_Identity=31.6964285714286, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=65.7738095238095, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=29.9120234604106, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1787863, Length=298, Percent_Identity=31.8791946308725, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=27.6657060518732, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788073, Length=265, Percent_Identity=31.6981132075472, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI226510992, Length=326, Percent_Identity=28.5276073619632, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082401, Length=342, Percent_Identity=26.6081871345029, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=28.1976744186047, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790718, Length=310, Percent_Identity=29.0322580645161, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786552, Length=246, Percent_Identity=33.739837398374, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI87082125, Length=264, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=297, Percent_Identity=27.9461279461279, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786825, Length=358, Percent_Identity=26.536312849162, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=340, Percent_Identity=38.5294117647059, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71988145, Length=339, Percent_Identity=37.1681415929204, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=37.7581120943953, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17562876, Length=264, Percent_Identity=32.9545454545455, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=271, Percent_Identity=32.1033210332103, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=285, Percent_Identity=28.4210526315789, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=285, Percent_Identity=27.3684210526316, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=263, Percent_Identity=27.3764258555133, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=40.2941176470588, Blast_Score=235, Evalue=9e-63,
Organism=Saccharomyces cerevisiae, GI6323961, Length=341, Percent_Identity=39.5894428152493, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6319621, Length=341, Percent_Identity=39.2961876832845, Blast_Score=229, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6323729, Length=322, Percent_Identity=40.3726708074534, Blast_Score=227, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319949, Length=335, Percent_Identity=29.2537313432836, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=28.2131661442006, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=230, Percent_Identity=35.6521739130435, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=285, Percent_Identity=29.4736842105263, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=285, Percent_Identity=29.1228070175439, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=271, Percent_Identity=31.3653136531365, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=289, Percent_Identity=24.5674740484429, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17737895, Length=345, Percent_Identity=28.9855072463768, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137530, Length=222, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17737897, Length=322, Percent_Identity=27.0186335403727, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551930, Length=280, Percent_Identity=23.9285714285714, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221457811, Length=280, Percent_Identity=23.9285714285714, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550770, Length=280, Percent_Identity=23.9285714285714, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35367; Mature: 35367

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVVNQASTGVEVVEHDLPNVGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHE
CCEEEEECCCCCHHHHHHCCCCCCCCCEEEEEEECCEECCCEEEECCCCCCCCCEEECCC
GIGIVEEIGEGVTSLKVGDRVSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSE
CCCHHHHHCCCCEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
YAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGAAPGQWIVIFGAGGLGNLAVQ
EEEEEECEEEECCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
YAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
HHHHHHCCEEEEEECCCCHHHHHHHCCCEEEECCCCCCCCCCHHHHCCCCCCEEHHHHHH
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGA
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
EGLVVPVVEKVPVDTAPEVFDEMERGLIQGRKVLDFIS
CCEEEEEHHHCCCCCCHHHHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MKAVVVNQASTGVEVVEHDLPNVGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHE
CCEEEEECCCCCHHHHHHCCCCCCCCCEEEEEEECCEECCCEEEECCCCCCCCCEEECCC
GIGIVEEIGEGVTSLKVGDRVSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSE
CCCHHHHHCCCCEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
YAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGAAPGQWIVIFGAGGLGNLAVQ
EEEEEECEEEECCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
YAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
HHHHHHCCEEEEEECCCCHHHHHHHCCCEEEECCCCCCCCCCHHHHCCCCCCEEHHHHHH
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGA
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
EGLVVPVVEKVPVDTAPEVFDEMERGLIQGRKVLDFIS
CCEEEEEHHHCCCCCCHHHHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185223; 8320209; 2935393 [H]