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The map label for this gene is parC [H]

Identifier: 161485747

GI number: 161485747

Start: 685684

End: 688143

Strand: Direct

Name: parC [H]

Synonym: SpyM3_0625

Alternate gene names: 161485747

Gene position: 685684-688143 (Clockwise)

Preceding gene: 21910160

Following gene: 21910162

Centisome position: 36.08

GC content: 40.24

Gene sequence:

>2460_bases
ATGTCAAACATTCAAAACATGTCCCTTGAGGATATTATGGGAGAACGCTTCGGCCGTTATTCCAAGTATATTATTCAGGA
ACGGGCACTTCCTGATATTCGAGATGGATTGAAACCCGTTCAGCGTCGGATTCTTTATTCGATGAATAAGGATGGCAATA
CTTTTGAAAAAGGTTACCGTAAATCAGCCAAATCAGTTGGTAATATTATGGGGAATTTCCACCCACATGGGGATTCCTCT
ATTTATGATGCCATGGTACGGATGAGTCAAGATTGGAAGAACCGTGAAATCCTTGTTGAAATGCACGGAAATAATGGTTC
AATGGATGGTGATCCGCCTGCGGCTATGCGTTATACAGAAGCTCGCTTGTCTGAAATTGCGGGTTATCTTCTTCAAGACA
TTGAGAAAAATACGGTCTCTTTTGCGTGGAACTTTGATGACACAGAAAAAGAACCCACCGTTTTACCAGCAGCTTTTCCT
AACTTACTTGTCAATGGGTCTTCTGGTATTTCCGCAGGCTATGCGACAGATATTCCACCGCACAATTTGTCAGAAGTGAT
TGATGCTGTTGTGTATATGATTGATCATCCCAAAGCTAGTTTAGAGAAATTGATGGAATTTTTGCCTGGGCCAGATTTCC
CGACAGGAGGCATTATCCAAGGAGCTGACGAAATCAAAAAAGCCTACGAAACAGGTAAGGGACGTGTCGTTGTTCGCTCT
AGGACAGAAATCGAGGAACTTAAAGGTGGTAAACAACAAATTATTGTCACTGAGATTCCTTATGAAGTTAACAAAGCAGT
CTTGGTCAAAAAGATTGACGATGTGCGTGTTAACAATAAAGTCCCAGGCATCGTAGAAGTACGCGATGAATCTGATCGCA
CAGGTCTTCGCATAGCTATTGAGTTGAAAAAAGAGGCTGATAGCCAAACCATTTTGAATTATTTGTTGAAATACACAGAT
CTTCAAGTTAATTACAATTTCAATATGGTTGCTATTGATCACTTTACGCCACGCCAAGTAGGTCTTCAAAAAATCTTATC
AAGCTATATCAGCCACCGCAAAGATATTATTATTGAGCGGTCTAAATTCGATAAAGCCAAAGCTGAAAAACGCCTCCACA
TTGTTGAAGGATTGATTCGTGTCTTGTCCATCTTAGATGAGATTATTGCTTTGATTAGATCGTCTGACAATAAGGCTGAT
GCTAAAGAAAATCTGAAAGTCAGCTATGATTTCTCTGAGGAACAAGCAGAAGCGATTGTAACCTTGCAGCTTTATCGTTT
AACTAATACCGATATTGTTACTCTCCAAAATGAAGAAAATGATTTAAGAGACTTAATCACGACCCTTTCCGCTATTATCG
GTGACGAAGCAACCATGTATAACGTCATGAAACGTGAATTAAGAGAAGTGAAAAAGAAATTTGCCAATCCTCGTTTATCA
GAGTTACAAGCGGAAAGTCAAATCATTGAGATTGACACTGCCAGCTTGATTGCAGAGGAAGAAACTTTTGTTAGTGTGAC
ACGGGGCGGATACCTCAAAAGAACCAGCCCACGATCCTTCAATGCGTCTAGTTTAGAAGAAGTTGGCAAGAGAGATGATG
ATGAACTCATCTTCGTTAAACAGGCCAAAACAACAGAACACCTTTTGTTGTTTACAACTTTAGGCAATGTCATTTACCGA
CCAATCCATGAATTGACCGATTTACGTTGGAAGGATATCGGTGAACATTTATCACAAACCATTTCAAACTTCGCGACAGA
AGAAGAGATTCTCTACGCTGATATTGTGACTTCCTTTGACCAGGGCTTGTATGTGGCTGTCACACAAAATGGTTTTATCA
AACGCTTTGATCGTAAAGAACTAAGTCCTTGGCGAACTTATAAATCTAAATCAACCAAATATGTGAAGCTAAAGGATGAC
AAAGACCGCGTGGTTACCTTGTCACCAGTTATTATGGAAGACCTCCTATTAGTGACTAAAAATGGTTATGCTTTGCGATT
CTCCAGTCAGGAAGTGCCTATTCAAGGGTTGAAATCTGCTGGTGTTAAAGGCATTAACTTGAAAAATGATGACAGCCTTG
CCTCAGCCTTTGCTGTGACAAGTAACTCTTTCTTTGTCTTAACTCAGAGGGGTTCTCTCAAACGGATGGCTGTCGATGAT
ATTCCTCAGACAAGTCGTGCCAATCGTGGACTATTGGTTCTACGAGAGTTAAAAACCAAACCTCATAGAGTTTTTCTGGC
CGGAGGCGTTCAATCAGATACTTCAGCTGAGCAGTTTGATTTGTTCACTGATATACCTGAAGAAGAAACTAATCAACAAA
TGCTTGAAGTCATTAGTAAGACTGGTCAAACCTACGAGATTGCTTTAGAAACGCTTTCGTTATCGGAAAGAACCAGCAAT
GGCTCCTTTATTTCAGACACTATTTCGGATCAAGAAGTACTGGTAGCTAGAACACGTTAA

Upstream 100 bases:

>100_bases
GGTGTTTTAGTCATACAAGTTTCTCACAGATAATTACAAGTGCTAAAGACGATTGTTTTTTAGGTAATTAATAAATAATG
AAAAAGAAAGCTATTTGAAT

Downstream 100 bases:

>100_bases
AAAGAGTGAAAACTCTTTTTAATTTTATGGTAAATTTAGAATATTAATGCAAAAGAGTAGAATAAACTTGAAAATTATTG
AAAAAAAGTTACAATAGAAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSS
IYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFP
NLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS
RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTD
LQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKAD
AKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS
ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYR
PIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDD
KDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD
IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERTSN
GSFISDTISDQEVLVARTR

Sequences:

>Translated_819_residues
MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSS
IYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFP
NLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS
RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTD
LQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKAD
AKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS
ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYR
PIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDD
KDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD
IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERTSN
GSFISDTISDQEVLVARTR
>Mature_818_residues
SNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSSI
YDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPN
LLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRSR
TEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTDL
QVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADA
KENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLSE
LQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYRP
IHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDK
DRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDDI
PQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERTSNG
SFISDTISDQEVLVARTR

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=318, Percent_Identity=25.1572327044025, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI19913406, Length=318, Percent_Identity=24.5283018867925, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788562, Length=804, Percent_Identity=37.3134328358209, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI1789396, Length=728, Percent_Identity=32.2802197802198, Blast_Score=351, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17535065, Length=181, Percent_Identity=29.2817679558011, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=179, Percent_Identity=29.0502793296089, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=398, Percent_Identity=25.1256281407035, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=187, Percent_Identity=26.7379679144385, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17136538, Length=231, Percent_Identity=26.8398268398268, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 92467; Mature: 92336

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYR
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
ARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPNLLVNGSSGISAGYATDIPP
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCCCEEECCCCCCCCCCCCCCC
HNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC
RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAI
CHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCEEEEE
ELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIER
EECCCCCHHHHHHHHHHHHEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCHHEEEEC
SKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADAKENLKVSYDFSEEQAEAIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHEEE
TLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS
EEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH
ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVK
HHHCCCEEEEEEHHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHCCCCCCCEEEEE
QAKTTEHLLLFTTLGNVIYRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFD
ECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
QGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLVTK
CCEEEEEECCCHHHHCCHHCCCHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHEEC
NGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD
CCEEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEECCCEEEEECCCCCCHHHHHC
IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISK
CCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
TGQTYEIALETLSLSERTSNGSFISDTISDQEVLVARTR
CCCEEEEEEEHHHHHCCCCCCCEEECCCCCCEEEEEECC
>Mature Secondary Structure 
SNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
ARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPNLLVNGSSGISAGYATDIPP
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCCCEEECCCCCCCCCCCCCCC
HNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC
RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAI
CHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCEEEEE
ELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIER
EECCCCCHHHHHHHHHHHHEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCHHEEEEC
SKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADAKENLKVSYDFSEEQAEAIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHEEE
TLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS
EEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH
ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVK
HHHCCCEEEEEEHHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHCCCCCCCEEEEE
QAKTTEHLLLFTTLGNVIYRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFD
ECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
QGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLVTK
CCEEEEEECCCHHHHCCHHCCCHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHEEC
NGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD
CCEEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEECCCEEEEECCCCCCHHHHHC
IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISK
CCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
TGQTYEIALETLSLSERTSNGSFISDTISDQEVLVARTR
CCCEEEEEEEHHHHHCCCCCCCEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]