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The map label for this gene is fkpA

Identifier: 21672779

GI number: 21672779

Start: 566949

End: 567707

Strand: Reverse

Name: fkpA

Synonym: BUsg514

Alternate gene names: 21672779

Gene position: 567707-566949 (Counterclockwise)

Preceding gene: 21672780

Following gene: 21672778

Centisome position: 88.5

GC content: 23.06

Gene sequence:

>759_bases
ATGATTGTTTTTTTATTAAAAAGAATTTTATTATTATATTTAATTTTTTTTGTTCCGAAATCTTTTTCAGAAAACCTACC
TTTTTTTAAAATTAAATCTTATTCAGAGAAGAAAGAATTTTTTCAAAATGATAACGAAAAAGTAGGATACTCTTTAGGAG
TATCTTTAGGTAATTATGTAAATGAATCTTTTGAAAGACAAAAAAAAATGGGAATAAACTTAGACAAATATAATATTTTG
TTAGGAGTACAAGACGCTATTTCAGGTAATTTAAAATTATCAAATGAAGAAATTTCAACAATTCTTCAAAAATTAGAAAA
AAATTTGAAGAATGCAGCAAAAATTGAATTTGAAAAAAGTGAAAAAGAAAACTTAATTCAAGGAAAATTATATATGAAAA
AATTTTCTGAAATGAAAGGAGTAAGTAAAACCTCTAGCGGTCTTTTATATATTATTGATAAATTAGGTGAAGGTGAAGAG
ATAAAAACAAAAAATGCAGAAATTACAGTTCATTATAAAGGATCACTAATCAATGGTACAGAATTTGACAGTTCTTATAA
ACGAGGAAAGCCTATAACATTAATGTTAAAAGATGTTATATTAGGTTGGCAAGAAGGTTTAAAGTATATTAAAAAAGGTG
GTAAAATTAAATTAATCATACCTCCTAATTTAGGGTACGGAAGCAATAGAATTAATGAAATACCAGCAAATTCTATTTTA
ATTTTTGATATAGAATTATTAGATATCAAAAATATTTAA

Upstream 100 bases:

>100_bases
AATATTAATTAAATAATTTTATATTAAAAAATAAGAATTTAATATAAAATTTTTTAAATGTAAAATAAATTTATTATTTT
TTACATTTTGGGAGTAATAA

Downstream 100 bases:

>100_bases
TATTAGTATTCTTTTAACATTTATAGAAATTATTTTTTAGTTCAAATAATTTTAATTTTGAATCAAGATATTTTAATATG
AATTATACAGTTTTAGTTAC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase FkpA precursor

Products: NA

Alternate protein names: PPIase; Rotamase

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIVFLLKRILLLYLIFFVPKSFSENLPFFKIKSYSEKKEFFQNDNEKVGYSLGVSLGNYVNESFERQKKMGINLDKYNIL
LGVQDAISGNLKLSNEEISTILQKLEKNLKNAAKIEFEKSEKENLIQGKLYMKKFSEMKGVSKTSSGLLYIIDKLGEGEE
IKTKNAEITVHYKGSLINGTEFDSSYKRGKPITLMLKDVILGWQEGLKYIKKGGKIKLIIPPNLGYGSNRINEIPANSIL
IFDIELLDIKNI

Sequences:

>Translated_252_residues
MIVFLLKRILLLYLIFFVPKSFSENLPFFKIKSYSEKKEFFQNDNEKVGYSLGVSLGNYVNESFERQKKMGINLDKYNIL
LGVQDAISGNLKLSNEEISTILQKLEKNLKNAAKIEFEKSEKENLIQGKLYMKKFSEMKGVSKTSSGLLYIIDKLGEGEE
IKTKNAEITVHYKGSLINGTEFDSSYKRGKPITLMLKDVILGWQEGLKYIKKGGKIKLIIPPNLGYGSNRINEIPANSIL
IFDIELLDIKNI
>Mature_252_residues
MIVFLLKRILLLYLIFFVPKSFSENLPFFKIKSYSEKKEFFQNDNEKVGYSLGVSLGNYVNESFERQKKMGINLDKYNIL
LGVQDAISGNLKLSNEEISTILQKLEKNLKNAAKIEFEKSEKENLIQGKLYMKKFSEMKGVSKTSSGLLYIIDKLGEGEE
IKTKNAEITVHYKGSLINGTEFDSSYKRGKPITLMLKDVILGWQEGLKYIKKGGKIKLIIPPNLGYGSNRINEIPANSIL
IFDIELLDIKNI

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Homo sapiens, GI224809329, Length=113, Percent_Identity=41.5929203539823, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI224809327, Length=113, Percent_Identity=41.5929203539823, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4758384, Length=113, Percent_Identity=41.5929203539823, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI224809331, Length=113, Percent_Identity=41.5929203539823, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI17149836, Length=98, Percent_Identity=38.7755102040816, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4503725, Length=98, Percent_Identity=38.7755102040816, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI8923659, Length=96, Percent_Identity=46.875, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI33469985, Length=95, Percent_Identity=37.8947368421053, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4758380, Length=98, Percent_Identity=38.7755102040816, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI206725530, Length=95, Percent_Identity=41.0526315789474, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI17149844, Length=95, Percent_Identity=41.0526315789474, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI17149842, Length=95, Percent_Identity=41.0526315789474, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1789745, Length=215, Percent_Identity=48.8372093023256, Blast_Score=196, Evalue=9e-52,
Organism=Escherichia coli, GI87082390, Length=212, Percent_Identity=30.6603773584906, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17540882, Length=109, Percent_Identity=41.2844036697248, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=98, Percent_Identity=40.8163265306122, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561782, Length=111, Percent_Identity=36.9369369369369, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=89, Percent_Identity=46.0674157303371, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324194, Length=103, Percent_Identity=38.8349514563107, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323566, Length=122, Percent_Identity=36.8852459016393, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24655568, Length=98, Percent_Identity=42.8571428571429, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281363946, Length=97, Percent_Identity=46.3917525773196, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17352457, Length=97, Percent_Identity=46.3917525773196, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356629, Length=87, Percent_Identity=45.9770114942529, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): FKBA_BUCAP (Q8K943)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660846.1
- ProteinModelPortal:   Q8K943
- SMR:   Q8K943
- EnsemblBacteria:   EBBUCT00000000212
- GeneID:   1005657
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg514
- GeneTree:   EBGT00050000007922
- HOGENOM:   HBG731200
- OMA:   VVENKST
- ProtClustDB:   CLSK390914
- BioCyc:   BAPH198804:BUSG514-MONOMER
- InterPro:   IPR001179
- InterPro:   IPR000774
- Gene3D:   G3DSA:1.10.287.460
- PANTHER:   PTHR10516

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N

EC number: =5.2.1.8

Molecular weight: Translated: 28737; Mature: 28737

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVFLLKRILLLYLIFFVPKSFSENLPFFKIKSYSEKKEFFQNDNEKVGYSLGVSLGNYV
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCEEECCHHHHHH
NESFERQKKMGINLDKYNILLGVQDAISGNLKLSNEEISTILQKLEKNLKNAAKIEFEKS
HHHHHHHHHHCCCCCCEEEEEEEHHHCCCCEEECHHHHHHHHHHHHHHHHHHHEEEECCC
EKENLIQGKLYMKKFSEMKGVSKTSSGLLYIIDKLGEGEEIKTKNAEITVHYKGSLINGT
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEECCCEEEEEECCCEECCC
EFDSSYKRGKPITLMLKDVILGWQEGLKYIKKGGKIKLIIPPNLGYGSNRINEIPANSIL
CCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEE
IFDIELLDIKNI
EEEEEEEEECCC
>Mature Secondary Structure
MIVFLLKRILLLYLIFFVPKSFSENLPFFKIKSYSEKKEFFQNDNEKVGYSLGVSLGNYV
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCEEECCHHHHHH
NESFERQKKMGINLDKYNILLGVQDAISGNLKLSNEEISTILQKLEKNLKNAAKIEFEKS
HHHHHHHHHHCCCCCCEEEEEEEHHHCCCCEEECHHHHHHHHHHHHHHHHHHHEEEECCC
EKENLIQGKLYMKKFSEMKGVSKTSSGLLYIIDKLGEGEEIKTKNAEITVHYKGSLINGT
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEECCCEEEEEECCCEECCC
EFDSSYKRGKPITLMLKDVILGWQEGLKYIKKGGKIKLIIPPNLGYGSNRINEIPANSIL
CCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEE
IFDIELLDIKNI
EEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438