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The map label for this gene is clpX

Identifier: 21672725

GI number: 21672725

Start: 521832

End: 523115

Strand: Direct

Name: clpX

Synonym: BUsg460

Alternate gene names: 21672725

Gene position: 521832-523115 (Clockwise)

Preceding gene: 21672724

Following gene: 21672726

Centisome position: 81.35

GC content: 27.88

Gene sequence:

>1284_bases
ATGACAGATAAGAGTAAAGACAATTCTAAAAAATTACTTCAATGCTCTTTTTGTGGTAAAAATCAAAAAGAAGTAAAAAA
ATTAATAGCTGGTCCAGCCGTTTATATATGTGATGAATGTATAAGACTGTGTAATAATATTATTCAAGAAACTAAAACTA
CAAAAAAAATAGAAGATGATGAATTAAGTTACTTGCCGACACCACATGAAATTAAAAAACATCTTGATAATTATGTAATA
GGTCAAAACCATACAAAAAAAGTTTTATCTGTAGCAGTTTATAATCATTATCAACGAATTCGTAATGTATCTAAAAATAA
AGATAACGTTGAACTTGGAAAAAGTAATATTTTATTAATTGGACCAACTGGAAGTGGAAAAACTTTATTGGCAGAAACAT
TAGCAAAATTATTAAATGTACCTTTTAGCATTGCTGACGCAACTACTTTAACTGAAGCAGGATACGTCGGAGAAGACGTG
GAAAACGTCATACAAAAACTTTTACAAAAATGCGAATATAATGTTAAAAAGGCAGAATTAGGTATTGTTTATATAGATGA
AATAGATAAAATTTCAAGAAAATCTGATAATCCTTCTATTACCAGAGATGTGTCTGGAGAGGGAGTACAGCAGGCTTTGT
TAAAATTAATCGAAGGAACTCTAGCATCAATTCCGCCACAAGGTGGAAGAAAGCATCCACAACAAGAATTTTTACAAGTC
AATACTGCAAATATTCTATTTATATGTGCAGGAGCGTTTTCAGAACTTTCTAAAATTATTTCTAAAAGAATTGATACTGG
AAATACAATTGGTTTTAACTGTAATCTTAAAAAACAGAAAAAGAAAAAATCAGAACAATATTTTTTGCAACAAGTGCAAT
CAAAAGATTTAATAAAATTTGGATTAATTCCTGAATTTATTGGTCGTTTACCTATAATAACTATTCTAAAAGAATTAAAT
GAAACTGCTCTCGTTCAAATATTGTGTAAACCTAAAAACGCTTTAATCAAACAATATCAAACATTATTTAATTTAGAAAA
AGTAAAATTAGAATTTACAAAAGAAGCGGTTACGTCAATCGCAAAAAAAGCGTTATCTAAAAAAACAGGGGCGAGAGGAT
TAAGATCTATTATTGAAAATATTTTATTAGATATCATGTATGAGTTACCATCTATGAAAAATGTAGAAAAAATATTAATC
GATGAATCAGTTGTAAATTCTCATTCCTTACCGAAAATAATATATGAAGAAAAAAACAAATCCAAAAAAGCATCCGGTGA
ATAA

Upstream 100 bases:

>100_bases
TTAACTCAACGTTAAGAAAAATTTTTATTAAAAATAATAAAACAGAATCTATTTACTCAAAAAAAAATCGATAAATATAT
GAATTAAAGAGGTTAAAAAT

Downstream 100 bases:

>100_bases
AAAATAAAGACATCAGATAATCTCAAACAAGGGCATTCTCCCTTTATTTTGCCAAACGCTTCAGATTAAATGTCAAGCGA
CCATTCCAATATACTTGGCT

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTDKSKDNSKKLLQCSFCGKNQKEVKKLIAGPAVYICDECIRLCNNIIQETKTTKKIEDDELSYLPTPHEIKKHLDNYVI
GQNHTKKVLSVAVYNHYQRIRNVSKNKDNVELGKSNILLIGPTGSGKTLLAETLAKLLNVPFSIADATTLTEAGYVGEDV
ENVIQKLLQKCEYNVKKAELGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTLASIPPQGGRKHPQQEFLQV
NTANILFICAGAFSELSKIISKRIDTGNTIGFNCNLKKQKKKKSEQYFLQQVQSKDLIKFGLIPEFIGRLPIITILKELN
ETALVQILCKPKNALIKQYQTLFNLEKVKLEFTKEAVTSIAKKALSKKTGARGLRSIIENILLDIMYELPSMKNVEKILI
DESVVNSHSLPKIIYEEKNKSKKASGE

Sequences:

>Translated_427_residues
MTDKSKDNSKKLLQCSFCGKNQKEVKKLIAGPAVYICDECIRLCNNIIQETKTTKKIEDDELSYLPTPHEIKKHLDNYVI
GQNHTKKVLSVAVYNHYQRIRNVSKNKDNVELGKSNILLIGPTGSGKTLLAETLAKLLNVPFSIADATTLTEAGYVGEDV
ENVIQKLLQKCEYNVKKAELGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTLASIPPQGGRKHPQQEFLQV
NTANILFICAGAFSELSKIISKRIDTGNTIGFNCNLKKQKKKKSEQYFLQQVQSKDLIKFGLIPEFIGRLPIITILKELN
ETALVQILCKPKNALIKQYQTLFNLEKVKLEFTKEAVTSIAKKALSKKTGARGLRSIIENILLDIMYELPSMKNVEKILI
DESVVNSHSLPKIIYEEKNKSKKASGE
>Mature_426_residues
TDKSKDNSKKLLQCSFCGKNQKEVKKLIAGPAVYICDECIRLCNNIIQETKTTKKIEDDELSYLPTPHEIKKHLDNYVIG
QNHTKKVLSVAVYNHYQRIRNVSKNKDNVELGKSNILLIGPTGSGKTLLAETLAKLLNVPFSIADATTLTEAGYVGEDVE
NVIQKLLQKCEYNVKKAELGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTLASIPPQGGRKHPQQEFLQVN
TANILFICAGAFSELSKIISKRIDTGNTIGFNCNLKKQKKKKSEQYFLQQVQSKDLIKFGLIPEFIGRLPIITILKELNE
TALVQILCKPKNALIKQYQTLFNLEKVKLEFTKEAVTSIAKKALSKKTGARGLRSIIENILLDIMYELPSMKNVEKILID
ESVVNSHSLPKIIYEEKNKSKKASGE

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=411, Percent_Identity=43.0656934306569, Blast_Score=302, Evalue=3e-82,
Organism=Escherichia coli, GI1786642, Length=427, Percent_Identity=70.2576112412178, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI1790366, Length=122, Percent_Identity=40.1639344262295, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=343, Percent_Identity=40.8163265306122, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71982905, Length=325, Percent_Identity=41.2307692307692, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71988663, Length=423, Percent_Identity=36.1702127659575, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71988660, Length=258, Percent_Identity=39.5348837209302, Blast_Score=174, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6319704, Length=447, Percent_Identity=40.2684563758389, Blast_Score=285, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24648289, Length=340, Percent_Identity=43.5294117647059, Blast_Score=291, Evalue=7e-79,
Organism=Drosophila melanogaster, GI24648291, Length=340, Percent_Identity=43.5294117647059, Blast_Score=290, Evalue=9e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_BUCAP (Q8K989)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660792.1
- ProteinModelPortal:   Q8K989
- EnsemblBacteria:   EBBUCT00000000214
- GeneID:   1005705
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg460
- GeneTree:   EBGT00050000007932
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   BAPH198804:BUSG460-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 47831; Mature: 47700

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKSKDNSKKLLQCSFCGKNQKEVKKLIAGPAVYICDECIRLCNNIIQETKTTKKIEDD
CCCCCCCCCHHEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ELSYLPTPHEIKKHLDNYVIGQNHTKKVLSVAVYNHYQRIRNVSKNKDNVELGKSNILLI
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEE
GPTGSGKTLLAETLAKLLNVPFSIADATTLTEAGYVGEDVENVIQKLLQKCEYNVKKAEL
ECCCCCCHHHHHHHHHHHCCCCCHHCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHC
GIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTLASIPPQGGRKHPQQEFLQV
CEEECCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
NTANILFICAGAFSELSKIISKRIDTGNTIGFNCNLKKQKKKKSEQYFLQQVQSKDLIKF
CCCCEEEEECHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHH
GLIPEFIGRLPIITILKELNETALVQILCKPKNALIKQYQTLFNLEKVKLEFTKEAVTSI
CCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKALSKKTGARGLRSIIENILLDIMYELPSMKNVEKILIDESVVNSHSLPKIIYEEKNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCC
SKKASGE
CCCCCCC
>Mature Secondary Structure 
TDKSKDNSKKLLQCSFCGKNQKEVKKLIAGPAVYICDECIRLCNNIIQETKTTKKIEDD
CCCCCCCCHHEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ELSYLPTPHEIKKHLDNYVIGQNHTKKVLSVAVYNHYQRIRNVSKNKDNVELGKSNILLI
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEE
GPTGSGKTLLAETLAKLLNVPFSIADATTLTEAGYVGEDVENVIQKLLQKCEYNVKKAEL
ECCCCCCHHHHHHHHHHHCCCCCHHCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHC
GIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTLASIPPQGGRKHPQQEFLQV
CEEECCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
NTANILFICAGAFSELSKIISKRIDTGNTIGFNCNLKKQKKKKSEQYFLQQVQSKDLIKF
CCCCEEEEECHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHH
GLIPEFIGRLPIITILKELNETALVQILCKPKNALIKQYQTLFNLEKVKLEFTKEAVTSI
CCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKALSKKTGARGLRSIIENILLDIMYELPSMKNVEKILIDESVVNSHSLPKIIYEEKNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCC
SKKASGE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438