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The map label for this gene is lysA

Identifier: 21672689

GI number: 21672689

Start: 479204

End: 480451

Strand: Direct

Name: lysA

Synonym: BUsg423

Alternate gene names: 21672689

Gene position: 479204-480451 (Clockwise)

Preceding gene: 21672688

Following gene: 21672690

Centisome position: 74.71

GC content: 29.33

Gene sequence:

>1248_bases
ATGCCAGAATTATTAAATAAAACTAAAACAAATCTTAATTTTGAAAACATTAAAATACTAATAAAAAAATTCCAGTCTCC
ATTTTGGGTTTATGATTCAAATATAATCCATAAAAAAATCAACTTACTAAAAGAATTTGATATTGTTCGATTTGCTCAAA
AAGCGTGTTCAAATATTCATATATTGCGTTTAATGAAACAAAAAAATATAAAAGTAGATGCAGTTTCATTAGGTGAAATA
GAACGAGCTTTAGTAGCTGGATTTAAACCTAATTCCAACGAAATAATTTTTACTGCAGATCTCTTTGATGAAGAAACCTT
ATCTAAGGTAATTGATTTTAAAATTCCAGTTAATGCCGGATCAATAGATATGCTAGAACAATTAGGTAAACTTTCCCCTG
GTCATCATGTTTGGTTAAGAATTAATCCAGGATTTGGACATGGACATAGCAAAAAAACTAATACTGGAGGGGAAAACAGT
AAACACGGCATTTGGAATCCTCGTTTAGCGATACCTATTATAAAAAAATATAAATTAAAACTGATAGGTCTACATATGCA
TATTGGTTCCGGAGTCAACTATAAACACCTTAAAAAAGTCGGTCAGGCCATGATAGAAAAGGCAATGGAAATAAATGAAA
AAATATTATTTATTTCCGCTGGAGGTGGTTTGCCAATACCCTATACATTTAATGAAAAACCTATTGATACCAAAAAATAC
TTTATAATTTGGGATGAAGCAAGAAAAAAAATATCTCGTTTTTTAAATACACCAATACAATTAGAGATTGAACCAGGTAG
ATTTTTAGTAGCAGAATCAGGAATTTTAATTTCACAGGTAAGAGCAATTAAAAAAATGGGAGATAAAAATTTTGTTTTAA
TTGATGCTGGTTTTAACGACCTTATGCGTCCAACTATGTATGGAAGTTATCATCATGTATCTGTTGTTACTAAAGATGAT
CGGAATATACACGAAACAGAAACAATAGATACGATTATAGGTGGTCCTTTGTGCGAATCAGGTGATATTTTTACACAAAA
AGAAGGAGGAAATATAACTACTAGAAAATTACCAATATTAAAAATAGGGGATTATTTGATTTTTCACGATGTAGGTGCTT
ATGGTGCTTCAATGTCGTCTAATTACAATACAAGACCACTTATTCAAGAAATTTTGCTAGAAAACAACACATTTAGAACA
ATTAGAAGACGACAAAAAATCAATGAATTATTAAATTTAGAAAAATAA

Upstream 100 bases:

>100_bases
TTATTTCCAACATTACGTTCATTTAAAAAATAATTCTTATTTTTTTATAAATTTATTTTGAGTAGGTGTGTAATTATACA
ATAATAAAATAGGAAAAAAA

Downstream 100 bases:

>100_bases
TACTTTTAAAAATATTATTTATTACACTAAAATCTAATTTCAGTTTAAAAGGATACAATACAATATATGTATATCAATTT
TCCAAATATCAATCCTATTA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MPELLNKTKTNLNFENIKILIKKFQSPFWVYDSNIIHKKINLLKEFDIVRFAQKACSNIHILRLMKQKNIKVDAVSLGEI
ERALVAGFKPNSNEIIFTADLFDEETLSKVIDFKIPVNAGSIDMLEQLGKLSPGHHVWLRINPGFGHGHSKKTNTGGENS
KHGIWNPRLAIPIIKKYKLKLIGLHMHIGSGVNYKHLKKVGQAMIEKAMEINEKILFISAGGGLPIPYTFNEKPIDTKKY
FIIWDEARKKISRFLNTPIQLEIEPGRFLVAESGILISQVRAIKKMGDKNFVLIDAGFNDLMRPTMYGSYHHVSVVTKDD
RNIHETETIDTIIGGPLCESGDIFTQKEGGNITTRKLPILKIGDYLIFHDVGAYGASMSSNYNTRPLIQEILLENNTFRT
IRRRQKINELLNLEK

Sequences:

>Translated_415_residues
MPELLNKTKTNLNFENIKILIKKFQSPFWVYDSNIIHKKINLLKEFDIVRFAQKACSNIHILRLMKQKNIKVDAVSLGEI
ERALVAGFKPNSNEIIFTADLFDEETLSKVIDFKIPVNAGSIDMLEQLGKLSPGHHVWLRINPGFGHGHSKKTNTGGENS
KHGIWNPRLAIPIIKKYKLKLIGLHMHIGSGVNYKHLKKVGQAMIEKAMEINEKILFISAGGGLPIPYTFNEKPIDTKKY
FIIWDEARKKISRFLNTPIQLEIEPGRFLVAESGILISQVRAIKKMGDKNFVLIDAGFNDLMRPTMYGSYHHVSVVTKDD
RNIHETETIDTIIGGPLCESGDIFTQKEGGNITTRKLPILKIGDYLIFHDVGAYGASMSSNYNTRPLIQEILLENNTFRT
IRRRQKINELLNLEK
>Mature_414_residues
PELLNKTKTNLNFENIKILIKKFQSPFWVYDSNIIHKKINLLKEFDIVRFAQKACSNIHILRLMKQKNIKVDAVSLGEIE
RALVAGFKPNSNEIIFTADLFDEETLSKVIDFKIPVNAGSIDMLEQLGKLSPGHHVWLRINPGFGHGHSKKTNTGGENSK
HGIWNPRLAIPIIKKYKLKLIGLHMHIGSGVNYKHLKKVGQAMIEKAMEINEKILFISAGGGLPIPYTFNEKPIDTKKYF
IIWDEARKKISRFLNTPIQLEIEPGRFLVAESGILISQVRAIKKMGDKNFVLIDAGFNDLMRPTMYGSYHHVSVVTKDDR
NIHETETIDTIIGGPLCESGDIFTQKEGGNITTRKLPILKIGDYLIFHDVGAYGASMSSNYNTRPLIQEILLENNTFRTI
RRRQKINELLNLEK

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family

Homologues:

Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=59.8540145985402, Blast_Score=561, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17562780, Length=419, Percent_Identity=23.8663484486874, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCDA_BUCAP (Q8K9C4)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660756.1
- ProteinModelPortal:   Q8K9C4
- SMR:   Q8K9C4
- EnsemblBacteria:   EBBUCT00000000158
- GeneID:   1005740
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg423
- GeneTree:   EBGT00050000007753
- HOGENOM:   HBG672375
- OMA:   VGLHMHI
- ProtClustDB:   PRK11165
- BioCyc:   BAPH198804:BUSG423-MONOMER
- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR01181
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01048

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC; SSF50621 Racem_decarbox_C

EC number: =4.1.1.20

Molecular weight: Translated: 47183; Mature: 47052

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELLNKTKTNLNFENIKILIKKFQSPFWVYDSNIIHKKINLLKEFDIVRFAQKACSNIH
CCCHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEE
ILRLMKQKNIKVDAVSLGEIERALVAGFKPNSNEIIFTADLFDEETLSKVIDFKIPVNAG
EEEHHHHCCCEEEEEEHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHEEEEECCCC
SIDMLEQLGKLSPGHHVWLRINPGFGHGHSKKTNTGGENSKHGIWNPRLAIPIIKKYKLK
CHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEECEECCCEEEE
LIGLHMHIGSGVNYKHLKKVGQAMIEKAMEINEKILFISAGGGLPIPYTFNEKPIDTKKY
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCEE
FIIWDEARKKISRFLNTPIQLEIEPGRFLVAESGILISQVRAIKKMGDKNFVLIDAGFND
EEEEHHHHHHHHHHHCCCEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCEEEEECCCHH
LMRPTMYGSYHHVSVVTKDDRNIHETETIDTIIGGPLCESGDIFTQKEGGNITTRKLPIL
HHCHHHCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEEEEE
KIGDYLIFHDVGAYGASMSSNYNTRPLIQEILLENNTFRTIRRRQKINELLNLEK
EECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PELLNKTKTNLNFENIKILIKKFQSPFWVYDSNIIHKKINLLKEFDIVRFAQKACSNIH
CCHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEE
ILRLMKQKNIKVDAVSLGEIERALVAGFKPNSNEIIFTADLFDEETLSKVIDFKIPVNAG
EEEHHHHCCCEEEEEEHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHEEEEECCCC
SIDMLEQLGKLSPGHHVWLRINPGFGHGHSKKTNTGGENSKHGIWNPRLAIPIIKKYKLK
CHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEECEECCCEEEE
LIGLHMHIGSGVNYKHLKKVGQAMIEKAMEINEKILFISAGGGLPIPYTFNEKPIDTKKY
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCEE
FIIWDEARKKISRFLNTPIQLEIEPGRFLVAESGILISQVRAIKKMGDKNFVLIDAGFND
EEEEHHHHHHHHHHHCCCEEEEECCCEEEEEECCHHHHHHHHHHHCCCCCEEEEECCCHH
LMRPTMYGSYHHVSVVTKDDRNIHETETIDTIIGGPLCESGDIFTQKEGGNITTRKLPIL
HHCHHHCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEEEEE
KIGDYLIFHDVGAYGASMSSNYNTRPLIQEILLENNTFRTIRRRQKINELLNLEK
EECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438