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The map label for this gene is serC

Identifier: 21672578

GI number: 21672578

Start: 345790

End: 346875

Strand: Reverse

Name: serC

Synonym: BUsg302

Alternate gene names: 21672578

Gene position: 346875-345790 (Counterclockwise)

Preceding gene: 21672579

Following gene: 21672577

Centisome position: 54.08

GC content: 25.87

Gene sequence:

>1086_bases
ATGAATTTGATTTATAATTTTAGTGCTGGACCAGCTATGATTCCAAAAGATGTTCTTTATCAAGCAAAAAAAGAACTACA
AAACTGGAATCAAATAGGTTGTTCTATTATGGAAATTAGTCATCGTAGTAAAGAATTTATTCAAGTAGCTTTAGAAGCAG
AACAAGATTTGAGAGATTTATTAAATATATCAAATTCATATGAAATATTATTTTGTCAAGGAGGTGCTAGAGGGCAGTTT
GCTGCTGTTCCAATGAATTTATTAGGCAATTTTAAAGAAACAGATTATATTAATAGTGGATATTGGTCAAATTGTGCATT
AATAGAAGCTAAAAAATATTGTATTCCTAAAAATATATCAGTTAGACAAAAAAAGAATGGAAAAAGTTTTCTGTTAAAAC
CTTCTCAGTGGAATATAAGTGATAATTCTGCATATATTCATTATTGCCCGAATGAAACTATAGATGGAATGTCAATTTAT
GAAGAACCAAATTTTAAAAATAAAATAATAGTAGGAGATTTTTCATCATTTATTTTATCTCGTAGAATTAATATTGAAAA
TTATGGTTTAATTTATGCAGGTGCTCAAAAAAACATCGGTCCTTCAGGTATCACAATTATTCTTATTAGGAAAGATTTAA
TAGGATATGCCTCTAAGATATCTCCTTCTATTTTTAATTACTACATAATATCAAAATATAATTCTATGTTTAATACACCA
CCTACATTTTCTTGGTATTTATCAGGATTAGTGTTTAAATGGTTAAAAAAGCAAGGTGGAATAAAAAAAATTGAACAACT
AAATCAAAAAAAATCAAATTTATTATATCAAATAATTGATAATAGCAATTTTTATATTAATGATATAGATAAAAGAAATC
GATCTCAAATGAATGTTGTATTCCATTTATATAATTCTAAGTTAGATAACTTATTTTTAAAAGAAGCAAAAAATGCAGGT
TTAAATGCTTTGAAGGGACACAATGTCATTGGAGGAATGCGTGCTTCTATTTATAATGCTATGCCATTAGAAGGTGTTCA
GTCTTTAGCAAAATTTATGTTATATTTTGAAAAAAAGTATGGATAA

Upstream 100 bases:

>100_bases
GGTCGAGTTACTATTCCAAAAATTTTACAAAAAAAATATATGCAAGGTATAGAATATATAAATTAATTAAATATATAAAA
AAATGATTATTGGTGAAAAA

Downstream 100 bases:

>100_bases
AACATTTTTTTATTTTTGAAGAAATAAATTAAAAATTTTATTTTAATTAGAGCGTATTTTTATTATGCAAAAATTTTTGG
AGTTAAAACCAGTTTCTTAT

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MNLIYNFSAGPAMIPKDVLYQAKKELQNWNQIGCSIMEISHRSKEFIQVALEAEQDLRDLLNISNSYEILFCQGGARGQF
AAVPMNLLGNFKETDYINSGYWSNCALIEAKKYCIPKNISVRQKKNGKSFLLKPSQWNISDNSAYIHYCPNETIDGMSIY
EEPNFKNKIIVGDFSSFILSRRINIENYGLIYAGAQKNIGPSGITIILIRKDLIGYASKISPSIFNYYIISKYNSMFNTP
PTFSWYLSGLVFKWLKKQGGIKKIEQLNQKKSNLLYQIIDNSNFYINDIDKRNRSQMNVVFHLYNSKLDNLFLKEAKNAG
LNALKGHNVIGGMRASIYNAMPLEGVQSLAKFMLYFEKKYG

Sequences:

>Translated_361_residues
MNLIYNFSAGPAMIPKDVLYQAKKELQNWNQIGCSIMEISHRSKEFIQVALEAEQDLRDLLNISNSYEILFCQGGARGQF
AAVPMNLLGNFKETDYINSGYWSNCALIEAKKYCIPKNISVRQKKNGKSFLLKPSQWNISDNSAYIHYCPNETIDGMSIY
EEPNFKNKIIVGDFSSFILSRRINIENYGLIYAGAQKNIGPSGITIILIRKDLIGYASKISPSIFNYYIISKYNSMFNTP
PTFSWYLSGLVFKWLKKQGGIKKIEQLNQKKSNLLYQIIDNSNFYINDIDKRNRSQMNVVFHLYNSKLDNLFLKEAKNAG
LNALKGHNVIGGMRASIYNAMPLEGVQSLAKFMLYFEKKYG
>Mature_361_residues
MNLIYNFSAGPAMIPKDVLYQAKKELQNWNQIGCSIMEISHRSKEFIQVALEAEQDLRDLLNISNSYEILFCQGGARGQF
AAVPMNLLGNFKETDYINSGYWSNCALIEAKKYCIPKNISVRQKKNGKSFLLKPSQWNISDNSAYIHYCPNETIDGMSIY
EEPNFKNKIIVGDFSSFILSRRINIENYGLIYAGAQKNIGPSGITIILIRKDLIGYASKISPSIFNYYIISKYNSMFNTP
PTFSWYLSGLVFKWLKKQGGIKKIEQLNQKKSNLLYQIIDNSNFYINDIDKRNRSQMNVVFHLYNSKLDNLFLKEAKNAG
LNALKGHNVIGGMRASIYNAMPLEGVQSLAKFMLYFEKKYG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=361, Percent_Identity=40.7202216066482, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI10863955, Length=357, Percent_Identity=36.6946778711485, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1787136, Length=362, Percent_Identity=58.5635359116022, Blast_Score=476, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17506897, Length=361, Percent_Identity=43.213296398892, Blast_Score=300, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6324758, Length=384, Percent_Identity=39.5833333333333, Blast_Score=254, Evalue=1e-68,
Organism=Drosophila melanogaster, GI21356589, Length=364, Percent_Identity=43.1318681318681, Blast_Score=301, Evalue=5e-82,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_BUCAP (P81435)

Other databases:

- EMBL:   L43549
- EMBL:   AE013218
- RefSeq:   NP_660645.1
- ProteinModelPortal:   P81435
- SMR:   P81435
- EnsemblBacteria:   EBBUCT00000000495
- GeneID:   1005506
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg302
- GeneTree:   EBGT00050000007909
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   BAPH198804:BUSG302-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 41261; Mature: 41261

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 102-102 BINDING 153-153 BINDING 173-173 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIYNFSAGPAMIPKDVLYQAKKELQNWNQIGCSIMEISHRSKEFIQVALEAEQDLRDL
CCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHH
LNISNSYEILFCQGGARGQFAAVPMNLLGNFKETDYINSGYWSNCALIEAKKYCIPKNIS
HCCCCCEEEEEECCCCCCCEEEECHHHHCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCC
VRQKKNGKSFLLKPSQWNISDNSAYIHYCPNETIDGMSIYEEPNFKNKIIVGDFSSFILS
EEECCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCEEEEECHHHHHHH
RRINIENYGLIYAGAQKNIGPSGITIILIRKDLIGYASKISPSIFNYYIISKYNSMFNTP
HCCCCCCCEEEEECCCCCCCCCCEEEEEEECHHHHHHHHCCHHHHEEEEEEEHHHHCCCC
PTFSWYLSGLVFKWLKKQGGIKKIEQLNQKKSNLLYQIIDNSNFYINDIDKRNRSQMNVV
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCEEEEEECCCCEEEECCCCCCCCCEEEE
FHLYNSKLDNLFLKEAKNAGLNALKGHNVIGGMRASIYNAMPLEGVQSLAKFMLYFEKKY
EEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCC
G
C
>Mature Secondary Structure
MNLIYNFSAGPAMIPKDVLYQAKKELQNWNQIGCSIMEISHRSKEFIQVALEAEQDLRDL
CCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHH
LNISNSYEILFCQGGARGQFAAVPMNLLGNFKETDYINSGYWSNCALIEAKKYCIPKNIS
HCCCCCEEEEEECCCCCCCEEEECHHHHCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCC
VRQKKNGKSFLLKPSQWNISDNSAYIHYCPNETIDGMSIYEEPNFKNKIIVGDFSSFILS
EEECCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCEEEEECHHHHHHH
RRINIENYGLIYAGAQKNIGPSGITIILIRKDLIGYASKISPSIFNYYIISKYNSMFNTP
HCCCCCCCEEEEECCCCCCCCCCEEEEEEECHHHHHHHHCCHHHHEEEEEEEHHHHCCCC
PTFSWYLSGLVFKWLKKQGGIKKIEQLNQKKSNLLYQIIDNSNFYINDIDKRNRSQMNVV
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCEEEEEECCCCEEEECCCCCCCCCEEEE
FHLYNSKLDNLFLKEAKNAGLNALKGHNVIGGMRASIYNAMPLEGVQSLAKFMLYFEKKY
EEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438