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The map label for this gene is serS

Identifier: 21672579

GI number: 21672579

Start: 346910

End: 348193

Strand: Reverse

Name: serS

Synonym: BUsg303

Alternate gene names: 21672579

Gene position: 348193-346910 (Counterclockwise)

Preceding gene: 21672583

Following gene: 21672578

Centisome position: 54.28

GC content: 26.79

Gene sequence:

>1284_bases
ATGTTAAATCCTTATTTATTACGTAACCAAATAGATGCAATATCAAAAAAATTATTAAAAAAAAAATTTAAATTAGATAT
ATCACTAATATCTTCTTTAGAAAAAAAACGGAAAAAATTGCAAATTAAAACAGACAATTTGCAATACAAGCACAATACTT
TATCAGCGTTATTTAAAAAAGAAAAAAAAATTCAAGAATTAGATGAAAATTTAAAAAGAACACTTACCAAATCTAGTAAA
AATTTATCTGAATTAAAAATTGAACTCAATCTATTACAAGAAAAAATTCATAATTTTTCTTTATCTATACCTAATATTCC
TTCTGATGATGTTCCAGAAGGAAATTCATCAGAAAACAATAAAATTGTAAAATATTGGGGTAAAAAAAGGGAATATAGTT
TTGCAGTTCGAGATCATGTAGAAATAGGAAATAAATTGAATCAATTAGATTGGAAATCTTCAGCAAAAATATCAGGTGCA
CGATTTATTGTTATGAAAGGAAATATAGCTCTTTTACATCGTGCATTAAGTCAATTTATGTTAGATTTACATACTATAAA
GCATGGGTATACAGAAACTTATGTACCTTATTTAGTAAATCATGATTCGCTATACGGAACAGGGCAATTACCAAAATTTA
CTGATGATTTATTTCATATAAATTCTATTGATAAAAAAAAATATGTATTAATTCCGACAGCTGAAGTACCATTAACGAAT
TTGTTTTCTAATCAGATATTAAATGAAACAGAACTGCCTATTATGTTAACTGCTCATACTCCTTGTTTTCGATCTGAAGC
TTCTTCTTATGGACGTGATAGTAAGGGATTAATTCGATTACATCAATTTGATAAAGTAGAACTTGTGCAAATTATACAAC
CTGAATTGTCTATGAATGCTTTAGAGTTGTTAACTCATCATGCAGAAAAAGTTCTACAACTTTTAGAATTACCATATAGA
AAGGTACTTTTATGTGGAGGAGAAATGGGTTTTTCTGCAACTAAAACATATGATTTAGAAGTATGGTTTCCTTCTCAGAA
AAAATACAGAGAAATTTCTTCGTGTTCTAATATGAGCGACTTTCAAGCTCGTCGTATGAAAACTCGTTATAAGAAAAAAA
AGGAAAAAAGTAACAGTTTTGTTCATACATTAAATGGTTCAGGTTTAGCAATTGGTAGAACATTAGCTGCTATATTAGAA
AATTATCAAGATAGTGATGGTCGAGTTACTATTCCAAAAATTTTACAAAAAAAATATATGCAAGGTATAGAATATATAAA
TTAA

Upstream 100 bases:

>100_bases
GTTTTATCTTTTAATATATTAGATATCATTTTTATTTTTTTAAAAAATTTATAATATATTTATAATAATTTTCATTATCA
ATTATAAAGACTTAAAAATT

Downstream 100 bases:

>100_bases
TTAAATATATAAAAAAATGATTATTGGTGAAAAAATGAATTTGATTTATAATTTTAGTGCTGGACCAGCTATGATTCCAA
AAGATGTTCTTTATCAAGCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLNPYLLRNQIDAISKKLLKKKFKLDISLISSLEKKRKKLQIKTDNLQYKHNTLSALFKKEKKIQELDENLKRTLTKSSK
NLSELKIELNLLQEKIHNFSLSIPNIPSDDVPEGNSSENNKIVKYWGKKREYSFAVRDHVEIGNKLNQLDWKSSAKISGA
RFIVMKGNIALLHRALSQFMLDLHTIKHGYTETYVPYLVNHDSLYGTGQLPKFTDDLFHINSIDKKKYVLIPTAEVPLTN
LFSNQILNETELPIMLTAHTPCFRSEASSYGRDSKGLIRLHQFDKVELVQIIQPELSMNALELLTHHAEKVLQLLELPYR
KVLLCGGEMGFSATKTYDLEVWFPSQKKYREISSCSNMSDFQARRMKTRYKKKKEKSNSFVHTLNGSGLAIGRTLAAILE
NYQDSDGRVTIPKILQKKYMQGIEYIN

Sequences:

>Translated_427_residues
MLNPYLLRNQIDAISKKLLKKKFKLDISLISSLEKKRKKLQIKTDNLQYKHNTLSALFKKEKKIQELDENLKRTLTKSSK
NLSELKIELNLLQEKIHNFSLSIPNIPSDDVPEGNSSENNKIVKYWGKKREYSFAVRDHVEIGNKLNQLDWKSSAKISGA
RFIVMKGNIALLHRALSQFMLDLHTIKHGYTETYVPYLVNHDSLYGTGQLPKFTDDLFHINSIDKKKYVLIPTAEVPLTN
LFSNQILNETELPIMLTAHTPCFRSEASSYGRDSKGLIRLHQFDKVELVQIIQPELSMNALELLTHHAEKVLQLLELPYR
KVLLCGGEMGFSATKTYDLEVWFPSQKKYREISSCSNMSDFQARRMKTRYKKKKEKSNSFVHTLNGSGLAIGRTLAAILE
NYQDSDGRVTIPKILQKKYMQGIEYIN
>Mature_427_residues
MLNPYLLRNQIDAISKKLLKKKFKLDISLISSLEKKRKKLQIKTDNLQYKHNTLSALFKKEKKIQELDENLKRTLTKSSK
NLSELKIELNLLQEKIHNFSLSIPNIPSDDVPEGNSSENNKIVKYWGKKREYSFAVRDHVEIGNKLNQLDWKSSAKISGA
RFIVMKGNIALLHRALSQFMLDLHTIKHGYTETYVPYLVNHDSLYGTGQLPKFTDDLFHINSIDKKKYVLIPTAEVPLTN
LFSNQILNETELPIMLTAHTPCFRSEASSYGRDSKGLIRLHQFDKVELVQIIQPELSMNALELLTHHAEKVLQLLELPYR
KVLLCGGEMGFSATKTYDLEVWFPSQKKYREISSCSNMSDFQARRMKTRYKKKKEKSNSFVHTLNGSGLAIGRTLAAILE
NYQDSDGRVTIPKILQKKYMQGIEYIN

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=355, Percent_Identity=32.9577464788732, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI8923421, Length=328, Percent_Identity=31.4024390243902, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI225579074, Length=328, Percent_Identity=31.4024390243902, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=58.0046403712297, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17539260, Length=338, Percent_Identity=33.7278106508876, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=31.7365269461078, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320226, Length=430, Percent_Identity=33.0232558139535, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6321799, Length=390, Percent_Identity=30.7692307692308, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24581334, Length=467, Percent_Identity=29.5503211991435, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17737985, Length=337, Percent_Identity=29.3768545994065, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_BUCAP (P81434)

Other databases:

- EMBL:   L43549
- EMBL:   AE013218
- RefSeq:   NP_660646.1
- ProteinModelPortal:   P81434
- SMR:   P81434
- EnsemblBacteria:   EBBUCT00000000097
- GeneID:   1005507
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg303
- GeneTree:   EBGT00050000008015
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   BAPH198804:BUSG303-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 49239; Mature: 49239

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNPYLLRNQIDAISKKLLKKKFKLDISLISSLEKKRKKLQIKTDNLQYKHNTLSALFKK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEHHHHHHHHHHH
EKKIQELDENLKRTLTKSSKNLSELKIELNLLQEKIHNFSLSIPNIPSDDVPEGNSSENN
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCC
KIVKYWGKKREYSFAVRDHVEIGNKLNQLDWKSSAKISGARFIVMKGNIALLHRALSQFM
CEEEECCCCCCEEEHHHHHHHHCCHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
LDLHTIKHGYTETYVPYLVNHDSLYGTGQLPKFTDDLFHINSIDKKKYVLIPTAEVPLTN
HHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCHHH
LFSNQILNETELPIMLTAHTPCFRSEASSYGRDSKGLIRLHQFDKVELVQIIQPELSMNA
HHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCHHH
LELLTHHAEKVLQLLELPYRKVLLCGGEMGFSATKTYDLEVWFPSQKKYREISSCSNMSD
HHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCHH
FQARRMKTRYKKKKEKSNSFVHTLNGSGLAIGRTLAAILENYQDSDGRVTIPKILQKKYM
HHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
QGIEYIN
HHHCCCC
>Mature Secondary Structure
MLNPYLLRNQIDAISKKLLKKKFKLDISLISSLEKKRKKLQIKTDNLQYKHNTLSALFKK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEHHHHHHHHHHH
EKKIQELDENLKRTLTKSSKNLSELKIELNLLQEKIHNFSLSIPNIPSDDVPEGNSSENN
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCC
KIVKYWGKKREYSFAVRDHVEIGNKLNQLDWKSSAKISGARFIVMKGNIALLHRALSQFM
CEEEECCCCCCEEEHHHHHHHHCCHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
LDLHTIKHGYTETYVPYLVNHDSLYGTGQLPKFTDDLFHINSIDKKKYVLIPTAEVPLTN
HHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCHHH
LFSNQILNETELPIMLTAHTPCFRSEASSYGRDSKGLIRLHQFDKVELVQIIQPELSMNA
HHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCHHH
LELLTHHAEKVLQLLELPYRKVLLCGGEMGFSATKTYDLEVWFPSQKKYREISSCSNMSD
HHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCHH
FQARRMKTRYKKKKEKSNSFVHTLNGSGLAIGRTLAAILENYQDSDGRVTIPKILQKKYM
HHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
QGIEYIN
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438