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The map label for this gene is trpC

Identifier: 21672548

GI number: 21672548

Start: 304157

End: 305512

Strand: Reverse

Name: trpC

Synonym: BUsg268

Alternate gene names: 21672548

Gene position: 305512-304157 (Counterclockwise)

Preceding gene: 21672549

Following gene: 21672547

Centisome position: 47.63

GC content: 24.56

Gene sequence:

>1356_bases
ATGCAAGAAACAATACTAAATAAAATTATAAAAGATAAAATAGATTGGATTAAATATAGAAAAAAAATACAACCATTAAT
TAAATTTAAAAACAAAATTAATAAAGAAACACGTAACTTTTATAATTCTTTAAAAGAAAAACGTCCCTTTTTTATATTAG
AATGCAAAAAAAGTTCTCCTTCTTTAGGAATAATTAGAAAAAAATTTAATTTGATTGAAATTGCAAATATTTATAAAAAT
TATGCTTCAGCTATTTCAGTTCTTACAGATGAAAAATATTTTCATGGAAATATAGAATATATCAATGTTGTAAGAAGATG
TGTATCTCAACCGATTTTATGCAAAGATTTTTTTATTGATTCATATCAAGTTTATTTAGCAAGATATTATAGTGCTGATG
CTATTTTATTGATGTTATCTGTATTAAACGATAGTCAATATCTCGAACTATCTAGAATTGCAAAAGAATTAAATATGGGA
GTACTGACAGAAATTAATAATATTAAAGAATTAAAGCGAGCTATCAAATTGAATGCTTCTGTTATTGGAATAAATAACCG
TAATTTACACGATTTATCAATAGATTTGAATAGAACACGAACTTTATCACCTTTAATTAAAAATAAAATCATTGTTAGTG
AATCAGGAATAAAAAAAAACCATCAGATAAAAGAATTAAGTAACATTGTTCATGGTTTTTTAATAGGTTCAAGTTTAATG
TACAGGACAAATTTAGAAACAAATATCAAATCTTTAATCATAGGAGATAATAAGGTATGTGGACTGACTCGTATTATTGA
CGCAAAAATTGTAGAAAGTTGTGGTGCAGTCTATGGAGGATTAATTTTTGCAGACAATTCTTTACGTAAAACTAACGAAA
AAATAGCAGAAAAAATGATTTTTGAAAATAATTTAAGATTCATAGGTGTTTTTCAAAATCAAGATATAGAAAAAATTGTT
AATATAGCTCAACGACTTTCTTTATATGCTGTTCAATTACATGGTTCTGAAAATCAAAAATATATTAATATATTAAGAAA
AAAATTATGTAAAAAAATAAAGATTTGGAAAGCTTTTTCTATTCAATCTACACTGCCATTATTAAATTGGGATCATATCG
ATAAATATATTTTTGATTCTGGTTCAGGAGGGACTAACAAAACTTTTAATTGGTCGATTTTAAAAGGATCTATTCTAGAA
AATGTCATCCTAGCAGGGGGTATTAATACAGACAATGTTCTTATTGCATCGCAATTAAACTGTTCAGGATTAGATTTTAA
TTCAGGAGTAGAAAAATCTCCTGGCATCAAAGATCACAAAAAAATTAGTTTAATTTTTAAAAAACTAACTTTTTAA

Upstream 100 bases:

>100_bases
AATTTAAAAGAAAATACAAAAATAGCACTGAAAAAAATTCGCAGTGGAGACGTTTATAAACATATAATGCAAGTTTCTAA
TATGTTGAAAGAAGATTAAT

Downstream 100 bases:

>100_bases
TCAATTATATTAAAAACATATTGGAAATCAACGAAAAATGACTTTACTTAATCCTTATTTTGGCAAATTTGGAGGTATGT
ATGTTCCTCAAATATTAATG

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MQETILNKIIKDKIDWIKYRKKIQPLIKFKNKINKETRNFYNSLKEKRPFFILECKKSSPSLGIIRKKFNLIEIANIYKN
YASAISVLTDEKYFHGNIEYINVVRRCVSQPILCKDFFIDSYQVYLARYYSADAILLMLSVLNDSQYLELSRIAKELNMG
VLTEINNIKELKRAIKLNASVIGINNRNLHDLSIDLNRTRTLSPLIKNKIIVSESGIKKNHQIKELSNIVHGFLIGSSLM
YRTNLETNIKSLIIGDNKVCGLTRIIDAKIVESCGAVYGGLIFADNSLRKTNEKIAEKMIFENNLRFIGVFQNQDIEKIV
NIAQRLSLYAVQLHGSENQKYINILRKKLCKKIKIWKAFSIQSTLPLLNWDHIDKYIFDSGSGGTNKTFNWSILKGSILE
NVILAGGINTDNVLIASQLNCSGLDFNSGVEKSPGIKDHKKISLIFKKLTF

Sequences:

>Translated_451_residues
MQETILNKIIKDKIDWIKYRKKIQPLIKFKNKINKETRNFYNSLKEKRPFFILECKKSSPSLGIIRKKFNLIEIANIYKN
YASAISVLTDEKYFHGNIEYINVVRRCVSQPILCKDFFIDSYQVYLARYYSADAILLMLSVLNDSQYLELSRIAKELNMG
VLTEINNIKELKRAIKLNASVIGINNRNLHDLSIDLNRTRTLSPLIKNKIIVSESGIKKNHQIKELSNIVHGFLIGSSLM
YRTNLETNIKSLIIGDNKVCGLTRIIDAKIVESCGAVYGGLIFADNSLRKTNEKIAEKMIFENNLRFIGVFQNQDIEKIV
NIAQRLSLYAVQLHGSENQKYINILRKKLCKKIKIWKAFSIQSTLPLLNWDHIDKYIFDSGSGGTNKTFNWSILKGSILE
NVILAGGINTDNVLIASQLNCSGLDFNSGVEKSPGIKDHKKISLIFKKLTF
>Mature_451_residues
MQETILNKIIKDKIDWIKYRKKIQPLIKFKNKINKETRNFYNSLKEKRPFFILECKKSSPSLGIIRKKFNLIEIANIYKN
YASAISVLTDEKYFHGNIEYINVVRRCVSQPILCKDFFIDSYQVYLARYYSADAILLMLSVLNDSQYLELSRIAKELNMG
VLTEINNIKELKRAIKLNASVIGINNRNLHDLSIDLNRTRTLSPLIKNKIIVSESGIKKNHQIKELSNIVHGFLIGSSLM
YRTNLETNIKSLIIGDNKVCGLTRIIDAKIVESCGAVYGGLIFADNSLRKTNEKIAEKMIFENNLRFIGVFQNQDIEKIV
NIAQRLSLYAVQLHGSENQKYINILRKKLCKKIKIWKAFSIQSTLPLLNWDHIDKYIFDSGSGGTNKTFNWSILKGSILE
NVILAGGINTDNVLIASQLNCSGLDFNSGVEKSPGIKDHKKISLIFKKLTF

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=448, Percent_Identity=53.125, Blast_Score=513, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322638, Length=228, Percent_Identity=36.8421052631579, Blast_Score=126, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BUCAP (P42393)

Other databases:

- EMBL:   Z19055
- EMBL:   AE013218
- PIR:   B49897
- RefSeq:   NP_660615.1
- ProteinModelPortal:   P42393
- SMR:   P42393
- EnsemblBacteria:   EBBUCT00000000292
- GeneID:   1005470
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg268
- GeneTree:   EBGT00050000008187
- HOGENOM:   HBG296890
- OMA:   YILECKK
- ProtClustDB:   PRK09427
- BioCyc:   BAPH198804:BUSG268-MONOMER
- HAMAP:   MF_00134_B
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48; =5.3.1.24

Molecular weight: Translated: 51595; Mature: 51595

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS00614 IGPS; PS00123 ALKALINE_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETILNKIIKDKIDWIKYRKKIQPLIKFKNKINKETRNFYNSLKEKRPFFILECKKSSP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCCCC
SLGIIRKKFNLIEIANIYKNYASAISVLTDEKYFHGNIEYINVVRRCVSQPILCKDFFID
CCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCCEEHHHHHH
SYQVYLARYYSADAILLMLSVLNDSQYLELSRIAKELNMGVLTEINNIKELKRAIKLNAS
HHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCE
VIGINNRNLHDLSIDLNRTRTLSPLIKNKIIVSESGIKKNHQIKELSNIVHGFLIGSSLM
EEECCCCCEEEEEEECCCCCHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCE
YRTNLETNIKSLIIGDNKVCGLTRIIDAKIVESCGAVYGGLIFADNSLRKTNEKIAEKMI
EECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHH
FENNLRFIGVFQNQDIEKIVNIAQRLSLYAVQLHGSENQKYINILRKKLCKKIKIWKAFS
HHCCCEEEEEECCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEE
IQSTLPLLNWDHIDKYIFDSGSGGTNKTFNWSILKGSILENVILAGGINTDNVLIASQLN
CCCCCCCCCHHHHHHHHEECCCCCCCCEEEEEEEECHHHHHHHHCCCCCCCCEEEEEECC
CSGLDFNSGVEKSPGIKDHKKISLIFKKLTF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQETILNKIIKDKIDWIKYRKKIQPLIKFKNKINKETRNFYNSLKEKRPFFILECKKSSP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCCCC
SLGIIRKKFNLIEIANIYKNYASAISVLTDEKYFHGNIEYINVVRRCVSQPILCKDFFID
CCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCCEEHHHHHH
SYQVYLARYYSADAILLMLSVLNDSQYLELSRIAKELNMGVLTEINNIKELKRAIKLNAS
HHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCE
VIGINNRNLHDLSIDLNRTRTLSPLIKNKIIVSESGIKKNHQIKELSNIVHGFLIGSSLM
EEECCCCCEEEEEEECCCCCHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCE
YRTNLETNIKSLIIGDNKVCGLTRIIDAKIVESCGAVYGGLIFADNSLRKTNEKIAEKMI
EECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHH
FENNLRFIGVFQNQDIEKIVNIAQRLSLYAVQLHGSENQKYINILRKKLCKKIKIWKAFS
HHCCCEEEEEECCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEE
IQSTLPLLNWDHIDKYIFDSGSGGTNKTFNWSILKGSILENVILAGGINTDNVLIASQLN
CCCCCCCCCHHHHHHHHEECCCCCCCCEEEEEEEECHHHHHHHHCCCCCCCCEEEEEECC
CSGLDFNSGVEKSPGIKDHKKISLIFKKLTF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8407819; 12089438