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The map label for this gene is rnc [H]

Identifier: 21672530

GI number: 21672530

Start: 284091

End: 284771

Strand: Reverse

Name: rnc [H]

Synonym: BUsg249

Alternate gene names: 21672530

Gene position: 284771-284091 (Counterclockwise)

Preceding gene: 21672531

Following gene: 21672529

Centisome position: 44.39

GC content: 31.72

Gene sequence:

>681_bases
ATGAACCATATCGTAGCAAATAAAATACAGCAAATATTAGGATATACCTTTACTCATCAAGAGTTGTTAAAACAGGCATT
AACCCATCGTAGTGCAAGTAGTAAACATAATGAAAGACTCGAATTTTTAGGAGATTCAATTCTAAGCTTTGTAATTGCTA
ATGCTTTATATCAGCATTTTCCGTATATTGATGAAGGTGATATGAGTCGTATGAGAGCTACTTTAGTAAGAGGTAATACC
TTAGCAGAAATAGCATATGAATTTGATTTAGGAGAATATCTCCAATTAGGTCAAGGTGAATTGAAAAGCGGAGGTTTCCG
TCGTGAATCTATTTTAGCTAATACTGTAGAAGCTTTAATCGGTAGTATTTATTTAGATAGTAATATTAAAACAGTAGAAG
AATTAATACTTAAATGGTACGAAAAACGTTTAGAAAAAATCAGTCCTGGAGACACACAAAAAGATCCTAAGACACGATTG
CAAGAATATTTACAATCTAAACATTTATCCTTACCTTCATATTTTATTGTTGAAGTTTATGGCGAAGCACACAATCAATT
GTTTACTATTCATTGTGAAGTGAGTACACTTTCAACAAGTTTCATTGGTAAAGGTACAAGTAGAAGAAAAGCAGAACAAG
ATGCAGCAAGAAAAGCATTAATTAAATTAGGTGTAGAGTGA

Upstream 100 bases:

>100_bases
TATATTAATATTTGAAATATATCTTCAATGTTATCAAAATTTTACTGTTTTTCCTGTTATATGTAAAAATCAATTAAAAT
ATTATTGAAATTGGTATAAC

Downstream 100 bases:

>100_bases
AAAAAAGAAAACAATATTGCGGATACATAGCGATTGTTGGTAAGCCAAATGTGGGTAAATCAACTTTAATTAACGAAATA
ATCGAGAATGAAATTTCTAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNHIVANKIQQILGYTFTHQELLKQALTHRSASSKHNERLEFLGDSILSFVIANALYQHFPYIDEGDMSRMRATLVRGNT
LAEIAYEFDLGEYLQLGQGELKSGGFRRESILANTVEALIGSIYLDSNIKTVEELILKWYEKRLEKISPGDTQKDPKTRL
QEYLQSKHLSLPSYFIVEVYGEAHNQLFTIHCEVSTLSTSFIGKGTSRRKAEQDAARKALIKLGVE

Sequences:

>Translated_226_residues
MNHIVANKIQQILGYTFTHQELLKQALTHRSASSKHNERLEFLGDSILSFVIANALYQHFPYIDEGDMSRMRATLVRGNT
LAEIAYEFDLGEYLQLGQGELKSGGFRRESILANTVEALIGSIYLDSNIKTVEELILKWYEKRLEKISPGDTQKDPKTRL
QEYLQSKHLSLPSYFIVEVYGEAHNQLFTIHCEVSTLSTSFIGKGTSRRKAEQDAARKALIKLGVE
>Mature_226_residues
MNHIVANKIQQILGYTFTHQELLKQALTHRSASSKHNERLEFLGDSILSFVIANALYQHFPYIDEGDMSRMRATLVRGNT
LAEIAYEFDLGEYLQLGQGELKSGGFRRESILANTVEALIGSIYLDSNIKTVEELILKWYEKRLEKISPGDTQKDPKTRL
QEYLQSKHLSLPSYFIVEVYGEAHNQLFTIHCEVSTLSTSFIGKGTSRRKAEQDAARKALIKLGVE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=225, Percent_Identity=30.2222222222222, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI155030234, Length=225, Percent_Identity=30.2222222222222, Blast_Score=100, Evalue=8e-22,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=75.2212389380531, Blast_Score=344, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17506883, Length=193, Percent_Identity=29.5336787564767, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193202651, Length=193, Percent_Identity=29.5336787564767, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=28.9473684210526, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25682; Mature: 25682

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHIVANKIQQILGYTFTHQELLKQALTHRSASSKHNERLEFLGDSILSFVIANALYQHF
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PYIDEGDMSRMRATLVRGNTLAEIAYEFDLGEYLQLGQGELKSGGFRRESILANTVEALI
CCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GSIYLDSNIKTVEELILKWYEKRLEKISPGDTQKDPKTRLQEYLQSKHLSLPSYFIVEVY
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHEEC
GEAHNQLFTIHCEVSTLSTSFIGKGTSRRKAEQDAARKALIKLGVE
CCCCCEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNHIVANKIQQILGYTFTHQELLKQALTHRSASSKHNERLEFLGDSILSFVIANALYQHF
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PYIDEGDMSRMRATLVRGNTLAEIAYEFDLGEYLQLGQGELKSGGFRRESILANTVEALI
CCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GSIYLDSNIKTVEELILKWYEKRLEKISPGDTQKDPKTRLQEYLQSKHLSLPSYFIVEVY
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHEEC
GEAHNQLFTIHCEVSTLSTSFIGKGTSRRKAEQDAARKALIKLGVE
CCCCCEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA