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The map label for this gene is era

Identifier: 21672529

GI number: 21672529

Start: 283258

End: 284094

Strand: Reverse

Name: era

Synonym: BUsg248

Alternate gene names: 21672529

Gene position: 284094-283258 (Counterclockwise)

Preceding gene: 21672530

Following gene: 21672528

Centisome position: 44.29

GC content: 21.74

Gene sequence:

>837_bases
GTGAAAAAAAGAAAACAATATTGCGGATACATAGCGATTGTTGGTAAGCCAAATGTGGGTAAATCAACTTTAATTAACGA
AATAATCGAGAATGAAATTTCTATTACATCAAAAAAGAAAAATACAACACAAAAAAACATCCTAGGTATAAAAACAAAAC
AATTACATCAATTTATCTACGTAGATACACCAGGAATATATTTGAATAACGAAAAAGATGATAGTTTTAAAATTATAAAA
AGTTCAATATTAATTTTATTTATTGTAGATCGTACTGTCTGGAAAACAGATGACGAAATAGTGTTAAATAAAATTAAAAA
AAATAAGATTCCAATTATTTGTGTTATCAATAAGATTGATAAAATTTTAGATAAAAGTATAATTTTACCACATATTAATT
TTCTTTTAAAAAAAATTAATCCAATAGAAATTATACCTATTTCGGCAAAAAAAAGAGAAAATATAGTTCTTTTAGAAAAT
TTAATATACCCCTATTTACCAAATAACAATCATATTTTTCCTAAAAAATATATTACAACACATTCTTTATCTTTTTCAAT
ATCTGAAATCATTCGTCAAAAGTTAATATTTTTTTTAAGAGATGAATTACCTTCAATAATAACAGTAAAAATTGAATCAA
TTGAGGAAAAATTCAAAAAAAAACTGTATATTAGAGCTGCAATTTATGTAAAACATGAAAGACAAAAAAAAATTATTATT
GGAAAAAAAGCTGAAGGGATTAAAAAAATTAGTATTGCATCTAGGTTAGATATTGAAAAAAAAATAAATATGAAAATATA
TCTTATAATATGGGTGAAGGTGAAAATTAAAAAATAG

Upstream 100 bases:

>100_bases
AAGTGAGTACACTTTCAACAAGTTTCATTGGTAAAGGTACAAGTAGAAGAAAAGCAGAACAAGATGCAGCAAGAAAAGCA
TTAATTAAATTAGGTGTAGA

Downstream 100 bases:

>100_bases
TTTTTAAAATTAGTTAAAATACTTAAAAATTTTAACTAATTTTAAAAATCAAACTAAACATTTTACTAAAACAAAGGAAA
TTTTACTACTAAAATGTCTA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKKRKQYCGYIAIVGKPNVGKSTLINEIIENEISITSKKKNTTQKNILGIKTKQLHQFIYVDTPGIYLNNEKDDSFKIIK
SSILILFIVDRTVWKTDDEIVLNKIKKNKIPIICVINKIDKILDKSIILPHINFLLKKINPIEIIPISAKKRENIVLLEN
LIYPYLPNNNHIFPKKYITTHSLSFSISEIIRQKLIFFLRDELPSIITVKIESIEEKFKKKLYIRAAIYVKHERQKKIII
GKKAEGIKKISIASRLDIEKKINMKIYLIIWVKVKIKK

Sequences:

>Translated_278_residues
MKKRKQYCGYIAIVGKPNVGKSTLINEIIENEISITSKKKNTTQKNILGIKTKQLHQFIYVDTPGIYLNNEKDDSFKIIK
SSILILFIVDRTVWKTDDEIVLNKIKKNKIPIICVINKIDKILDKSIILPHINFLLKKINPIEIIPISAKKRENIVLLEN
LIYPYLPNNNHIFPKKYITTHSLSFSISEIIRQKLIFFLRDELPSIITVKIESIEEKFKKKLYIRAAIYVKHERQKKIII
GKKAEGIKKISIASRLDIEKKINMKIYLIIWVKVKIKK
>Mature_278_residues
MKKRKQYCGYIAIVGKPNVGKSTLINEIIENEISITSKKKNTTQKNILGIKTKQLHQFIYVDTPGIYLNNEKDDSFKIIK
SSILILFIVDRTVWKTDDEIVLNKIKKNKIPIICVINKIDKILDKSIILPHINFLLKKINPIEIIPISAKKRENIVLLEN
LIYPYLPNNNHIFPKKYITTHSLSFSISEIIRQKLIFFLRDELPSIITVKIESIEEKFKKKLYIRAAIYVKHERQKKIII
GKKAEGIKKISIASRLDIEKKINMKIYLIIWVKVKIKK

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=315, Percent_Identity=24.7619047619048, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788919, Length=278, Percent_Identity=43.5251798561151, Blast_Score=239, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24646434, Length=313, Percent_Identity=24.9201277955272, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_BUCAP (Q8K9R2)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660596.1
- ProteinModelPortal:   Q8K9R2
- SMR:   Q8K9R2
- EnsemblBacteria:   EBBUCT00000000441
- GeneID:   1005450
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg248
- GeneTree:   EBGT00050000007774
- HOGENOM:   HBG561652
- OMA:   QNATRRK
- ProtClustDB:   PRK00089
- BioCyc:   BAPH198804:BUSG248-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 32488; Mature: 32488

Theoretical pI: Translated: 10.62; Mature: 10.62

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRKQYCGYIAIVGKPNVGKSTLINEIIENEISITSKKKNTTQKNILGIKTKQLHQFIY
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCHHHEEECCHHHEEEEEE
VDTPGIYLNNEKDDSFKIIKSSILILFIVDRTVWKTDDEIVLNKIKKNKIPIICVINKID
EECCCEEEECCCCCHHHHHHHCEEEEEEECCCEECCCCHHHHHHHHCCCCCEEEEEHHHH
KILDKSIILPHINFLLKKINPIEIIPISAKKRENIVLLENLIYPYLPNNNHIFPKKYITT
HHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCEECCCCEEEE
HSLSFSISEIIRQKLIFFLRDELPSIITVKIESIEEKFKKKLYIRAAIYVKHERQKKIII
EECCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHEEEEEEEEEEECCCCEEEE
GKKAEGIKKISIASRLDIEKKINMKIYLIIWVKVKIKK
ECCCCCCEEEEHHHHCCCCEECCEEEEEEEEEEEEECC
>Mature Secondary Structure
MKKRKQYCGYIAIVGKPNVGKSTLINEIIENEISITSKKKNTTQKNILGIKTKQLHQFIY
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCHHHEEECCHHHEEEEEE
VDTPGIYLNNEKDDSFKIIKSSILILFIVDRTVWKTDDEIVLNKIKKNKIPIICVINKID
EECCCEEEECCCCCHHHHHHHCEEEEEEECCCEECCCCHHHHHHHHCCCCCEEEEEHHHH
KILDKSIILPHINFLLKKINPIEIIPISAKKRENIVLLENLIYPYLPNNNHIFPKKYITT
HHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCEECCCCEEEE
HSLSFSISEIIRQKLIFFLRDELPSIITVKIESIEEKFKKKLYIRAAIYVKHERQKKIII
EECCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHEEEEEEEEEEECCCCEEEE
GKKAEGIKKISIASRLDIEKKINMKIYLIIWVKVKIKK
ECCCCCCEEEEHHHHCCCCEECCEEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438