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The map label for this gene is thrC [H]

Identifier: 77748613

GI number: 77748613

Start: 2118238

End: 2119542

Strand: Direct

Name: thrC [H]

Synonym: XAC1823

Alternate gene names: 77748613

Gene position: 2118238-2119542 (Clockwise)

Preceding gene: 161485716

Following gene: 21242568

Centisome position: 40.93

GC content: 69.04

Gene sequence:

>1305_bases
ATGTTTATCTCCACCCGTGGCGGTGCCCCCGCCGCAAGCCTGAGCCAAGCCATTGCCGCCGGGCTGGCGCCCGATGGCGG
CCTCTACGTGCCGCAGACCCTGCCACCTGCCCGTACGCTGGTTGCGGGCGCCGGCCTGGCCGACACCGCCACTGCGCTGT
TGCAGCCATTTTTCGAGGGCGACGCACTGGCGGCCGAACTGCCTGCCATCTGTGCCGAAGCCTTCGATTTCCCGGCGCCA
TTGGTGGCGCTGGGTACGCCGGGCGATTACGCGCTGGAGCTGTTTCATGGCCCCACGGCGGCGTTCAAGGATTTCGGTGC
GCGCTTCCTGGCTGCCTGCCTGACCCGCTTGCGCCGCGCTGAAGACCGCCCGCTCACCATCCTGGTCGCCACCTCCGGCG
ACACCGGCGCCGCCGTGGCCGCCGCGTTCCATCGCCAGCCCGGCCTGCGCGTGGTGGTGCTGTATCCGGACGGCCGCGTG
TCGCCGCGGCAGGCGCATCAGTTGGGGTGTTTCGGCGACAACATCCAGGCCCTGCGCGTGGCCGGCTCGTTCGACGACTG
CCAGGCGATGGTCAAGCAGGCCTTGAACGATGCCGCGTTGCAGACGCAGGTGCCGCTGAGTTCGGCCAACAGCATCAGTC
TGGGCCGGCTGCTGCCGCAGATGAGTTACTACGCGCATGCCGCCCTGCAGCATCATGCGGCGTCGGGCAGCGTGCTCAAT
CTGGTGATACCCACCGGTAACCTGGGCAACGCGCTGGCGGCGATCATCGCGCGCGCGCTCGGGGTGCCGTTGGGCCGCAT
CGCGCTGGCGTCCAACGCCAATCACGTGTTGCCGGACTATTTCGCGGGCGATGCCTACGCACCGCAGCCCAGCGTGTCCA
CCCTGGCCAATGCGATGGACGTGGGCGCGCCGAGCAACTTCGAGCGGCTGCGGTGGCTCTACAACGGCGACGATGCCGCC
TTGCGTGAGGAATTCCGGGCCTTGTCGGTGGACGATGCGGCGATTCGCAACACCGTGCAGCAGCGCTTCGCGCGCTACGG
CGAGGTGCATTGCCCGCATACCGCCACCGCGGTGCATGTGCTCGAACAACTGCGTGCCGAAGGCGCGGAGGGCGGCACTG
GCGACTGGGCGGTAGCGGCCACCGCGCATCCGGCAAAGTTCGAGGGCGTGGTGGAGCCGCTGATTGGCCGTTCCGTAGAG
GTTCCGCCGGCACTGGCCGCACTGCTGCAGCGCCCAGCGCATGCCGAAGCACTGGCGCCGGACTACGCCGCCCTTCGGCA
GCGCTTGCTTGCCGATGCCACCTGA

Upstream 100 bases:

>100_bases
TGCGGCCGAACGCCGGCGCAACGCGACGCCCGGCGACGTCACACGCGGCACCGCTTGTCACGGGCACCGCCCAGCCTTCG
CTTTATCTGGAGTCATGCTG

Downstream 100 bases:

>100_bases
CCCAACGCGTTCAGCCACCGGGGTTGGAAAGTGGCCCATATGCGGCTATTTCTAGGGGGTGCGGCCCCGCTGTGGCGCCG
CGTCCGCTGTGGGTTGTTGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLVAGAGLADTATALLQPFFEGDALAAELPAICAEAFDFPAP
LVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRAEDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRV
SPRQAHQLGCFGDNIQALRVAGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAASGSVLN
LVIPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVSTLANAMDVGAPSNFERLRWLYNGDDAA
LREEFRALSVDDAAIRNTVQQRFARYGEVHCPHTATAVHVLEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRSVE
VPPALAALLQRPAHAEALAPDYAALRQRLLADAT

Sequences:

>Translated_434_residues
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLVAGAGLADTATALLQPFFEGDALAAELPAICAEAFDFPAP
LVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRAEDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRV
SPRQAHQLGCFGDNIQALRVAGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAASGSVLN
LVIPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVSTLANAMDVGAPSNFERLRWLYNGDDAA
LREEFRALSVDDAAIRNTVQQRFARYGEVHCPHTATAVHVLEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRSVE
VPPALAALLQRPAHAEALAPDYAALRQRLLADAT
>Mature_434_residues
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLVAGAGLADTATALLQPFFEGDALAAELPAICAEAFDFPAP
LVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRAEDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRV
SPRQAHQLGCFGDNIQALRVAGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAASGSVLN
LVIPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVSTLANAMDVGAPSNFERLRWLYNGDDAA
LREEFRALSVDDAAIRNTVQQRFARYGEVHCPHTATAVHVLEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRSVE
VPPALAALLQRPAHAEALAPDYAALRQRLLADAT

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=500, Percent_Identity=32.4, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI149193323, Length=401, Percent_Identity=30.6733167082294, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1786185, Length=421, Percent_Identity=38.0047505938242, Blast_Score=257, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6319901, Length=451, Percent_Identity=31.0421286031042, Blast_Score=202, Evalue=6e-53,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 45231; Mature: 45231

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLVAGAGLADTATALLQPFFEG
CEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCC
DALAAELPAICAEAFDFPAPLVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRA
CHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
EDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRVSPRQAHQLGCFGDNIQALRV
CCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCEEEEE
AGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAASGSVLN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LVIPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVSTLANAMD
EEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VGAPSNFERLRWLYNGDDAALREEFRALSVDDAAIRNTVQQRFARYGEVHCPHTATAVHV
CCCCCCHHHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRSVEVPPALAALLQRPAHAEALAP
HHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHCCC
DYAALRQRLLADAT
CHHHHHHHHHHCCC
>Mature Secondary Structure
MFISTRGGAPAASLSQAIAAGLAPDGGLYVPQTLPPARTLVAGAGLADTATALLQPFFEG
CEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCC
DALAAELPAICAEAFDFPAPLVALGTPGDYALELFHGPTAAFKDFGARFLAACLTRLRRA
CHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
EDRPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRVSPRQAHQLGCFGDNIQALRV
CCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCEEEEE
AGSFDDCQAMVKQALNDAALQTQVPLSSANSISLGRLLPQMSYYAHAALQHHAASGSVLN
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LVIPTGNLGNALAAIIARALGVPLGRIALASNANHVLPDYFAGDAYAPQPSVSTLANAMD
EEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VGAPSNFERLRWLYNGDDAALREEFRALSVDDAAIRNTVQQRFARYGEVHCPHTATAVHV
CCCCCCHHHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LEQLRAEGAEGGTGDWAVAATAHPAKFEGVVEPLIGRSVEVPPALAALLQRPAHAEALAP
HHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHCCC
DYAALRQRLLADAT
CHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]