Click here to switch to the map view.

The map label for this gene is cycA [H]

Identifier: 77748539

GI number: 77748539

Start: 703667

End: 705043

Strand: Direct

Name: cycA [H]

Synonym: XAC0600

Alternate gene names: 77748539

Gene position: 703667-705043 (Clockwise)

Preceding gene: 21241368

Following gene: 21241373

Centisome position: 13.6

GC content: 61.87

Gene sequence:

>1377_bases
ATGTCTGACCCGTCCGCGCCCGATCATCTGCAACGCAGCCTGTCCAATCGCCACCTGCAGTTGATCGCCATTGGCGGGGC
GATCGGTACCGGCCTGTTCATGGGCTCTGGCAAGACGATCAGTCTGGCCGGGCCGTCGATCCTGTTCGTCTATCTCATCA
TTGGCGCGATGCTGTTCTTCGTCATGCGCGCAATGGGCGAACTGCTGCTCTCCAACCTGGAATACAAGTCGTTCATCGAT
TTTTCCACCGACCTGCTCGGGCCGTGGGCCGGGTTCTTCTGTGGGTGGACGTACTGGTTTTGCTGGATCATCACCGCCAT
TGCCGATGTCATCGCGATTGCGGCCTATGCGCAATTCTGGTTTCCAGGGTTGGCGCCGTGGATTCCCGCGATCTTGTGCG
TGTTGTTGCTGCTGGGCCTGAATCTGGTCACGGTGAAATTGTTCGGCGAGATGGAATTCTGGTTCGCGCTGATCAAGATC
ATCGCCATTGCCGCGTTGATCGTCACTGGCGCCGGGCTGGTGGTGTGGGGCTTTCGCTCGCCGTCGGGCAACGTGGCCTC
GCTGTCGAATCTGTGGAACGACGGCGGCATGTTCCCCATGGGTATCGGCGGGTTCTTTGCCGGCTTCCAGATTGCGGTGT
TCGCCTTCGTCGGTATCGAGTTGGTGGGTACCACGGCTGCAGAAACGGCCGATCCGCGCCGCAACCTGCCCAAGGCGATC
AACTCGATTCCGGTGCGCATCTTGATTTTCTACGTGCTTGCGCTGATCGCCATCATGGCGGTGACGCCGTGGCGGCAGGT
GGTGGCCGACAAGAGCCCGTTCGTGGAGTTGTTCGTGCTGGCCGGCGTGCCGGCGGCAGCCAGCCTGATCAACTTCGTGG
TGCTGACCTCGGCCACCTCGTCGGCCAATAGCGGCATCTTTTCCACCAGCCGCATGCTCTACGGCCTGGCCGAAGAACAG
CATGCGCCCAAGGGCTTCGCCAAGCTGTCGCGTGCGGCGATACCGGCGCGCGGCCTGCTGTTTTCCTGCCTGTGCCTGCT
GCTGGGCGCAATGCTGGTGTATCTGATTCCCAACCTGGTCACCGCGTTTACGCTGGTCACCACGCTGTCGGCGGTGCTTT
TCATGTTCGTGTGGTCGCTGATCCTGTGCGCCTACATCGCCTACCGCCGCAAGCGCCCGGAGCAACACGCCGCCTCGGCG
TTCAAGATGCCCGGCGGCGTGCTGATGTGCTACGTGTGCCTGGCATTCTTCGCCTTCGTCATCGTGCTGCTGACCCTGCA
GGACGACACGCGTCAGGCATTGCTGGCAAGCCCGGTGTGGTTCCTGCTCCTGGCCATTGGCTATGCAGTCAAACGCCGCG
GGAACCGGCAGCGCTGA

Upstream 100 bases:

>100_bases
GCGCATGCATGGCCTCGCGGCTACCGCAGCGCAAACCCCTGGTATGCGCTGGCGCGATCTCGTATTTTTGACGGCTTGTT
CACTTGCCGGTGCCGTGCCC

Downstream 100 bases:

>100_bases
GCGATCCGTGCGGAACTCATTGCGTGCGCAGCGTGCGGCAGTGACGCACGCTGCGGGCGGTCATGTCGATGCGCGTGGAC
GGCGGATCATTCGCCGTTCG

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFFVMRAMGELLLSNLEYKSFID
FSTDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFWFPGLAPWIPAILCVLLLLGLNLVTVKLFGEMEFWFALIKI
IAIAALIVTGAGLVVWGFRSPSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAI
NSIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATSSANSGIFSTSRMLYGLAEEQ
HAPKGFAKLSRAAIPARGLLFSCLCLLLGAMLVYLIPNLVTAFTLVTTLSAVLFMFVWSLILCAYIAYRRKRPEQHAASA
FKMPGGVLMCYVCLAFFAFVIVLLTLQDDTRQALLASPVWFLLLAIGYAVKRRGNRQR

Sequences:

>Translated_458_residues
MSDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFFVMRAMGELLLSNLEYKSFID
FSTDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFWFPGLAPWIPAILCVLLLLGLNLVTVKLFGEMEFWFALIKI
IAIAALIVTGAGLVVWGFRSPSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAI
NSIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATSSANSGIFSTSRMLYGLAEEQ
HAPKGFAKLSRAAIPARGLLFSCLCLLLGAMLVYLIPNLVTAFTLVTTLSAVLFMFVWSLILCAYIAYRRKRPEQHAASA
FKMPGGVLMCYVCLAFFAFVIVLLTLQDDTRQALLASPVWFLLLAIGYAVKRRGNRQR
>Mature_457_residues
SDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFFVMRAMGELLLSNLEYKSFIDF
STDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFWFPGLAPWIPAILCVLLLLGLNLVTVKLFGEMEFWFALIKII
AIAALIVTGAGLVVWGFRSPSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAIN
SIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATSSANSGIFSTSRMLYGLAEEQH
APKGFAKLSRAAIPARGLLFSCLCLLLGAMLVYLIPNLVTAFTLVTTLSAVLFMFVWSLILCAYIAYRRKRPEQHAASAF
KMPGGVLMCYVCLAFFAFVIVLLTLQDDTRQALLASPVWFLLLAIGYAVKRRGNRQR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=330, Percent_Identity=23.030303030303, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI110347453, Length=357, Percent_Identity=22.96918767507, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790653, Length=462, Percent_Identity=68.6147186147186, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=42.2319474835886, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI1786302, Length=453, Percent_Identity=39.7350993377483, Blast_Score=340, Evalue=8e-95,
Organism=Escherichia coli, GI1786789, Length=456, Percent_Identity=38.1578947368421, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI48994972, Length=461, Percent_Identity=40.1301518438178, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI87081915, Length=452, Percent_Identity=38.2743362831858, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1789017, Length=451, Percent_Identity=31.2638580931264, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87081708, Length=400, Percent_Identity=33.75, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1788480, Length=443, Percent_Identity=34.9887133182844, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI2367353, Length=396, Percent_Identity=24.4949494949495, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=357, Percent_Identity=21.8487394957983, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=345, Percent_Identity=28.4057971014493, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324924, Length=420, Percent_Identity=34.0476190476191, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6324061, Length=443, Percent_Identity=33.8600451467269, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=444, Percent_Identity=31.0810810810811, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=454, Percent_Identity=30.6167400881057, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=480, Percent_Identity=29.1666666666667, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6324553, Length=391, Percent_Identity=29.923273657289, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324059, Length=447, Percent_Identity=31.0961968680089, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320251, Length=481, Percent_Identity=26.6112266112266, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319824, Length=400, Percent_Identity=28, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=26.8472906403941, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6319542, Length=407, Percent_Identity=26.044226044226, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321629, Length=407, Percent_Identity=27.7641277641278, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=421, Percent_Identity=28.0285035629454, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319543, Length=410, Percent_Identity=28.0487804878049, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319608, Length=395, Percent_Identity=26.5822784810127, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321053, Length=397, Percent_Identity=27.2040302267003, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=424, Percent_Identity=27.122641509434, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=445, Percent_Identity=24.2696629213483, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550968, Length=415, Percent_Identity=26.5060240963855, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19921172, Length=415, Percent_Identity=26.5060240963855, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49760; Mature: 49629

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFF
CCCCCCHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHHHHHHHHH
VMRAMGELLLSNLEYKSFIDFSTDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFW
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPGLAPWIPAILCVLLLLGLNLVTVKLFGEMEFWFALIKIIAIAALIVTGAGLVVWGFRS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
PSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAI
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHH
NSIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC
SANSGIFSTSRMLYGLAEEQHAPKGFAKLSRAAIPARGLLFSCLCLLLGAMLVYLIPNLV
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TAFTLVTTLSAVLFMFVWSLILCAYIAYRRKRPEQHAASAFKMPGGVLMCYVCLAFFAFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
IVLLTLQDDTRQALLASPVWFLLLAIGYAVKRRGNRQR
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFF
CCCCCHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHHHHHHHHH
VMRAMGELLLSNLEYKSFIDFSTDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFW
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPGLAPWIPAILCVLLLLGLNLVTVKLFGEMEFWFALIKIIAIAALIVTGAGLVVWGFRS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
PSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAI
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHH
NSIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC
SANSGIFSTSRMLYGLAEEQHAPKGFAKLSRAAIPARGLLFSCLCLLLGAMLVYLIPNLV
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TAFTLVTTLSAVLFMFVWSLILCAYIAYRRKRPEQHAASAFKMPGGVLMCYVCLAFFAFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
IVLLTLQDDTRQALLASPVWFLLLAIGYAVKRRGNRQR
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]