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The map label for this gene is cobB

Identifier: 77748522

GI number: 77748522

Start: 381527

End: 382408

Strand: Direct

Name: cobB

Synonym: XAC0320

Alternate gene names: 77748522

Gene position: 381527-382408 (Clockwise)

Preceding gene: 21241093

Following gene: 21241095

Centisome position: 7.37

GC content: 66.55

Gene sequence:

>882_bases
ATGACTGCTGTCCCTGCCCACGACCACCACACGCTGCAGGACTTCATCGAGCGCCATCAGCGGCTGTTCGTGCTGACCGG
TGCCGGCTGCAGCACCGATTCGGGCATTCCCGATTATCGGGACCTGCAAGGCGGCTGGAAGCGCCCGCAGCCGGTGACGT
TCCAGGCGTTCATGGGCGAGCTGTCCACGCGGCAGCGCTATTGGGCGCGCAGCCTGGTCGGCTGGCCGCGCTTCGGTCTG
GCGCAACCCAATGCCACCCATCATGCGCTCGCTGCGCTGGAGGCGCGTGGCCAGTTGGAAGTGCTGCTCACCCAGAACGT
GGACCGCCTGCATCAGGCCGCTGGTAGCCAGGCGGTGATCGATCTGCATGGCCGGCTCGATGTGGTGCGCTGCATGGGCT
GCGAGCGGCGCATGCCACGCACCGAATTTCAAGTGTTGCTTGAGCAGGCCAATCCAGGCTGGGCAGCGCTAGAGGCCGCG
CAAGCGCCCGATGGCGATGCCGATCTGGACGATGTGGCCTTCGAGCATTTCGTGGTGCCGCCGTGCCCGGTGTGCGGTGG
CGTGCTCAAGCCGAATGTGGTGTTCTTCGGCGAAAACGTGCCGCGCGCGCGGGTGGAGCGTGCCTTCGCGCATCTGCAGG
CCGCCGATGCAGTGCTGGTGGTGGGCTCGTCGCTGATGGTGTATTCGGGCTTTCGTTTCGTGCAGACCGCTGCACGCAAC
GGGTTGCCGATCGCCGCACTCAACTTCGGGCGCACACGCGCGGACGAGCTGCTGACGTTGAAGGTGGAGCAGTCGTGCGC
GCAGGCGCTGGCGTTCCTGCACGCGCCGCCGCATTTGCCGCGTGCACGCAGCGTCAATGACGCCAGTGCACGCTCTGCAT
GA

Upstream 100 bases:

>100_bases
GCGCGAGCAAGCGCGCCGGTCTGGTGGCCGACACGGCGCCGCAGCGGGCCGTGCACGTGGCGCTGTTGCAAAGTGCTCCC
ATGGCTTCCGGAATGACCAC

Downstream 100 bases:

>100_bases
CGCAGTGATCCATCGCAGCGGTTGTGCCGGCGCGCGCGGCGCAGTGCAATAAGCACCCCATGTCAGCTGTGGATGCCGCC
TTGAGCCAGTTGTTCTCCCC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTAVPAHDHHTLQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGELSTRQRYWARSLVGWPRFGL
AQPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGCERRMPRTEFQVLLEQANPGWAALEAA
QAPDGDADLDDVAFEHFVVPPCPVCGGVLKPNVVFFGENVPRARVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARN
GLPIAALNFGRTRADELLTLKVEQSCAQALAFLHAPPHLPRARSVNDASARSA

Sequences:

>Translated_293_residues
MTAVPAHDHHTLQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGELSTRQRYWARSLVGWPRFGL
AQPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGCERRMPRTEFQVLLEQANPGWAALEAA
QAPDGDADLDDVAFEHFVVPPCPVCGGVLKPNVVFFGENVPRARVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARN
GLPIAALNFGRTRADELLTLKVEQSCAQALAFLHAPPHLPRARSVNDASARSA
>Mature_292_residues
TAVPAHDHHTLQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGELSTRQRYWARSLVGWPRFGLA
QPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGCERRMPRTEFQVLLEQANPGWAALEAAQ
APDGDADLDDVAFEHFVVPPCPVCGGVLKPNVVFFGENVPRARVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARNG
LPIAALNFGRTRADELLTLKVEQSCAQALAFLHAPPHLPRARSVNDASARSA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI6912662, Length=265, Percent_Identity=47.1698113207547, Blast_Score=236, Evalue=1e-62,
Organism=Homo sapiens, GI6912664, Length=274, Percent_Identity=29.9270072992701, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI13787215, Length=258, Percent_Identity=31.0077519379845, Blast_Score=121, Evalue=9e-28,
Organism=Homo sapiens, GI300795542, Length=282, Percent_Identity=27.6595744680851, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI308199517, Length=235, Percent_Identity=32.3404255319149, Blast_Score=81, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71990482, Length=270, Percent_Identity=41.8518518518518, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71990487, Length=272, Percent_Identity=41.5441176470588, Blast_Score=207, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17567771, Length=256, Percent_Identity=39.453125, Blast_Score=195, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28571445, Length=269, Percent_Identity=44.2379182156134, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI28571443, Length=217, Percent_Identity=44.7004608294931, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28571441, Length=217, Percent_Identity=44.7004608294931, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17137536, Length=224, Percent_Identity=29.9107142857143, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24650933, Length=280, Percent_Identity=26.7857142857143, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_XANAC (Q8PQK3)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640676.2
- ProteinModelPortal:   Q8PQK3
- SMR:   Q8PQK3
- GeneID:   1154391
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0320
- NMPDR:   fig|190486.1.peg.320
- HOGENOM:   HBG641281
- OMA:   LSHSFFM
- ProtClustDB:   PRK05333
- BioCyc:   XAXO190486:XAC0320-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 32066; Mature: 31935

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVPAHDHHTLQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGE
CCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCEEHHHHHHH
LSTRQRYWARSLVGWPRFGLAQPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVI
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCEEE
DLHGRLDVVRCMGCERRMPRTEFQVLLEQANPGWAALEAAQAPDGDADLDDVAFEHFVVP
EECCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCC
PCPVCGGVLKPNVVFFGENVPRARVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARN
CCHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCEEEECCCHHHHHHCHHHHHHHHCC
GLPIAALNFGRTRADELLTLKVEQSCAQALAFLHAPPHLPRARSVNDASARSA
CCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAVPAHDHHTLQDFIERHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPVTFQAFMGE
CCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCEEHHHHHHH
LSTRQRYWARSLVGWPRFGLAQPNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVI
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCEEE
DLHGRLDVVRCMGCERRMPRTEFQVLLEQANPGWAALEAAQAPDGDADLDDVAFEHFVVP
EECCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCC
PCPVCGGVLKPNVVFFGENVPRARVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARN
CCHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCEEEECCCHHHHHHCHHHHHHHHCC
GLPIAALNFGRTRADELLTLKVEQSCAQALAFLHAPPHLPRARSVNDASARSA
CCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217