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The map label for this gene is aroE

Identifier: 21244751

GI number: 21244751

Start: 4724103

End: 4724954

Strand: Reverse

Name: aroE

Synonym: XAC4034

Alternate gene names: 21244751

Gene position: 4724954-4724103 (Counterclockwise)

Preceding gene: 77748751

Following gene: 21244750

Centisome position: 91.29

GC content: 69.95

Gene sequence:

>852_bases
ATGCCCGTCTCCCGTTATGCCGTATTCGGTCACCCCGTCGCCCATTCGCTGTCGCCGGCCATCCATGCCGACTTCGGGAA
GCAGACCGGCATTGCGCTGGACTACACCGCCATCGACGCGTCGCTGGAAGACTTCAGCGCCGCGCTGCAACGCTTCGCCG
ATGAAGGCGGCAAAGGCGCGAACGTCACCCTGCCGTTGAAGGAAGCCGCCTATGCGCTGGCCAGCAGCCTGAGCGATCGC
GCGCGGCTGGCCGGGGCGGTGAACACGTTGGTGCGTAACGACGGCCAGTGGCAGGGCGACAACACCGACGGCGCCGGCCT
GGTGCGCGACCTCACCGAGCGCCAGGGCCTGGATCTGCGTGGCCGCCGCGTGCTGCTGCTGGGCGCCGGCGGCGCTGCTC
GCGGCGTGGCGCCGGCGCTGCTGGAGGCGGGCATCACCGCAATGGTGGTGGTGAACCGCTCGCCCGAGCGCGCCGATGCC
TTGTGCGATGCGCTGGGCGAGCCGGCGCGGGTGACGTCGCGTTACATCGAGGACCTGCGCGAGCTCGGCGATTTCGAACT
GATCGTCAATGCCACTGCCGCCGGCCGCGACCGCGATGCCGGCGCGTTCGCATTGCCACTGGGCCTGGTCAACAGCCTGA
CTGCCGCGGTCGATCTGAATTACGGCGATACCGCGATTGCGTTCCTTGCCTGGGCGCGTGCGGCGCAATGCCGGTACGCC
ATCGACGGGCTGGGCATGCTGGTGGAGCAGGCCGCCGAGAGCTTCGCGCTGTGGCATGGCGTGCGCCCGGATACCGACCC
GGTCTACGCCGCGCTGCGCGCGCGCGAGGCCGTGCTGATCAGTGCCGACTGA

Upstream 100 bases:

>100_bases
TGCCGCCAGCGTGAGCAGCGTCCATCGATAGTGCATGCGGTGTTCCTGCCTCAAGAGCGGCTCTAAGTCGCGCACAGTCT
AGTCAACCAGAGAGCGTTTC

Downstream 100 bases:

>100_bases
CGTGGGCAGCGCCGATGCCACCGCGATCCTCCTGACCCTGGTCACCAGCCTGCTGTCGCGTGTGCCGATGTTGATTGCGC
TGCTGCTCGGGCTGGTCCTG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPVSRYAVFGHPVAHSLSPAIHADFGKQTGIALDYTAIDASLEDFSAALQRFADEGGKGANVTLPLKEAAYALASSLSDR
ARLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLRGRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADA
LCDALGEPARVTSRYIEDLRELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYA
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLISAD

Sequences:

>Translated_283_residues
MPVSRYAVFGHPVAHSLSPAIHADFGKQTGIALDYTAIDASLEDFSAALQRFADEGGKGANVTLPLKEAAYALASSLSDR
ARLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLRGRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADA
LCDALGEPARVTSRYIEDLRELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYA
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLISAD
>Mature_282_residues
PVSRYAVFGHPVAHSLSPAIHADFGKQTGIALDYTAIDASLEDFSAALQRFADEGGKGANVTLPLKEAAYALASSLSDRA
RLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLRGRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADAL
CDALGEPARVTSRYIEDLRELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYAI
DGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLISAD

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=44.8529411764706, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1787983, Length=274, Percent_Identity=29.1970802919708, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320332, Length=280, Percent_Identity=25, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_XANAC (Q8PFE9)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644333.1
- ProteinModelPortal:   Q8PFE9
- SMR:   Q8PFE9
- GeneID:   1158105
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC4034
- NMPDR:   fig|190486.1.peg.3977
- HOGENOM:   HBG553408
- OMA:   DQYVVFG
- ProtClustDB:   PRK00258
- BioCyc:   XAXO190486:XAC4034-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29743; Mature: 29612

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: ACT_SITE 67-67

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSRYAVFGHPVAHSLSPAIHADFGKQTGIALDYTAIDASLEDFSAALQRFADEGGKGA
CCCCCEEEECCCHHHHCCCHHHHCCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHCCCCCC
NVTLPLKEAAYALASSLSDRARLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLR
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
GRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADALCDALGEPARVTSRYIEDLR
CCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHH
ELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYA
HCCCEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHH
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLISAD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECC
>Mature Secondary Structure 
PVSRYAVFGHPVAHSLSPAIHADFGKQTGIALDYTAIDASLEDFSAALQRFADEGGKGA
CCCCEEEECCCHHHHCCCHHHHCCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHCCCCCC
NVTLPLKEAAYALASSLSDRARLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLR
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
GRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADALCDALGEPARVTSRYIEDLR
CCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHH
ELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYA
HCCCEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHH
IDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLISAD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217