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The map label for this gene is cioA [H]

Identifier: 21244460

GI number: 21244460

Start: 4409767

End: 4411176

Strand: Direct

Name: cioA [H]

Synonym: XAC3735

Alternate gene names: 21244460

Gene position: 4409767-4411176 (Clockwise)

Preceding gene: 21244459

Following gene: 21244461

Centisome position: 85.2

GC content: 63.33

Gene sequence:

>1410_bases
GTGGAAGCGCTGCTGCTGTCCCGTATCCAGTTCGCCTTCGTCATTTCGTTCCATGTGTTGTTTCCGGCCTTCACCATTGG
CCTGGCGAACCTGCTCGGTTTTCTGGAATGGCGGTGGCTGCGCACGCACGACGAGACCTGGAAGCGGCTGTACTTTTTCT
GGTTGCGCATTTTTGCGGTGTCGTTCGGCATGGGTGTGGTCAGCGGCATCGTCATGGCCTTCCAGTTCGGCGCCAACTGG
CCCGAGCTGAGCCGCATTGCCGGTAGTGTGATCGGCCCGTTGCTGAGCTATGAGGTGCTTACTGCGTTCTTCCTGGAAGC
CAGCTTCCTGGGGGTGATGCTGTTCGGCTGGGGCCGGGTGTCCGAACGCCTGCATTTCTTCGCCACCTGCATGGTGGCGA
TCGGCACGCTGGTGTCCACGTTCTGGATCTTGTCGTCCAACAGCTGGCTGCACACCCCGCGTGGCTACACGATGGTCAAC
GGCATCGTGCAACCGGTCAGCTGGCTGCAGATCATCTTCAACCCGTCGTTTCCGTATCGCCTGGCCCATATGGCGCTGGG
TTCGTTCATCACCACCTGCTTCGTGGTTGGCGGCGTCGGCGCTTACTACCTGCGCAAAGGGCTGCATGTGGATGCCGGCG
CCCGCATGTTGCGCTTGTCGGTGGCATTTGCCGCCATCGTGCTACCGATCCAGATACTGGTGGGCGACCAGCACGGGCTC
AACACGTTGGAACATCAGCCGCTCAAAGTCGCCGCGATGGAGGCGCACTGGCACAGCGAAGGCCATGGCGCCGGCGTGCC
CTTGGTGGTGTTTGCGCTGCCCAATGCAGAGGCCGAGCGCAACGACTATGAGGTGGCCATCCCGCGCCTGGGTAGCCTGA
TCCTGACCCACAGCGCAGACGGCGACATTACGCCGCTGACGTCGGTGCCGCCCGATCAACGGCCGCCGGTGGCGCCGGTA
TTCTTCGCCTTCCGCATCATGGTGGGTCTGGGGATGACGATGTTGTTGCTGGCGTGGATCTCGGCCATTGCATGGTGGCG
TGGCCGCCTGCATGCCAGGCCGCTGATCCTGGCATGGAACCTCATGCTGCCGGCGGGATTGATGGCGCTGGTGGCCGGCT
GGTTCGTCACCGAGATCGGGCGCCAGCCGTGGGTGGTGTACGGGCTGCTGCGTACTGCCGACGCGGTGGGCCCGCAATCG
ACTGCGACAGTGGCGGTATCGCTGCTGGTGTATTTGCTGGGCTACGCATTCGTGTTCGGCTTCGGCATCTTTTATCTGAC
CAAGCTGGTACGCGCCGGGCCGCAACCCAGCCGCGACGGGCCGGATGTGGCCGGTGGCGACCACACGCCGGCACGCCCGC
TGTCTGCAGCACAGACGTCACTGGAACAGGAGAACACGCCATGGAACTGA

Upstream 100 bases:

>100_bases
GCGCGCCGGGCAGGTGCCAGCTGCGCCTGACCGGCCAGCATCCCGTCCCGTGGCCCCTGTGCCGGCACTACCGTACCCGA
CCAGGCGTTAGGAGAAACCT

Downstream 100 bases:

>100_bases
GTTACTGGTTGCCGGTGGTGTGGTTTGGCGTGATCGGTTTCGGCGTGCTGATGTACGTGGTGCTGGACGGCTTCGTGCTC
GGGCTGGGCATGCTGGCGCC

Product: cyanide insensitive terminal oxidase

Products: NA

Alternate protein names: Cytochrome d ubiquinol oxidase subunit I [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MEALLLSRIQFAFVISFHVLFPAFTIGLANLLGFLEWRWLRTHDETWKRLYFFWLRIFAVSFGMGVVSGIVMAFQFGANW
PELSRIAGSVIGPLLSYEVLTAFFLEASFLGVMLFGWGRVSERLHFFATCMVAIGTLVSTFWILSSNSWLHTPRGYTMVN
GIVQPVSWLQIIFNPSFPYRLAHMALGSFITTCFVVGGVGAYYLRKGLHVDAGARMLRLSVAFAAIVLPIQILVGDQHGL
NTLEHQPLKVAAMEAHWHSEGHGAGVPLVVFALPNAEAERNDYEVAIPRLGSLILTHSADGDITPLTSVPPDQRPPVAPV
FFAFRIMVGLGMTMLLLAWISAIAWWRGRLHARPLILAWNLMLPAGLMALVAGWFVTEIGRQPWVVYGLLRTADAVGPQS
TATVAVSLLVYLLGYAFVFGFGIFYLTKLVRAGPQPSRDGPDVAGGDHTPARPLSAAQTSLEQENTPWN

Sequences:

>Translated_469_residues
MEALLLSRIQFAFVISFHVLFPAFTIGLANLLGFLEWRWLRTHDETWKRLYFFWLRIFAVSFGMGVVSGIVMAFQFGANW
PELSRIAGSVIGPLLSYEVLTAFFLEASFLGVMLFGWGRVSERLHFFATCMVAIGTLVSTFWILSSNSWLHTPRGYTMVN
GIVQPVSWLQIIFNPSFPYRLAHMALGSFITTCFVVGGVGAYYLRKGLHVDAGARMLRLSVAFAAIVLPIQILVGDQHGL
NTLEHQPLKVAAMEAHWHSEGHGAGVPLVVFALPNAEAERNDYEVAIPRLGSLILTHSADGDITPLTSVPPDQRPPVAPV
FFAFRIMVGLGMTMLLLAWISAIAWWRGRLHARPLILAWNLMLPAGLMALVAGWFVTEIGRQPWVVYGLLRTADAVGPQS
TATVAVSLLVYLLGYAFVFGFGIFYLTKLVRAGPQPSRDGPDVAGGDHTPARPLSAAQTSLEQENTPWN
>Mature_469_residues
MEALLLSRIQFAFVISFHVLFPAFTIGLANLLGFLEWRWLRTHDETWKRLYFFWLRIFAVSFGMGVVSGIVMAFQFGANW
PELSRIAGSVIGPLLSYEVLTAFFLEASFLGVMLFGWGRVSERLHFFATCMVAIGTLVSTFWILSSNSWLHTPRGYTMVN
GIVQPVSWLQIIFNPSFPYRLAHMALGSFITTCFVVGGVGAYYLRKGLHVDAGARMLRLSVAFAAIVLPIQILVGDQHGL
NTLEHQPLKVAAMEAHWHSEGHGAGVPLVVFALPNAEAERNDYEVAIPRLGSLILTHSADGDITPLTSVPPDQRPPVAPV
FFAFRIMVGLGMTMLLLAWISAIAWWRGRLHARPLILAWNLMLPAGLMALVAGWFVTEIGRQPWVVYGLLRTADAVGPQS
TATVAVSLLVYLLGYAFVFGFGIFYLTKLVRAGPQPSRDGPDVAGGDHTPARPLSAAQTSLEQENTPWN

Specific function: Cytochrome Oxidase Subunit. [C]

COG id: COG1271

COG function: function code C; Cytochrome bd-type quinol oxidase, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome ubiquinol oxidase subunit 1 family [H]

Homologues:

Organism=Escherichia coli, GI1787212, Length=501, Percent_Identity=27.9441117764471, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87081779, Length=311, Percent_Identity=31.1897106109325, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002585 [H]

Pfam domain/function: PF01654 Bac_Ubq_Cox [H]

EC number: 1.10.3.-

Molecular weight: Translated: 51740; Mature: 51740

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on diphenols and related substances as donors; With oxygen as acceptor [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969509; 9384377 [H]