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The map label for this gene is glmU [H]

Identifier: 21244369

GI number: 21244369

Start: 4323867

End: 4325240

Strand: Reverse

Name: glmU [H]

Synonym: XAC3644

Alternate gene names: 21244369

Gene position: 4325240-4323867 (Counterclockwise)

Preceding gene: 21244371

Following gene: 21244362

Centisome position: 83.57

GC content: 65.57

Gene sequence:

>1374_bases
TTGATGACCCTGCCCCTGCACGTTTTGATCCTGGCCGCGGGCGAAGGCAAGCGCATGCGCTCCTCGCTGCCCAAGGTGCT
GCAGCCGCTGGCGGGCCAGCCGATGCTGGCGCATGTGATCGCCACTGCGCGGCAGCTACAGCCGGCGGCGATCCATATCG
TATACGGGCATGGCGGCGATCAGGTGCAGGCAGCCTTCGCCGATCAAGGCGATCTGCAGTGGGCCGAACAGCGCGAGCAG
TTGGGCACCGGACATGCCGTGCAGCAGGCAATGCCCGCGATTCCCGATGCGGCAACCGTGCTGGTGTTGTATGGCGATGT
GCCGTTGATCCGCAGCGAGAGCCTGCTGCAGCTGCTGCATGCGCCGGGCCGCATGGCGGTGCTGGTCGCCGAACTGGCCA
ATCCCACCGGCTATGGACGCATCCTGCGCGATGCGGAGGGCAAGGTGGCCGCCATCGTCGAGCAGAAGGATGCCAATGAC
GAGCAGCGCCGCATTCGCACCATCAATACCGGCATCCTCACCGCTGAATCCACCGCACTGCGCCGTTGGCTGGCTGGCTT
GTCCAACGACAATGCGCAAGCCGAGTTCTATCTCACCGACGTGTTCGCCAGCGCCGCTGCCGATTTCACGCCGGCCGACA
TGGTGCACGTGGCCGACCCGCAGGACGTGGAGGGTGCCAACGACCCGTGGCAACTCGCCCAGCTTGAGCGTGCCTGGCAG
CTGCGCGCCGCGCGCACGCTTTGCCTGCAGGGCGTGCGCATGGCCGACCCAGCGCGTGTGGAGCAGCGTGGCAGCGTGCA
GGTGGGCCGCGATGTGCAGCTGGATATCGATGTGATCCTGGAAGGCAATGTGACCCTGGGCGATGACGTGGTGATCGGCC
CGTTCGTGCGCTTGCGCGACGTCACGCTCGGTGCCGGCACCCAGGTGCGTGCGCACAGCGATCTGGAAGGCGTGATCACC
GAGGGCGCGGTGCAGATCGGCCCATTCGCGCGCCTGCGCCCCGGCACCGTGCTGGCCGATGGCGTGCATATCGGCAATTT
CGTGGAAACCAAAAAGGTCACCATGGGCGTCGGCAGCAAGGCCAACCATCTGACCTATCTGGGCGATGCGGTGATCGGCA
GCAAGGTCAACATCGGTGCCGGCACCATCACCTGCAACTACGACGGGGTGAACAAGTCACAGACCACCATCGGCGATGGC
GCCTTTATCGGCTCCAATAGCGCATTGGTGGCACCGATCCAGATTGGCGCCAATTCCACCATCGGTGCCGGCTCGGTGAT
CACGAGCGATGCGCCTGCGGGTCAGCTCAGTGTGACGCGTGCGCGGCAGACCGTGGTCGAAGGCTGGAAGCGGCCGACCA
AGAAATCGCCGTAG

Upstream 100 bases:

>100_bases
CGCGGCGCAAACGCTGTTAGCGCGGGCGAACGCTGCATTCGGGCAACGACGCGACGGGGCGCAGCGACTAGAATTTGGAC
ATCTCCATGCCTGGAATGTC

Downstream 100 bases:

>100_bases
CGCTGCGACTGTTCTCTGCGCGGTGGCCGTCTGCGCCGTGCGTGCGCATCGCAGCCAGCGGCAGGAATACGCAGAGCGTG
TTGCCTGAGTAATGCGGTGT

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MMTLPLHVLILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGGDQVQAAFADQGDLQWAEQREQ
LGTGHAVQQAMPAIPDAATVLVLYGDVPLIRSESLLQLLHAPGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDAND
EQRRIRTINTGILTAESTALRRWLAGLSNDNAQAEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQ
LRAARTLCLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGNVTLGDDVVIGPFVRLRDVTLGAGTQVRAHSDLEGVIT
EGAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVGSKANHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDG
AFIGSNSALVAPIQIGANSTIGAGSVITSDAPAGQLSVTRARQTVVEGWKRPTKKSP

Sequences:

>Translated_457_residues
MMTLPLHVLILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGGDQVQAAFADQGDLQWAEQREQ
LGTGHAVQQAMPAIPDAATVLVLYGDVPLIRSESLLQLLHAPGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDAND
EQRRIRTINTGILTAESTALRRWLAGLSNDNAQAEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQ
LRAARTLCLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGNVTLGDDVVIGPFVRLRDVTLGAGTQVRAHSDLEGVIT
EGAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVGSKANHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDG
AFIGSNSALVAPIQIGANSTIGAGSVITSDAPAGQLSVTRARQTVVEGWKRPTKKSP
>Mature_457_residues
MMTLPLHVLILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGGDQVQAAFADQGDLQWAEQREQ
LGTGHAVQQAMPAIPDAATVLVLYGDVPLIRSESLLQLLHAPGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDAND
EQRRIRTINTGILTAESTALRRWLAGLSNDNAQAEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQ
LRAARTLCLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGNVTLGDDVVIGPFVRLRDVTLGAGTQVRAHSDLEGVIT
EGAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVGSKANHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDG
AFIGSNSALVAPIQIGANSTIGAGSVITSDAPAGQLSVTRARQTVVEGWKRPTKKSP

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=458, Percent_Identity=51.0917030567686, Blast_Score=453, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48378; Mature: 48378

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTLPLHVLILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGGD
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCC
QVQAAFADQGDLQWAEQREQLGTGHAVQQAMPAIPDAATVLVLYGDVPLIRSESLLQLLH
EEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHH
APGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDANDEQRRIRTINTGILTAESTAL
CCCCEEEEEEECCCCCCCCHHEECCCCCEEEEEECCCCCHHHHHEEEECCCEEEECHHHH
RRWLAGLSNDNAQAEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQ
HHHHHCCCCCCCCEEEEEEEHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
LRAARTLCLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGNVTLGDDVVIGPFVRLRD
HHHHHHHHHCCCCCCCCHHHHCCCCEEECCEEEEEEEEEEECCEEECCCEEECCCEEEEE
VTLGAGTQVRAHSDLEGVITEGAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVGSK
EEECCCCEEEECCCCHHHHHCCCEEECCCCCCCCCCEEECCEEECCEEECEEEEECCCCC
ANHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDGAFIGSNSALVAPIQIGANST
CCCEEEECCHHCCCEEECCCEEEEEECCCCCCCCCCCCCCEEECCCCEEEEEEEECCCCC
IGAGSVITSDAPAGQLSVTRARQTVVEGWKRPTKKSP
CCCCCEEECCCCCCCEEHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MMTLPLHVLILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGGD
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCC
QVQAAFADQGDLQWAEQREQLGTGHAVQQAMPAIPDAATVLVLYGDVPLIRSESLLQLLH
EEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHH
APGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDANDEQRRIRTINTGILTAESTAL
CCCCEEEEEEECCCCCCCCHHEECCCCCEEEEEECCCCCHHHHHEEEECCCEEEECHHHH
RRWLAGLSNDNAQAEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQ
HHHHHCCCCCCCCEEEEEEEHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
LRAARTLCLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGNVTLGDDVVIGPFVRLRD
HHHHHHHHHCCCCCCCCHHHHCCCCEEECCEEEEEEEEEEECCEEECCCEEECCCEEEEE
VTLGAGTQVRAHSDLEGVITEGAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVGSK
EEECCCCEEEECCCCHHHHHCCCEEECCCCCCCCCCEEECCEEECCEEECEEEEECCCCC
ANHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDGAFIGSNSALVAPIQIGANST
CCCEEEECCHHCCCEEECCCEEEEEECCCCCCCCCCCCCCEEECCCCEEEEEEEECCCCC
IGAGSVITSDAPAGQLSVTRARQTVVEGWKRPTKKSP
CCCCCEEECCCCCCCEEHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]