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The map label for this gene is glmS

Identifier: 21244362

GI number: 21244362

Start: 4313701

End: 4315530

Strand: Reverse

Name: glmS

Synonym: XAC3637

Alternate gene names: 21244362

Gene position: 4315530-4313701 (Counterclockwise)

Preceding gene: 21244369

Following gene: 21244361

Centisome position: 83.38

GC content: 65.03

Gene sequence:

>1830_bases
ATGTGCGGCATTGTCGGAGCGATCGCCGGGCGCGATGTGGTCCCGGTCCTGATCGAGGGACTCAAGCGCCTGGAATACCG
CGGCTACGATTCCTCCGGCATTGCAGTGCTCGACGGCGCGCAGGTGCGCCGGGTGCGTCGCACCGGGCGGGTGGCCGAGA
TGGCGCAGGCCGCGCAGGCCGAACAGCTCGGCGCCACCCTGGGCATCGGCCATACGCGCTGGGCCACCCATGGCGGGGTG
ACCGAGGCCAACGCGCACCCGCACATCAGCGCCGGCGTGGCGCTGGTGCATAACGGCATCATCGAAAACCACGAAGCGCA
GCGCGAAAAACTGCGCGCGCTCGGCTACACCTTCGAGTCGCAGACCGACACCGAGGTCATCGCGCATCTGATCCATCACC
ATCTGGGCAGCGCCGGCGACCTGCTCACCGCGCTGCAGCACACCGTCAAGGAACTGACCGGTGCCTATGCGCTGGCGGTG
GTGAGCCAGGCCGAACCGGAACGCTTCGTCTGCGCGCGCATGGGCTGCCCGTTGCTGATCGGGGTAGGCGAGGGCGAGAA
CTTCGTCGCCTCCGATGTCTCGGCGATCGTGCAGGCCACACGCCAGGTGATCTTCCTCGAAGAAGGCGATACCGCCGAAC
TGCGCCGCGATGGCGTGCGCATCTTCGACGGTAACGATGCGCCGGTGGAGCGCCCGCTGCACCTGTCGGACGTGTCGCTG
GCCTCGCTGGAACTGGGCCCGTTCCGCCATTTCATGCAGAAGGAAATCCACGAGCAGCCGCGCGCCTTGGCCGACACCAT
CGAGGCGGCGATCGATGCCAAGGGTTTCCCTGCATCGCTGTTCGGCGCCAACGCAGAAGCGGTGCTGCGCGACATCGAAG
GCGTGCAGATCCTGGCCTGCGGTACCAGCTACTACGCCGGCATGACCGCGCGTTACTGGATCGAAGCCATTGCCGGGCTG
CCATGCAGTGTGGAGATCGCCAGCGAATACCGCTACCGCGCCGCCTATGCCAACCCGAAGCATCTGATCGTGACCATCTC
CCAGTCCGGCGAAACGCTGGACACGATGGAAGCGCTGAAATACGCCAAATCGCTTGGGCATCTGCACACGCTGTCGATCT
GCAACGTGCCGGAAAGTGCGATCCCGCGCGCCAGCGAACTGGTCTGTTATACACGTGCCGGCGCCGAGATCGGCGTGGCC
TCGACCAAGGCCTTTACCACCCAGCTGGCGGTGTTGTTCCAGCTCACCATGGTGCTGGGAACGTTGCAGGGCCGCATCAG
TGACGCCGAAGAAGCCGAGTATCTGGAGCAGCTGCGCTTTTTGCCCGGCAGCGTGCAGCATGCGTTGAATCTGGAACCGC
AGATCATGGCCTGGGCCGAACGATTTTCGCCCAAGGAGAATGCTTTGTTCCTCGGTCGCGGCCTGCATTACCCGATTGCA
TTGGAGGGCGCGCTCAAGCTCAAGGAAATCTCCTATATCCACGCCGAAGCGTACCCGGCCGGCGAGTTGAAGCACGGCCC
GCTGGCGCTGGTGGACGCGGCGATGCCGGTGGTGGTGATCGCACCGAACGACCGCCTGCTGGAGAAGGTCAAGTCCAACA
TGCAGGAAGTGCGCGCACGCGGCGGCGAGCTGTTCGTGTTCGCCGACCAGGACAGCCACTTCAGCGACTCCGAAGGCGTG
CATGTCATCCGCACCCCACGCCATGCCGGCGTGCTGTCGCCGGTGATCCACACCATCCCGGTGCAATTGCTGGCCTACCA
CACCGCCCTGGCGCGCGGCACCGATGTGGACAAGCCGCGCAATCTGGCCAAGTCGGTGACGGTGGAATAA

Upstream 100 bases:

>100_bases
TCCGCGGACACTGGTGGCGGACACGCTGTCCGGGCACGGTCATGCAGCGGACAAGAGCGGACACGCTAAAATGTGCGACT
TCTTTTGCGAGAGCTGTCTT

Downstream 100 bases:

>100_bases
GCGCTGACGCGGTGGCGGCTGCGCGCACTGCCAGCTGCGTGCAGTCAGTGCATGGTCGGCTCTGTCGCTGTCATGTTCCC
GGATGGCGATTGCTTGCGAC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQAEQLGATLGIGHTRWATHGGV
TEANAHPHISAGVALVHNGIIENHEAQREKLRALGYTFESQTDTEVIAHLIHHHLGSAGDLLTALQHTVKELTGAYALAV
VSQAEPERFVCARMGCPLLIGVGEGENFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNDAPVERPLHLSDVSL
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPASLFGANAEAVLRDIEGVQILACGTSYYAGMTARYWIEAIAGL
PCSVEIASEYRYRAAYANPKHLIVTISQSGETLDTMEALKYAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVA
STKAFTTQLAVLFQLTMVLGTLQGRISDAEEAEYLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAAMPVVVIAPNDRLLEKVKSNMQEVRARGGELFVFADQDSHFSDSEGV
HVIRTPRHAGVLSPVIHTIPVQLLAYHTALARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQAEQLGATLGIGHTRWATHGGV
TEANAHPHISAGVALVHNGIIENHEAQREKLRALGYTFESQTDTEVIAHLIHHHLGSAGDLLTALQHTVKELTGAYALAV
VSQAEPERFVCARMGCPLLIGVGEGENFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNDAPVERPLHLSDVSL
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPASLFGANAEAVLRDIEGVQILACGTSYYAGMTARYWIEAIAGL
PCSVEIASEYRYRAAYANPKHLIVTISQSGETLDTMEALKYAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVA
STKAFTTQLAVLFQLTMVLGTLQGRISDAEEAEYLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAAMPVVVIAPNDRLLEKVKSNMQEVRARGGELFVFADQDSHFSDSEGV
HVIRTPRHAGVLSPVIHTIPVQLLAYHTALARGTDVDKPRNLAKSVTVE
>Mature_609_residues
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQAEQLGATLGIGHTRWATHGGV
TEANAHPHISAGVALVHNGIIENHEAQREKLRALGYTFESQTDTEVIAHLIHHHLGSAGDLLTALQHTVKELTGAYALAV
VSQAEPERFVCARMGCPLLIGVGEGENFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNDAPVERPLHLSDVSL
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPASLFGANAEAVLRDIEGVQILACGTSYYAGMTARYWIEAIAGL
PCSVEIASEYRYRAAYANPKHLIVTISQSGETLDTMEALKYAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVA
STKAFTTQLAVLFQLTMVLGTLQGRISDAEEAEYLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAAMPVVVIAPNDRLLEKVKSNMQEVRARGGELFVFADQDSHFSDSEGV
HVIRTPRHAGVLSPVIHTIPVQLLAYHTALARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=35.5072463768116, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=35.3711790393013, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI29570798, Length=178, Percent_Identity=29.7752808988764, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=55.7377049180328, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=172, Percent_Identity=30.8139534883721, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=716, Percent_Identity=33.9385474860335, Blast_Score=357, Evalue=8e-99,
Organism=Caenorhabditis elegans, GI17532899, Length=723, Percent_Identity=33.195020746888, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17532897, Length=736, Percent_Identity=32.4728260869565, Blast_Score=332, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6322745, Length=441, Percent_Identity=38.5487528344671, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=27.6744186046512, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=38.3495145631068, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=35.2173913043478, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI28573187, Length=266, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_XANAC (Q8PGH9)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643944.1
- ProteinModelPortal:   Q8PGH9
- SMR:   Q8PGH9
- GeneID:   1157708
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3637
- NMPDR:   fig|190486.1.peg.3588
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- ProtClustDB:   PRK00331
- BioCyc:   XAXO190486:XAC3637-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 65876; Mature: 65876

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 604-604

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQA
CCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
EQLGATLGIGHTRWATHGGVTEANAHPHISAGVALVHNGIIENHEAQREKLRALGYTFES
HHHCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHHHCCCCCC
QTDTEVIAHLIHHHLGSAGDLLTALQHTVKELTGAYALAVVSQAEPERFVCARMGCPLLI
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEE
GVGEGENFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNDAPVERPLHLSDVSL
ECCCCCCHHHHHHHHHHHHHHEEEEEECCCHHHHHHCCEEEECCCCCCCCCCCCCCCCCH
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPASLFGANAEAVLRDIEGVQILAC
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHCCCCEEEEE
GTSYYAGMTARYWIEAIAGLPCSVEIASEYRYRAAYANPKHLIVTISQSGETLDTMEALK
CCHHHHCCHHHHHHHHHHCCCCEEEHHHHHHHHEECCCCCEEEEEEECCCCHHHHHHHHH
YAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVASTKAFTTQLAVLFQLTMVLG
HHHHHCCEEEEEECCCCHHHCCCCHHEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHH
TLQGRISDAEEAEYLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
HHHCCCCCHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCCEE
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAAMPVVVIAPNDRLLEKVKSNMQEVRAR
ECCCEEHHHHHEEEECCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGELFVFADQDSHFSDSEGVHVIRTPRHAGVLSPVIHTIPVQLLAYHTALARGTDVDKPR
CCEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQA
CCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
EQLGATLGIGHTRWATHGGVTEANAHPHISAGVALVHNGIIENHEAQREKLRALGYTFES
HHHCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHHHCCCCCC
QTDTEVIAHLIHHHLGSAGDLLTALQHTVKELTGAYALAVVSQAEPERFVCARMGCPLLI
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEE
GVGEGENFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNDAPVERPLHLSDVSL
ECCCCCCHHHHHHHHHHHHHHEEEEEECCCHHHHHHCCEEEECCCCCCCCCCCCCCCCCH
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPASLFGANAEAVLRDIEGVQILAC
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHCCCCEEEEE
GTSYYAGMTARYWIEAIAGLPCSVEIASEYRYRAAYANPKHLIVTISQSGETLDTMEALK
CCHHHHCCHHHHHHHHHHCCCCEEEHHHHHHHHEECCCCCEEEEEEECCCCHHHHHHHHH
YAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVASTKAFTTQLAVLFQLTMVLG
HHHHHCCEEEEEECCCCHHHCCCCHHEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHH
TLQGRISDAEEAEYLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
HHHCCCCCHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCCEE
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAAMPVVVIAPNDRLLEKVKSNMQEVRAR
ECCCEEHHHHHEEEECCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGELFVFADQDSHFSDSEGVHVIRTPRHAGVLSPVIHTIPVQLLAYHTALARGTDVDKPR
CCEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217