Click here to switch to the map view.

The map label for this gene is cysM [C]

Identifier: 21244353

GI number: 21244353

Start: 4302866

End: 4303987

Strand: Reverse

Name: cysM [C]

Synonym: XAC3628

Alternate gene names: 21244353

Gene position: 4303987-4302866 (Counterclockwise)

Preceding gene: 21244360

Following gene: 21244352

Centisome position: 83.16

GC content: 67.74

Gene sequence:

>1122_bases
TTGCAGCCAAGTCCTGCCATGTCGCAGCGCCAGTGGGTGGCCGCCGCCATCCAGAAGATCGAAGCCGATTTCAATCGGTC
GGCCGACACCCACCTGATTCCGATGGAACTGCCGGGCTATCCGGGCATCGACCTGTACTTCAAGGACGAGTCCAGCCACC
CGACCGGCAGCCTCAAGCACCGCCTGGCGCGCTCGCTATTCCTGTACGCGCTCACCAATGGCTGGCTGCGCGCCGGGCGC
CCGGTGATCGAGGCGTCCAGCGGCTCCACGGCCATTTCCGAAGCGTATTTCGCGCGCCTGCTCGGCGTGCCTTTCATCGC
GGTGATGCCGGCCTCGACCTCGCCGGAGAAGATCGCCGCGATCGAGTTCCAGGGCGGCCGCTGCCACCTGGTCGAGCGCG
CCTGCGATCTGGACAGCGCCTCGCACCAGCTCGCACGCGAGACCGGCGGGCACTTCATGGACCAGTTCACCTACGCCGAG
CGCGCCACCGACTGGCGCGCCAACAACAACATCGCCGAATCGATCTTCAAGCAACTGGCCGAAGAGCCGCACCCGATCCC
GGACTGGATCGTCTGCAGCCCCGGCACTGGCGGTACCAGCGCCACCCTGGGCCGCTACGTGCGCTATCGGCGCCATGCCA
CCCGCATCCTGTGCGCCGACCCGGAAGTGTCGGTGTTCTTCGACGGCTATTGCCGCGCAGTGGACGGCCAATGCCCCAAG
GAGCTGGCCATCACCGGCGGCTCGCGCATCGAAGGCATCGGCCGCCCGCGGGTGGAATCGAGCTTCATCGCCAGCTGCGT
GGATGTGATGATCAAGGTGCCCGATGCGCTGAGCCTGGCGGCGATGCGCCACGTCAGCGCCACGCTGGGCCGCCGCGTGG
GCGGCTCCACCGGCACCAACTTCGTCGGCGTGCTGCACGCCGCCCGGCGCATGCGCGACGAGGGCCGGCAGGGCTCCATC
GTCACCATCCTGTGCGATGCTGGCGAACGTTACGCGCACAGTTATTACGACCCGGCCTGGTACGAGGCGCGCGCGATCGA
TGTCAGCGACAGCGATGCCGCCATTGCGCTGGCCGTGAACGGCGGCGATTTGCCTGCCTTGCCTTGTGCGGCGCTGGAAT
GA

Upstream 100 bases:

>100_bases
GCAGTGACAGGTGCGGCGAGCATAGCATCGGCCCCAGCTGTCCGCCCGATGCGCTGGCTGCGTAGGCGGGCAGGCGACGG
CGGTAGAATTACCGCTACTT

Downstream 100 bases:

>100_bases
CCGCCATATCCGGGACGTGAGCATCAAGGCGCTGCGCTCACCGCCACGCCGGTGCGATCGGTGTCCGCAGTCGGCAGGTA
CGGGCGGGCACCGTGCCCCT

Product: cysteine synthase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MQPSPAMSQRQWVAAAIQKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALTNGWLRAGR
PVIEASSGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIEFQGGRCHLVERACDLDSASHQLARETGGHFMDQFTYAE
RATDWRANNNIAESIFKQLAEEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPK
ELAITGGSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLHAARRMRDEGRQGSI
VTILCDAGERYAHSYYDPAWYEARAIDVSDSDAAIALAVNGGDLPALPCAALE

Sequences:

>Translated_373_residues
MQPSPAMSQRQWVAAAIQKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALTNGWLRAGR
PVIEASSGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIEFQGGRCHLVERACDLDSASHQLARETGGHFMDQFTYAE
RATDWRANNNIAESIFKQLAEEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPK
ELAITGGSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLHAARRMRDEGRQGSI
VTILCDAGERYAHSYYDPAWYEARAIDVSDSDAAIALAVNGGDLPALPCAALE
>Mature_373_residues
MQPSPAMSQRQWVAAAIQKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALTNGWLRAGR
PVIEASSGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIEFQGGRCHLVERACDLDSASHQLARETGGHFMDQFTYAE
RATDWRANNNIAESIFKQLAEEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPK
ELAITGGSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLHAARRMRDEGRQGSI
VTILCDAGERYAHSYYDPAWYEARAIDVSDSDAAIALAVNGGDLPALPCAALE

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=306, Percent_Identity=27.4509803921569, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI295821200, Length=306, Percent_Identity=27.4509803921569, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4557415, Length=306, Percent_Identity=27.4509803921569, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=27.6094276094276, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71996324, Length=370, Percent_Identity=33.7837837837838, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17539800, Length=359, Percent_Identity=30.3621169916435, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17539640, Length=355, Percent_Identity=29.0140845070423, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17562970, Length=329, Percent_Identity=26.7477203647416, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=27.2425249169435, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321449, Length=344, Percent_Identity=28.1976744186047, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321594, Length=343, Percent_Identity=25.9475218658892, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24643623, Length=319, Percent_Identity=29.4670846394984, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI20129101, Length=319, Percent_Identity=29.4670846394984, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 40460; Mature: 40460

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSPAMSQRQWVAAAIQKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKH
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHH
RLARSLFLYALTNGWLRAGRPVIEASSGSTAISEAYFARLLGVPFIAVMPASTSPEKIAA
HHHHHHHHHHHHHCHHHCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEE
IEFQGGRCHLVERACDLDSASHQLARETGGHFMDQFTYAERATDWRANNNIAESIFKQLA
EEECCCEEEEEHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
EEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPK
HCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCEEEECCCCEEEEECCEEEECCCCCCH
ELAITGGSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTN
HHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCH
FVGVLHAARRMRDEGRQGSIVTILCDAGERYAHSYYDPAWYEARAIDVSDSDAAIALAVN
HHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCEEEEEEC
GGDLPALPCAALE
CCCCCCCCCCCCC
>Mature Secondary Structure
MQPSPAMSQRQWVAAAIQKIEADFNRSADTHLIPMELPGYPGIDLYFKDESSHPTGSLKH
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHH
RLARSLFLYALTNGWLRAGRPVIEASSGSTAISEAYFARLLGVPFIAVMPASTSPEKIAA
HHHHHHHHHHHHHCHHHCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEE
IEFQGGRCHLVERACDLDSASHQLARETGGHFMDQFTYAERATDWRANNNIAESIFKQLA
EEECCCEEEEEHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
EEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRAVDGQCPK
HCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCEEEECCCCEEEEECCEEEECCCCCCH
ELAITGGSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTN
HHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCH
FVGVLHAARRMRDEGRQGSIVTILCDAGERYAHSYYDPAWYEARAIDVSDSDAAIALAVN
HHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCCEEEEEECCCCCCEEEEEEC
GGDLPALPCAALE
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]