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The map label for this gene is prlC [H]

Identifier: 21244352

GI number: 21244352

Start: 4300642

End: 4302666

Strand: Reverse

Name: prlC [H]

Synonym: XAC3627

Alternate gene names: 21244352

Gene position: 4302666-4300642 (Counterclockwise)

Preceding gene: 21244353

Following gene: 21244351

Centisome position: 83.13

GC content: 64.94

Gene sequence:

>2025_bases
ATGACCAACCCGCTGCTCGATCTGTCCGGACTGCCGTCCTTCGATGCGATCCGCCCCGAACACGTGGGCCCGGCGATCGA
CCAATTGCTCGCCGAGGCCGAGGCGGCGGTGAAGGCAGCCGAGCAGGTCAGCCCGGTGCGCTGGGACAGCTTCGTCACGC
CGCTGGACGATGCCACCGAGCGGCTATGGCGTGCCTGGGGGCAGGTGGGGCATCTGCAGGCGGTGGTCAACACGCCCGAG
CTGCGCGAGGCCTACAACAGCAACCTGCCCAAGGTGAGCCGCTTCGGCAGCGCGCTGGCGCAGAACCTGGCGTTGTATGC
GCAATACAAGGCACTGGCACAATCGCCGGAAGCCGCACACTTCGATGAGGCGCGTCGCAAGGTGCTGGACAATGCGCTAC
GCGATTTCCGCTTGGGCGGTGCCGAACTCGATGATGCCGCCAAGGCGCGGTTCGCGCAGATCCAGGAAGAACTCTCGGCG
TTGGCAGCCAGGTTTTCGCAGAACGTGCTCGACGCCACCGATGCGTGGTCGTACCTGACCGAAGACCAAACCCAGCTGTC
GGGACTGCCGGCCGAAGTGATTGCCGCCGCACGCGCGGCCGCCGAAAAGGACGGCGTGCCGGGCTGGAAATTCACCTTGC
AGATGCCGTGCTATCTGCCGGTGCAGAGCGATGCCGACAGCCGCGACCTGCGCGCGCGGCTGTATCGCGCCAATGCCGAG
CGCGCGTCCGAATTCGGCGATGCCACGCTGGACAACAGCGCCAACATCGATCGCATCCTGGCCCTGCGCGCCGAGTTGGC
ACAGCTGCTCGGCTTTGCCAGTTACGCCGACTATTCGGTTGCTACCAAAATGGCGCAGAGCCCCGACGAGGTGATGGGCT
TCCTGCGCGATCTGGCTGCGCGCGCCAAGCCGCATGCACAGCGCGACCGCGCCGAACTGGAAGCCTTTGCGCGCGACGAG
TTGGGTCTGGATGAACTGCAGGCCTGGGACCTGGCCTACGCTTCGGAAAAACTCAAGCAGGCGCGTTACAGCTTTTCCGA
GCAGGAGGTGAAGCAGTACTTCACCGAGCCGAAGGTGCTGGCCGGCCTGTTCGATGTGATCCACAGCCTGTATGGGCTCA
CCGTCAAACCCGACAGCGCACCGGTCTGGCACCCGGATGTGCGGTTTTACCGGTTGGAAGATGCGCACGGCGCCCTGGTC
GGCCAGTTCTATCTGGACCTGTACGCGCGTGAAGGCAAACGTGGCGGCGCGTGGATGGACGATTGCCGCAACCGCCGCAA
CACCGCCAACGGCGTGCAGACGCCGCTGGTGTATCTGGTGTGCAACTTCGGGCGCGGCAGCGGCGATGCGCCGGCCACCT
TTCGCCACGGCGAAGTCACCACGCTGTTCCATGAAATGGGCCACGGCCTGCATCAGTTGCTCACGCGCGTTGGCGAGCTG
GGCGTGGCCGGCATCAACGGCGTGGAATGGGACGCGGTTGAGTTGCCCAGCCAGTTCATGGAAAACTTCTGCTGGGAGTG
GGCGCGCGTGCAGGCGATGACCGCGCACGTGCAGACCGGCGAGCCGTTGCCGCGTAACCTGTTCGATCGCCTGCTGGCGG
CGCGTAATTTCCAGAGCGGCATGTTCACCGTGCGTCAGCTGGAATTCGCCTTATTCGACATGCAGCTGCACGGCAGCTAC
GACCCGGCCCAGGACAGCGTGCTGCAATTGATCGAGCGCGTGCGCGACGAAGTGGCGGTCAATCGGCCGCCGGCATGGAA
TCGCTTTCCGCATCAGTTCAGCCATATTTTTGTCGGCGGCTATGCGGCCGGCTATTACAGCTATAAATGGGCCGAAGTGC
TCAGCGCCGATGCCTATGCCGCATTCGAAGAAGCGCCAGATCAACTGGAGCAGACCGGCGCACGGTTCCGCGCCGAGGTG
CTTGCGCGTGGCGGCAGTCGTCCGGCGGCAGAGAACTTCCGCGCCTTCCGCGGTCGGGCCCCGACCATCGATGCGCTGCT
ACGGCATAACGGCATGGCGGGCTGA

Upstream 100 bases:

>100_bases
TGGCGCCGTGCTCAGCCTGCTGGCGGTTGTGCGCCACGGTTTGCCTGCCACGTTTGCCGATCTTTGAATCTACTTATCCA
GTCCATTGCCGGAGCGCTCC

Downstream 100 bases:

>100_bases
GAGGCCTGTACGGCCAATTGGCATCTGCATTGCATTGGTGAACGGTGCAGTCCACGCAAGCGTTATGCGAAATTTATGCT
TCATTCCTACTGGATTGCAG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 674; Mature: 673

Protein sequence:

>674_residues
MTNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATERLWRAWGQVGHLQAVVNTPE
LREAYNSNLPKVSRFGSALAQNLALYAQYKALAQSPEAAHFDEARRKVLDNALRDFRLGGAELDDAAKARFAQIQEELSA
LAARFSQNVLDATDAWSYLTEDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAE
RASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAARAKPHAQRDRAELEAFARDE
LGLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVLAGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAHGALV
GQFYLDLYAREGKRGGAWMDDCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTRVGEL
GVAGINGVEWDAVELPSQFMENFCWEWARVQAMTAHVQTGEPLPRNLFDRLLAARNFQSGMFTVRQLEFALFDMQLHGSY
DPAQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFVGGYAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEV
LARGGSRPAAENFRAFRGRAPTIDALLRHNGMAG

Sequences:

>Translated_674_residues
MTNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATERLWRAWGQVGHLQAVVNTPE
LREAYNSNLPKVSRFGSALAQNLALYAQYKALAQSPEAAHFDEARRKVLDNALRDFRLGGAELDDAAKARFAQIQEELSA
LAARFSQNVLDATDAWSYLTEDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAE
RASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAARAKPHAQRDRAELEAFARDE
LGLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVLAGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAHGALV
GQFYLDLYAREGKRGGAWMDDCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTRVGEL
GVAGINGVEWDAVELPSQFMENFCWEWARVQAMTAHVQTGEPLPRNLFDRLLAARNFQSGMFTVRQLEFALFDMQLHGSY
DPAQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFVGGYAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEV
LARGGSRPAAENFRAFRGRAPTIDALLRHNGMAG
>Mature_673_residues
TNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATERLWRAWGQVGHLQAVVNTPEL
REAYNSNLPKVSRFGSALAQNLALYAQYKALAQSPEAAHFDEARRKVLDNALRDFRLGGAELDDAAKARFAQIQEELSAL
AARFSQNVLDATDAWSYLTEDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAER
ASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAARAKPHAQRDRAELEAFARDEL
GLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVLAGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAHGALVG
QFYLDLYAREGKRGGAWMDDCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTRVGELG
VAGINGVEWDAVELPSQFMENFCWEWARVQAMTAHVQTGEPLPRNLFDRLLAARNFQSGMFTVRQLEFALFDMQLHGSYD
PAQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFVGGYAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEVL
ARGGSRPAAENFRAFRGRAPTIDALLRHNGMAG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=612, Percent_Identity=31.3725490196078, Blast_Score=273, Evalue=5e-73,
Organism=Homo sapiens, GI14149738, Length=668, Percent_Identity=27.2455089820359, Blast_Score=244, Evalue=3e-64,
Organism=Homo sapiens, GI156105687, Length=670, Percent_Identity=24.6268656716418, Blast_Score=168, Evalue=2e-41,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=48.9705882352941, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=686, Percent_Identity=31.1953352769679, Blast_Score=270, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71999758, Length=560, Percent_Identity=24.4642857142857, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32565901, Length=589, Percent_Identity=23.4295415959253, Blast_Score=118, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319793, Length=686, Percent_Identity=27.8425655976676, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6322715, Length=606, Percent_Identity=25.4125412541254, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI21356111, Length=680, Percent_Identity=30.1470588235294, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI20129717, Length=419, Percent_Identity=28.4009546539379, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 74994; Mature: 74863

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATE
CCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHH
RLWRAWGQVGHLQAVVNTPELREAYNSNLPKVSRFGSALAQNLALYAQYKALAQSPEAAH
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FDEARRKVLDNALRDFRLGGAELDDAAKARFAQIQEELSALAARFSQNVLDATDAWSYLT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAE
CCHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHH
RASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAA
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RAKPHAQRDRAELEAFARDELGLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVL
HCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHH
AGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAHGALVGQFYLDLYAREGKRGGAWMD
HHHHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHH
DCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTRVGEL
HHHCCCCCCCCHHCCEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHC
GVAGINGVEWDAVELPSQFMENFCWEWARVQAMTAHVQTGEPLPRNLFDRLLAARNFQSG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHH
MFTVRQLEFALFDMQLHGSYDPAQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFVGG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEECC
YAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEVLARGGSRPAAENFRAFRGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
PTIDALLRHNGMAG
CHHHHHHHCCCCCC
>Mature Secondary Structure 
TNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATE
CCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHH
RLWRAWGQVGHLQAVVNTPELREAYNSNLPKVSRFGSALAQNLALYAQYKALAQSPEAAH
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FDEARRKVLDNALRDFRLGGAELDDAAKARFAQIQEELSALAARFSQNVLDATDAWSYLT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDQTQLSGLPAEVIAAARAAAEKDGVPGWKFTLQMPCYLPVQSDADSRDLRARLYRANAE
CCHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHH
RASEFGDATLDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAA
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RAKPHAQRDRAELEAFARDELGLDELQAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVL
HCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHH
AGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAHGALVGQFYLDLYAREGKRGGAWMD
HHHHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHH
DCRNRRNTANGVQTPLVYLVCNFGRGSGDAPATFRHGEVTTLFHEMGHGLHQLLTRVGEL
HHHCCCCCCCCHHCCEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHC
GVAGINGVEWDAVELPSQFMENFCWEWARVQAMTAHVQTGEPLPRNLFDRLLAARNFQSG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHH
MFTVRQLEFALFDMQLHGSYDPAQDSVLQLIERVRDEVAVNRPPAWNRFPHQFSHIFVGG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEECC
YAAGYYSYKWAEVLSADAYAAFEEAPDQLEQTGARFRAEVLARGGSRPAAENFRAFRGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
PTIDALLRHNGMAG
CHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]