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The map label for this gene is dinP

Identifier: 21244347

GI number: 21244347

Start: 4296418

End: 4297497

Strand: Reverse

Name: dinP

Synonym: XAC3622

Alternate gene names: 21244347

Gene position: 4297497-4296418 (Counterclockwise)

Preceding gene: 21244348

Following gene: 21244346

Centisome position: 83.03

GC content: 64.91

Gene sequence:

>1080_bases
ATGCGCAAGATCGTGCACGTGGACATGGATGCGTTCTACGCGTCCGTGGAGCAGCGTGACGACCCTAGCCTGCGTGGCAA
GCCGGTGGTGGTGGCCTGGCGCGGTGCGCGTTCGGTGGTGTGCGCGGCCTCCTACGAAGCGCGGATCTTCGGCATTCGCT
CGGCAATGCCGGCCGTGCGTGCCGAACGCCTGTGCCCGGATGCGATCTTCGTGCCGCCGGATTTTACGCGCTACAAGGCG
GTGTCGCGGCAAGTGCGCGAAATTTTCCATCGTCATACCGACTTGGTGGAGCCGTTGTCGCTGGACGAGGCATATCTGGA
CGTCACGCACGCCAAAACCGGCATGCAGCTGGCCACCGAGGTCGCGCAGTTGATCCGCACGCAGATCCGCGAAGAAACCC
AGCTCACGGCATCGGCCGGCATCGCGCCGAACAAGTTCCTGGCCAAGATCGCGTCGGATTGGCGAAAGCCCGATGGCCAG
TTCGTGATCGCGCCCAGCCGCGTGGATGCATTTCTGCTGCCGCTCAAGGTCAATCGCATTCCCGGCGTGGGCAAGGTGAT
GGATGGCAAGTTGGCGGCGCTGGGCATCGTCACCGTGGCCGATCTGCGCCAGCGGCCATTGGAAGAACTGCAGGCGCATT
TCGGCAGTTTCGGTCAGAGTCTGTATCGCCGCGCGCGCGGCATCGACGAGCGCCCGGTCGAGCCGGATCAGGAAGTGCAA
TCGGTCTCCTCGGAAGACACCTTCAGCGAAGACCTGGCGCTTGATGCGTTGGCCCCGCACATCCTGCGCCTGGCCGAAAA
AACCTGGCTGGCCACGCGCCGCACCGAACGCATCGGCCGCACCGTCGTGCTGAAATTGAAGACCTCGAATTTTCGCATCC
TGACGCGCTCGTACACGCCCGAGCAGCCGCCTACCTCGCAGGAGGCGCTGGCGCAGATCGCCCTGGCATTGACCCGCCGC
GTGGAGCTGCCCGCGCAGACGCGCTATCGCCTGGTCGGTGTGGGCTTGGGCGGTTTCAGCGATGTCGAGAATGGCGCGGT
GCAGGGGCAGCTGTTCGGCCAGATGCCGCCGTTGGAGTGA

Upstream 100 bases:

>100_bases
TCGTGCTCGCTTTACGAATGCGCGGTGATGTCCCTCGACGCAAGATGTGAGACGGCGCTGGCTTATCATGGGCGCAGACC
TGCGACAGAGAATCCGCTTG

Downstream 100 bases:

>100_bases
GCGGTCCGTGCCGCATTGCGTGTCGCATGCGGCGATGGCTGCATCTGACGCAGGCGGCGAGCAATCCCCAGCGCTTCGCA
GTGACGCGCGCTGAATCTTG

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MRKIVHVDMDAFYASVEQRDDPSLRGKPVVVAWRGARSVVCAASYEARIFGIRSAMPAVRAERLCPDAIFVPPDFTRYKA
VSRQVREIFHRHTDLVEPLSLDEAYLDVTHAKTGMQLATEVAQLIRTQIREETQLTASAGIAPNKFLAKIASDWRKPDGQ
FVIAPSRVDAFLLPLKVNRIPGVGKVMDGKLAALGIVTVADLRQRPLEELQAHFGSFGQSLYRRARGIDERPVEPDQEVQ
SVSSEDTFSEDLALDALAPHILRLAEKTWLATRRTERIGRTVVLKLKTSNFRILTRSYTPEQPPTSQEALAQIALALTRR
VELPAQTRYRLVGVGLGGFSDVENGAVQGQLFGQMPPLE

Sequences:

>Translated_359_residues
MRKIVHVDMDAFYASVEQRDDPSLRGKPVVVAWRGARSVVCAASYEARIFGIRSAMPAVRAERLCPDAIFVPPDFTRYKA
VSRQVREIFHRHTDLVEPLSLDEAYLDVTHAKTGMQLATEVAQLIRTQIREETQLTASAGIAPNKFLAKIASDWRKPDGQ
FVIAPSRVDAFLLPLKVNRIPGVGKVMDGKLAALGIVTVADLRQRPLEELQAHFGSFGQSLYRRARGIDERPVEPDQEVQ
SVSSEDTFSEDLALDALAPHILRLAEKTWLATRRTERIGRTVVLKLKTSNFRILTRSYTPEQPPTSQEALAQIALALTRR
VELPAQTRYRLVGVGLGGFSDVENGAVQGQLFGQMPPLE
>Mature_359_residues
MRKIVHVDMDAFYASVEQRDDPSLRGKPVVVAWRGARSVVCAASYEARIFGIRSAMPAVRAERLCPDAIFVPPDFTRYKA
VSRQVREIFHRHTDLVEPLSLDEAYLDVTHAKTGMQLATEVAQLIRTQIREETQLTASAGIAPNKFLAKIASDWRKPDGQ
FVIAPSRVDAFLLPLKVNRIPGVGKVMDGKLAALGIVTVADLRQRPLEELQAHFGSFGQSLYRRARGIDERPVEPDQEVQ
SVSSEDTFSEDLALDALAPHILRLAEKTWLATRRTERIGRTVVLKLKTSNFRILTRSYTPEQPPTSQEALAQIALALTRR
VELPAQTRYRLVGVGLGGFSDVENGAVQGQLFGQMPPLE

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI84043967, Length=380, Percent_Identity=31.5789473684211, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI7706681, Length=381, Percent_Identity=31.496062992126, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI154350220, Length=357, Percent_Identity=29.4117647058824, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI7705344, Length=106, Percent_Identity=51.8867924528302, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI5729982, Length=331, Percent_Identity=29.3051359516616, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1786425, Length=253, Percent_Identity=52.5691699604743, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI1787432, Length=380, Percent_Identity=28.6842105263158, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193205700, Length=403, Percent_Identity=32.0099255583127, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17537959, Length=239, Percent_Identity=32.6359832635983, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193205702, Length=348, Percent_Identity=30.4597701149425, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI115534089, Length=345, Percent_Identity=26.9565217391304, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324921, Length=249, Percent_Identity=27.3092369477912, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19923006, Length=431, Percent_Identity=25.5220417633411, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21355641, Length=283, Percent_Identity=28.2685512367491, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24644984, Length=283, Percent_Identity=28.2685512367491, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24668444, Length=119, Percent_Identity=35.2941176470588, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_XANAC (Q8PGJ4)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643929.1
- ProteinModelPortal:   Q8PGJ4
- SMR:   Q8PGJ4
- GeneID:   1157693
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3622
- NMPDR:   fig|190486.1.peg.3573
- HOGENOM:   HBG734504
- OMA:   VICAASY
- ProtClustDB:   PRK02406
- BioCyc:   XAXO190486:XAC3622-MONOMER
- BRENDA:   2.7.7.7
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 39931; Mature: 39931

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 103-103

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIVHVDMDAFYASVEQRDDPSLRGKPVVVAWRGARSVVCAASYEARIFGIRSAMPAVR
CCCEEEECHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEHHHHHHHHH
AERLCPDAIFVPPDFTRYKAVSRQVREIFHRHTDLVEPLSLDEAYLDVTHAKTGMQLATE
HHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VAQLIRTQIREETQLTASAGIAPNKFLAKIASDWRKPDGQFVIAPSRVDAFLLPLKVNRI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEEECCC
PGVGKVMDGKLAALGIVTVADLRQRPLEELQAHFGSFGQSLYRRARGIDERPVEPDQEVQ
CCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
SVSSEDTFSEDLALDALAPHILRLAEKTWLATRRTERIGRTVVLKLKTSNFRILTRSYTP
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCC
EQPPTSQEALAQIALALTRRVELPAQTRYRLVGVGLGGFSDVENGAVQGQLFGQMPPLE
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCC
>Mature Secondary Structure
MRKIVHVDMDAFYASVEQRDDPSLRGKPVVVAWRGARSVVCAASYEARIFGIRSAMPAVR
CCCEEEECHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEHHHHHHHHH
AERLCPDAIFVPPDFTRYKAVSRQVREIFHRHTDLVEPLSLDEAYLDVTHAKTGMQLATE
HHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VAQLIRTQIREETQLTASAGIAPNKFLAKIASDWRKPDGQFVIAPSRVDAFLLPLKVNRI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEEECCC
PGVGKVMDGKLAALGIVTVADLRQRPLEELQAHFGSFGQSLYRRARGIDERPVEPDQEVQ
CCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
SVSSEDTFSEDLALDALAPHILRLAEKTWLATRRTERIGRTVVLKLKTSNFRILTRSYTP
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCC
EQPPTSQEALAQIALALTRRVELPAQTRYRLVGVGLGGFSDVENGAVQGQLFGQMPPLE
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217