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The map label for this gene is cysB [H]

Identifier: 21244328

GI number: 21244328

Start: 4274966

End: 4276336

Strand: Reverse

Name: cysB [H]

Synonym: XAC3603

Alternate gene names: 21244328

Gene position: 4276336-4274966 (Counterclockwise)

Preceding gene: 21244329

Following gene: 21244327

Centisome position: 82.63

GC content: 63.24

Gene sequence:

>1371_bases
ATGGCGATTCATTCCTCCGTACTCGAGCTGATTGGCAACACGCCGATCGTCAAGGCCCAGCGCCTGGACACCGGCGTCTG
CGAGCTGTTCCTCAAGCTGGAGGCGAATAATCCCGGTGGATCGATCAAGGACCGCATCGGTCTGTCGATGATCGAAGCGG
CCGAGCGGCGCGGCGATCTCAAGCCCGGCGCTACCCTGGTCGAGGGAACTGCCGGCAACACCGGCCTGGGCTTGGCCCTG
GTGGCGCAGCAGAAGGGCTACCAGTTGATCCTGGTGGTGCCGGACAAGATGAGTCGCGAGAAGATCTTCAATCTCAAGGC
CATGGGCGCCAACGTGGTGCTGACCCGCTCGGATGTAGCCAAGGGCCATCCCGAGTACTACCAGGACCTGGCTGCCAGGA
TCGCAGCCGAGACTCCTGGCGCCTACTTCATCAACCAGTTCGGCAACCCGGACAACCCGGCCGCGCACGAATTCGGCACC
GGCCCGGAAATCCTGGCGCAGATGGACGGCCAGCTGGACGCCATCGTGTTCGGCTGCGGCAGCTCCGGCACCATGACCGG
CCTGTCGCGCGCCTTCGCCAGCGCCTCGCCGCACACCGAACTGGTATTGGCCGACCCGGTCGGCTCGATCCTGACCCAGT
ACATCGAAGAAGGCACGGTCAGCGAAAAGTCCGGCAGCTGGTTGGTCGAAGGCATCGGCGAGGATTTCCTCCCGGATATC
TCCGACTTTTCGCGGGTCAAGAAGGCCTACTCCATCAGCGACGCGGAAAGCTTCCATACCGCGCGCGAGCTGCTGGCCAA
GGAGGGCATCCTCGGCGGCTCGTCCACCGGCACCCTGCTGGCCGCCGCATTGAAGTATTGCCGCGAACAAACCACGCCCA
AGCGCGTGCTGGTGTTCGTCTGCGATACCGGCAACAAGTACCTGTCGAAGATGTACAACGACTACTGGATGCTCGACAAC
GGCTTCCTGGAGCGCCCGCAACACGGCGATCTGCGCGACCTGATCCTGCGCCCGTACAACAAGCGCGACACCGTGGTGGT
GGGCTCGAAGGATCTGCTGACTACTGCCTACCAGCGCATGAAGTTGTACGACGTGTCGCAGTTGCCGGTGATCGACGACG
GCGAACTGGTGGGCATCGTGGACGAAAGCGACGTGTTGCTGCATGTGTATGGCGACGAAGCCCGCTTCCGCGACCCGATT
TCCACGGCCATGGTCAGCAAGCTGGATCGTCTGGACGTGGCTTCGCCGATCGAAGCGCTGCTGCCGGTGTTCGACCGTGG
CCAGGTCGCCATCGTCATGGACGGCACGCAATTCCTTGGCCTGATCACCCGCATCGACCTGCTCAACTACCTGCGCCGCC
GCGTGCAGTGA

Upstream 100 bases:

>100_bases
TCATCGGCCTGCGCAGTCGGTTCGATGCTGAATGAGCATTCCCCCGCGGTTCGTCGGATAATGACCGGTCTAGCCCGCGT
GGCGCAGCGACGATACTCCG

Downstream 100 bases:

>100_bases
TCGTGCAGTAATCCGGCACCGCCGCGCGCTCGGATGCGACGCGCGGCACGGGCCATTCAGACCTGCTTGTTACAATCGCC
CACTTTTTCGGGAACCTCCA

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MAIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAERRGDLKPGATLVEGTAGNTGLGLAL
VAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVAKGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGT
GPEILAQMDGQLDAIVFGCGSSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
SDFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFVCDTGNKYLSKMYNDYWMLDN
GFLERPQHGDLRDLILRPYNKRDTVVVGSKDLLTTAYQRMKLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPI
STAMVSKLDRLDVASPIEALLPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ

Sequences:

>Translated_456_residues
MAIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAERRGDLKPGATLVEGTAGNTGLGLAL
VAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVAKGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGT
GPEILAQMDGQLDAIVFGCGSSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
SDFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFVCDTGNKYLSKMYNDYWMLDN
GFLERPQHGDLRDLILRPYNKRDTVVVGSKDLLTTAYQRMKLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPI
STAMVSKLDRLDVASPIEALLPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ
>Mature_455_residues
AIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAERRGDLKPGATLVEGTAGNTGLGLALV
AQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVAKGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGTG
PEILAQMDGQLDAIVFGCGSSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDIS
DFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFVCDTGNKYLSKMYNDYWMLDNG
FLERPQHGDLRDLILRPYNKRDTVVVGSKDLLTTAYQRMKLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPIS
TAMVSKLDRLDVASPIEALLPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=472, Percent_Identity=35.8050847457627, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI295821200, Length=472, Percent_Identity=35.8050847457627, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI4557415, Length=472, Percent_Identity=35.8050847457627, Blast_Score=268, Evalue=7e-72,
Organism=Escherichia coli, GI2367138, Length=308, Percent_Identity=40.5844155844156, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=42.7631578947368, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=42.0731707317073, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=38.719512195122, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=37.012987012987, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=37.5415282392027, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=37.2549019607843, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI115535073, Length=345, Percent_Identity=36.5217391304348, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=34.9673202614379, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=33.4821428571429, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71996324, Length=343, Percent_Identity=27.4052478134111, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539800, Length=344, Percent_Identity=23.546511627907, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=503, Percent_Identity=33.2007952286282, Blast_Score=256, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6321449, Length=338, Percent_Identity=33.4319526627219, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24643623, Length=466, Percent_Identity=34.1201716738197, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI20129101, Length=466, Percent_Identity=34.1201716738197, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49679; Mature: 49548

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAERRGDL
CCCHHHHHHHHCCCCCEEHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
KPGATLVEGTAGNTGLGLALVAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVA
CCCCEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHEECCCEEEEEECHHC
KGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGTGPEILAQMDGQLDAIVFGCG
CCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEECC
SSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
CCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCH
SDFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
CDTGNKYLSKMYNDYWMLDNGFLERPQHGDLRDLILRPYNKRDTVVVGSKDLLTTAYQRM
ECCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPISTAMVSKLDRLDVASPIEAL
HHCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
LPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ
HHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEANNPGGSIKDRIGLSMIEAAERRGDL
CCHHHHHHHHCCCCCEEHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
KPGATLVEGTAGNTGLGLALVAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVA
CCCCEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHEECCCEEEEEECHHC
KGHPEYYQDLAARIAAETPGAYFINQFGNPDNPAAHEFGTGPEILAQMDGQLDAIVFGCG
CCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEECC
SSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
CCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCH
SDFSRVKKAYSISDAESFHTARELLAKEGILGGSSTGTLLAAALKYCREQTTPKRVLVFV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
CDTGNKYLSKMYNDYWMLDNGFLERPQHGDLRDLILRPYNKRDTVVVGSKDLLTTAYQRM
ECCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPISTAMVSKLDRLDVASPIEAL
HHCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
LPVFDRGQVAIVMDGTQFLGLITRIDLLNYLRRRVQ
HHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]