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The map label for this gene is metB [H]

Identifier: 21244327

GI number: 21244327

Start: 4273670

End: 4274866

Strand: Reverse

Name: metB [H]

Synonym: XAC3602

Alternate gene names: 21244327

Gene position: 4274866-4273670 (Counterclockwise)

Preceding gene: 21244328

Following gene: 21244326

Centisome position: 82.6

GC content: 64.49

Gene sequence:

>1197_bases
ATGTCCAATCGCACCACTCATAGCCATGACGGCGAGCGCGCGCTGTCGCTCGCAACGCTGGCGATCCATGGAGGGCAGTC
GCCAGATCCGAGCACCGGCGCGGTGATGCCGCCGATCTACGCGACGTCCACCTATGCGCAGTCCAGCCCCGGCGAGCATC
AGGGTTTCGAGTATTCGCGTACCCATAACCCCACGCGCTTCGCCTACGAGCGTTGCGTCGCCGCGCTGGAAGGAGGCACG
CGCGCATATGCGTTCGCCTCCGGCATGGCCGCCACCTCGACGGTGATGGAGTTGCTGGATGCCGGCAGCCACGTGGTGGC
GATGGACGACCTGTACGGCGGCACCTTTCGCTTGTTCGAGCGCGTGCGTCGCCGCACTGCCGGCCTGGATTTCAGCTTCG
TCGACCTGACCGACCCGGCTGCGTTCGAGGCGGCGATTCGCCCCGATACCAAGATGGTGTGGATCGAGACCCCGACCAAC
CCGATGCTCAAGCTGGTCGATATCGCTGCCATTGCCGAGATCGCGCGCAAGCGCGGCCTGCTGATCGTGGTCGACAACAC
CTTTGCTTCCCCGATGCTGCAGCGCCCGCTCAGCCTGGGTGCGGACATCGTCGTGCACTCGGCCACCAAGTATCTCAACG
GCCACTCGGACATGGTGGGCGGTATCGCGGTCGTTGGCGACAACGCCGAGCTCGCCGAGCAGATGGCGTTCCTGCAGAAC
TCCATCGGCGGCGTCCAGGGCCCGTTCGACAGCTTCCTCGCCTTGCGCGGCCTCAAGACCCTCCCGCTGCGCATGCGGGC
GCACTGCGAAAACGCACTGGCGCTTGCGCAATGGCTGGAAACCCACCCTGCGATCGAAAAGGTCATTTACCCCGGCCTTG
CCTCGCACCCGCAACATGCGCTCGCGAAGAGCCAGATGTCCGGCTTCGGCGGCATCGTCTCCATCGTCCTCAAGGGCGGC
TTCGACGCAGCCAAGCGTTTCTGCGAAAAGACCGAATTGTTCACCCTGGCCGAATCGCTCGGTGGTGTGGAAAGCCTGGT
GAATCATCCCGCCGTCATGACGCACGCCTCCATTCCGGTGGCCCGCCGCGACCAGCTCGGTATCAGCGATGCGCTGGTGC
GGTTGAGTGTGGGGATCGAGGATGTGGAGGATTTGCGTGGGGATTTGCAGGCTGCTTTGGCGGGAGATGAAGGGTAA

Upstream 100 bases:

>100_bases
ATCGTGCAGTAATCCGGCACCGCCGCGCGCTCGGATGCGACGCGCGGCACGGGCCATTCAGACCTGCTTGTTACAATCGC
CCACTTTTTCGGGAACCTCC

Downstream 100 bases:

>100_bases
TGCAGAGCCATGCAAATCTGATTTTCTTGTTTCGCCAATTGCTCGCGCGCGAACTTGCATTAAAGTATAAAACGACGGTT
CTCGGCGCGCTTTGGCTGGT

Product: cystathionine gamma-lyase-like protein

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGT
RAYAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFEAAIRPDTKMVWIETPTN
PMLKLVDIAAIAEIARKRGLLIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHALAKSQMSGFGGIVSIVLKGG
FDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARRDQLGISDALVRLSVGIEDVEDLRGDLQAALAGDEG

Sequences:

>Translated_398_residues
MSNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGT
RAYAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFEAAIRPDTKMVWIETPTN
PMLKLVDIAAIAEIARKRGLLIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHALAKSQMSGFGGIVSIVLKGG
FDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARRDQLGISDALVRLSVGIEDVEDLRGDLQAALAGDEG
>Mature_397_residues
SNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTR
AYAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFEAAIRPDTKMVWIETPTNP
MLKLVDIAAIAEIARKRGLLIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNS
IGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHALAKSQMSGFGGIVSIVLKGGF
DAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARRDQLGISDALVRLSVGIEDVEDLRGDLQAALAGDEG

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=365, Percent_Identity=55.3424657534247, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=50.1369863013699, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI25453487, Length=364, Percent_Identity=48.6263736263736, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI1790375, Length=374, Percent_Identity=45.4545454545455, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=29.873417721519, Blast_Score=168, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=367, Percent_Identity=52.5885558583106, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17560056, Length=367, Percent_Identity=50.9536784741144, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71980708, Length=379, Percent_Identity=39.0501319261214, Blast_Score=252, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=47.5452196382429, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6321254, Length=404, Percent_Identity=34.9009900990099, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323333, Length=430, Percent_Identity=34.8837209302326, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321170, Length=324, Percent_Identity=31.7901234567901, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321904, Length=398, Percent_Identity=30.9045226130653, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322970, Length=249, Percent_Identity=25.3012048192771, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322590, Length=251, Percent_Identity=27.0916334661355, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922554, Length=381, Percent_Identity=48.8188976377953, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42539; Mature: 42408

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSR
CCCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
THNPTRFAYERCVAALEGGTRAYAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFE
CCCCHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHH
RVRRRTAGLDFSFVDLTDPAAFEAAIRPDTKMVWIETPTNPMLKLVDIAAIAEIARKRGL
HHHHHHCCCCEEEEECCCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCE
LIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
EEEECCCCCCHHHHHHHHCCCHHEEEHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHH
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHA
HCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LAKSQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPV
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCC
ARRDQLGISDALVRLSVGIEDVEDLRGDLQAALAGDEG
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNRTTHSHDGERALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSR
CCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
THNPTRFAYERCVAALEGGTRAYAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFE
CCCCHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHH
RVRRRTAGLDFSFVDLTDPAAFEAAIRPDTKMVWIETPTNPMLKLVDIAAIAEIARKRGL
HHHHHHCCCCEEEEECCCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCE
LIVVDNTFASPMLQRPLSLGADIVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
EEEECCCCCCHHHHHHHHCCCHHEEEHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHH
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHA
HCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LAKSQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPV
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCC
ARRDQLGISDALVRLSVGIEDVEDLRGDLQAALAGDEG
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]