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The map label for this gene is cebR [H]

Identifier: 21244212

GI number: 21244212

Start: 4120821

End: 4121852

Strand: Direct

Name: cebR [H]

Synonym: XAC3487

Alternate gene names: 21244212

Gene position: 4120821-4121852 (Clockwise)

Preceding gene: 21244211

Following gene: 21244214

Centisome position: 79.62

GC content: 65.6

Gene sequence:

>1032_bases
ATGGCCAAACCTTCAGACCGCACAACGCTCACTGCCCGTCCGCAGATGGCCGACATCGCGCGCATGGCGGGCGTGTCCGA
ATCCACTGTGTCGCGTGCCCTGGCCGGCAGCCCGGTCGTGGCCGAACGCACCCGCGCCTACATCAAGCAGATTGCGGCCG
ATGCCGGCTACCAGGTCGACCCGGTGGCACGCAGCCTGCGCGCCAAACGCTCCAACACCGTGAGCGTGGCAGTGCCGATG
ATGCATGCGCTGGATCAGCCGCTCTCGGACCCGTTCCTGATGACCATGCTGGCGCTGCTGGCCGAAGAGCTCACCGGACG
CGGTTACAGCATGCTGCTCTCCAAACTGGACCGGCATCAGGATGGCTGGGTGGAACAACTTGCGCGCGGCAGCCGCTCCG
ACGGCGTCATCGTGCTGGGGCAAAGTTCCGAACACGCCGCGCTGGATGCAGCCGCACGCGACGGCCTGCCGATGGCGGTC
TGGGGCAGCCGCATCGATGGGCAGTCGTACATCAGCGTGGGCAGCGACAATTTCCAGGGCGGCGTACTCGCCACCGAACA
TCTCATCGCCAGCGGCCGCCAACGCATCGCCTTCTTGGGCGATGACCAATTACCAGAGGTGGCGCCGCGATTTGCCGGCT
ATCGCCACACGCTGGAACGGCACGGGCTGGAATTCGATACGCGGCTGCACGCGCGCAGCCATTTCGTCAGCGAAGATGCT
TACCGCCTCACCCGCGCGATGCTCAAGAAAACCGACCCACCCGATGGCTTGTTCGCCGCTTCCGATGTGATCGCCGTGGG
CGCAATCCGCGCCCTGGTCGAGGCCGGCCACCGCGTGCCGCAAGACATCTCGCTGGTGGGCTTCGACAATATCCCGCTGG
CTGCCTATAGCCAACCGCCGTTGACCACCGTGCAGCAGGATCTGGGCTTGGCGGCGCGGCTGTTGGTCGATCGGCTGCTG
GCGTTGATTGCAGGCGAGCAAGTGCAATCGGTTGAAATGCCGGTGAAGCTGGTGGTGCGCGAGTCGGCGTGA

Upstream 100 bases:

>100_bases
CGTGTGCGCCCCGCCCGCGTGCACAAGCAGCCGCCACCGTGCGGACGACCCGCCTCTAGTGCGAACTGATTACACTCTGG
CTTTTCCGCAGCGCGCTGCC

Downstream 100 bases:

>100_bases
GGCCGGGAATCGGGAATCGGGAATCGGGAATCGGGAATCGGGAATCGGGAATCGGGAATCGCAAGAGCGTGCTTGACCGC
GAGCCGAGCGCAACTGCGCG

Product: transcriptional regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MAKPSDRTTLTARPQMADIARMAGVSESTVSRALAGSPVVAERTRAYIKQIAADAGYQVDPVARSLRAKRSNTVSVAVPM
MHALDQPLSDPFLMTMLALLAEELTGRGYSMLLSKLDRHQDGWVEQLARGSRSDGVIVLGQSSEHAALDAAARDGLPMAV
WGSRIDGQSYISVGSDNFQGGVLATEHLIASGRQRIAFLGDDQLPEVAPRFAGYRHTLERHGLEFDTRLHARSHFVSEDA
YRLTRAMLKKTDPPDGLFAASDVIAVGAIRALVEAGHRVPQDISLVGFDNIPLAAYSQPPLTTVQQDLGLAARLLVDRLL
ALIAGEQVQSVEMPVKLVVRESA

Sequences:

>Translated_343_residues
MAKPSDRTTLTARPQMADIARMAGVSESTVSRALAGSPVVAERTRAYIKQIAADAGYQVDPVARSLRAKRSNTVSVAVPM
MHALDQPLSDPFLMTMLALLAEELTGRGYSMLLSKLDRHQDGWVEQLARGSRSDGVIVLGQSSEHAALDAAARDGLPMAV
WGSRIDGQSYISVGSDNFQGGVLATEHLIASGRQRIAFLGDDQLPEVAPRFAGYRHTLERHGLEFDTRLHARSHFVSEDA
YRLTRAMLKKTDPPDGLFAASDVIAVGAIRALVEAGHRVPQDISLVGFDNIPLAAYSQPPLTTVQQDLGLAARLLVDRLL
ALIAGEQVQSVEMPVKLVVRESA
>Mature_342_residues
AKPSDRTTLTARPQMADIARMAGVSESTVSRALAGSPVVAERTRAYIKQIAADAGYQVDPVARSLRAKRSNTVSVAVPMM
HALDQPLSDPFLMTMLALLAEELTGRGYSMLLSKLDRHQDGWVEQLARGSRSDGVIVLGQSSEHAALDAAARDGLPMAVW
GSRIDGQSYISVGSDNFQGGVLATEHLIASGRQRIAFLGDDQLPEVAPRFAGYRHTLERHGLEFDTRLHARSHFVSEDAY
RLTRAMLKKTDPPDGLFAASDVIAVGAIRALVEAGHRVPQDISLVGFDNIPLAAYSQPPLTTVQQDLGLAARLLVDRLLA
LIAGEQVQSVEMPVKLVVRESA

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=335, Percent_Identity=30.4477611940298, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790194, Length=334, Percent_Identity=28.4431137724551, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1789068, Length=317, Percent_Identity=29.6529968454259, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787948, Length=344, Percent_Identity=28.7790697674419, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786540, Length=337, Percent_Identity=30.2670623145401, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788474, Length=320, Percent_Identity=29.6875, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789456, Length=301, Percent_Identity=30.8970099667774, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789202, Length=295, Percent_Identity=28.135593220339, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787580, Length=316, Percent_Identity=25.3164556962025, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787906, Length=355, Percent_Identity=29.5774647887324, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790715, Length=318, Percent_Identity=25.4716981132075, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI48994940, Length=319, Percent_Identity=25.0783699059561, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786268, Length=302, Percent_Identity=23.841059602649, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790689, Length=335, Percent_Identity=23.8805970149254, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37008; Mature: 36877

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPSDRTTLTARPQMADIARMAGVSESTVSRALAGSPVVAERTRAYIKQIAADAGYQVD
CCCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
PVARSLRAKRSNTVSVAVPMMHALDQPLSDPFLMTMLALLAEELTGRGYSMLLSKLDRHQ
HHHHHHHHHCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
DGWVEQLARGSRSDGVIVLGQSSEHAALDAAARDGLPMAVWGSRIDGQSYISVGSDNFQG
CHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEECCCCCCCCCEEEECCCCCCC
GVLATEHLIASGRQRIAFLGDDQLPEVAPRFAGYRHTLERHGLEFDTRLHARSHFVSEDA
CHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
YRLTRAMLKKTDPPDGLFAASDVIAVGAIRALVEAGHRVPQDISLVGFDNIPLAAYSQPP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCC
LTTVQQDLGLAARLLVDRLLALIAGEQVQSVEMPVKLVVRESA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
AKPSDRTTLTARPQMADIARMAGVSESTVSRALAGSPVVAERTRAYIKQIAADAGYQVD
CCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
PVARSLRAKRSNTVSVAVPMMHALDQPLSDPFLMTMLALLAEELTGRGYSMLLSKLDRHQ
HHHHHHHHHCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
DGWVEQLARGSRSDGVIVLGQSSEHAALDAAARDGLPMAVWGSRIDGQSYISVGSDNFQG
CHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEECCCCCCCCCEEEECCCCCCC
GVLATEHLIASGRQRIAFLGDDQLPEVAPRFAGYRHTLERHGLEFDTRLHARSHFVSEDA
CHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
YRLTRAMLKKTDPPDGLFAASDVIAVGAIRALVEAGHRVPQDISLVGFDNIPLAAYSQPP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCC
LTTVQQDLGLAARLLVDRLLALIAGEQVQSVEMPVKLVVRESA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA