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The map label for this gene is hppA

Identifier: 21244165

GI number: 21244165

Start: 4050502

End: 4052529

Strand: Direct

Name: hppA

Synonym: XAC3440

Alternate gene names: 21244165

Gene position: 4050502-4052529 (Clockwise)

Preceding gene: 21244163

Following gene: 21244167

Centisome position: 78.26

GC content: 63.36

Gene sequence:

>2028_bases
ATGCTGGAACACTACGGGTTGTGGCTTGCGCTGGGTTGTGCGGTCTTGGCAATCGTCTATGGAATCGTGTCGGCGCGCTG
GGTGGTCGCGCAGCCGAGCGGCAATGCACGCATGCAGGAGATCGCCGCCGCGATCCAGGAAGGCGCGCGTGCCTATCTCA
ACCGGCAATACCTCACCATTTCGGTTGCTGGGGCGGTGCTGTTCGTGTTGGTCGGGCTGTTCCTGAGTTGGTACACCGCG
ATCGGGTTTGCACTGGGTGCGGTGTTGTCCGGGTTAGCCGGCTATATCGGCATGAACGTGTCGGTGCGCGCCAATGTCCG
CACCGCCGAAGCGGCGCGGCATGGCATTGGCAAGGCGATGGATGTGGCGTTCCGTGGCGGGGCGATCACCGGCATGCTGG
TGGTCGGCCTGGGGCTGCTCGGCGTGGCGGGCTACTTTGCTGTGCTGCAAGGCATGGGGCTGCCACTGGAGCAGAACCTG
CATGCATTGGTCGGGTTGGCCTTCGGGTCGTCGTTGATCTCGATCTTCGCGCGCCTGGGTGGCGGAATTTTCACCAAGGG
CGCAGATGTGGGCGCCGATCTTGTCGGCAAGGTCGAGGCCGGCATTCCCGAGGACGATCCACGCAACCCGGCGGTGATTG
CGGACAATGTCGGCGACAACGTGGGCGACTGCGCCGGCATGGCGGCCGATCTGTTCGAAACCTACGCAGTCACCGTGATC
GCCACCATGCTGCTCGGCAGTCTGACGTTGGCCGACACCGGTTCGCATGCCGTGCTCTATCCATTGGTGCTCGGCGGGGT
ATCGATCATCGCCTCGATCGTGGGCGCGGCCTTCGTCAAGGTCAAAGACGGCGGTTCGATCATGGGTGCGCTTTACAAAG
GCGTCATCGTATCGGGCGTACTGGCGGCGTTGGCTTACTGGCCCATCACCCAATCGCTGATGCGCGACAACATCCACGGC
GCCACGGCGTTGTACGCCTGCGCACTGATCGGCCTGGTGCTCACCGGCCTGATCGTGTGGATCACCGAGTACTACACCGG
CACGCAGTACACCCCGGTGCAGCATGTTGCATCGGCCAGCACCACCGGGCACGGCACCAACATCATCGCAGGGCTCGGTA
TTTCGATGAAATCTACCGCGCTGCCGGTGATCGCGGTCTGTGCAGCAATCTGGGGGGCGTTCCATTTCGGCGGCTTGTAC
GGCATTGCGATTGCAGCGACGGCCATGTTGTCGATGGCCGGCATGATCGTTGCCCTGGATGCGTATGGGCCGATTACCGA
TAACGCCGGCGGCATCGCCGAGATGGCCGAGCTCCCCCCTGAGGTCCGCAACATCACCGACCCGCTGGACGCGGTGGGCA
ACACCACCAAGGCAGTGACCAAGGGCTACGCGATCGGATCGGCGGCGCTGGCTGCGTTGGTGCTGTTTGCCGACTACACG
CACAACCTGCAGGCGGCCAATCCCGACCAGGTGTACGCCTTCGATCTATCCGACCACACGGTGATCATCGGGCTGCTGAT
TGGCGGGCTGATTCCGTATCTGTTCGGCGCGATGGCGATGGAAGCGGTCGGCCGCGCCGCGGGCGCCGTGGTGGAAGAAG
TGCGCCGCCAGTTCCGCGAGCTTCCCGGCATCATGGCCGGCACCGCCAAGCCGCAGTACGACCGCGCGGTCGATATGCTG
ACCCGTTCGGCGATTGGCGAAATGATCGTGCCTTCGCTGCTGCCGGTGGTGGTTCCGATCATCGTCGGGTTGCTACTGGG
GCCGCGTGCACTGGGTGGCTTGTTGATCGGCACGATTGTCACTGGCTTGTTCCTGGCGATTTCGATGACCACTGGCGGCG
GCGCCTGGGACAACGCCAAGAAATACATCGAGGACGGCCACTTCGGCGGGAAAGGCAGCGAGGCGCACAAGGCTGCGATT
ACCGGCGACACAGTCGGTGACCCATACAAAGACACCGCGGGGCCGGCGATCAACCCGTTGATCAAGATCATCAACATCGT
GGCCTTATTGCTCGTGCCACTGCTGTAA

Upstream 100 bases:

>100_bases
GCCCAGGCGGCCGTCGAGTCCGTATTCGTCAGTCCACTCGTTGTGTGCATCGCCCTTGGTTCGTCCCGACCGGACGACAT
CCATTCTCTTGGGAGGGGTC

Downstream 100 bases:

>100_bases
CGCTGCGACGACCGCAGGTCGCGTGACCTGCGGTCGCGACGACGGGAGCAGCCGACCAACCAAACCAGTCGCGGCAGGTC
AAGCGGAAAGTGGCAACGCT

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MLEHYGLWLALGCAVLAIVYGIVSARWVVAQPSGNARMQEIAAAIQEGARAYLNRQYLTISVAGAVLFVLVGLFLSWYTA
IGFALGAVLSGLAGYIGMNVSVRANVRTAEAARHGIGKAMDVAFRGGAITGMLVVGLGLLGVAGYFAVLQGMGLPLEQNL
HALVGLAFGSSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVI
ATMLLGSLTLADTGSHAVLYPLVLGGVSIIASIVGAAFVKVKDGGSIMGALYKGVIVSGVLAALAYWPITQSLMRDNIHG
ATALYACALIGLVLTGLIVWITEYYTGTQYTPVQHVASASTTGHGTNIIAGLGISMKSTALPVIAVCAAIWGAFHFGGLY
GIAIAATAMLSMAGMIVALDAYGPITDNAGGIAEMAELPPEVRNITDPLDAVGNTTKAVTKGYAIGSAALAALVLFADYT
HNLQAANPDQVYAFDLSDHTVIIGLLIGGLIPYLFGAMAMEAVGRAAGAVVEEVRRQFRELPGIMAGTAKPQYDRAVDML
TRSAIGEMIVPSLLPVVVPIIVGLLLGPRALGGLLIGTIVTGLFLAISMTTGGGAWDNAKKYIEDGHFGGKGSEAHKAAI
TGDTVGDPYKDTAGPAINPLIKIINIVALLLVPLL

Sequences:

>Translated_675_residues
MLEHYGLWLALGCAVLAIVYGIVSARWVVAQPSGNARMQEIAAAIQEGARAYLNRQYLTISVAGAVLFVLVGLFLSWYTA
IGFALGAVLSGLAGYIGMNVSVRANVRTAEAARHGIGKAMDVAFRGGAITGMLVVGLGLLGVAGYFAVLQGMGLPLEQNL
HALVGLAFGSSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVI
ATMLLGSLTLADTGSHAVLYPLVLGGVSIIASIVGAAFVKVKDGGSIMGALYKGVIVSGVLAALAYWPITQSLMRDNIHG
ATALYACALIGLVLTGLIVWITEYYTGTQYTPVQHVASASTTGHGTNIIAGLGISMKSTALPVIAVCAAIWGAFHFGGLY
GIAIAATAMLSMAGMIVALDAYGPITDNAGGIAEMAELPPEVRNITDPLDAVGNTTKAVTKGYAIGSAALAALVLFADYT
HNLQAANPDQVYAFDLSDHTVIIGLLIGGLIPYLFGAMAMEAVGRAAGAVVEEVRRQFRELPGIMAGTAKPQYDRAVDML
TRSAIGEMIVPSLLPVVVPIIVGLLLGPRALGGLLIGTIVTGLFLAISMTTGGGAWDNAKKYIEDGHFGGKGSEAHKAAI
TGDTVGDPYKDTAGPAINPLIKIINIVALLLVPLL
>Mature_675_residues
MLEHYGLWLALGCAVLAIVYGIVSARWVVAQPSGNARMQEIAAAIQEGARAYLNRQYLTISVAGAVLFVLVGLFLSWYTA
IGFALGAVLSGLAGYIGMNVSVRANVRTAEAARHGIGKAMDVAFRGGAITGMLVVGLGLLGVAGYFAVLQGMGLPLEQNL
HALVGLAFGSSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVI
ATMLLGSLTLADTGSHAVLYPLVLGGVSIIASIVGAAFVKVKDGGSIMGALYKGVIVSGVLAALAYWPITQSLMRDNIHG
ATALYACALIGLVLTGLIVWITEYYTGTQYTPVQHVASASTTGHGTNIIAGLGISMKSTALPVIAVCAAIWGAFHFGGLY
GIAIAATAMLSMAGMIVALDAYGPITDNAGGIAEMAELPPEVRNITDPLDAVGNTTKAVTKGYAIGSAALAALVLFADYT
HNLQAANPDQVYAFDLSDHTVIIGLLIGGLIPYLFGAMAMEAVGRAAGAVVEEVRRQFRELPGIMAGTAKPQYDRAVDML
TRSAIGEMIVPSLLPVVVPIIVGLLLGPRALGGLLIGTIVTGLFLAISMTTGGGAWDNAKKYIEDGHFGGKGSEAHKAAI
TGDTVGDPYKDTAGPAINPLIKIINIVALLLVPLL

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPA_XANAC (Q8PH20)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643747.1
- GeneID:   1157511
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3440
- NMPDR:   fig|190486.1.peg.3391
- HOGENOM:   HBG593668
- OMA:   AYLARQY
- ProtClustDB:   PRK00733
- BioCyc:   XAXO190486:XAC3440-MONOMER
- BRENDA:   3.6.1.1
- HAMAP:   MF_01129
- InterPro:   IPR004131
- PIRSF:   PIRSF001265
- TIGRFAMs:   TIGR01104

Pfam domain/function: PF03030 H_PPase

EC number: =3.6.1.1

Molecular weight: Translated: 69286; Mature: 69286

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x124a1c20)-; HASH(0x127aaaec)-; HASH(0x12194f18)-; HASH(0x1240adb4)-; HASH(0x124a4b54)-; HASH(0x12780a6c)-; HASH(0x12455044)-; HASH(0x11ffb084)-; HASH(0x1229a6a0)-; HASH(0x127aada4)-; HASH(0x124a4974)-; HASH(0x1264b88c)-; HASH(0x121d9844)-; HASH(0xce09820)-; HASH(0xe7c737c)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHYGLWLALGCAVLAIVYGIVSARWVVAQPSGNARMQEIAAAIQEGARAYLNRQYLTI
CCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEE
SVAGAVLFVLVGLFLSWYTAIGFALGAVLSGLAGYIGMNVSVRANVRTAEAARHGIGKAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCHHH
DVAFRGGAITGMLVVGLGLLGVAGYFAVLQGMGLPLEQNLHALVGLAFGSSLISIFARLG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVI
CCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
ATMLLGSLTLADTGSHAVLYPLVLGGVSIIASIVGAAFVKVKDGGSIMGALYKGVIVSGV
HHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHH
LAALAYWPITQSLMRDNIHGATALYACALIGLVLTGLIVWITEYYTGTQYTPVQHVASAS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
TTGHGTNIIAGLGISMKSTALPVIAVCAAIWGAFHFGGLYGIAIAATAMLSMAGMIVALD
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
AYGPITDNAGGIAEMAELPPEVRNITDPLDAVGNTTKAVTKGYAIGSAALAALVLFADYT
CCCCCCCCCCCHHHHHHCCHHHHHCCCHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHC
HNLQAANPDQVYAFDLSDHTVIIGLLIGGLIPYLFGAMAMEAVGRAAGAVVEEVRRQFRE
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGIMAGTAKPQYDRAVDMLTRSAIGEMIVPSLLPVVVPIIVGLLLGPRALGGLLIGTIV
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
TGLFLAISMTTGGGAWDNAKKYIEDGHFGGKGSEAHKAAITGDTVGDPYKDTAGPAINPL
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCHHHHH
IKIINIVALLLVPLL
HHHHHHHHHHHHHCH
>Mature Secondary Structure
MLEHYGLWLALGCAVLAIVYGIVSARWVVAQPSGNARMQEIAAAIQEGARAYLNRQYLTI
CCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEE
SVAGAVLFVLVGLFLSWYTAIGFALGAVLSGLAGYIGMNVSVRANVRTAEAARHGIGKAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCHHH
DVAFRGGAITGMLVVGLGLLGVAGYFAVLQGMGLPLEQNLHALVGLAFGSSLISIFARLG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVI
CCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
ATMLLGSLTLADTGSHAVLYPLVLGGVSIIASIVGAAFVKVKDGGSIMGALYKGVIVSGV
HHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHH
LAALAYWPITQSLMRDNIHGATALYACALIGLVLTGLIVWITEYYTGTQYTPVQHVASAS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
TTGHGTNIIAGLGISMKSTALPVIAVCAAIWGAFHFGGLYGIAIAATAMLSMAGMIVALD
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
AYGPITDNAGGIAEMAELPPEVRNITDPLDAVGNTTKAVTKGYAIGSAALAALVLFADYT
CCCCCCCCCCCHHHHHHCCHHHHHCCCHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHC
HNLQAANPDQVYAFDLSDHTVIIGLLIGGLIPYLFGAMAMEAVGRAAGAVVEEVRRQFRE
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGIMAGTAKPQYDRAVDMLTRSAIGEMIVPSLLPVVVPIIVGLLLGPRALGGLLIGTIV
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
TGLFLAISMTTGGGAWDNAKKYIEDGHFGGKGSEAHKAAITGDTVGDPYKDTAGPAINPL
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCHHHHH
IKIINIVALLLVPLL
HHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217