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The map label for this gene is cobT

Identifier: 21243912

GI number: 21243912

Start: 3749087

End: 3750133

Strand: Reverse

Name: cobT

Synonym: XAC3186

Alternate gene names: 21243912

Gene position: 3750133-3749087 (Counterclockwise)

Preceding gene: 21243913

Following gene: 21243911

Centisome position: 72.46

GC content: 69.53

Gene sequence:

>1047_bases
GTGAGGAGCGATTGGATCTTTGGTGCCTGCGCAGTGCCGGACGCGCGCATGCGCTCTGCCGCGCTTGCCCGGCAGGAACA
GCTGACCAAGCCGCCCGGCGCGCTGGGCCGGCTGGAACACCTGGCGGTGCAGCTGGCAGCCTGGCAACGCACCGAACGGC
CAGGAGCGCAGCGGGTCTGGATCGCGGTGTATGCCGCCGACCATGGCGTAGCGGCCGAAGGGGTCTCGGCATTTCCGCAG
GCGGTCACCGGCGAGATGGTGCGCAATTTCGCACGCGGTGGCGCCGCCATTGCGGTACTGGCGCGCGAGCTGGGCGCGCG
GCTGGAAGTGGTGAATCTGGGCGTGGTCAACGACCCCGGCGACCTGCCGCGGGTGCGGCGTGCCTGGATTGCGCCTAGCA
GCGCCAATATCTGCGAACAGCCGGCGATGACGGCCACCCAATTGCGCGATGCGATCGCCGCCGGTGCCGACAGCATCGCG
CAGGCCAGGAGCTGCGATACCCAGCTATTTGTCGGCGGCGAGATGGGCATCGGCAACACCACCTCTGCCGCGGCGCTGGC
TTGCGCCTTGCTGTCGCAGTTCCCGCAGGCGATGGCCGGTGCAGGCACCGGCCTGGATGCCGAAGGCATCGCGCACAAGG
CCACCGTGATCACGCGTGCGCTGGCCTTGCATGCCGATGCATCGAGCCCGCTGGAGCGTCTGCGTCGGCTGGGCGGATTC
GAAATCGCTGCCCTCGTCGGCGCCTATATCGCCGCCGCGCAGGCCGGCATCCCGGTGCTGGTGGATGGCTTCATCACCAC
GGCGGCGGCACTGGTGGCCACGCGCCTGAATCCCGGCGTGCGCGAGTGGTTGTTGTTCGGGCATCGCTCGCAGGAGCGTG
GGCATGCGGCACTGCTGCGTGCGCTGGATGCCGAGCCCTTGCTGCAACTGGATCTGCGTCTGGGCGAAGCCAGCGGCGCG
GCGGTGGCGATTCCGCTACTGCGCAGCGCCTGCGCCTTGCACAACGGCATGGCGACCTTCGCCGAAGCCGGGGTGTCGGA
CGCATGA

Upstream 100 bases:

>100_bases
TGGACGAGGCTGGCTGGCTGCATCAGGCATTGGCGCTACAGTGCGAGCGTGTGGTGTTGGTGGTGGCAGGGTTGCCGATG
GTGTTGAAAGGAGAGCGCGT

Downstream 100 bases:

>100_bases
GCGCGCAGATCACCTTGTTGCGGCATGGCGACACGGGGCAACGCAGTTATCGCGGCCAGCTCGACGACCCGCTCACCGAG
CTGGGCTGGCAGCAATTACG

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MRSDWIFGACAVPDARMRSAALARQEQLTKPPGALGRLEHLAVQLAAWQRTERPGAQRVWIAVYAADHGVAAEGVSAFPQ
AVTGEMVRNFARGGAAIAVLARELGARLEVVNLGVVNDPGDLPRVRRAWIAPSSANICEQPAMTATQLRDAIAAGADSIA
QARSCDTQLFVGGEMGIGNTTSAAALACALLSQFPQAMAGAGTGLDAEGIAHKATVITRALALHADASSPLERLRRLGGF
EIAALVGAYIAAAQAGIPVLVDGFITTAAALVATRLNPGVREWLLFGHRSQERGHAALLRALDAEPLLQLDLRLGEASGA
AVAIPLLRSACALHNGMATFAEAGVSDA

Sequences:

>Translated_348_residues
MRSDWIFGACAVPDARMRSAALARQEQLTKPPGALGRLEHLAVQLAAWQRTERPGAQRVWIAVYAADHGVAAEGVSAFPQ
AVTGEMVRNFARGGAAIAVLARELGARLEVVNLGVVNDPGDLPRVRRAWIAPSSANICEQPAMTATQLRDAIAAGADSIA
QARSCDTQLFVGGEMGIGNTTSAAALACALLSQFPQAMAGAGTGLDAEGIAHKATVITRALALHADASSPLERLRRLGGF
EIAALVGAYIAAAQAGIPVLVDGFITTAAALVATRLNPGVREWLLFGHRSQERGHAALLRALDAEPLLQLDLRLGEASGA
AVAIPLLRSACALHNGMATFAEAGVSDA
>Mature_348_residues
MRSDWIFGACAVPDARMRSAALARQEQLTKPPGALGRLEHLAVQLAAWQRTERPGAQRVWIAVYAADHGVAAEGVSAFPQ
AVTGEMVRNFARGGAAIAVLARELGARLEVVNLGVVNDPGDLPRVRRAWIAPSSANICEQPAMTATQLRDAIAAGADSIA
QARSCDTQLFVGGEMGIGNTTSAAALACALLSQFPQAMAGAGTGLDAEGIAHKATVITRALALHADASSPLERLRRLGGF
EIAALVGAYIAAAQAGIPVLVDGFITTAAALVATRLNPGVREWLLFGHRSQERGHAALLRALDAEPLLQLDLRLGEASGA
AVAIPLLRSACALHNGMATFAEAGVSDA

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=343, Percent_Identity=34.6938775510204, Blast_Score=193, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_XANAC (Q8PHR3)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643494.1
- ProteinModelPortal:   Q8PHR3
- SMR:   Q8PHR3
- GeneID:   1157257
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3186
- NMPDR:   fig|190486.1.peg.3138
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- ProtClustDB:   PRK00105
- BioCyc:   XAXO190486:XAC3186-MONOMER
- BRENDA:   2.4.2.21
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 36035; Mature: 36035

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: ACT_SITE 316-316

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDWIFGACAVPDARMRSAALARQEQLTKPPGALGRLEHLAVQLAAWQRTERPGAQRVW
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
IAVYAADHGVAAEGVSAFPQAVTGEMVRNFARGGAAIAVLARELGARLEVVNLGVVNDPG
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCC
DLPRVRRAWIAPSSANICEQPAMTATQLRDAIAAGADSIAQARSCDTQLFVGGEMGIGNT
CCHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHCHHHHHHHHCCCCEEEECCCCCCCCC
TSAAALACALLSQFPQAMAGAGTGLDAEGIAHKATVITRALALHADASSPLERLRRLGGF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCH
EIAALVGAYIAAAQAGIPVLVDGFITTAAALVATRLNPGVREWLLFGHRSQERGHAALLR
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHH
ALDAEPLLQLDLRLGEASGAAVAIPLLRSACALHNGMATFAEAGVSDA
HHCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCHHHHHHCCCCCC
>Mature Secondary Structure
MRSDWIFGACAVPDARMRSAALARQEQLTKPPGALGRLEHLAVQLAAWQRTERPGAQRVW
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
IAVYAADHGVAAEGVSAFPQAVTGEMVRNFARGGAAIAVLARELGARLEVVNLGVVNDPG
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCC
DLPRVRRAWIAPSSANICEQPAMTATQLRDAIAAGADSIAQARSCDTQLFVGGEMGIGNT
CCHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHCHHHHHHHHCCCCEEEECCCCCCCCC
TSAAALACALLSQFPQAMAGAGTGLDAEGIAHKATVITRALALHADASSPLERLRRLGGF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCH
EIAALVGAYIAAAQAGIPVLVDGFITTAAALVATRLNPGVREWLLFGHRSQERGHAALLR
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHH
ALDAEPLLQLDLRLGEASGAAVAIPLLRSACALHNGMATFAEAGVSDA
HHCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217