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The map label for this gene is proC [H]

Identifier: 21243653

GI number: 21243653

Start: 3433126

End: 3433980

Strand: Direct

Name: proC [H]

Synonym: XAC2926

Alternate gene names: 21243653

Gene position: 3433126-3433980 (Clockwise)

Preceding gene: 21243652

Following gene: 21243654

Centisome position: 66.33

GC content: 69.01

Gene sequence:

>855_bases
ATGAACACACCGGCTTCGTCCTCGCCCTCGTCTTCCGCTACGACGTCCATCGCCTTCGTCGGCGGCGGCAACATGGCGCG
TAGCTTGATCGCCGGGCTGATCCGGCAGGGTACGCCGGCTGCCAGCATCCGCGTAGCCGAGCCGGTGGCCGATCTGCGCG
CAGCCTTGGCGCGCGACTTCGGCGTGCAGGTGGTCGAGGATGCGCGCGCCGCTGTCGACGCGACGACGACCTGGGTCTTG
GCGGTCAAGCCTCAGGTCCTGCCAATGGTGTGCGCGCAACTGGCCGATCTCGCGCAGGCCCAACAACCGCTACTGGTTTC
CATCGCTGCCGGCATCACCGCCACGCAGCTGCAGCGCTGGTCTGGCGGAGATATCGCCGTGGTTCGTGCCATGCCCAACA
CACCCGCCCTGCTCGGCGCCGGTGTCACCGGGCTGTACGCCAACGCGCGCGTGTCCGCAGCGCAACGCCAACAGGCGACC
CAGCTACTGGACAGCGCCGGCGTCACCGTCTGGATCGACGACGAAGCGCAGATGGATGCGGTGACCGCCGTCTCCGGCAG
CGGACCGGCCTATGTCTTTCTCTTGGCCGAAGCGATGGAAGCTGCCGCGCAAGCGCAGGGCCTGCCCGCCGCAGCCGCGC
GTACGTTGGTGCTGCAAACGCTGCTCGGCGCCGCACGCATGCTCACCGAATCGGGCGAAGCACCGGAGGTCCTGCGTCGC
CGCGTGACCTCGCCCAACGGCACGACCCATGCCGCCATCGAGACGTTCCAGGCCGGCGGCTTTGAGGCCCTCACCGCCCA
GGCCATTGCCGCAGCGACCGAACGCGGCCGCAGTTTATCGGCCGCCAACGACTGA

Upstream 100 bases:

>100_bases
CGGGTGGGCACGGCGTTGTTCGGCGCGCGCGGTCAAGCGCCGGACGCCGCTGCCTGATCGCATCGCCTCCCACATCGACT
CGTCTTACCAAGGTGCTGCA

Downstream 100 bases:

>100_bases
TTGAAACGCGGCGGGTCTGCATGTCGCGCATCGCGCAGCCCCTTCGCGCGGCGCGGATGGCAAGACGGAAACGATTCGAA
CATCTGCGCAAACCGCCGCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNTPASSSPSSSATTSIAFVGGGNMARSLIAGLIRQGTPAASIRVAEPVADLRAALARDFGVQVVEDARAAVDATTTWVL
AVKPQVLPMVCAQLADLAQAQQPLLVSIAAGITATQLQRWSGGDIAVVRAMPNTPALLGAGVTGLYANARVSAAQRQQAT
QLLDSAGVTVWIDDEAQMDAVTAVSGSGPAYVFLLAEAMEAAAQAQGLPAAAARTLVLQTLLGAARMLTESGEAPEVLRR
RVTSPNGTTHAAIETFQAGGFEALTAQAIAAATERGRSLSAAND

Sequences:

>Translated_284_residues
MNTPASSSPSSSATTSIAFVGGGNMARSLIAGLIRQGTPAASIRVAEPVADLRAALARDFGVQVVEDARAAVDATTTWVL
AVKPQVLPMVCAQLADLAQAQQPLLVSIAAGITATQLQRWSGGDIAVVRAMPNTPALLGAGVTGLYANARVSAAQRQQAT
QLLDSAGVTVWIDDEAQMDAVTAVSGSGPAYVFLLAEAMEAAAQAQGLPAAAARTLVLQTLLGAARMLTESGEAPEVLRR
RVTSPNGTTHAAIETFQAGGFEALTAQAIAAATERGRSLSAAND
>Mature_284_residues
MNTPASSSPSSSATTSIAFVGGGNMARSLIAGLIRQGTPAASIRVAEPVADLRAALARDFGVQVVEDARAAVDATTTWVL
AVKPQVLPMVCAQLADLAQAQQPLLVSIAAGITATQLQRWSGGDIAVVRAMPNTPALLGAGVTGLYANARVSAAQRQQAT
QLLDSAGVTVWIDDEAQMDAVTAVSGSGPAYVFLLAEAMEAAAQAQGLPAAAARTLVLQTLLGAARMLTESGEAPEVLRR
RVTSPNGTTHAAIETFQAGGFEALTAQAIAAATERGRSLSAAND

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=279, Percent_Identity=31.8996415770609, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI24797097, Length=278, Percent_Identity=34.8920863309352, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI24797095, Length=278, Percent_Identity=34.8920863309352, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI21361454, Length=274, Percent_Identity=32.4817518248175, Blast_Score=128, Evalue=6e-30,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=37.218045112782, Blast_Score=157, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17569021, Length=264, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17540664, Length=283, Percent_Identity=28.2685512367491, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=160, Percent_Identity=35, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=36.1623616236162, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24648116, Length=274, Percent_Identity=32.4817518248175, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=38.8235294117647, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28857; Mature: 28857

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPASSSPSSSATTSIAFVGGGNMARSLIAGLIRQGTPAASIRVAEPVADLRAALARDF
CCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHH
GVQVVEDARAAVDATTTWVLAVKPQVLPMVCAQLADLAQAQQPLLVSIAAGITATQLQRW
CHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHC
SGGDIAVVRAMPNTPALLGAGVTGLYANARVSAAQRQQATQLLDSAGVTVWIDDEAQMDA
CCCCEEEEEECCCCCHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
VTAVSGSGPAYVFLLAEAMEAAAQAQGLPAAAARTLVLQTLLGAARMLTESGEAPEVLRR
EEEECCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RVTSPNGTTHAAIETFQAGGFEALTAQAIAAATERGRSLSAAND
HCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNTPASSSPSSSATTSIAFVGGGNMARSLIAGLIRQGTPAASIRVAEPVADLRAALARDF
CCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHH
GVQVVEDARAAVDATTTWVLAVKPQVLPMVCAQLADLAQAQQPLLVSIAAGITATQLQRW
CHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHC
SGGDIAVVRAMPNTPALLGAGVTGLYANARVSAAQRQQATQLLDSAGVTVWIDDEAQMDA
CCCCEEEEEECCCCCHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
VTAVSGSGPAYVFLLAEAMEAAAQAQGLPAAAARTLVLQTLLGAARMLTESGEAPEVLRR
EEEECCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RVTSPNGTTHAAIETFQAGGFEALTAQAIAAATERGRSLSAAND
HCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]