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The map label for this gene is gyaR [H]

Identifier: 21243451

GI number: 21243451

Start: 3185441

End: 3186514

Strand: Reverse

Name: gyaR [H]

Synonym: XAC2724

Alternate gene names: 21243451

Gene position: 3186514-3185441 (Counterclockwise)

Preceding gene: 21243452

Following gene: 21243450

Centisome position: 61.57

GC content: 68.62

Gene sequence:

>1074_bases
ATGTCTGACGGCCGTCGCGCCAGGGTGTGGGTCAGCCAGCCGTTGTTCGACGATGTCGTCGCGCAGCTGGGCGAGCATTT
CGAGCTGACCACCACGCAGCGCGTCAGCGCGTATTCGCCGGCCGAACTGGCCGCGCAGCTGGCACCGCTGGACGGCGCCC
TGATCACCCTCAACGAGCGCATCGGCGCGGCCGAAATCGCGGCGGCCCCGCAGTTGCGCGCCATCGCCAATGTCGGCGTG
GGCTACAACAATCTGGATCTGGATGCGCTGAGCGCGGCCGGCATCCTGGCCAGCAACACGCCCGACGTGCTCACCGAAAC
CACGGCCGACCTGGGTTTTGCGTTGCTGATGGCCACCGCGCGCCGCATCACCGAATCCGAGCGCTGGCTGCGCGACGGGC
AATGGGGGCAATGGTCGTTCAAGACCATGCTCGGTGCCGATATCCATGGCAGCACGCTCGGCATCCTGGGCATGGGCCGG
ATCGGGCAGGGCATCGCACGGCGCGGCGCGCACGGCTTCGGCATGCGCGTGCTGTATCACAACCGCAGCCAGTTGCCGGC
CGCTACCGAACAGGCGCTGGGCGCACGGTACGTGGATTTCGACACCCTACTGGCGCAGTCCGATCACCTGGTGCTGGTGT
TGCCATACACCAAGGACTCGCACCACATCGTCGACGCGGCGGCGCTGGGCAAGATGCGCGCCACCGCCACACTGGTGAAC
ATCGCGCGCGGCGGCATCGTCGATGAGCTGGCGCTGGCCGATGCGCTGGCCAACGGGCGTTTGGCTGGCGCCGGCCTGGA
TGTCTACGAGGGCGAGCCGCGCGTGCGGCCGGAGCTGCTGGCGCTCAATAACGTGGTGCTCACCCCGCATATCGGCAGCG
CCAGCCTGGCCACGCGCCGCGCGATGGTGCAACTGGCGGTGGACAACCTGATCGCTGCGCTGGGCAAGGGCCCTCGTGCC
GGCCATCCGCCGAGCGCGCTCAATGCCGCCGCGGTTGCCGCTGCCAAACGTGGCGGCACCGGCGCGGATGCGAAAAAAGC
CGGCGTCACCGGCACCATCTCGACCAAACGATAG

Upstream 100 bases:

>100_bases
GAGGCGATGATGGCGCTGGTGCTGATGGACCAGGCGCTGCGCCACCGTGCGCAGTGCGGCGATGTAGGTGAGGTGTCGCC
GCGCATTCCCGGTCAGGTCG

Downstream 100 bases:

>100_bases
GGAACCTCCGCGGCCAGCATTGGAGGTTCCCCGAACCCAGCGCGCAGTGCTTCCTCATTTCCCCTTTCGATAAAGACAAA
CTCATGAGCAACGAAAACCG

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSDGRRARVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQLAPLDGALITLNERIGAAEIAAAPQLRAIANVGV
GYNNLDLDALSAAGILASNTPDVLTETTADLGFALLMATARRITESERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGR
IGQGIARRGAHGFGMRVLYHNRSQLPAATEQALGARYVDFDTLLAQSDHLVLVLPYTKDSHHIVDAAALGKMRATATLVN
IARGGIVDELALADALANGRLAGAGLDVYEGEPRVRPELLALNNVVLTPHIGSASLATRRAMVQLAVDNLIAALGKGPRA
GHPPSALNAAAVAAAKRGGTGADAKKAGVTGTISTKR

Sequences:

>Translated_357_residues
MSDGRRARVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQLAPLDGALITLNERIGAAEIAAAPQLRAIANVGV
GYNNLDLDALSAAGILASNTPDVLTETTADLGFALLMATARRITESERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGR
IGQGIARRGAHGFGMRVLYHNRSQLPAATEQALGARYVDFDTLLAQSDHLVLVLPYTKDSHHIVDAAALGKMRATATLVN
IARGGIVDELALADALANGRLAGAGLDVYEGEPRVRPELLALNNVVLTPHIGSASLATRRAMVQLAVDNLIAALGKGPRA
GHPPSALNAAAVAAAKRGGTGADAKKAGVTGTISTKR
>Mature_356_residues
SDGRRARVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQLAPLDGALITLNERIGAAEIAAAPQLRAIANVGVG
YNNLDLDALSAAGILASNTPDVLTETTADLGFALLMATARRITESERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGRI
GQGIARRGAHGFGMRVLYHNRSQLPAATEQALGARYVDFDTLLAQSDHLVLVLPYTKDSHHIVDAAALGKMRATATLVNI
ARGGIVDELALADALANGRLAGAGLDVYEGEPRVRPELLALNNVVLTPHIGSASLATRRAMVQLAVDNLIAALGKGPRAG
HPPSALNAAAVAAAKRGGTGADAKKAGVTGTISTKR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=254, Percent_Identity=40.9448818897638, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI23308577, Length=279, Percent_Identity=32.258064516129, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI145580578, Length=242, Percent_Identity=38.4297520661157, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4557499, Length=242, Percent_Identity=38.4297520661157, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4557497, Length=253, Percent_Identity=36.7588932806324, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI61743967, Length=253, Percent_Identity=36.7588932806324, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI145580575, Length=242, Percent_Identity=38.4297520661157, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI87082289, Length=310, Percent_Identity=43.8709677419355, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1787645, Length=260, Percent_Identity=31.1538461538462, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789279, Length=297, Percent_Identity=30.6397306397306, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87081824, Length=171, Percent_Identity=33.9181286549708, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=298, Percent_Identity=28.8590604026846, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=240, Percent_Identity=28.3333333333333, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=239, Percent_Identity=37.6569037656904, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6320925, Length=313, Percent_Identity=29.3929712460064, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=307, Percent_Identity=28.6644951140065, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=272, Percent_Identity=25, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=170, Percent_Identity=32.3529411764706, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=226, Percent_Identity=26.1061946902655, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=184, Percent_Identity=27.1739130434783, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45552429, Length=322, Percent_Identity=38.8198757763975, Blast_Score=200, Evalue=9e-52,
Organism=Drosophila melanogaster, GI45551003, Length=322, Percent_Identity=38.8198757763975, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574284, Length=322, Percent_Identity=38.8198757763975, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24585514, Length=322, Percent_Identity=38.8198757763975, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574282, Length=322, Percent_Identity=38.8198757763975, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28571528, Length=310, Percent_Identity=38.3870967741935, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=42.0849420849421, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=32.4110671936759, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI19921140, Length=326, Percent_Identity=29.4478527607362, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646446, Length=268, Percent_Identity=33.2089552238806, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24646448, Length=268, Percent_Identity=33.2089552238806, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24646452, Length=268, Percent_Identity=33.2089552238806, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24646450, Length=268, Percent_Identity=33.2089552238806, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI62472511, Length=267, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37362; Mature: 37231

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDGRRARVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQLAPLDGALITLNER
CCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECC
IGAAEIAAAPQLRAIANVGVGYNNLDLDALSAAGILASNTPDVLTETTADLGFALLMATA
CCHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHH
RRITESERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGRIGQGIARRGAHGFGMRVLYH
HHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEEE
NRSQLPAATEQALGARYVDFDTLLAQSDHLVLVLPYTKDSHHIVDAAALGKMRATATLVN
CCCCCCCHHHHHHCCEEECHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHH
IARGGIVDELALADALANGRLAGAGLDVYEGEPRVRPELLALNNVVLTPHIGSASLATRR
HHCCCCHHHHHHHHHHHCCCEECCCCEEECCCCCCCHHEEEECCEEEECCCCCHHHHHHH
AMVQLAVDNLIAALGKGPRAGHPPSALNAAAVAAAKRGGTGADAKKAGVTGTISTKR
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHCCCEEEECCCC
>Mature Secondary Structure 
SDGRRARVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQLAPLDGALITLNER
CCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECC
IGAAEIAAAPQLRAIANVGVGYNNLDLDALSAAGILASNTPDVLTETTADLGFALLMATA
CCHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHH
RRITESERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGRIGQGIARRGAHGFGMRVLYH
HHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEEE
NRSQLPAATEQALGARYVDFDTLLAQSDHLVLVLPYTKDSHHIVDAAALGKMRATATLVN
CCCCCCCHHHHHHCCEEECHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHH
IARGGIVDELALADALANGRLAGAGLDVYEGEPRVRPELLALNNVVLTPHIGSASLATRR
HHCCCCHHHHHHHHHHHCCCEECCCCEEECCCCCCCHHEEEECCEEEECCCCCHHHHHHH
AMVQLAVDNLIAALGKGPRAGHPPSALNAAAVAAAKRGGTGADAKKAGVTGTISTKR
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA