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The map label for this gene is nuoN [H]

Identifier: 21243419

GI number: 21243419

Start: 3150586

End: 3152046

Strand: Reverse

Name: nuoN [H]

Synonym: XAC2691

Alternate gene names: 21243419

Gene position: 3152046-3150586 (Counterclockwise)

Preceding gene: 21243420

Following gene: 21243418

Centisome position: 60.9

GC content: 63.79

Gene sequence:

>1461_bases
ATGACCACGCCAACGCTCGCGCCGTTGACCACCGCTGACCTGGCTCCGCTCGTACCGGAGCTGGTGCTGATCGGCGGCGC
CTTCGCACTGCTGATGCTCGACCTGTTCGTGAGCCAGCGGAACAAGGTCTGGACCCACCTGTCCTCCGTTGCCGTGCTTG
CCGTGGTGCTCGTGTTGCTTGCGACCGGCACGGGCGGGCAGGGCGATATCTTCAACGGCATGTTCGTCCGCGACACGGCG
GCCGATGTCATGAAGACCGTGATCGTGCTGGTCAGCGGGCTGAGCCTGGTCTACGGCTGGACCTACCTGCGCGAGCGCAA
TCTCTACCAGGGCGAAATCCCGGTATTGGTACTGTTCGCCACCGCCGGCATGATGTTGCTGGCATCGGCCGGTAGCCTGC
TGATGGTGTATCTGGGTCTGGAGCTGCTGGCGCTGTGCTCCTACGCACTGGTCGCCTCCAACCGCGACAATGGCCTGGCC
ACCGAAGCGGCGATGAAGTATTTCGTCCTGGGCTCGCTCGCGTCGGGTCTGCTGCTGTACGGCATGTCGCTGGTCTACGG
CGCCACCGGTACGCTCAGCCTGGCCGGCATCCATGATGCGATCGAAGGCTCCAACGAGCGCACGTTGCTGCTGACCGGCA
CCATCTTCATGATCGCCGGCGTCGCCTTCAAGCTCGGTGCTGCGCCCTTCCACATGTGGCTGCCCGACGTGTATCAGGGT
GCGCCTGCACCGATCGCGTTGTTCATCAGCTCGGCGCCCAAGCTTGCAGCGTTCGGTATGGCCTATCGCCTGCTGGAAGT
CGGCATGGGTCCGTTGTCGCCGCAGTGGCATCTGCTGATCGGCGGCTTGTCGGCGGTGTCGCTGGTGGTCGGTAACCTGA
TGGCCATTGCGCAGAGCAACCTCAAGCGCATGCTCGCGTACTCGACGGTCTCGCATATCGGCTTCCTGCTGATGGGCGTG
GCTGGCGGCGGGGAAGAAGGCTACGCGGCCGCGATGTTCTATGCGGTCAGCTACACGATCATGTCCACCGCTTCGTTCGG
CGCCATCATCGCGCTGTCGCGTAACGGGTTCGAAGCGGAAAACATCGACGACTTCAAGGGACTCAACGCGCGCAATCCGT
GGATGGCTGGCCTGGTGCTGTGCATCATGGCGTCTTTGGCAGGTATCCCCCCGTTCCTCGGTTTCTGGACCAAGCTGGCG
GTGCTGGGCGCGGCAGTGAAGGGCGACATGCTGTGGCTGGCGTTGGTCGGCGTGATCTGCGCAGTGATCGGCGCGTACTA
CTACCTGCGCGTCATCAAGGTCATGTACTTCGACGAGCCGGTAGGCGAGCCGTTGCCGGCCAATAACGATCGTGTGCTGG
GTACCGTGCTCGGCGTCAATGCGCTGGCCCTGCTTGCACTTGGCCTGGCCTGGAGTCCGATCATGGTGTGGTGCCAGCGC
GCGTTCGCCGGCCTCGCGTAA

Upstream 100 bases:

>100_bases
GCTGACCGATCTGATGGAACCCTCGATCGCCAAGCTGGCAACCCAGATTGCCGCGACCAAGCTCTGACCGCTCGTACGTT
TTGATTTCCAGGATTTAATG

Downstream 100 bases:

>100_bases
GGCCTCTACGCAACGCTGGGTCTCGCAGTGCCACATCGTGTGGTTGGCATCGCACTGAAATAAACCGTGTTTACTGTTTC
GTTTTTGTTGCATTGCGGGT

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLSSVAVLAVVLVLLATGTGGQGDIFNGMFVRDTA
ADVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLFATAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGLA
TEAAMKYFVLGSLASGLLLYGMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQG
APAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQSNLKRMLAYSTVSHIGFLLMGV
AGGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEAENIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKLA
VLGAAVKGDMLWLALVGVICAVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQR
AFAGLA

Sequences:

>Translated_486_residues
MTTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLSSVAVLAVVLVLLATGTGGQGDIFNGMFVRDTA
ADVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLFATAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGLA
TEAAMKYFVLGSLASGLLLYGMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQG
APAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQSNLKRMLAYSTVSHIGFLLMGV
AGGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEAENIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKLA
VLGAAVKGDMLWLALVGVICAVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQR
AFAGLA
>Mature_485_residues
TTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLSSVAVLAVVLVLLATGTGGQGDIFNGMFVRDTAA
DVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLFATAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGLAT
EAAMKYFVLGSLASGLLLYGMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQGA
PAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQSNLKRMLAYSTVSHIGFLLMGVA
GGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEAENIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKLAV
LGAAVKGDMLWLALVGVICAVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQRA
FAGLA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=325, Percent_Identity=25.8461538461538, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI145693160, Length=475, Percent_Identity=34.3157894736842, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1788614, Length=376, Percent_Identity=28.4574468085106, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788827, Length=330, Percent_Identity=27.5757575757576, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788831, Length=327, Percent_Identity=26.2996941896024, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788829, Length=355, Percent_Identity=25.9154929577465, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788613, Length=333, Percent_Identity=26.4264264264264, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 51213; Mature: 51082

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLSSVAVLAVVLVLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATGTGGQGDIFNGMFVRDTAADVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLFA
HCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHH
TAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGLATEAAMKYFVLGSLASGLLLY
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQG
HHHHHHCCCCCEEEHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHCCHHHCC
APAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQSN
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
LKRMLAYSTVSHIGFLLMGVAGGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEAE
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
NIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKLAVLGAAVKGDMLWLALVGVIC
CCCHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFAGLA
HHHCCC
>Mature Secondary Structure 
TTPTLAPLTTADLAPLVPELVLIGGAFALLMLDLFVSQRNKVWTHLSSVAVLAVVLVLL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATGTGGQGDIFNGMFVRDTAADVMKTVIVLVSGLSLVYGWTYLRERNLYQGEIPVLVLFA
HCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHH
TAGMMLLASAGSLLMVYLGLELLALCSYALVASNRDNGLATEAAMKYFVLGSLASGLLLY
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GMSLVYGATGTLSLAGIHDAIEGSNERTLLLTGTIFMIAGVAFKLGAAPFHMWLPDVYQG
HHHHHHCCCCCEEEHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHCCHHHCC
APAPIALFISSAPKLAAFGMAYRLLEVGMGPLSPQWHLLIGGLSAVSLVVGNLMAIAQSN
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
LKRMLAYSTVSHIGFLLMGVAGGGEEGYAAAMFYAVSYTIMSTASFGAIIALSRNGFEAE
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
NIDDFKGLNARNPWMAGLVLCIMASLAGIPPFLGFWTKLAVLGAAVKGDMLWLALVGVIC
CCCHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIGAYYYLRVIKVMYFDEPVGEPLPANNDRVLGTVLGVNALALLALGLAWSPIMVWCQR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFAGLA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA