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The map label for this gene is nuoM [H]

Identifier: 21243420

GI number: 21243420

Start: 3152080

End: 3153582

Strand: Reverse

Name: nuoM [H]

Synonym: XAC2692

Alternate gene names: 21243420

Gene position: 3153582-3152080 (Counterclockwise)

Preceding gene: 21243421

Following gene: 21243419

Centisome position: 60.93

GC content: 60.94

Gene sequence:

>1503_bases
GTGTCGAACTGGCCTTTACTGTCTATCTTGATCTGGCTGCCGATTATCGGTGGCGCCCTGATCCTTGCGTTGCGCAACGC
CGAGACTGCCCGCTGGGCGTCTTTGGCGGTAGCGGTGGCGACCTTTGCGCTGAGTCTGCCGCTGCTGGGCTACGACACGG
CCAATGACGCCATGCAGTTCATCGAACTGCATGCCTGGATCCCGGCTTATAACATCGGCTACAACCTGGGCGTGGATGGC
ATCGCGGTCGCGTTGATCGTGCTGACCACGCTGGTGACGGTGCTGGCCCTGATGGGTGCCTGGCGCTCGATCGACAAGCG
CGTCAATCAGTACGTCGCTGCCTTCCTGATCCTGGAAGGTGTCACCGTTGGCATCTTCGCCGCCACCGACGCGATGTTGT
TCTACGTGTTCTTCGAAGCCATGCTGATCCCGATGTTCCTGATCATCGGTGTCTGGGGCGGCCCGCGGCGCATCTACGCG
GCGATGAAGTTCTTCCTGTATACCTTCCTTGGCTCGGTGCTGATGCTGGTGGGCCTGGTGTATCTGTATTTGAAGGGCGG
CAGCTTCCAGCTCGCCGATCTCTACGCGCTGCAGCTGACCGCCAAGGAACAGACCTGGATCTTCTTTGCGTTTCTGATCG
CCTTTGCGGTCAAGGTGCCGATGTTCCCGGTGCACACCTGGTTGCCGGACGCGCACGTCGAGGCGCCGACGGCCGGTTCG
GTGATCCTGGCGGCGATTGCGTTGAAGATCGGCGGCTACGGCTTCCTGCGCTTCAACCTGCCGATCGTGCCGGATGCGAG
TCATGAGTTCGCCTGGCTGGTCATCACGCTGTCGCTGATTGCGGTGATCTATGTCGGCCTGGTGGCGTTGGTACAGGACG
ACATGAAGAAGCTGGTGGCGTATTCGTCCATCGCGCACATGGGTTTCGTCACGCTCGGTACCTTTATCGCCTTCACTTTG
GTGCGCGAGTATGGCAGCACCGATGCTGCCCGTCTGGGCCTGCAGGGCGCGATGGTGCAGATGATTTCGCACGGTTTCGT
ATCCGGTGCGATGTTCTCATGCATCGGCGTGCTCTACGACCGCATGCATACCCGTCGCATCGCCGACTACGGCGGCGTGG
TCAACGTGATGCCGTGGTTCGCCACGTTCTCCATGTTGTTCTTCATGGCCAATGCCGGCTTGCCTGGAACGAGTGGCTTT
GTCGGCGAGTTCATGGTCATCCTGGCCAGCTTCCAGAAGCATCCGCTGGTTGCCTTCGCTGCAGCCACCACGCTGGTGAT
CACCGCGGCGTACACACTGTGGCTCTACAAGCGCGTGTTCTTCGGCGAAGTGGCCAATGCACACGTGGCCGAGCTGAAGG
ACATCAATGGCCGCGAAGCGTTCGTGCTGGGGGTGTTCGCCGCCGGCGTGCTCGCCCTGGGCCTGTATCCGAAGCCGCTG
ACCGATCTGATGGAACCCTCGATCGCCAAGCTGGCAACCCAGATTGCCGCGACCAAGCTCTGA

Upstream 100 bases:

>100_bases
GTTTCCTCTATCACTACGCCTTCGCAATGATCATCGGTTTGATCGCCTTGTTGGCGGTACTGATGCATTTCTGGCGTTGA
CCTGTACGGAATAAGAAAAC

Downstream 100 bases:

>100_bases
CCGCTCGTACGTTTTGATTTCCAGGATTTAATGATGACCACGCCAACGCTCGCGCCGTTGACCACCGCTGACCTGGCTCC
GCTCGTACCGGAGCTGGTGC

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQFIELHAWIPAYNIGYNLGVDG
IAVALIVLTTLVTVLALMGAWRSIDKRVNQYVAAFLILEGVTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYA
AMKFFLYTFLGSVLMLVGLVYLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGS
VILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVAYSSIAHMGFVTLGTFIAFTL
VREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYDRMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGF
VGEFMVILASFQKHPLVAFAAATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
TDLMEPSIAKLATQIAATKL

Sequences:

>Translated_500_residues
MSNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQFIELHAWIPAYNIGYNLGVDG
IAVALIVLTTLVTVLALMGAWRSIDKRVNQYVAAFLILEGVTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYA
AMKFFLYTFLGSVLMLVGLVYLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGS
VILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVAYSSIAHMGFVTLGTFIAFTL
VREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYDRMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGF
VGEFMVILASFQKHPLVAFAAATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
TDLMEPSIAKLATQIAATKL
>Mature_499_residues
SNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQFIELHAWIPAYNIGYNLGVDGI
AVALIVLTTLVTVLALMGAWRSIDKRVNQYVAAFLILEGVTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYAA
MKFFLYTFLGSVLMLVGLVYLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGSV
ILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVAYSSIAHMGFVTLGTFIAFTLV
REYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYDRMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGFV
GEFMVILASFQKHPLVAFAAATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPLT
DLMEPSIAKLATQIAATKL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=383, Percent_Identity=33.1592689295039, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI251831117, Length=378, Percent_Identity=24.6031746031746, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1788613, Length=508, Percent_Identity=36.8110236220472, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1788827, Length=284, Percent_Identity=26.4084507042254, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788831, Length=301, Percent_Identity=26.578073089701, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788829, Length=309, Percent_Identity=27.5080906148867, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI145693160, Length=434, Percent_Identity=23.7327188940092, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788614, Length=473, Percent_Identity=24.9471458773784, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI2367154, Length=287, Percent_Identity=25.4355400696864, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54403; Mature: 54272

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IELHAWIPAYNIGYNLGVDGIAVALIVLTTLVTVLALMGAWRSIDKRVNQYVAAFLILEG
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYAAMKFFLYTFLGSVLMLVGLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGS
HHHHCCCCEEEEHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHH
VILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVA
HHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSSIAHMGFVTLGTFIAFTLVREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGFVGEFMVILASFQKHPLVAFA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
AATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCH
TDLMEPSIAKLATQIAATKL
HHHHCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNWPLLSILIWLPIIGGALILALRNAETARWASLAVAVATFALSLPLLGYDTANDAMQF
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IELHAWIPAYNIGYNLGVDGIAVALIVLTTLVTVLALMGAWRSIDKRVNQYVAAFLILEG
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYAAMKFFLYTFLGSVLMLVGLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLYLKGGSFQLADLYALQLTAKEQTWIFFAFLIAFAVKVPMFPVHTWLPDAHVEAPTAGS
HHHHCCCCEEEEHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHH
VILAAIALKIGGYGFLRFNLPIVPDASHEFAWLVITLSLIAVIYVGLVALVQDDMKKLVA
HHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSSIAHMGFVTLGTFIAFTLVREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMHTRRIADYGGVVNVMPWFATFSMLFFMANAGLPGTSGFVGEFMVILASFQKHPLVAFA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
AATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCH
TDLMEPSIAKLATQIAATKL
HHHHCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]