Click here to switch to the map view.

The map label for this gene is purK [H]

Identifier: 21243407

GI number: 21243407

Start: 3136762

End: 3137907

Strand: Reverse

Name: purK [H]

Synonym: XAC2678

Alternate gene names: 21243407

Gene position: 3137907-3136762 (Counterclockwise)

Preceding gene: 21243408

Following gene: 21243405

Centisome position: 60.63

GC content: 66.67

Gene sequence:

>1146_bases
ATGAGCACGCTCGGCATTCTGGGTGGCGGCCAGCTGGCGCGCATGCTGGTACTTGCCGGTGCGCCGCTCGGCATACGCTT
TGCGGTCTTCGATCCGGTAGCCGATGCCTGCGCTGGCCAGGTGGCACCGCTGCAGGTTGGCGCGTTCGATGACGTGGCGA
CCCTTGCCGCATTCGCCGAGCAGGTGGATGTGATCACTTTCGATTTCGAAAACGTGCCGGCCACCAGCGCGCAGCAACTT
GCCGCCCAGGTGCCGGTGTTTCCCAGTCCGGCTGCGCTTGCGGTTGCGCAGGACCGGCTCAGCGAAAAAACCTTGTTCCG
CGAGCTCGGCATTCCGGTGCCGGAGTTTGCCGCGATCGACGACCGCGCCGGCCTGGATGCAGCGCTCGCACGGATCGGCA
CGCCCTGCGTGCTGAAGACGCGCCGCTTCGGCTACGACGGCAAGGGCCAGTTCCGTATCAAGTCGCTCGCCGATGCCGAT
GCAGCGTGGGACGCGCTGGGCGCACAGGCGGCGCACGTCGGATTGATCGTGGAAGCGTTCGTGCCGTTCCAGCGCGAGGT
CAGCGTGGTTGCAGTGCGTGGGCGCGATGGCGAATTCCGCGCCTGGCCATTGACCGAAAACTGGCATGTGGACGGTGTGC
TGTCGGCCAGCCTGGCACCGGCCAGCGTGGAGGCGGCACTCCAAGCCTCGGCCGAATCGCACGCGCGTGCCGTGGCGGAA
AAGCTCGACTACGTCGGCGTATTTGCGCTGGAGCTGTTCATGCGCGACGGTGAGTTGCTTGCCAACGAAATGGCGCCGCG
CGTGCATAACTCGGGGCATTGGACCATCGAAGGCGCCGAGACCTCGCAATTCGAAAATCATGTGCGGGCGGTCCTTGGCT
TGCCACTGGGCAGTACTGCGATGCGTGGCCACGCCTGCATGCTCAACTGGCTGGGTGCGATGCCAGACGCCAGGGCGTTT
CTGGCGGTGCCCGGTGGGCATTGGCACGACTATGGCAAGCAAGCCCGCGATGGACGCAAGGTGGGGCACGCAACGCTGCG
CGCGGAGACGGCGCAGGCGCTTGCGCTGGCAGTGAGCGACGCCGGCGCGGCGCTGCAGCGCGATGCGCAAGCCCGGCCGG
TGGTTGCGCGTTTGAACGAAGGGTGA

Upstream 100 bases:

>100_bases
CGGCCATGCTGGCGCCGGAGCAGACGCAGATCGGTCAGGCGCTGGCGCAGTTCCGCGCCAAGCAGACCGACGATGTCATG
GCCAGCGACGACCCGCGCCA

Downstream 100 bases:

>100_bases
TGGGCGCAGCATGTCGGTGGCCATGACGTGCGACGTCACGCGCCGTCTGCGAGGCAAGTCGGTGTCGGACGCGGACCCGT
CCTGCAATGTTTCAGCAGAT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSTLGILGGGQLARMLVLAGAPLGIRFAVFDPVADACAGQVAPLQVGAFDDVATLAAFAEQVDVITFDFENVPATSAQQL
AAQVPVFPSPAALAVAQDRLSEKTLFRELGIPVPEFAAIDDRAGLDAALARIGTPCVLKTRRFGYDGKGQFRIKSLADAD
AAWDALGAQAAHVGLIVEAFVPFQREVSVVAVRGRDGEFRAWPLTENWHVDGVLSASLAPASVEAALQASAESHARAVAE
KLDYVGVFALELFMRDGELLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTAMRGHACMLNWLGAMPDARAF
LAVPGGHWHDYGKQARDGRKVGHATLRAETAQALALAVSDAGAALQRDAQARPVVARLNEG

Sequences:

>Translated_381_residues
MSTLGILGGGQLARMLVLAGAPLGIRFAVFDPVADACAGQVAPLQVGAFDDVATLAAFAEQVDVITFDFENVPATSAQQL
AAQVPVFPSPAALAVAQDRLSEKTLFRELGIPVPEFAAIDDRAGLDAALARIGTPCVLKTRRFGYDGKGQFRIKSLADAD
AAWDALGAQAAHVGLIVEAFVPFQREVSVVAVRGRDGEFRAWPLTENWHVDGVLSASLAPASVEAALQASAESHARAVAE
KLDYVGVFALELFMRDGELLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTAMRGHACMLNWLGAMPDARAF
LAVPGGHWHDYGKQARDGRKVGHATLRAETAQALALAVSDAGAALQRDAQARPVVARLNEG
>Mature_380_residues
STLGILGGGQLARMLVLAGAPLGIRFAVFDPVADACAGQVAPLQVGAFDDVATLAAFAEQVDVITFDFENVPATSAQQLA
AQVPVFPSPAALAVAQDRLSEKTLFRELGIPVPEFAAIDDRAGLDAALARIGTPCVLKTRRFGYDGKGQFRIKSLADADA
AWDALGAQAAHVGLIVEAFVPFQREVSVVAVRGRDGEFRAWPLTENWHVDGVLSASLAPASVEAALQASAESHARAVAEK
LDYVGVFALELFMRDGELLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTAMRGHACMLNWLGAMPDARAFL
AVPGGHWHDYGKQARDGRKVGHATLRAETAQALALAVSDAGAALQRDAQARPVVARLNEG

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=346, Percent_Identity=38.4393063583815, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1788155, Length=307, Percent_Identity=29.3159609120521, Blast_Score=98, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324702, Length=371, Percent_Identity=33.1536388140162, Blast_Score=202, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40209; Mature: 40078

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLGILGGGQLARMLVLAGAPLGIRFAVFDPVADACAGQVAPLQVGAFDDVATLAAFAE
CCCEEECCCHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCCEEEECCCHHHHHHHHHHH
QVDVITFDFENVPATSAQQLAAQVPVFPSPAALAVAQDRLSEKTLFRELGIPVPEFAAID
HCEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
DRAGLDAALARIGTPCVLKTRRFGYDGKGQFRIKSLADADAAWDALGAQAAHVGLIVEAF
CCCCHHHHHHHCCCCEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHH
VPFQREVSVVAVRGRDGEFRAWPLTENWHVDGVLSASLAPASVEAALQASAESHARAVAE
CCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
KLDYVGVFALELFMRDGELLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTA
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHH
MRGHACMLNWLGAMPDARAFLAVPGGHWHDYGKQARDGRKVGHATLRAETAQALALAVSD
HCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECC
AGAALQRDAQARPVVARLNEG
CCHHHHCCCCCCCEEEECCCC
>Mature Secondary Structure 
STLGILGGGQLARMLVLAGAPLGIRFAVFDPVADACAGQVAPLQVGAFDDVATLAAFAE
CCEEECCCHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCCEEEECCCHHHHHHHHHHH
QVDVITFDFENVPATSAQQLAAQVPVFPSPAALAVAQDRLSEKTLFRELGIPVPEFAAID
HCEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
DRAGLDAALARIGTPCVLKTRRFGYDGKGQFRIKSLADADAAWDALGAQAAHVGLIVEAF
CCCCHHHHHHHCCCCEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHH
VPFQREVSVVAVRGRDGEFRAWPLTENWHVDGVLSASLAPASVEAALQASAESHARAVAE
CCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHH
KLDYVGVFALELFMRDGELLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTA
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHH
MRGHACMLNWLGAMPDARAFLAVPGGHWHDYGKQARDGRKVGHATLRAETAQALALAVSD
HCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECC
AGAALQRDAQARPVVARLNEG
CCHHHHCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]