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The map label for this gene is uvrB [H]

Identifier: 21243355

GI number: 21243355

Start: 3091075

End: 3093096

Strand: Reverse

Name: uvrB [H]

Synonym: XAC2625

Alternate gene names: 21243355

Gene position: 3093096-3091075 (Counterclockwise)

Preceding gene: 21243357

Following gene: 21243354

Centisome position: 59.76

GC content: 60.48

Gene sequence:

>2022_bases
ATGACCGACCGTTTTCAGCTCGTATCCCCTTATTCGCCAGCGGGCGACCAGCCTGCAGCCATCGACAAGCTGGTCGCCAA
CTTCGAGGCTGGCTTGGCCAAGCAGACCTTGTTGGGTGTAACGGGCTCGGGCAAGACCTACACCATTGCCAATGTGGTCC
AGCAGGTGCAGAGGCCGACGCTGGTGATGGCGCCGAACAAGACGTTGGCGGCGCAGCTGTACGGCGAGTTCAAGTCGTTC
TTCCCGCATAACGCAGTCGAGTACTTCGTCAGCTACTACGACTACTACCAGCCGGAGGCTTATGTGCCATCGTCTGACAC
CTTCATCGAGAAGGACAGTTCGATCAATGAACACATCGAGCAGATGCGCTTGTCGGCGACCAAGACCCTGCTGTCTCGGC
GCGATTCGCTGGTGGTGGCGACCGTGTCGGCGATCTATGGCCTTGGCGCGCCGGAGGACTACCTATCGCTGCGGCTGATC
CTGTCGGTTGGCGAGCACATCGATCAGCGCCAGTTGATCCGCCATCTCACCGATTTGCAATACACCCGCAACGAGTTCGA
ACTGACGCGTGGCGCCTTTCGCGTGCGCGGCGAGGTGTTGGATGTGTTCCCGGCCGAGTCGGATACCGAAGCCTTGCGCA
TCGAGTTGTTCGATGGCGACATCGAACAACTGACGTTGTTCGATCCGCTCACTGGCGAAACCTTGCGCAAGTTGCAGCGC
TACACCGTGTACCCGAAAACCCATTACGCCACGACGCGTGAGCGTACCTTGAGTGCGGTGGACACCATCAAGGAAGAGCT
GAAAGAGCGCCTGGAGCAACTCTACTCGCAGAACAAGCTGGTCGAGGCGCAACGCCTGGCGCAGCGCACGCAATTCGATC
TGGAAATGATGGCCGAGGTTGGGTTTTGCAACGGTATCGAAAACTACTCGCGGCATCTCACCGGCAAGGCGCCGGGAGAG
CCGCCGCCGACCTTGTTCGACTACCTGCCGCCCGACGCACTGCTGGTCATCGACGAGTCGCATGTGACGATCCCGCAGAT
CGGTGCGATGTACAAGGGCGACCGTTCGCGCAAGGAAACGCTGGTGGAGTTCGGTTTTCGGCTGCCCTCCGCACTGGACA
ACCGTCCCTTGCGTTTCGAAGAGTGGGAGGCGCGTTCGCCACGCAGCATCTACGTTTCGGCAACGCCCGGTCCTTACGAG
GTGCGCGAGTCGGCTGGCGAAGTCACGGAGCTGGTGGTGCGCCCGACCGGGTTGATCGACCCGGTCGTGGAGATCCGCCC
GGTCGGCACACAGGTCGACGACCTGATGTCCGAAGTCCACGAGCGCATCAAGCTTGGCGATCGCGTATTGGTGACCACGT
TGACCAAGCGCATGGCCGAAAACCTCACCGAGTACCTGGGCGAACACGGGATTCGGGTGCGCTACCTGCATTCGGATATC
GACACCGTCGAGCGCGTGGAAATCATTCGCGATCTGCGTCTGGGCAAGTTCGATGTACTCGTGGGCATCAATCTGCTGCG
CGAGGGTTTGGACATGCCGGAAGTCTCGCTGGTGGCGATCCTGGATGCCGACAAGGAAGGCTTCCTGCGGTCGACCGGTT
CGCTGATCCAGACCATTGGCCGTGCCGCACGCAATCTGCGCGGCAAGGCCATCCTGTATGCCGACAAGATGACGCGTTCG
ATGCAGGCGGCGATCGACGAGACCGATCGTCGCCGTGAGAAGCAGGTCGAGTACAACCTGGAACATGGCATCACTCCGAA
ATCCGTCGAGCGGCCGATCGCCGACATCATGGAAGGCGCGCGCGACGATGCGGCCGAGAAGAAGTCGGGCAAGGGCCGTT
CGAAATCACGCCATGTAGCCGAGGAGACGCCCGATTACCGTGCCATGAAGCCTGCGGAAATCGCTGGCAAGCTCAAGAGC
CTGGAGCAGAAGATGTATCAGCACGCAAAGGATCTGGAGTTCGAGGCCGCAGCCCAGATTCGCGACCAGATCCAGAAGTT
GAAAGCGGCAAGTCTGGGCTAG

Upstream 100 bases:

>100_bases
TTTCCGCGATCGGCCTAAAGCCCGTAAGAAGGTAGGGAAACCGCAAACATCGCCGTCATCCGCCATCGCTATACTTATTG
GTCGTTCGAAGGTGCGCTCC

Downstream 100 bases:

>100_bases
GGCAGGGTAGTCTTGGGGCGCGGGGAGGGCTTGTGGTCCTTAAATCCCTGCGCTAGAATGCGCGCCCTGCACAGCGCAAT
GCTAATGCAGCGAACGGGCG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MTDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQRPTLVMAPNKTLAAQLYGEFKSF
FPHNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLI
LSVGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQR
YTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEVGFCNGIENYSRHLTGKAPGE
PPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYE
VRESAGEVTELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIGRAARNLRGKAILYADKMTRS
MQAAIDETDRRREKQVEYNLEHGITPKSVERPIADIMEGARDDAAEKKSGKGRSKSRHVAEETPDYRAMKPAEIAGKLKS
LEQKMYQHAKDLEFEAAAQIRDQIQKLKAASLG

Sequences:

>Translated_673_residues
MTDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQRPTLVMAPNKTLAAQLYGEFKSF
FPHNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLI
LSVGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQR
YTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEVGFCNGIENYSRHLTGKAPGE
PPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYE
VRESAGEVTELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIGRAARNLRGKAILYADKMTRS
MQAAIDETDRRREKQVEYNLEHGITPKSVERPIADIMEGARDDAAEKKSGKGRSKSRHVAEETPDYRAMKPAEIAGKLKS
LEQKMYQHAKDLEFEAAAQIRDQIQKLKAASLG
>Mature_672_residues
TDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQRPTLVMAPNKTLAAQLYGEFKSFF
PHNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLIL
SVGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQRY
TVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEVGFCNGIENYSRHLTGKAPGEP
PPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYEV
RESAGEVTELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDID
TVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIGRAARNLRGKAILYADKMTRSM
QAAIDETDRRREKQVEYNLEHGITPKSVERPIADIMEGARDDAAEKKSGKGRSKSRHVAEETPDYRAMKPAEIAGKLKSL
EQKMYQHAKDLEFEAAAQIRDQIQKLKAASLG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=68.562874251497, Blast_Score=929, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=309, Percent_Identity=21.3592233009709, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76006; Mature: 75875

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQRPT
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHHHCCCE
LVMAPNKTLAAQLYGEFKSFFPHNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIE
EEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLILSVGEHIDQRQLIRHLTDLQ
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQR
HHHHHHHHHHHHHHHCCHHHEECCCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHH
YTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEV
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
GFCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKET
HHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHH
LVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYEVRESAGEVTELVVRPTGLID
HHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
PVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDI
CCHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCH
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLRGKAILYADKMTRSMQAAIDETDRRREKQVEYNLEHGITPKSVERPIADIMEGA
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
RDDAAEKKSGKGRSKSRHVAEETPDYRAMKPAEIAGKLKSLEQKMYQHAKDLEFEAAAQI
CCHHHHHCCCCCCCHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RDQIQKLKAASLG
HHHHHHHHHHCCC
>Mature Secondary Structure 
TDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQVQRPT
CCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHHHCCCE
LVMAPNKTLAAQLYGEFKSFFPHNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIE
EEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLSLRLILSVGEHIDQRQLIRHLTDLQ
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIELFDGDIEQLTLFDPLTGETLRKLQR
HHHHHHHHHHHHHHHCCHHHEECCCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHH
YTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYSQNKLVEAQRLAQRTQFDLEMMAEV
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
GFCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKET
HHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHH
LVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATPGPYEVRESAGEVTELVVRPTGLID
HHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
PVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTKRMAENLTEYLGEHGIRVRYLHSDI
CCHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCH
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLRGKAILYADKMTRSMQAAIDETDRRREKQVEYNLEHGITPKSVERPIADIMEGA
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
RDDAAEKKSGKGRSKSRHVAEETPDYRAMKPAEIAGKLKSLEQKMYQHAKDLEFEAAAQI
CCHHHHHCCCCCCCHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RDQIQKLKAASLG
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA