Click here to switch to the map view.

The map label for this gene is coaD

Identifier: 21243259

GI number: 21243259

Start: 2959239

End: 2959745

Strand: Reverse

Name: coaD

Synonym: XAC2526

Alternate gene names: 21243259

Gene position: 2959745-2959239 (Counterclockwise)

Preceding gene: 21243260

Following gene: 21243258

Centisome position: 57.19

GC content: 66.47

Gene sequence:

>507_bases
ATGAGCGTTGCCAATAGCCGCACCGCCGTCTATCCCGGTACCTTCGACCCGATCACCAATGGGCATATCGACCTGGTGAA
TCGCGCCGCGCCGTTGTTCGAGCGGGTGGTGGTGGGCGTGGCGTACAGCCCCTCCAAGGGCCCGGCGTTGTCGCTGGAGC
GCCGCGTGGCGCTGGCCCAGGAAGCGCTGGCGGCGCATGCCAATGTGGAAGTGCGCGGCTTCGATACCTTGCTGGCGCAT
TTCGTGCGCGAGATGGGCGCCGGCGTGCTGCTGCGCGGCCTGCGCGCAGTGTCCGACTTCGAATACGAATTCCAGATGGC
CAGCATGAACCGCCATCTGATCCCGGAGGTGGAAACGCTGTTTCTCACCCCGGCCGAGCAATACAGCTTCATCTCGTCCT
CGCTGGTGCGCGAAATCGCGCGGCTGGGCGGGGATGTGTCCGGCTTCGTGCCGGCATCGGTTGTCGAGGCCTTGCGGCAG
GTGCGGCAGTCCCGCGCGCAGGCCTGA

Upstream 100 bases:

>100_bases
GGCACCTGCACCGCGAGGGCGCCACCCGTGAGGTGCGCTATGCGCTGTACCGCCGGGCCGCTGCTACACTGAAGAGCGAT
CCGACCCCGGTAGTCTCCGT

Downstream 100 bases:

>100_bases
TCATCTGCAGTTACATCACCACACGCATTTCAAAGGGAGGAGTTTCATGAAACACACCATGCGCGCTCTGGCGCTCGCTT
CGATCGCCGCTCTGGCGGTC

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MSVANSRTAVYPGTFDPITNGHIDLVNRAAPLFERVVVGVAYSPSKGPALSLERRVALAQEALAAHANVEVRGFDTLLAH
FVREMGAGVLLRGLRAVSDFEYEFQMASMNRHLIPEVETLFLTPAEQYSFISSSLVREIARLGGDVSGFVPASVVEALRQ
VRQSRAQA

Sequences:

>Translated_168_residues
MSVANSRTAVYPGTFDPITNGHIDLVNRAAPLFERVVVGVAYSPSKGPALSLERRVALAQEALAAHANVEVRGFDTLLAH
FVREMGAGVLLRGLRAVSDFEYEFQMASMNRHLIPEVETLFLTPAEQYSFISSSLVREIARLGGDVSGFVPASVVEALRQ
VRQSRAQA
>Mature_167_residues
SVANSRTAVYPGTFDPITNGHIDLVNRAAPLFERVVVGVAYSPSKGPALSLERRVALAQEALAAHANVEVRGFDTLLAHF
VREMGAGVLLRGLRAVSDFEYEFQMASMNRHLIPEVETLFLTPAEQYSFISSSLVREIARLGGDVSGFVPASVVEALRQV
RQSRAQA

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG0669

COG function: function code H; Phosphopantetheine adenylyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial CoaD family

Homologues:

Organism=Escherichia coli, GI1790065, Length=152, Percent_Identity=60.5263157894737, Blast_Score=200, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_XANAC (Q8PJK5)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642841.1
- ProteinModelPortal:   Q8PJK5
- SMR:   Q8PJK5
- GeneID:   1156597
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2526
- NMPDR:   fig|190486.1.peg.2485
- HOGENOM:   HBG288308
- OMA:   VRQIAAM
- ProtClustDB:   PRK00168
- BioCyc:   XAXO190486:XAC2526-MONOMER
- BRENDA:   2.7.7.3
- GO:   GO:0005737
- HAMAP:   MF_00151
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR001980
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01020
- TIGRFAMs:   TIGR01510
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 18270; Mature: 18139

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVANSRTAVYPGTFDPITNGHIDLVNRAAPLFERVVVGVAYSPSKGPALSLERRVALAQ
CCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
EALAAHANVEVRGFDTLLAHFVREMGAGVLLRGLRAVSDFEYEFQMASMNRHLIPEVETL
HHHHHHCCCEECHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHE
FLTPAEQYSFISSSLVREIARLGGDVSGFVPASVVEALRQVRQSRAQA
EECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVANSRTAVYPGTFDPITNGHIDLVNRAAPLFERVVVGVAYSPSKGPALSLERRVALAQ
CCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
EALAAHANVEVRGFDTLLAHFVREMGAGVLLRGLRAVSDFEYEFQMASMNRHLIPEVETL
HHHHHHCCCEECHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHE
FLTPAEQYSFISSSLVREIARLGGDVSGFVPASVVEALRQVRQSRAQA
EECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217