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The map label for this gene is fruA [H]

Identifier: 21243236

GI number: 21243236

Start: 2927995

End: 2929737

Strand: Direct

Name: fruA [H]

Synonym: XAC2503

Alternate gene names: 21243236

Gene position: 2927995-2929737 (Clockwise)

Preceding gene: 21243235

Following gene: 21243237

Centisome position: 56.57

GC content: 70.34

Gene sequence:

>1743_bases
ATGTCCTCTTCCATCGTGGTCATCGCCGCTGGCGAACGCAGTACCGAAGCCGTGCTGGCGGCCGAAGCGCTGCGCCGCGC
GGCCACTGCCGCCGGCCGTCGCGTGACGATCGAAATCCGCAGCGACCAGGGCGTACTCGGCGCCTTGCCGGGCGAACTCG
CCAGCGGTGCCGCCCAGGTCCTGGTGGTCGGCGACGCCGATGCCGACACCACTCGCTTTGGCGATGCGCAACTGGTGCGC
CTGAGCCTGGGCGCGGTGCTGGACGACCCGGCCGCTGCGATCGGCAAGCTGGCCGCCCACGCCGACCCGGCCGTCGCCGG
CAGTCCCGGTGGCGCCGCCAGCGACAGCAAGCGCATCGTCGCCATCACCTCCTGCCCTACCGGCATCGCGCACACCTTCA
TGGCCGCCGAAGGCCTGCAGCAGGCCGCCAAGAAGCTCGGCTACCAGATGCGGGTGGAAACCCAGGGCTCGGTGGGTGCG
CAGGACGCGCTCACCGACGATGAAATCCGTGCGGCAGACGTGGTCATCATCGCGGCCGACCGCGAGGTCGACCTGGCCCG
CTTCGGCGGCAAGCGCGTGTTCAAGAGCGGCACCAAGCCGGCGATCAACGATGGCCCGGCGCTGATCAACAAGGCCCTGG
CCGAGGCCAGCGTGCAGGGCGGCGCCATGCCCGCCACCGGCAGCGCTGCCAGCGCCGCGGGGAACAAGGGCAATGGCCGC
ACCGGCGCCTACAAGCACCTGATGACCGGCGTCTCGTTCATGCTGCCGTTCGTGACTGCCGGCGGCCTGCTGATTGCGCT
GGCCTTTGCGCTGGGCGGCATCTACGCCGGCGACGATGCGCACCAGGGCACGTTGGCCTGGTCGCTGTTCCAGATCGGCG
CCAAGGCCGGCTTCACCCTGATGGTGCCGGCCCTGGCCGGTTACATCGCCTACTCCATCGCCGACCGCCCCGGCATCGCG
CCCGGCATGATCGGCGGCCTGGTGGCGGCCAATCTCAATGCCGGTTTCCTCGGCGGGATCATTGCCGGTTTCATCGCCGG
CTACGGCGTGGCTGCGCTCAACCGCTACGTCCGCCTGCCGCGCAACCTGGAAGGCCTCAAGCCGGTGCTGATCCTGCCGG
TGCTGGGCACCCTGCTGGTCGGGCTGGCGATGATGTACGTGTTCGGCCAGCCGGTGGCCGACCTGCTGGCCTGGCTCACC
GCCTGGCTGCGCGGCATGCAGGGCAGCAGCGCGTTGCTGCTGGGCCTGCTGCTCGGCGGCATGATGGCCTTCGACATGGG
CGGGCCGGTCAACAAGGCGGCCTATGCGTTTTCCACCGGCCTGATCGCCAGCCAGGTCTATACCCCGATGGCCGCTGCCA
TGGTGGCCGGCATGACCCCGCCGCTGGGCATCGCGCTGGCGACCTGGGTGTTCCGCAACCGCTTCACCGCCGAAGAACGC
GGCTCGGCCACTGCCGCCGGCGTGCTCGGGCTGGCCTTCGTCACCGAAGGCGCCATCCCGTACGCTGCGCGCGACCCATT
GCGCACCATCCCGGCGCTGGTGATCGGCTCGGCCGTGGCCGGCGCCATCTCGATGACCGCCGGTGCCGAATTGAAGGCGC
CGCATGGCGGCATCTTCGTGCTGCTGATCCCCAACGCCGTCACCCACCTGCTCAACTACGTGCTGGCCCTGGCGGTCGGC
GTCGTGGTCACGGCCATCGCGCTGCGCCTGCTCAAGAAACCGGTGACCGACGTCGTCGCCTGA

Upstream 100 bases:

>100_bases
GTTGCAGACAGCGGCAGATCGCGCGCATCACCGCCACGCATAACGCTTGAAATTCCCCCGCCGACAACACCGGCGACCGC
AACACAGCAGGAGTTTTGCC

Downstream 100 bases:

>100_bases
TCCAGCAACGGCGGCACGGACCTGCCGCCGCACCTGACGCGCCCGAGTGTTCCCGCGCGCCCCTGACCTGCTTCACCGCT
GCGCTGCGCCCCCAGGTGCG

Product: PTS system fructose-specific transporter subunit IIBC

Products: NA

Alternate protein names: EIIBC-Fru; EII-Fru; Fructose-specific phosphotransferase enzyme IIB component; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSSSIVVIAAGERSTEAVLAAEALRRAATAAGRRVTIEIRSDQGVLGALPGELASGAAQVLVVGDADADTTRFGDAQLVR
LSLGAVLDDPAAAIGKLAAHADPAVAGSPGGAASDSKRIVAITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVGA
QDALTDDEIRAADVVIIAADREVDLARFGGKRVFKSGTKPAINDGPALINKALAEASVQGGAMPATGSAASAAGNKGNGR
TGAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTLMVPALAGYIAYSIADRPGIA
PGMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYVRLPRNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLT
AWLRGMQGSSALLLGLLLGGMMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTAEER
GSATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFVLLIPNAVTHLLNYVLALAVG
VVVTAIALRLLKKPVTDVVA

Sequences:

>Translated_580_residues
MSSSIVVIAAGERSTEAVLAAEALRRAATAAGRRVTIEIRSDQGVLGALPGELASGAAQVLVVGDADADTTRFGDAQLVR
LSLGAVLDDPAAAIGKLAAHADPAVAGSPGGAASDSKRIVAITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVGA
QDALTDDEIRAADVVIIAADREVDLARFGGKRVFKSGTKPAINDGPALINKALAEASVQGGAMPATGSAASAAGNKGNGR
TGAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTLMVPALAGYIAYSIADRPGIA
PGMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYVRLPRNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLT
AWLRGMQGSSALLLGLLLGGMMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTAEER
GSATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFVLLIPNAVTHLLNYVLALAVG
VVVTAIALRLLKKPVTDVVA
>Mature_579_residues
SSSIVVIAAGERSTEAVLAAEALRRAATAAGRRVTIEIRSDQGVLGALPGELASGAAQVLVVGDADADTTRFGDAQLVRL
SLGAVLDDPAAAIGKLAAHADPAVAGSPGGAASDSKRIVAITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVGAQ
DALTDDEIRAADVVIIAADREVDLARFGGKRVFKSGTKPAINDGPALINKALAEASVQGGAMPATGSAASAAGNKGNGRT
GAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTLMVPALAGYIAYSIADRPGIAP
GMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYVRLPRNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLTA
WLRGMQGSSALLLGLLLGGMMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTAEERG
SATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFVLLIPNAVTHLLNYVLALAVGV
VVTAIALRLLKKPVTDVVA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=554, Percent_Identity=48.5559566787004, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI1786951, Length=504, Percent_Identity=36.9047619047619, Blast_Score=279, Evalue=4e-76,
Organism=Escherichia coli, GI87082348, Length=472, Percent_Identity=36.228813559322, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1790386, Length=297, Percent_Identity=47.8114478114478, Blast_Score=242, Evalue=6e-65,
Organism=Escherichia coli, GI1788729, Length=404, Percent_Identity=27.2277227722772, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790387, Length=95, Percent_Identity=41.0526315789474, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788730, Length=98, Percent_Identity=38.7755102040816, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 58569; Mature: 58438

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSIVVIAAGERSTEAVLAAEALRRAATAAGRRVTIEIRSDQGVLGALPGELASGAAQV
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCHHCCCCEEE
LVVGDADADTTRFGDAQLVRLSLGAVLDDPAAAIGKLAAHADPAVAGSPGGAASDSKRIV
EEEECCCCCCCCCCCHHEEEEHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
AITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVGAQDALTDDEIRAADVVIIAAD
EEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECC
REVDLARFGGKRVFKSGTKPAINDGPALINKALAEASVQGGAMPATGSAASAAGNKGNGR
CCCHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCC
TGAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHCCCEE
MVPALAGYIAYSIADRPGIAPGMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYVRLP
EHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLTAWLRGMQGSSALLLGLLLGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTAEER
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHC
GSATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFV
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEE
LLIPNAVTHLLNYVLALAVGVVVTAIALRLLKKPVTDVVA
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSSIVVIAAGERSTEAVLAAEALRRAATAAGRRVTIEIRSDQGVLGALPGELASGAAQV
CCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCHHCCCCEEE
LVVGDADADTTRFGDAQLVRLSLGAVLDDPAAAIGKLAAHADPAVAGSPGGAASDSKRIV
EEEECCCCCCCCCCCHHEEEEHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
AITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVGAQDALTDDEIRAADVVIIAAD
EEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECC
REVDLARFGGKRVFKSGTKPAINDGPALINKALAEASVQGGAMPATGSAASAAGNKGNGR
CCCHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCC
TGAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHCCCEE
MVPALAGYIAYSIADRPGIAPGMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYVRLP
EHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLTAWLRGMQGSSALLLGLLLGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTAEER
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHC
GSATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFV
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEE
LLIPNAVTHLLNYVLALAVGVVVTAIALRLLKKPVTDVVA
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1655739; 12024217; 1650911 [H]