Click here to switch to the map view.

The map label for this gene is glnA [H]

Identifier: 21243211

GI number: 21243211

Start: 2885439

End: 2886824

Strand: Reverse

Name: glnA [H]

Synonym: XAC2478

Alternate gene names: 21243211

Gene position: 2886824-2885439 (Counterclockwise)

Preceding gene: 21243212

Following gene: 21243210

Centisome position: 55.78

GC content: 63.85

Gene sequence:

>1386_bases
ATGTCCATCCGCACACGTTCGCGCAAGACCACGTCCACGCAGCCGGAGAGCGCGCTGCGCCGCTGGCTCAAGGAGCGCAG
CATCACCGAGGTGGAATGCCTGGTGCCGGACATCACCGGCAACGCCCGCGGCAAGATCATTCCCGCCGACAAGTTCTCGC
ACGATTACGGCACGCGCCTGCCGGAAGGCATCTTCGCCACTACCGTGACCGGCGATTTCCCGGACGACTACTACGCGCTG
ACCTCGCCATCGGATTCGGACATGCATCTGCGCCCGGACGCCAGCACCGTGCGCATGGTGCCGTGGGCGGCAGACCCCAC
TGCGCAGGTCATCCACGACTGCTATACCAAGGATGGCCAGCCGCACGAACTTGCCCCGCGCAACGTGCTGCGCCGCGTGC
TGGATGCCTATGCCCAGGCCGAGCTGCAACCGGTGGTGGCGCCAGAGCTGGAATTCTTCCTGGTGCAGAAAAACACCGAC
CCCGACTTCCCGCTGTTGCCGCCGGCCGGGCGCTCGGGGCGGCCGGAAACGGCGCGGCAGTCGTACTCGATCGACGCAGT
CAACGAGTTCGACCCCATCCTGGACCTGATGTACGACTATTGCGATGCGATGGAACTGGACGTGGACACGCTGATCCACG
AATCCGGCGCCGCGCAGTTGGAAGTCAACTTCACCCATGCCGACCCGATGTCGCGCGCGGACCAGGTGTTCCTGTTCAAG
CGCACCATGCGCGAAGCCGCGCTGCGGCACGGTGTGTATGCCACGTTCCTGGCCAAGCCAATGGAAACCGAGCCAGGCAG
TGCGATGCATATCCACCAGAGCCTGCTGCATGCCGGCACCGGCAAGAACGTGTTCAGCGGCAAGCGCGAGGGCGGTTTCA
GCGATACCTTCGCGCATTATCTGGGTGGCCTGCAGAAATACATCCCGATGGCGATGGGCCTGCTGGCGCCCAACGTCAAT
TCTTACCGGCGGTTGATGTTCGGCGAGGTGTCGCCGAGCAATGTGCTGTGGGGCTTCGACAACCGCACCTGCGGGCTGCG
CGTGCCCATCGATGTGCCGCAGAACATGCGGGTGGAAAGCCGCTTCGCCGGCTCAGACGCCAACCCGTATCTGGCCATGG
CCGCGACGCTGGCCTGCGGGTTATTGGGGATCGGCGAAAAGCTCGAGCCGACCGCGCCGATCAGCAGCAATGGCAAGGAG
CAAGGCTACGATTTGCCGCGCTCGCTGGGCGAGGCGCTAGATGAGCTGGAAGGCTGCCAGGCGTTGCAGGAGATGTTGGG
GCGGCGGTTCGTGCGTGCGTACATCTCGGTGAAGCGAAAAGAGTACGAGACGTTTTTCCGGGTCATCAGTTCGTGGGAAC
GGGAGTTCCTGCTGTTGAATGTGTGA

Upstream 100 bases:

>100_bases
GGAATGGCGTGTCACACAGCATCCGTTCTACCGTGCCATCTTTCAGGCCTTCGGCGAGGCCTGTCGCCAATACGCCGCGC
GACGCGGCAAGTGAGGTTGC

Downstream 100 bases:

>100_bases
GCTGCGTGATTGAGACCCGTGCCGAGCGGTTTCCTTCTCCCGTCGGGAGAAGGTGCCCGAAGGGCGGATGAGGGCGACTT
TGGCGGCAGTTGAAGTTCTC

Product: glutamine synthetase

Products: NA

Alternate protein names: Gamma-Glu-Put synthetase; Glutamate--putrescine ligase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSIRTRSRKTTSTQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRLPEGIFATTVTGDFPDDYYAL
TSPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQPHELAPRNVLRRVLDAYAQAELQPVVAPELEFFLVQKNTD
PDFPLLPPAGRSGRPETARQSYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFK
RTMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHYLGGLQKYIPMAMGLLAPNVN
SYRRLMFGEVSPSNVLWGFDNRTCGLRVPIDVPQNMRVESRFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKE
QGYDLPRSLGEALDELEGCQALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV

Sequences:

>Translated_461_residues
MSIRTRSRKTTSTQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRLPEGIFATTVTGDFPDDYYAL
TSPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQPHELAPRNVLRRVLDAYAQAELQPVVAPELEFFLVQKNTD
PDFPLLPPAGRSGRPETARQSYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFK
RTMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHYLGGLQKYIPMAMGLLAPNVN
SYRRLMFGEVSPSNVLWGFDNRTCGLRVPIDVPQNMRVESRFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKE
QGYDLPRSLGEALDELEGCQALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV
>Mature_460_residues
SIRTRSRKTTSTQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRLPEGIFATTVTGDFPDDYYALT
SPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQPHELAPRNVLRRVLDAYAQAELQPVVAPELEFFLVQKNTDP
DFPLLPPAGRSGRPETARQSYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFKR
TMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHYLGGLQKYIPMAMGLLAPNVNS
YRRLMFGEVSPSNVLWGFDNRTCGLRVPIDVPQNMRVESRFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKEQ
GYDLPRSLGEALDELEGCQALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV

Specific function: Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine [H]

COG id: COG0174

COG function: function code E; Glutamine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamine synthetase family [H]

Homologues:

Organism=Homo sapiens, GI221307485, Length=443, Percent_Identity=26.410835214447, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI87081870, Length=450, Percent_Identity=36.2222222222222, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1790301, Length=461, Percent_Identity=28.8503253796095, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008147
- InterPro:   IPR014746
- InterPro:   IPR008146 [H]

Pfam domain/function: PF00120 Gln-synt_C [H]

EC number: =6.3.1.11 [H]

Molecular weight: Translated: 51496; Mature: 51365

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00181 GLNA_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRTRSRKTTSTQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRL
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEECCCCCCCHHCCCC
PEGIFATTVTGDFPDDYYALTSPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQ
CCCEEEEEEECCCCCCCEEECCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHCCCCC
PHELAPRNVLRRVLDAYAQAELQPVVAPELEFFLVQKNTDPDFPLLPPAGRSGRPETARQ
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHH
SYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFK
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHH
RTMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHY
HHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LGGLQKYIPMAMGLLAPNVNSYRRLMFGEVSPSNVLWGFDNRTCGLRVPIDVPQNMRVES
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCHH
RFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKEQGYDLPRSLGEALDELEGCQ
HCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure 
SIRTRSRKTTSTQPESALRRWLKERSITEVECLVPDITGNARGKIIPADKFSHDYGTRL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEECCCCCCCHHCCCC
PEGIFATTVTGDFPDDYYALTSPSDSDMHLRPDASTVRMVPWAADPTAQVIHDCYTKDGQ
CCCEEEEEEECCCCCCCEEECCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHCCCCC
PHELAPRNVLRRVLDAYAQAELQPVVAPELEFFLVQKNTDPDFPLLPPAGRSGRPETARQ
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHH
SYSIDAVNEFDPILDLMYDYCDAMELDVDTLIHESGAAQLEVNFTHADPMSRADQVFLFK
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHH
RTMREAALRHGVYATFLAKPMETEPGSAMHIHQSLLHAGTGKNVFSGKREGGFSDTFAHY
HHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LGGLQKYIPMAMGLLAPNVNSYRRLMFGEVSPSNVLWGFDNRTCGLRVPIDVPQNMRVES
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCHH
RFAGSDANPYLAMAATLACGLLGIGEKLEPTAPISSNGKEQGYDLPRSLGEALDELEGCQ
HCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ALQEMLGRRFVRAYISVKRKEYETFFRVISSWEREFLLLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]