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The map label for this gene is mtaD [H]

Identifier: 21243112

GI number: 21243112

Start: 2771334

End: 2772683

Strand: Reverse

Name: mtaD [H]

Synonym: XAC2378

Alternate gene names: 21243112

Gene position: 2772683-2771334 (Counterclockwise)

Preceding gene: 77748651

Following gene: 21243111

Centisome position: 53.57

GC content: 65.56

Gene sequence:

>1350_bases
ATGGATCCACTCATGACCAATGCCCCGCCCGAACCCTGCGACCTGCTGATTGAGGCCGGCTATGTCGTGCCGATCGAACC
GCATGCGGTGGTGCTGGAAGACCACGCGGTGGCCGTCAGTCACGGCGTCATCGTTGCCGTGCTGCCGATTGCCGACGCGA
GCGCGCGTTTTGCGCCCAAGCAGACCGTGTCGCGGCCCGATGCTGCGTTGATGCCCGGCCTGGTCAATGCGCATACGCAT
AATCCGATGACGCTGCTGCGCGGCGTCGCCGACGACCTGCCGCTGATGGTGTGGTTGCAGCAGCACATCTGGCCGGTGGA
AGCGGCGGTGATCGGGCCGGAATTCGTAGCTGATGGCACCACGCTGGCAATTGCCGAAATGCTGCGCGGCGGTACGACCT
GCGTCAACGAAAACTACTTCTTCGCCGATGTGCAGGCGGCCGTCTACAAGCAGCATGGTTTCCGCGCGCTGGTGGGCGCG
GTGATCATCGATTTCCCGACTGCATGGGCATCGTCGGACGATGAATACTTCGCGCGTGCCGGCGAGTTGCACGACCAATG
GCGCGACGATCCGTTGATCAGTACCGCGTTCGCCCCGCATGCGCCGTACACCGTCAACGATGCCAACTTCGAACGCGTGC
GCATGCTGGCCGACCAGCTCGACATCCCCGTGCATCTGCATACGCACGAAACCGCGCAGGAAGTGGCCGATTCGATCAAG
CAGTACGGCCAGCGCCCGCTGGCGCGGCTGGATCGCCTGGGCCTGGTCAACGACCGCCTGATCGCGGTGCACATGACCCA
GCTCACCGATGCGGAAATCCATCTGTGCGCCGAGCGCGGCGTCAGCGTGGTGCATTGCCCCGAATCCAATCTCAAGCTCG
CCTCGGGTTTTTGCCCGGCATGCGCGCTGCAGCGCGCGGGCGTGAATCTGGCCATCGGCACCGACGGCTGCGCCAGCAAC
AACGACCTGGACATGTTCAGCGAGAACCGGACCGCCGCGATCCTGGCCAAGGCCGTGGCCAACGATGCGACCGCGCTGGA
TGCGGCCACCACCTTGCGCGCGGCCACCCTGGGCGGCGCGCGCGCCTTGGGCTTGGGCGACACCATCGGTTCGATCGAGG
TCGGCAAGCAGGCCGACCTGGTCTGCGTGGACCTGTCTGCACTGGAAACCCAGCCGCTGCACCATGTGTTGTCGCAGTTG
ATCTACGCGGCCGGCCGCCATCAGGTCACCGATGTGTGGATCGCCGGCAAGCCCAAACTGGTGCAGCGCGAGCTCATCGA
CATGGATACCGCCGCCCTGGTCGCCAACGCGCGGCAATGGCGCGAACGCATCCGCACCGTCCGCGCCTGA

Upstream 100 bases:

>100_bases
AGCGCACGCACCGCCAGCGCCAGCTGCTGCGCTACGACGGCACGCGGTATGTGCCTGTGTCACGCTCCGACGACTCCTGG
CCGTTCGGCAACTAACTTCA

Downstream 100 bases:

>100_bases
GCGCGCGTTACCGCATCACGGAGCCCCCCGCATGAATTCGAATACGCACGCCAAATCCAGCAATTTCCATCAGAGCGAGC
TGGATAAATTCGCCGCACTG

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSHGVIVAVLPIADASARFAPKQTVSRPDAALMPGLVNAHTH
NPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGA
VIIDFPTAWASSDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDIPVHLHTHETAQEVADSIK
QYGQRPLARLDRLGLVNDRLIAVHMTQLTDAEIHLCAERGVSVVHCPESNLKLASGFCPACALQRAGVNLAIGTDGCASN
NDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGARALGLGDTIGSIEVGKQADLVCVDLSALETQPLHHVLSQL
IYAAGRHQVTDVWIAGKPKLVQRELIDMDTAALVANARQWRERIRTVRA

Sequences:

>Translated_449_residues
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSHGVIVAVLPIADASARFAPKQTVSRPDAALMPGLVNAHTH
NPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGA
VIIDFPTAWASSDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDIPVHLHTHETAQEVADSIK
QYGQRPLARLDRLGLVNDRLIAVHMTQLTDAEIHLCAERGVSVVHCPESNLKLASGFCPACALQRAGVNLAIGTDGCASN
NDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGARALGLGDTIGSIEVGKQADLVCVDLSALETQPLHHVLSQL
IYAAGRHQVTDVWIAGKPKLVQRELIDMDTAALVANARQWRERIRTVRA
>Mature_449_residues
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSHGVIVAVLPIADASARFAPKQTVSRPDAALMPGLVNAHTH
NPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGA
VIIDFPTAWASSDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDIPVHLHTHETAQEVADSIK
QYGQRPLARLDRLGLVNDRLIAVHMTQLTDAEIHLCAERGVSVVHCPESNLKLASGFCPACALQRAGVNLAIGTDGCASN
NDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGARALGLGDTIGSIEVGKQADLVCVDLSALETQPLHHVLSQL
IYAAGRHQVTDVWIAGKPKLVQRELIDMDTAALVANARQWRERIRTVRA

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=443, Percent_Identity=25.7336343115124, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1789249, Length=337, Percent_Identity=27.0029673590504, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI87082177, Length=451, Percent_Identity=23.9467849223947, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540282, Length=389, Percent_Identity=23.3933161953728, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319963, Length=344, Percent_Identity=26.7441860465116, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24643849, Length=381, Percent_Identity=26.509186351706, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48415; Mature: 48415

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSHGVIVAVLPIADASARFAPK
CCCCCCCCCCCCHHHHEECCEEEECCCCEEEEECCEEEEECCEEEEEEECCCCCCCCCCH
QTVSRPDAALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGT
HHCCCCCHHHCCCHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHEEECCHHHCCCH
TLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGAVIIDFPTAWASSDDEYFARA
HHHHHHHHCCCCEEECCCEEEEHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
GELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDIPVHLHTHETAQEVADSIK
HHHHHHHCCCCCEEECCCCCCCEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHH
QYGQRPLARLDRLGLVNDRLIAVHMTQLTDAEIHLCAERGVSVVHCPESNLKLASGFCPA
HHCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHEEEHHCCCEEEECCCCCCEECCCCCHH
CALQRAGVNLAIGTDGCASNNDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGA
HHHHHCCCEEEECCCCCCCCCCCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RALGLGDTIGSIEVGKQADLVCVDLSALETQPLHHVLSQLIYAAGRHQVTDVWIAGKPKL
EEECCCCCCCCEECCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHH
VQRELIDMDTAALVANARQWRERIRTVRA
HHHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDPLMTNAPPEPCDLLIEAGYVVPIEPHAVVLEDHAVAVSHGVIVAVLPIADASARFAPK
CCCCCCCCCCCCHHHHEECCEEEECCCCEEEEECCEEEEECCEEEEEEECCCCCCCCCCH
QTVSRPDAALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGT
HHCCCCCHHHCCCHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHEEECCHHHCCCH
TLAIAEMLRGGTTCVNENYFFADVQAAVYKQHGFRALVGAVIIDFPTAWASSDDEYFARA
HHHHHHHHCCCCEEECCCEEEEHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
GELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDIPVHLHTHETAQEVADSIK
HHHHHHHCCCCCEEECCCCCCCEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHH
QYGQRPLARLDRLGLVNDRLIAVHMTQLTDAEIHLCAERGVSVVHCPESNLKLASGFCPA
HHCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHEEEHHCCCEEEECCCCCCEECCCCCHH
CALQRAGVNLAIGTDGCASNNDLDMFSENRTAAILAKAVANDATALDAATTLRAATLGGA
HHHHHCCCEEEECCCCCCCCCCCCHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RALGLGDTIGSIEVGKQADLVCVDLSALETQPLHHVLSQLIYAAGRHQVTDVWIAGKPKL
EEECCCCCCCCEECCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHH
VQRELIDMDTAALVANARQWRERIRTVRA
HHHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA