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The map label for this gene is ubiG

Identifier: 21243111

GI number: 21243111

Start: 2770583

End: 2771302

Strand: Reverse

Name: ubiG

Synonym: XAC2377

Alternate gene names: 21243111

Gene position: 2771302-2770583 (Counterclockwise)

Preceding gene: 21243112

Following gene: 21243110

Centisome position: 53.55

GC content: 64.44

Gene sequence:

>720_bases
ATGAATTCGAATACGCACGCCAAATCCAGCAATTTCCATCAGAGCGAGCTGGATAAATTCGCCGCACTGGCCAACCGCTG
GTGGGATGCCGATGGCCCGCAGAAGCCGCTGCATGCGCTCAATCCCGTGCGTCTGGAGTATGTGTCCGCGCGGCTGGAAC
CTGCCGGTGCGCGCGTGCTCGACGTCGGCTGCGGTGGCGGCTTGCTCAGCGAGTCGATGGCGCGCCTGGGCGCGCAGGTG
ACTGCCATCGACCTGGCGCCGGAACTGGTCAAGGTGGCGCGTCTGCACAGCCTGGAATCGGGCGTGCAGGTCGACTATCG
CGTGCAATCGGTGGAAGACCTGGCCGCCGAACAGGCCGGCAGTTTCGATGCGGTGACCTGCATGGAAATGCTCGAACACG
TGCCGGATCCGACCGCGATCATCCGTGCCTGCGCCAGCCTGCTCAAGCCGGGCGGCAAGCTGTTCCTGTCCACGCTCAAT
CGCACCCCGGCCGCGTTCGCGCTGGCGGTGGTGGGCGCCGAATACATCGCGCGTCTGCTGCCCAAGGGCACGCATCATTA
CAAGGATTTCATCAAGCCGGCCGAGCTTGCGGCATGGTTGCGCAACGCCGGGCTGCAGCTCGAAGACGTCAGCGGCATGC
TGTACGAGCCGTGGCGTAATCGCGCCCGCCTGTCTTCGCGTACCGAGGTGAATTACCTGGCGTATGCGGTGAAACCGTGA

Upstream 100 bases:

>100_bases
ATGGATACCGCCGCCCTGGTCGCCAACGCGCGGCAATGGCGCGAACGCATCCGCACCGTCCGCGCCTGAGCGCGCGTTAC
CGCATCACGGAGCCCCCCGC

Downstream 100 bases:

>100_bases
GCAGCCGGGGTTCGAAATTCGGGATTTGGGATTCGCAACGGCCGTTGGTTGGGGTCTTGATGATCTCGGTGGCGTGCCGG
GCGCTACGCAATTGACGACA

Product: 3-demethylubiquinone-9 3-methyltransferase

Products: NA

Alternate protein names: 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; DHHB methyltransferase

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MNSNTHAKSSNFHQSELDKFAALANRWWDADGPQKPLHALNPVRLEYVSARLEPAGARVLDVGCGGGLLSESMARLGAQV
TAIDLAPELVKVARLHSLESGVQVDYRVQSVEDLAAEQAGSFDAVTCMEMLEHVPDPTAIIRACASLLKPGGKLFLSTLN
RTPAAFALAVVGAEYIARLLPKGTHHYKDFIKPAELAAWLRNAGLQLEDVSGMLYEPWRNRARLSSRTEVNYLAYAVKP

Sequences:

>Translated_239_residues
MNSNTHAKSSNFHQSELDKFAALANRWWDADGPQKPLHALNPVRLEYVSARLEPAGARVLDVGCGGGLLSESMARLGAQV
TAIDLAPELVKVARLHSLESGVQVDYRVQSVEDLAAEQAGSFDAVTCMEMLEHVPDPTAIIRACASLLKPGGKLFLSTLN
RTPAAFALAVVGAEYIARLLPKGTHHYKDFIKPAELAAWLRNAGLQLEDVSGMLYEPWRNRARLSSRTEVNYLAYAVKP
>Mature_239_residues
MNSNTHAKSSNFHQSELDKFAALANRWWDADGPQKPLHALNPVRLEYVSARLEPAGARVLDVGCGGGLLSESMARLGAQV
TAIDLAPELVKVARLHSLESGVQVDYRVQSVEDLAAEQAGSFDAVTCMEMLEHVPDPTAIIRACASLLKPGGKLFLSTLN
RTPAAFALAVVGAEYIARLLPKGTHHYKDFIKPAELAAWLRNAGLQLEDVSGMLYEPWRNRARLSSRTEVNYLAYAVKP

Specific function: Ubiquinone biosynthesis. [C]

COG id: COG2227

COG function: function code H; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiG/COQ3 family

Homologues:

Organism=Homo sapiens, GI118600965, Length=237, Percent_Identity=41.7721518987342, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI1788564, Length=237, Percent_Identity=52.3206751054852, Blast_Score=267, Evalue=6e-73,
Organism=Escherichia coli, GI1787151, Length=175, Percent_Identity=29.1428571428571, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115533050, Length=236, Percent_Identity=34.7457627118644, Blast_Score=134, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324476, Length=271, Percent_Identity=32.4723247232472, Blast_Score=152, Evalue=5e-38,
Organism=Drosophila melanogaster, GI281365311, Length=244, Percent_Identity=35.655737704918, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24585589, Length=265, Percent_Identity=32.8301886792453, Blast_Score=148, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIG_XANAC (Q8PK00)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642693.1
- ProteinModelPortal:   Q8PK00
- SMR:   Q8PK00
- GeneID:   1156448
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2377
- NMPDR:   fig|190486.1.peg.2337
- HOGENOM:   HBG738842
- OMA:   DHAEIAK
- ProtClustDB:   PRK05134
- BioCyc:   XAXO190486:XAC2377-MONOMER
- BRENDA:   2.1.1.64
- HAMAP:   MF_00472
- InterPro:   IPR013216
- InterPro:   IPR010233
- TIGRFAMs:   TIGR01983

Pfam domain/function: PF08241 Methyltransf_11

EC number: =2.1.1.64

Molecular weight: Translated: 26060; Mature: 26060

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNTHAKSSNFHQSELDKFAALANRWWDADGPQKPLHALNPVRLEYVSARLEPAGARVL
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHCCCCCCEEE
DVGCGGGLLSESMARLGAQVTAIDLAPELVKVARLHSLESGVQVDYRVQSVEDLAAEQAG
EECCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCC
SFDAVTCMEMLEHVPDPTAIIRACASLLKPGGKLFLSTLNRTPAAFALAVVGAEYIARLL
CCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PKGTHHYKDFIKPAELAAWLRNAGLQLEDVSGMLYEPWRNRARLSSRTEVNYLAYAVKP
CCCCHHHHHHCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCEEEEEEEECC
>Mature Secondary Structure
MNSNTHAKSSNFHQSELDKFAALANRWWDADGPQKPLHALNPVRLEYVSARLEPAGARVL
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHCCCCCCEEE
DVGCGGGLLSESMARLGAQVTAIDLAPELVKVARLHSLESGVQVDYRVQSVEDLAAEQAG
EECCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCC
SFDAVTCMEMLEHVPDPTAIIRACASLLKPGGKLFLSTLNRTPAAFALAVVGAEYIARLL
CCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PKGTHHYKDFIKPAELAAWLRNAGLQLEDVSGMLYEPWRNRARLSSRTEVNYLAYAVKP
CCCCHHHHHHCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217