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The map label for this gene is argH [H]

Identifier: 21243079

GI number: 21243079

Start: 2740066

End: 2741409

Strand: Reverse

Name: argH [H]

Synonym: XAC2345

Alternate gene names: 21243079

Gene position: 2741409-2740066 (Counterclockwise)

Preceding gene: 21243080

Following gene: 21243078

Centisome position: 52.97

GC content: 65.25

Gene sequence:

>1344_bases
ATGTGCGGGGATCGAAACTGGACGACTTACTCGAGACGCTTTCCGATGACCAATCTGTTGTGGCAAAAACCTGGCGTTGC
CGTGGACGCCAAGATCCAGAGTTTCCTTGCCGGCGACGATGTGATCCTGGATCGCGAATTCTTCCTGTACGACATCGCCG
CCAGCAAGGCGCATGCGCAGGGGCTGCAGCATATCGGCATCTTGTCGTTGCAGGAGCTGGGTGGCTTGAGTGAGCAGCTC
GATCTGCTGGCGGCCGACTTCCGCAGCGGCGCATTCGTGCTCGATGCGCAATACGAGGATTGCCACTCGGCCATCGAAGC
GCGATTGACCGAGCGTCTGGGCGATGCAGGCCGCAAGATCCACACCGGCCGCAGCCGTAACGACCAGATTCTGGTCGCCA
CCCGCTTGTGGTTGAAGGACAAGCTGCAGCGCGTGGCCACGCTCAGCGCGGAGATCGCCGAGGTGGCGTTGGAGCGCGCA
CAGGCCGAGGCCGAGCTGCCAGTGCCGGGCTACACGCACATCCAGCGTGCGGTGGTGTCGTCGGCCGGCATGTGGTGGGC
GGGCTGGGCGGAAGCCTTCATCGACAATGCCGTGCGCGCCGGTGACACCGTCCACTTGGTCGACAGCAATCCGCTCGGCA
CGGCCGCGGGCTATGGCGTGAATCTGCCGCTGGATCGTGCGCATACCACCGCCGAACTGGGGTTTGCACGCCTGTTGGTC
TCGCCGATCTATGCCCAGCTTTCGCGCGGCAAATACGAACTGGCCGCGCTCGAAGCGCTGGGCAGCGCCACGCTGGATCT
GCGCCGCATCGCCTGGGATCTGTCGCTGTTCACCAGCGGCGAATTCGCGTTTGTCGCTTTGCCGGCGCAATACACCACCG
GCAGTTCGATCATGCCGAACAAGCGCAACCCGGACGTGATCGAGCTGATGCGCGCAACGCATGCCAGCGTGGCGGCAGCG
CGCACCGAGATCGAACAGCTGCTGTCGCTGCCGTCGGGTTATCACCGCGATCTTCAAAGTAGCAAGGGCGCGATCGTGCA
CGGCTTTGGCCGCGGACTTGCGGCGCTGGAACTGTTGCCGGCCTTGTTGGCCAATCTGGAATGGCGCCCCGATAAACTGC
GCGCAGCCATCGATTCGGGTATGTACGCCACCGACGTGGCAGTGGAAGCCGCCGTGGCCGGCGTGCCGTTCCGCGAGGCC
TACAAGGCGGCAGCGCAAGCCTCCGAGACCGCAGGGCAGGGACGCACGCCGGAAGGCAGCCTGGCTGCGCGCGTCTCGCC
CGGTGCGGCAGCCGACCTGCAGCTGGATGTGCTGCAGGCGCGCTGGCAGGCGCTGCGCGCATGA

Upstream 100 bases:

>100_bases
CCCTGTGCAGGGATTTAACGATGCGAGTCCCTCGCAACAGCCCGCACATCCCTGTGCAGGGATTTAACGATGCGGGTCCC
TCGCAACAGCCCGCACATCC

Downstream 100 bases:

>100_bases
CGACCCGTTACCTGGTGCTTGCGCTGCGCAAGCCGGGGTTTCCCGCCGATGTGGTGCAGCCGCATCTGGACTTTCTCGAT
GCGTTGCGCGCCGCCGGGCA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MCGDRNWTTYSRRFPMTNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLQELGGLSEQL
DLLAADFRSGAFVLDAQYEDCHSAIEARLTERLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVATLSAEIAEVALERA
QAEAELPVPGYTHIQRAVVSSAGMWWAGWAEAFIDNAVRAGDTVHLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLV
SPIYAQLSRGKYELAALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAA
RTEIEQLLSLPSGYHRDLQSSKGAIVHGFGRGLAALELLPALLANLEWRPDKLRAAIDSGMYATDVAVEAAVAGVPFREA
YKAAAQASETAGQGRTPEGSLAARVSPGAAADLQLDVLQARWQALRA

Sequences:

>Translated_447_residues
MCGDRNWTTYSRRFPMTNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLQELGGLSEQL
DLLAADFRSGAFVLDAQYEDCHSAIEARLTERLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVATLSAEIAEVALERA
QAEAELPVPGYTHIQRAVVSSAGMWWAGWAEAFIDNAVRAGDTVHLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLV
SPIYAQLSRGKYELAALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAA
RTEIEQLLSLPSGYHRDLQSSKGAIVHGFGRGLAALELLPALLANLEWRPDKLRAAIDSGMYATDVAVEAAVAGVPFREA
YKAAAQASETAGQGRTPEGSLAARVSPGAAADLQLDVLQARWQALRA
>Mature_447_residues
MCGDRNWTTYSRRFPMTNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLQELGGLSEQL
DLLAADFRSGAFVLDAQYEDCHSAIEARLTERLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVATLSAEIAEVALERA
QAEAELPVPGYTHIQRAVVSSAGMWWAGWAEAFIDNAVRAGDTVHLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLV
SPIYAQLSRGKYELAALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAA
RTEIEQLLSLPSGYHRDLQSSKGAIVHGFGRGLAALELLPALLANLEWRPDKLRAAIDSGMYATDVAVEAAVAGVPFREA
YKAAAQASETAGQGRTPEGSLAARVSPGAAADLQLDVLQARWQALRA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=393, Percent_Identity=34.6055979643766, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI68303542, Length=393, Percent_Identity=34.6055979643766, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI68303549, Length=393, Percent_Identity=34.3511450381679, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI68303547, Length=392, Percent_Identity=33.1632653061224, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1790398, Length=396, Percent_Identity=32.3232323232323, Blast_Score=195, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6321806, Length=372, Percent_Identity=31.1827956989247, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI221473854, Length=396, Percent_Identity=31.3131313131313, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI78706858, Length=396, Percent_Identity=31.3131313131313, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 48265; Mature: 48265

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGDRNWTTYSRRFPMTNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQ
CCCCCCCCCHHCCCCCHHHHHCCCCCEEHHHHHHHHCCCCEEECCCEEEEEHHHHHHHHH
GLQHIGILSLQELGGLSEQLDLLAADFRSGAFVLDAQYEDCHSAIEARLTERLGDAGRKI
HHHHHHHEEHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEE
HTGRSRNDQILVATRLWLKDKLQRVATLSAEIAEVALERAQAEAELPVPGYTHIQRAVVS
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
SAGMWWAGWAEAFIDNAVRAGDTVHLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLV
HCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SPIYAQLSRGKYELAALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPN
HHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCCCC
KRNPDVIELMRATHASVAAARTEIEQLLSLPSGYHRDLQSSKGAIVHGFGRGLAALELLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHH
ALLANLEWRPDKLRAAIDSGMYATDVAVEAAVAGVPFREAYKAAAQASETAGQGRTPEGS
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC
LAARVSPGAAADLQLDVLQARWQALRA
EEEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MCGDRNWTTYSRRFPMTNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQ
CCCCCCCCCHHCCCCCHHHHHCCCCCEEHHHHHHHHCCCCEEECCCEEEEEHHHHHHHHH
GLQHIGILSLQELGGLSEQLDLLAADFRSGAFVLDAQYEDCHSAIEARLTERLGDAGRKI
HHHHHHHEEHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEE
HTGRSRNDQILVATRLWLKDKLQRVATLSAEIAEVALERAQAEAELPVPGYTHIQRAVVS
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
SAGMWWAGWAEAFIDNAVRAGDTVHLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLV
HCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SPIYAQLSRGKYELAALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPN
HHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCCCC
KRNPDVIELMRATHASVAAARTEIEQLLSLPSGYHRDLQSSKGAIVHGFGRGLAALELLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHH
ALLANLEWRPDKLRAAIDSGMYATDVAVEAAVAGVPFREAYKAAAQASETAGQGRTPEGS
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC
LAARVSPGAAADLQLDVLQARWQALRA
EEEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]