Click here to switch to the map view.

The map label for this gene is cysG [H]

Identifier: 21242894

GI number: 21242894

Start: 2529415

End: 2530392

Strand: Direct

Name: cysG [H]

Synonym: XAC2159

Alternate gene names: 21242894

Gene position: 2529415-2530392 (Clockwise)

Preceding gene: 21242887

Following gene: 21242902

Centisome position: 48.87

GC content: 70.25

Gene sequence:

>978_bases
ATGCCGTTGTTCCCGTTGTTCGCCAACCTGCAGGGGCGCGCCGTGCTGGTCATCGGTGGCGGCGAAGTCGCCACACGCAA
GGTGCTGGCGCTGCTCAAGGCGCAGGCGCACATCCGGCTGTATGCGCACGCGCTTTCGCCCGAACTTGCCCAGCTGCTGC
AGGCCGGGCGCTTTGAACAGATGACAGGCGAGTTCGATCCTGGCTGGATCGACACCGTGTGGCTGGTCGTCGCGGCCACC
GACGATGTGGAGCTGAATCAACGTGTCGCCGCAGCGGCCGGCGCGCGCCAGCGCCTGGTCAATGTCGTGGACGATGCCGA
GCTCTCCACCTACCAGGTACCGGCCATTGTCGACCGCGATCCGCTGGTGGTTGCGATTTCGTCGGCAGGCGCGGCGCCGA
TGCTGGCGCGCCGACTGCGCGAGCGACTGGAGCGCGAACTGCATGCGTCGGTCGGTACGCTGGCGGCCTTGTTCGCCCAG
CACCGCGAGCGCATTCGTCAGCAGTTGCCGGACATGAACCGGCGGCGCCGCTGGTTCGATCAGGTGATCGACGGCCAGGT
GCCGCAATTGCTGCAGGCCGGCGATACCGCCGCCGCCGAAGCCGCCTTTGCCGCCGCGCTGGAGGCGGTGGACAGCGTTC
CGGCGCGCGGCAGCGTGCAATGGGTTGGTGCCGGCCCGGGCGATCCGGGCCTGCTTACGCTCAACGCCTTGCGCGCCCTG
AACCTGGCCGACGTGCTGCTGCTGGCGACGGACGTGCCCACCGCGGTGGTGGAACTGGCGCGCCGGGACGCGCAACGGCG
CGCCTGGCCGCAGACGCTGGGCGCGCAGCAGGCCGTCGTAGTGGAGTTGGTCGGCGCCGGTCTGCAGGTTGTGGTCCTGC
GCATGGGCAGCGGCGATGCCATCCCGGCGGAGCTGGAAGCCGCCCTGCACGCGCAGGGCATCCTGTCAGTGGGGGTGCCG
GGGTTGCCGCTCCGCTAG

Upstream 100 bases:

>100_bases
GTTGACCAGCAAAACACGCATTGACGGCAGCGAGGCATGGACGTGGCCCGATGGGGCCATGCAACATGCTGCTGCGAGCC
ATCTTTTCGGAGTGTGTCCG

Downstream 100 bases:

>100_bases
GTTTTGCCAAGCGCGTTGCCGGGTTCGCACACGGCCATGTCTGCCTGATGGTGACAGTCGTTGCTGTTCGCTGCGCTTCG
CAGACTTGGTCGAGATCTTG

Product: siroheme synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MPLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLLQAGRFEQMTGEFDPGWIDTVWLVVAAT
DDVELNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRDPLVVAISSAGAAPMLARRLRERLERELHASVGTLAALFAQ
HRERIRQQLPDMNRRRRWFDQVIDGQVPQLLQAGDTAAAEAAFAAALEAVDSVPARGSVQWVGAGPGDPGLLTLNALRAL
NLADVLLLATDVPTAVVELARRDAQRRAWPQTLGAQQAVVVELVGAGLQVVVLRMGSGDAIPAELEAALHAQGILSVGVP
GLPLR

Sequences:

>Translated_325_residues
MPLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLLQAGRFEQMTGEFDPGWIDTVWLVVAAT
DDVELNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRDPLVVAISSAGAAPMLARRLRERLERELHASVGTLAALFAQ
HRERIRQQLPDMNRRRRWFDQVIDGQVPQLLQAGDTAAAEAAFAAALEAVDSVPARGSVQWVGAGPGDPGLLTLNALRAL
NLADVLLLATDVPTAVVELARRDAQRRAWPQTLGAQQAVVVELVGAGLQVVVLRMGSGDAIPAELEAALHAQGILSVGVP
GLPLR
>Mature_324_residues
PLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLLQAGRFEQMTGEFDPGWIDTVWLVVAATD
DVELNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRDPLVVAISSAGAAPMLARRLRERLERELHASVGTLAALFAQH
RERIRQQLPDMNRRRRWFDQVIDGQVPQLLQAGDTAAAEAAFAAALEAVDSVPARGSVQWVGAGPGDPGLLTLNALRALN
LADVLLLATDVPTAVVELARRDAQRRAWPQTLGAQQAVVVELVGAGLQVVVLRMGSGDAIPAELEAALHAQGILSVGVPG
LPLR

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=335, Percent_Identity=38.2089552238806, Blast_Score=188, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 34664; Mature: 34533

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLLQAGRFEQ
CCCCCCHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHH
MTGEFDPGWIDTVWLVVAATDDVELNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRD
HCCCCCCCHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEECCC
PLVVAISSAGAAPMLARRLRERLERELHASVGTLAALFAQHRERIRQQLPDMNRRRRWFD
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QVIDGQVPQLLQAGDTAAAEAAFAAALEAVDSVPARGSVQWVGAGPGDPGLLTLNALRAL
HHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEHHHHHHH
NLADVLLLATDVPTAVVELARRDAQRRAWPQTLGAQQAVVVELVGAGLQVVVLRMGSGDA
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCEEEEEEEECCCCC
IPAELEAALHAQGILSVGVPGLPLR
CHHHHHHHHHHCCHHHCCCCCCCCC
>Mature Secondary Structure 
PLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLLQAGRFEQ
CCCCCHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHH
MTGEFDPGWIDTVWLVVAATDDVELNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRD
HCCCCCCCHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEECCC
PLVVAISSAGAAPMLARRLRERLERELHASVGTLAALFAQHRERIRQQLPDMNRRRRWFD
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QVIDGQVPQLLQAGDTAAAEAAFAAALEAVDSVPARGSVQWVGAGPGDPGLLTLNALRAL
HHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEHHHHHHH
NLADVLLLATDVPTAVVELARRDAQRRAWPQTLGAQQAVVVELVGAGLQVVVLRMGSGDA
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCEEEEEEEECCCCC
IPAELEAALHAQGILSVGVPGLPLR
CHHHHHHHHHHCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA