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The map label for this gene is lytS [H]

Identifier: 21242877

GI number: 21242877

Start: 2497050

End: 2498060

Strand: Reverse

Name: lytS [H]

Synonym: XAC2142

Alternate gene names: 21242877

Gene position: 2498060-2497050 (Counterclockwise)

Preceding gene: 21242878

Following gene: 21242876

Centisome position: 48.27

GC content: 63.7

Gene sequence:

>1011_bases
ATGCAGACGTTGGGCTGGTCGCTGTTCCTGGCGATTGCCTACGTGGCTCGGCCCAGCGAGGACGCGGTGCCCGATGGGCT
GCAGTTGGCCGCAGTGGCTGGCTTTAGCGTGGGCGGGTTGTTGGGCAGCCTGCTGCTGCGCCGGCTCTATCGAACGCTGC
AAGCCGATGGCTATGGCCAAGTGCGTTGGCTGGGCCTGTTGCTGGTTGCCAGCCTGCTGGCGGCGCTGGGCGTGGATGTG
TCGGTCCACAGCGTGCTGCTGGGCTTGCGCGGATTCTCGCCGGGGTGGATGGCGCTGTCCGAGGCGCAGCCGATGATCTC
GGGCACGGCCTTGCTATGGCCGGCCTACATCGCCTGGAGCCTGCTGTACCTGTCGATCAGCAGACAGACGCGGCTAGCCG
AAGCGACCCGCCACCAGAACGATCTGCGGCTGGCGCTCAAGGAGGCGCAGTTGCAACGTCTGCTCGGCCATATCAGCCCG
CATTTCACCTTCAACACGCTCAACAATATTCGAGCGCTCATCCTCATCGATCCAGCGCTGGCACGCGAACAGATCACCCG
CTTTGCCGGCACGCTGCGCTACCAGTTCACCGGCGGCGAAGAAGCCCTGGTGAGCGTGGACGAAGAAATGGGGGTCGTGC
GCGACTACCTGGGCTTGGTCGGCATGCAACTCGGCAAGCGCCTGCGCTATGCCGAACAAGTGGACGCAGCCGCATTGCTG
CGACGGGTGCCACGATTCTGTGTGCAACTGCTGGTGGAAAACGCGATCAAGCACGGCCTGGGACTCAGCAGCAGCGTTGG
CGACCTGCAGGTAGGCATTGCGGTGCAAGATGATGCGCTGCATCTCCGTGTGCGTAACAGCGGGCGATTGCAAGCCGGCT
GCAGCGGAGGCACGGGTCTTGCGAATCTGCGGCAACGCCTGCGGCTCTCGTTCGGATCACGTGCCGGTCTGGAATTACAT
GAAGAAGGCACGTGGGTGGTGGCACATGTATGGATTGGAGAAGGCGCGTGA

Upstream 100 bases:

>100_bases
CAGCGGCAATGCGTCGCTGGCATGCCGGACAGAGATGAGGCCGCGTGACAGAGACAAGGAAAGACCCGGCATGCGTGGAG
TAGGGCCCATGTTCTGGCTG

Downstream 100 bases:

>100_bases
TTGAAGCGGTGATCGTGGAAGATTCTGAGCTGGCCCGCTTCGAACTGGAGCACCAGCTCAAGGGCTACCCGCAGCTGCGT
GTGCTGGGCCACGCCGATGA

Product: two-component system sensor protein

Products: NA

Alternate protein names: Autolysin sensor kinase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MQTLGWSLFLAIAYVARPSEDAVPDGLQLAAVAGFSVGGLLGSLLLRRLYRTLQADGYGQVRWLGLLLVASLLAALGVDV
SVHSVLLGLRGFSPGWMALSEAQPMISGTALLWPAYIAWSLLYLSISRQTRLAEATRHQNDLRLALKEAQLQRLLGHISP
HFTFNTLNNIRALILIDPALAREQITRFAGTLRYQFTGGEEALVSVDEEMGVVRDYLGLVGMQLGKRLRYAEQVDAAALL
RRVPRFCVQLLVENAIKHGLGLSSSVGDLQVGIAVQDDALHLRVRNSGRLQAGCSGGTGLANLRQRLRLSFGSRAGLELH
EEGTWVVAHVWIGEGA

Sequences:

>Translated_336_residues
MQTLGWSLFLAIAYVARPSEDAVPDGLQLAAVAGFSVGGLLGSLLLRRLYRTLQADGYGQVRWLGLLLVASLLAALGVDV
SVHSVLLGLRGFSPGWMALSEAQPMISGTALLWPAYIAWSLLYLSISRQTRLAEATRHQNDLRLALKEAQLQRLLGHISP
HFTFNTLNNIRALILIDPALAREQITRFAGTLRYQFTGGEEALVSVDEEMGVVRDYLGLVGMQLGKRLRYAEQVDAAALL
RRVPRFCVQLLVENAIKHGLGLSSSVGDLQVGIAVQDDALHLRVRNSGRLQAGCSGGTGLANLRQRLRLSFGSRAGLELH
EEGTWVVAHVWIGEGA
>Mature_336_residues
MQTLGWSLFLAIAYVARPSEDAVPDGLQLAAVAGFSVGGLLGSLLLRRLYRTLQADGYGQVRWLGLLLVASLLAALGVDV
SVHSVLLGLRGFSPGWMALSEAQPMISGTALLWPAYIAWSLLYLSISRQTRLAEATRHQNDLRLALKEAQLQRLLGHISP
HFTFNTLNNIRALILIDPALAREQITRFAGTLRYQFTGGEEALVSVDEEMGVVRDYLGLVGMQLGKRLRYAEQVDAAALL
RRVPRFCVQLLVENAIKHGLGLSSSVGDLQVGIAVQDDALHLRVRNSGRLQAGCSGGTGLANLRQRLRLSFGSRAGLELH
EEGTWVVAHVWIGEGA

Specific function: Member of the two-component regulatory system lytR/lytS that regulates genes involved in autolysis and cell wall metabolism. Regulates the activity of the cell wall-associated murein hydrolase through regulation of lrgA and lrgB [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=216, Percent_Identity=27.3148148148148, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788446, Length=181, Percent_Identity=28.1767955801105, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 36520; Mature: 36520

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLGWSLFLAIAYVARPSEDAVPDGLQLAAVAGFSVGGLLGSLLLRRLYRTLQADGYGQ
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCH
VRWLGLLLVASLLAALGVDVSVHSVLLGLRGFSPGWMALSEAQPMISGTALLWPAYIAWS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHCCCCHHCCHHHHHHHHHHHH
LLYLSISRQTRLAEATRHQNDLRLALKEAQLQRLLGHISPHFTFNTLNNIRALILIDPAL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECHHH
AREQITRFAGTLRYQFTGGEEALVSVDEEMGVVRDYLGLVGMQLGKRLRYAEQVDAAALL
HHHHHHHHHHHEEEEEECCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVPRFCVQLLVENAIKHGLGLSSSVGDLQVGIAVQDDALHLRVRNSGRLQAGCSGGTGL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEECCCCCEEECCCCCCCH
ANLRQRLRLSFGSRAGLELHEEGTWVVAHVWIGEGA
HHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCC
>Mature Secondary Structure
MQTLGWSLFLAIAYVARPSEDAVPDGLQLAAVAGFSVGGLLGSLLLRRLYRTLQADGYGQ
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCH
VRWLGLLLVASLLAALGVDVSVHSVLLGLRGFSPGWMALSEAQPMISGTALLWPAYIAWS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHCCCCHHCCHHHHHHHHHHHH
LLYLSISRQTRLAEATRHQNDLRLALKEAQLQRLLGHISPHFTFNTLNNIRALILIDPAL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECHHH
AREQITRFAGTLRYQFTGGEEALVSVDEEMGVVRDYLGLVGMQLGKRLRYAEQVDAAALL
HHHHHHHHHHHEEEEEECCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVPRFCVQLLVENAIKHGLGLSSSVGDLQVGIAVQDDALHLRVRNSGRLQAGCSGGTGL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEECCCCCEEECCCCCCCH
ANLRQRLRLSFGSRAGLELHEEGTWVVAHVWIGEGA
HHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA